응급실에서 급성 췌장염 환자의 선별을 위한 actim pancreatitisR검사의 유용성

송석훈,도병수,이삼범 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Acute pancreatitis is a fairly common abdominal disorder that can be easily confronted in the emergency department(ED) and is one of the most complex and clinically challenging of all abdominal disorders. Currently, there is no gold standard for the diagnosis of acute pancreatitis. We evaluated the usefulness of the actim Pancreatitis□ rapid test, which has been recently developed in Europe, as a screening test of acute pancreatitis in our emergency department. Methods: We prospectively studied the urinary trypsinogen-2 dipstick tests(actim Pancreatitis□, Medix Biochemica, Kauniainen, Finland) of 200 patients with acute abdominal pain who were treated at our ED. All urine samples were collected from the patients within 12 hours of arrival at ED. We also measured serum amylase assay in the laboratory and compared the sensitivities and the specificities of the two test. Acute pancreatitis was diagnosed by authors according to standardized criteria. Abdominal USG or CT was performed when a patient with a normal serum amylase level had a typical clinical presentation. Results: The actim Pancreatitis□ rapid test was positive in 22 of the 25 patients with acute pancreatitis(sensitivity, 88.0 percent). The test was also positive in 6 of 175 patients without pancreatitis(specificity, 96.6 percent). The serum amylase assay had a sensitivity of 68.0 percent(with a cutoff value of 300 U per liter for the upper reference limit) and a specificity of 90.9 percent. But there were no statistical differences between the correlation coefficients of the two tests as diagnostic tool Conclusion: In patients with acute abdominal pain who are seen in the emergency department, the actim Pancreatitis□ urinary dipstick test has a high degree of probability as a screening test for acute pancreatitis. Also it can easily and rapidly be use at the bedside.

장벽경색이 선행한 Henoch-Schonlein 자반증 1례

한헌석,하태선,송형근,이상전,안묘순,박범수 충북대학교 의과대학 충북대학교 의학연구소 1993 忠北醫大學術誌 Vol.3 No.1

Henoch-Schonlein 자반증은 피부, 위장관, 관절, 신장 등을 주로 침범하며 소혈관염을 기본 병리 소견으로하는 전신성 혈관 장애 질환이다. 위장관계 증상으로는 복통, 오심 및 구토, 잠혈, 토혈, 흑색변 등이 있을 수 있고, 이러한 증상은 합병증 없이 회복되는 것이 보통이나 드물게는 장중첩증, 장벽경색 및 괴사, 장천공 등의 심한 합병증을 동반할 수도 있다. 이러한 위장관계 증상들은 특징적인 피부 소견에 선행하여 나타날 수도 있으며, 이때는 급성복증에 대한 감별진단이 중요하다. 저자들은 장벽경색이 선행하여 감별진단에 어려움을 겪고 시험적개복술을 시행한 이후에 특징적인 피부 자반이 발현되어 Henoch-Schonlein 자반증으로 진단할 수 있었던 증례를 경험하였기에 이를 보고하고자 한다. 본 증례는 입원 1일전부터 시작된 복통을 주소로 입원한 5세 남아가 배꼽 주위에 심한 경련성 복통을 지속적으로 호소하였고 이학적 소견상 배꼽주위의 압통, 장음의 감소, 흑색변 등이 있었으며 소장조영술상 공장 부위에 미만성의 불규칙한 점막비후 소견을 보여 제 8병일에 시험적개복술을 시행한 결과 근위 공장에 국한된 장괴사의 소견이 발견되어 절제 및 문합술을 실시 하였다. 병리학적 검사에서는 장벽경색의 소견을 보였다. 수술후에 복통은 완화되었으나 경미하게 지속되었고, 제 13병일경에 급성 부고환염이 병발되었다가 회복되었고 제 15병일경에는 하지에서부터 발현된 자반이 3일간 지속되었다. 결구 Henoch-Schonlein 자반증과 이의 합병증으로 발생한 근위 공장의 장벽경색으로 진단하였다. Colicky abdominal pain as symptom of Henoch-Schonlein purpura occurs in up to 70% of patients, and results from submucosal edema and hemorrhage. Abdominal pain and other GI symptoms such as nausea, vomiting, melena and hematemesis resolve mostly without any complications. But rarely life-threatening GI complications such as intussusception, intestinal mural infarction and necrosis, and massive hemorrhage may develope. In 14% of patients, abdominal pain may precede other symptoms, and creats diagnostic difficulties. We reports a case of the Henoch-Schonlein purpura presented with colicky abdominal pain which resulted from intestinal mural infarction and preceded characteristic purpuric skin lesion by several weeks. This 5 year old male patient complained of colicky abdominal pain, nausea and melena. Exploratory laparatomy was done and revealed intestinal mural infarction in proximal jejunum. One week later operation, purpuric skin lesion develiped in both leg and feet, and then, Henoch-Schonlein purpura was diagnosed.

극미세 입자 Aluminosilicate 계 졸의 합성 및 응용 : (Ⅰ) SiO₂및 γ-AIOOH졸의 제조 및 케릭터라이제이션

현상훈,송재권,강범석 연세대학교 산업기술연구소 1993 논문집 Vol.25 No.1

Nanoparticulate silica sols could be synthesized by an interfacial hydrolysis reaction between TEOS and high alkaline water. The silica sols were extremely stable at pH of 8 and their average particle sizes were less than 3 nm, while very unstable between 4 and 5 of pH. The sol particles grew up to about 10 nm within 1 day in the region of pH less than 7. It was found that the silica sol with pH less than 2 was stabilized without further growing after 1 day-aging. The particle size of γ-AlOOH sols synthesized via the modified Yoldas-method could be controlled according to the mole ratio of nitric acid/aluminium tri-sec-butoxide(0.07∼1.0). The stable γ-AlOOH sol with the average particle size of 45 nm, which was prepared using the mole ratio of 0.07, was estimated to be suitable for coating reproducible γ-AlOOH membrane layers with the high specific surface area.

Castleman 질환 1례

안묘순,송형근,박범수,한헌석,하태선 충북대학교 의과대학 충북대학교 의학연구소 1993 忠北醫大學術誌 Vol.3 No.1

Castleman 질환은 주로 종격동 임파선을 침범하여 임상적, 조직학적으로 흉성종과 유사한 소견을 보이는 질환이다. 보통 침범된 임파선은 3cm에서 7cm의 크기를 보이며 경계가 뚜렷한 종양으로 나타난다. 조직학적 소견상 hyaline-vascular형(H-V형)과 plasma cell형의 두가지로 나눈다. 임상적으로는 hyaline-vascular형은 별증상이 없으며 보통 우연히 발견되고 드물게 기도와 기관지를 압박하는 증세를 보이기도 한다. plasma cell형은 빈혈, 적혈구침강속도의 증가, 고감마글로불린혈증, 저알부민혈증, 그리고 저트란스페린혈증을 보이기도 한다. 저자들은 생후 2개월부터 반복되는 호흡기 감염과 거친 숨소리를 보이면서, 성장 및 발육장애를 보인 14개월된 남아에서, 기도에서 우측 주기관지까지를 압박하고 있는 종양을 흉부 전산화단층촬영에서 발견하고 떼어낸 후 조직소견상 hyaline-vascular형의 giant lymph node hyperplasia의 소견을 보이는 Castleman 질환 1례를 경험하였기에 보고하는 바이다. Castleman's disease(angiofollicular lymph node hyperplasia) can arise from lymph nodes or extranodal tissues and can be classified histologically into the hyaline-vascular form, characterized by hyaline follicle-like structures interspersed with vascular tissue, or the plasma cell variant, in which the follicle-like structures are seperated by sheets of plasma cells amidst vascular interfollicular tissue. The clinical manifestations of the multicentric variant can be protean and inculude fever, night sweats, weight loss, lymphadenopathy, hepatosplenomegaly, pleural effusion, ascites, anemia, thrombocytopenia, polyclonal hypergammaglobulinemia, and neurological and renal abnormalities. We report a case of Castleman's disease in 14-month old male patient with the chief complaints of recurrent respiratory symptoms and delayed growth and development, who was diagnosed as having a hyaline-vascular form of above disease after the excision of pulmonary mass which compressed the right main bronchus.

벼 乾畓直播栽培에서 Propyl Dihydro Jasmonate 種子處理에 따른 出芽 및 生育促進效果

박종현,이철원,송범헌,손석용 忠北大學校 農業科學硏究所 2003 農業科學硏究 Vol.20 No.-

This study was conducted to examine the effects of Propyl Dihydro Jasmonate on the growth responses, chilling tolerance and yields on the direct seeding on dry paddy at seedling stage in two rice cultivars The emergence rate of two rice cultivars (Seoan byeo and Dasanbyeo) were increased more by the treatment of 0.05μM PDJ than those of others. Higher concentration of PDJ was found to be inhibitory for germination. Number of emergence of cultivar Seoanbyeo was higher in 0.05μM PDJ treatment for 24hour as compared to 12hour, whereas, no significant difference was observed in case of cultivar Dasanbyeo Plant height and number of tillers of two rice cultivars were increased by the treatment of 0.05μM PDJ for 24 hour Rice yield of the tested cultivars were increased high in the PDJ treatment plot due to increment of the panicle number in the dry seesed paddy field.

Genotoxicity Test of Balanced Nutritional Food for Patients Pasteurized by Gamma-rays

Beom-Seok Song,Ha-Young Park,Jong-Heum Park,Jae-Kyung Kim,Dong-Ho Kim,Sang-Hee Jung 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

Toxicological evaluation of 2-dodecylcyclobutanone, a unique radiolytic compound of palmitic acid

Song, Beom-Seok,Kim, Yona,Jin, Yeung Bae,Kang, Il-Jun,Kim, Kang Sung,Park, Jong-Heum,Kim, Jae-Kyung,Park, Ha-Young,Jeong, Sang-Hee Elsevier 2018 Food and chemical toxicology Vol.121 No.-

<P><B>Abstract</B></P> <P>This study was conducted to evaluate the toxic effects and potency of 2-dodecylcyclobutanone (2-dDCB), a unique compound derived from palmitic acid via irradiation. In a series of assays of bacterial reverse-mutation, <I>in vitro</I> chromosomal aberration, and <I>in vivo</I> micronucleus, negative responses were found by the treatment of 2-dDCB comparing vehicle control, dimethyl sulfoxide or corn oil. In the acute oral toxicity test, all of the mice administrated 2-dDCB survived, and there were no clinical and necropsy signs observed at any doses (0, 300, and 2000 mg/kg body weight) during the experimental period of 14 days. These results suggested that 2-dDCB is a relatively non-toxic substance with median lethality dose higher than 2000 mg/kg body weight. Moreover, there were no adverse effects noted in rats orally administrated 2-dDCB everyday via gavage for 28 days, even at the highest dose (2.0 mg/kg body weight/day) tested, which is 1000-times higher than the human daily intake of 2-dDCB estimated through an extreme exposure scenario. Overall, these results indicate that 2-dDCB is not likely to raise any human health concerns and irradiated foods containing palmitic acid can be recognized as safe for human consumption under the current international regulation systems for food irradiation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The genotoxicity of 2-dodecylcyclobutanone (2-dDCB), a radiolytic compound of palmitic acid, was assessed. </LI> <LI> No toxic effects were detected in reverse-mutation, chromosomal aberration, and micronucleus assays compared to controls. </LI> <LI> LD<SUB>50</SUB> of 2-dDCB was higher than 2000 mg/kg BW when tested in accordance with OECD Guideline No. 423. </LI> <LI> The NOAEL of 2-dDCB was determined at 2.0 mg/kg BW/day, which is 1000-times higher than the estimated human exposure amount. </LI> <LI> Irradiation of palmitic acid-containing foods appears to be safe for human consumption. </LI> </UL> </P>

Combination Pretreatment of Calcium and Vitamin C to Enhance the Firmness of Kimchi Sterilized with High-dose Gamma Irradiation

Beom-Seok Song,Mi-Jung Kim,Jin-Gyu Park,Jae-Hun Kim,Duk-Jin Kim,Sang-Bae Han,Jung-Kue Shin,Myung-Woo Byun,Ju-Woon Lee 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.4

Texture analysis, sensory evaluation, and scanning electronic microscopic (SEM) observation were conducted to evaluate the effects of different calcium salts (calcium lactate, calcium acetate, and calcium chloride) and vitamin C on the textural properties of kimchi, gamma-irradiated at 25 kGy. Increase of the hardness and sensory score were observed in the kimchi pretreated with calcium salt or vitamin C as compared with the untreated and irradiated kimchi. And the hardness and sensory quality of the co-pretreated sample with 0.01% of calcium lactate and 0.3% of vitamin C were the highest after 30 days at 35℃, which indicates that the co-pretreatment is effective in preventing a decrease of the texture and sensory qualities of kimchi by gamma irradiation. Also, this result was supported by the SEM observation.

Radiation Effects on Physicochemical Properties of Xanthan Gum, Guar Gum and Locust Bean Gum (초)

( Beom Seok Song ),( Ju Woon Lee ),( Jin Gyu Park ),( Jong Il Choi ),( Jae Hun Kim ),( Jae Nam Park ),( In Jun Han ) 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2010 한국식품저장유통학회 학술대회 Vol.2010 No.-

[OP-3] Study on the structural and antioxidant properties of gamma irradiated hyaluronic acid

Beom-Seok Song,Hyun-Jin Park,Kyoung-Haeng Lee,Myung-Woo Byun  ,Jae-Kyung Kim,Ju-Woon Lee,Jae-Hun Kim,Jong-II Choi 한국식품영양과학회 2007 한국식품영양과학회 학술대회발표집 Vol.2007 No.10