원자력발전소 케이블관통부 충전시스템 평가용 소프트웨어 개발 Ⅰ

윤종필,권성필,조재규,윤인섭 한국화재소방학회 2004 한국화재소방학회논문지 Vol.18 No.1

본 논문은 원자력발전소 방화벽에 설치된 케이블관통부 충전시스템(CPFS: Cable Penetration Fire Stop)안에서 일어나는 동적 열전달 현상을 해석하기 위해 수행된 실험을 다루고 있다. Dow Coming사의 내화성 충전물에 대해서 내화실험이 수행되었으며, 본 실험을 통해 준비된 CPFS 시험체가 성능위주 시험방법인 ASTM I-81처 F-rating과 I-rating을 동시에 만족시킬 수 있는지를 알아보았다. 그리고 여기서 얻어진 실험결과는 CPFS시스템 내화성능 평가용 소프트웨어를 개발하기 위해 사용되었다. CPFS 시스템 내에서의 열전도 현상은 주어진 초기조건과 경계조건하에서 Parabolic PDE(Partial differential equation)로 수식화 되었으며, 이렇게 수식화된 PDE는 다시 연속과완화법(SOR: Sequential over-relaxation)과 Galerkin 유한요소법(FEM: Finite element method)로 구성된 혼합알고리즘에 따라 풀 수 있었다. PDE을 풀기 위해 널리 사용되고 있는 상응소프트웨어 Femlab을 이용하여 방화시스템 내에서의 온도분포를 계산하여 3차원 그래픽으로 나타내었다. 특히 CPFS시스템 내에서의 시간의 경과에 따른 온도분포의 변화에 대한 실험과 수치해석을 병행함으로써 결과에 대한 신뢰성을 높일 수 있었다. In this work the dynamic heat transfer occurring in a cable penetration fire stop system built in the firewall of nuclear power plants is three-dimensionally investigated to develop a test-simulator that can be used to verify effectiveness of the sealants. Here was carried out an experiment to observe the heat transfer in the cable penetration fire stop system made of DOW CORNING products. The dynamic heat transfer occurring in the fire stop system is formulated in a parabolic partial differential equation subjected to a set of initial and boundary conditions. And it was modeled. simulated, and analyzed. The simulation results were illustrated in three-dimensional graphics and were compared with experimental data. Through the simulations, it was shown clearly that the temperature distribution was influenced very much by the number, position, and temperature of the cable streams. It also was found that the dynamic heat transfer through the cable streams was one of the most dominant factors, and the feature of heat conduction could be understood as an unsteady-state process. It is certain that these numerical results are useful for making a performance-based design for the cable penetration fire stop system.

TNF-α 유전자형과 방광암과의 관계

정필두,김은정,엄민식,서정원,윤석중,김종석,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: TNF-α는 일부 종양의 종양화 과정과 관련이 있는 것으로 알려져 있다. 본 연구는 TNF-α 발현에 영향을 미치는 TNF-α 촉진자 -308 부위의 유전적 다형성이 방광암과 관련이 있는지 유무를 알고자 시행하였다. 대상 및 방법: 유전자 분석을 위하여 환자 113명 및 대조군 109명으로부터 혈액을 채취하여 genomic DNA를 분리한 후 PCR-RFLP 및 direct DNA sequencing을 통하여 TNF-α유전자의 다형성을 조사하여 방광암의 발생, 병기 및 분화도와 비교 검토하였다. 결과: TNF-α 촉진자 -308 부위의 유전형은 대조군에서는 GG형이 83.5%(90례 및 GA형이 16.5%(19례)로 관찰되었으며 AA형은 없었다. 환자군에서는 GG 형이 85.4%(97례), GA형 및 AA형은 각각 13.1%(15례)및 0.8%(1례)에서 관찰되었다. 두 군 모두에서 GG형이 가장 많이 나타났으며 다음으로 GA형을 보이고 AA형은 1례의 방광암 환자에서만 관찰되었다. -308부위의 경우도 두 군 사이에 유전자형의 차이는 없었다(p=0.259) 분화도별 분포를 보면 grade I이 20례, grade II가 49례, grade Ⅲ은 34례였고 병기별로 표재성인 경우가 90례였으며 침윤성은 14례였다. 분화도가 나빠질수록 GA형이 증가하였다(p=0.04). 그러나 병기와 TNF-α promoter -308부위의 유전자형 사이에는 유의한 상관 관계가 없었다(p=0.123). 결론: 방광암 환자의 혈액에서 GA genotype이 관찰되는 경우, 분화도가 나쁠 가능성이 매우 높기 때문에 좀 더 적극적인 치료와 세밀한 추적관찰을 함으로써 방광암으로 인한 사망과 암의 진행을 예방할 수 있을 것으로 기대한다. Purpose : Tumor necrosis factor-alpha (TNF-α) is involved in tumorigenesis of several cancers as an endogenous tumor promoter. The purpose of this study was to investigate whether genetic polymorphism of TNF-α promoter region (-308) was associated with human bladder tumor. Materials and Methods: The DNA from 113 and 109 respective blood samples of bladder tumor Patients and control group was analyzed by PCR-based restriction fragment length polymorphism (RFLP) and direct DNA sequencing methods to characterize the genetic polymorphism of -308 promoter region of the TNF-α gene in bladder tumor patients. We compared the association of bladder tumor with genetic Polymorphism of TNF-α promoter region(-308) in relation to the stage, grade, recurrence and progressio. Results : Eighty-six percents(97/113) of bladder tumor patients and 83.5% (90/109) of control group showed genotype GG at -308 region of TNF-α. Difference in genetic variations of TNF-α promoter (-308) did not exist between bladder tumor patients and control group(p=0.259). Tumor grade was significantly related to the GA genotype (p=0.04). The higher is the grade in bladder tumor, the more frequent was the GA genotype. Tumor stage, recurrence and progression were not significantly associated with genetic polymorphism of TNF-α promoter region (-308). Conclusion: The GA genotype of TNF-a promoter region (-308) had a significant impact on TNF-α production and was related to higher grade tumor compared to GG genotype. TNF-α serum levels in bladder tumor patients were significantly higher than controls. These data suggested that TNF-α might involve the tumorigenesis of the bladder rather than treatment or prevention of bladder tumor.

류마티스 관절염과 동반된 궤양성 대장염 1예

정종필,김윤아,서강석,김태현,김춘호,박정복,이광욱 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

The gastrointestinal involvement in rheumatoid arthritis may be broad and includes many causes: drug induced colitis, colitis associated with infectious agents, vasculitis in gut, autoimmune disease located in gut. Rheumatoid arthritis is a chronic multisystemic disease of unknown cause. Although a number of mixed autoimmue disease exist, there were rare reports about Ulcerative colitis with Rheumatoid arthritis associated. We report one case of Rheumatoid arthritis patient who diagnosed as Ucerative colitis by colonoscopic and histologic finding with review of literature.

수박 덩굴마름병 저항성 판별을 위한 SNP 표지인자 탐색

이혜은,홍종필,서혜영,허윤찬,안율균,김진희,김도선 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

:Watermelon (Citrullus lanatus) is an important vegetable crop in the world and contains various health promoting compounds including many antioxidants such as lycopene and beta-carotene. Genetic diversity of cultivated watermelon is very narrow, which is one of major factors limiting the improvement of watermelon breeding program. Gummy stem blight (Didymella bryoniae (Auersw.)) is one of the most destructive diseases and causes crown blight, defoliation and fruit rot, resulting in severe production loss in watermelon. Single nucleotide polymorphisms (SNPs), important molecular markers for genetic studies are frequent sequence variation in the plant genome. This study was performed to develop SNP markers related to gummy stem blight resistance from three watermelon lines, one susceptible and two resistant to gummy stem blight. Of them, 22 SNP primers which were sequence information on SNPs derived from comparing a resistant and susceptible line was used for high resolution melt analysis. A total of 14 candidate SNP primers were detected melt temperature difference. These SNP primers can be useful for developing disease resistance-related markers and, therefore, beneficial to watermelon breeding program.

관동맥풍선시술중 혈전동반 병변에 대한 구조치료(Rescue Utilization)로서의 Abciximab(ReoPro^(�)의 효과

두영철,채경수,최종형,허필석,송관욱,홍경순,박대균,한규록,오동진,유규형,임종윤,고영박,이광학,이영 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.12

Invited Mini Review : Poly (ADP-ribose) in the pathogenesis of Parkinson``s disease

( Yun Jong Lee ),( Ho Chul Kang ),( Byoung Dae Lee ),( Yun Il Lee ),( Young Pil Kim ),( Joo Ho Shin ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.8

The defining feature of Parkinson`s disease is a progressive andselective demise of dopaminergic neurons. A recent report onParkinson`s disease animal model demonstrates that poly(ADP-ribose) (PAR) dependent cell death, also namedparthanatos, is accountable for selective dopaminergic neuronalloss. Parthanatos is a programmed necrotic cell death, characterized by PARP1 activation, apoptosis inducing factor(AIF) nuclear translocation, and large scale DNA fragmentation. Besides cell death regulation via interaction with AIF, PARmolecule mediates diverse cellular processes including genomicstability, cell division, transcription, epigenetic regulation, andstress granule formation. In this review, we will discuss the rolesof PARP1 activation and PAR molecules in the pathologicalprocesses of Parkinson`s disease. Potential interaction betweenPAR molecule and Parkinson`s disease protein interactome arebriefly introduced. Finally, we suggest promising points oftherapeutic intervention in the pathological PAR signalingcascade to halt progression in Parkinson`s disease.

Development of Real-time Defect Detection Algorithm for High-speed Steel Bar in Coil(BIC)

Jong Pil Yun,YoungSu Park,Boyeul Seo,Sang Woo Kim 제어로봇시스템학회 2006 제어로봇시스템학회 국제학술대회 논문집 Vol.2006 No.10

Vision-based surface defect inspection for thick steel plates

Yun, Jong Pil,Kim, Dongseob,Kim, KyuHwan,Lee, Sang Jun,Park, Chang Hyun,Kim, Sang Woo SPIE - International Society for Optical Engineeri 2017 Optical engineering Vol.56 No.5

Detection of Line Defects in Steel Billets Using UndecimatedWavelet Transform

Jong Pil Yun,SungHoo Choi,Yong-ju Jeon,Doo-chul Choi,Sang Woo Kim 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10

In this paper, we present a new detection algorithm for line defects of scale-covered steel billets. Because of the presence of scales on the billet surface, features of surface images such as brightness and textures are non-uniform. To minimize the influence of scales and to improve the accuracy of detection, a new detection method based on undecimated wavelet transform is proposed. The vertical projection profile of subimage with high-frequency information produced by undecimated wavelet transform is used to detect the line defects. Experimental results conducted on billets surface image from actual steel production line show that the proposed algorithm is capable of detecting line defects on billet surface.

Vertical Scratch Detection Algorithm for High-speed Scale-covered Steel BIC(Bar in Coil)

Jong Pil Yun,Changhyun Park,Homoon Bae,Hwawon Hwang,Seho Choi 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10

Recently, vision-based inspection systems have been widely investigated for the defect inspection in various industrial products. This paper proposes a vision-based method for detection of scratches in the surfaces of scale-covered steel wire rods. Scales are formed on the surface of wire rods owing to the deposition of oxidized substances that are produces during manufacturing. Because of the variety in the types of steel, presence of scales, and manufacturing conditions, the features of wire rod surface images are not uniform. Moreover, the similarities in the gray-level and shape of the defect and defect-free regions make it very difficult to accurately detect defects. In order to solve the abovementioned problems and to detect defects more effectively, we propose a new defect detection algorithm, which is based on edge pair detection, binarization with double threshold, morphological operation, and SVM(Support Vector Machine). Finally, the experimental results conducted on steel wire rod images obtained from actual steel production lines show that the proposed algorithm is effective for defect detection of scale-covered steel wire rods.