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성낙창,박현석,이성식,이용희,이종팔,윤태경 한국환경과학회 2004 한국환경과학회지 Vol.13 No.1
The effect of ozone on the formation and the removal of disinfection byproducts(DBPs) of chlorination process was studied to elucidate the performance of water treatment process. The samples of raw water, prechlorination process, and preozonation process were analyzed quantitatively according to the Standard Methods for the Examination of drinking water. As a result, most of total trihalomethanes(THMs) which were formed in prechlorine treatment process was not removed in the preozonation process. Most of haloacetic acids(HAAs), haloacetonitriles(HANs), and chloral hydrate(CH) was removed in sedimentation and biological activated carbon(BAC) filtration processes. However, DBPs were increased more or less by postchlorine step. In particular, the formation of THMs and HAAs depends on ozone more than chlorine, but, the formation of HANs and CH depends on chlorine more than ozone. The seasonal variation of DBPs concentration for the year needs to be investigated to study the temperature effect because DBPs strongly depend on temperature among various efficient factors.
김종부,신명국,성낙환,최문정,김경주,이동석 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.A
This experiment was done to investigate the leaching and adsorption properties of heavy metals on porphyry. The comparison with respect to the leachability of heavy metals from porphyry between the Korea Standard Leaching Test (KSLT) and the Toxicity Characteristic Leaching Procedure (TCLP) was carried out. The fractional composition of leachate and the total concentration of heavy metal of porphyry were studied through Sequential Extraction Procedure (SEP) and EPA Method 3050. Adsorption experiment of porphyry has pointed out that the optimum dosage of porphyry for 50ppm Pb was over 10g/L, the effective particle size for absorption was below 200 mesh and the optimum pH was about 7. From the Freundlich' adsorption equation, l/n was 1.0722, and k was 0.0041. After adsorption, the fractional composition of Pb was changed. The exchangeable, carbonate, reducible fractions were increased, and the organic fraction was not changed, and the residual fraction was decreased.
Mycobacterium mageritense에 의한 당뇨병성 족부 감염증 1예
김충종,김낙현,김문석,김계형,전재현,박문석,박경운,박완범,박상원,김홍빈,김남중,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6
Diabetic foot infection is one of the important complications in patients with advanced diabetes mellitus. Limb threatening infections such as osteomyelitis, abscess, and necrotizing fasciitis are frequently accompanied by the disease. Non-tuberculous mycobacterium (NTM) is a rare causative organism of diabetic foot infection. Thus, if one is not suspicious or meticulous, infection due to NTM will be easily overlooked and this will result in delayed diagnose and treat. Therefore, it is necessary to consider NTM as the causative organism if the wound does not respond to the conventional antibiotic treatment and the culture from the adequately obtained specimen reveals atypical acid-fast bacilli. We present a case of diabetic foot infection with osteomyelitis and abscess due to Mycobacterium mageritense, one of the rapid growing mycobacteria, that was successfully treated with surgical debridement and appropriate antibiotic treatment.
이성식,성낙창,이종팔,박현석,정미은,이상준,윤태경 한국환경과학회 2004 한국환경과학회지 Vol.13 No.3
We have been proposed model equation which is able to predict the trihalomethane producing concentration formation, that is one of byproduct, in the water treatment processes. In proposed model, the effects of trihalomethane factors like chlorine contact time, pH, temperature, TOC and UV-254 are considered. The concentration of the trihalomethane produced is proportion to the contact with chlorine, pH of water, temperature of water TOC and UV-254, respectively. This proposed model could be predicted the formed concentration of trihalomethanes by trihalomethane factors.
이성식,박영민,이종팔,성낙창,박현석 동아대학교 기초과학연구소 2003 基礎科學硏究論文集 Vol.20 No.1
낙동강 상수 원수의 정수 처리시 염소소독시 생성 부산물의 평균농도는 THMs는 16.0~17.4mg/L 그리고 HAAs는 19.9~25.5mg/L의 범위이다. HAAs는 활성탄에 쉽게 흡착처리 되며 Freudlich 흡착등온식 모델에 따른다. 생성 THMs의 농도는 총 트리할로메탄 생성인자(TTF) 와 직선적 상관관계가 있다. log THMs = 0.058TTF + 1.12 여기서 TTF는 온도, pH, UV-254, TOC, 염소농도, 염소접촉시간 등과 다음과 같은 상관관계가 있다. TTF = 0.11 log [(TOC) (UV254)] + 0.391 log (Cl₂)) + 0.265 log(t) + 2.31 log (pH - 2.6) + 3.46 log (Temp) The objectives of this study are to determine the formation concentration of trihalomethane (THMs) and haloacetic acids(HAAs) during the drinking water treatment processes and to suggest the model equation which is able to expect producing concentration of the trihalomethane. The average concentration of THMs and HAAs in the basin of Nakdong River are formed during chlorination are detected from 16.0 to 17.4 and from 19.9 to 25.5 mg/g, respectively There is strong relationship between THMs and trihamethane facter(TTF) which are pH, temperature, UV-254 and total organic carbon of tap water and reaction time with chlorine. The adsorption isotherms of HAAs by adsorption carbon is adapted the Freundlich equation.
( Nak Yoon Sung ),( Seung Cheol Kim ),( Yun Hwan Kim ),( Gihyeon Kim ),( Yunmi Lee ),( Gi Ho Sung ),( Ji Hye Kim ),( Woo Seok Yang ),( Mi Seon Kim ),( Kwang Soo Baek ),( Jong Hoon Kim ),( Jae Youl Cho 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.4
It has been found that 4-isopropyl-2,6-bis(1-phenylethyl)phenol (KTH-13), a novel compound isolated from Cordyceps bassiana, is able to suppress tumor cell proliferation by inducing apoptosis. To mass-produce this compound, we established a total synthesis method. Using those conditions, we further synthesized various analogs with structural similarity to KTH-13. In this study, we aimed to test their anti-cancer activity by measuring anti-proliferative and pro-apoptotic activities. Of 8 compounds tested, 4-methyl-2,6-bis(1-phenylethyl)phenol (KTH-13-Me) exhibited the strongest anti-proliferative activity toward MDA-MB 231 cells. KTH-13-Me also similarly suppressed the survival of various cancer cell lines, including C6 glioma, HCT-15, and LoVo cells. Treatment of KTH-13-Me induced several apoptotic signs in C6 glioma cells, such as morphological changes, induction of apoptotic bodies, and nuclear fragmentation and chromatin condensation. Concordantly, early-apoptotic cells were also identified by staining with FITC-Annexin V/PI. Moreover, KTH-13-Me highly enhanced the activation of caspase-3 and caspase-9, and decreased the protein level of Bcl-2. In addition, the phosphorylation levels of Src and STAT3 were diminished in KTH-13-Me-treated C6 cells. Therefore, these results suggest that KTH-13-Me can be developed as a novel anti-cancer drug capable of blocking proliferation, inducing apoptosis, and blocking cell survival signaling in cancer cells.
Effect of Gamma Irradiation on the Structural and Physiological Properties of Silk Fibroin
Nak-Yun Sung,Eui-Baek Byun,Sun-Kyu Kwon,Jae-Hun Kim,Beom-Seok Song,Jong-il Choi,Jin-Kyu Kim,Yohan Yoon,Myung-Woo Byun,Mee-Ree Kim,Hong-Sun Yook,Ju-Woon Lee 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.1
This study was conducted to examine the changes in the molecular structure and physiological activities of silk fibroin by gamma irradiation. The results of gel permeation chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that the molecular weight of fibroin was increased depending upon the irradiation dose. Secondary structure of fibroin determined by using circular dichroism revealed that the ratio of α-helix was increased up to 10 kGy and then decreased depending upon the irradiation dose. Whereas, the ratio of β-sheet, β-turn, and random coil were decreased and then increased with an alteration in the α-helix secondary conformation. The 2.2-diphenyl-1-picryl-hydrazil (DPPH) radical scavenging activity of fibroin was increased by gamma irradiation at 5 kGy, but was decreased above 10 kGy depending upon the irradiation dose. Also, the inhibition activities of tyrosinase and melanin synthesis of fibroin were increased by gamma irradiation. These results indicated that gamma irradiation could be used as an efficient method to make fibroin more suitable for the development of functional foods and cosmetics.