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Choi, Seo Hee,Kim, Jun Won,Choi, Jinhyun,Sohn, Joohyuk,Kim, Seung Il,Park, Seho,Park, Hyung Seok,Jeong, Joon,Suh, Chang-Ok,Keum, Ki Chang,Kim, Yong Bae,Lee, Ik Jae Elsevier 2018 Clinical breast cancer Vol.18 No.2
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>The aim of this study was to assess the outcomes of patients with de novo stage IV breast cancer after locoregional treatment (LRT) of primary site.</P> <P><B>Patients and Methods</B></P> <P>We studied 245 patients diagnosed with de novo stage IV breast cancer. LRT of the primary tumor (+ systemic therapy) was performed in 82 (34%) patients (surgery, 27; surgery + radiotherapy (RT), 46; and RT, 9). Among those undergoing surgery, 64 (88%) patients underwent mastectomy, and 9 (12%) patients underwent breast-conserving surgery (BCS). Local recurrence-free survival (LRFS) and overall survival (OS) were investigated, and propensity score matching was used to balance patient distributions.</P> <P><B>Results</B></P> <P>The 5-year LRFS and OS rates were 27% and 50%, respectively. Advanced T stage (T4), liver or brain metastasis, ≥ 5 metastatic sites, and absence of hormone therapy were significant adverse factors for LRFS, whereas T4 stage and absence of hormone therapy were significant for OS. The LRT group demonstrated significantly more favorable outcomes (5-year LRFS, 61%; 5-year OS, 71%), especially after surgery. After matching, survival rates remained significantly higher for patients who received LRT (5-year LRFS, 62% vs. 20%; <I>P</I> < .001; 5-year OS, 73% vs. 45%; <I>P</I> = .02). BCS + RT was superior to mastectomy ± RT, which can be attributed to more patients with a low tumor burden undergoing BCS + RT. Outcomes were better with post-mastectomy RT in selected patients (≥ N2, ≥ T3, or T2N1).</P> <P><B>Conclusions</B></P> <P>Upfront LRT including RT is an important option together with systemic therapies for de novo stage IV breast cancer.</P>
Desing and Development of Monitoring System for Near-surface Disposal Facility Engineering Barrier
Seho Choi,Hyungoo Kang,Mijin Kwon,Chunhyung Cho 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.1
The disposing method of the low-intermediate-level radioactive waste, near-surface disposal facilities are generally used. This disposal method refers to a method of constructing a concrete structure on the surface of the ground, putting radioactive waste in it, and covering it with an engineered barrier to isolate human life. Among these, engineered barriers mean covering multiple layers of heterogeneous materials such as sand, clay, and gravel. Engineering barriers have the purpose of delaying the release of radioactive materials into the natural environment as much as possible, and maintaining the isolation of radioactive waste and human life for as long as possible. In this study, the design and construction method of the facility to demonstrate the performance of the engineered barrier that isolates the surface disposal facility from nature was described. In addition, the design and construction method of monitoring technology that can monitor the safety of engineered barriers by measuring information such as moisture, temperature, and slope safety in real time was also explained.
Han, Seungnam,Nam, Jungyong,Li, Yan,Kim, Seho,Cho, Suk-Hee,Cho, Yi Sul,Choi, So-Yeon,Choi, Jeonghoon,Han, Kihoon,Kim, Youngrim,Na, Moonseok,Kim, Hyun,Bae, Yong Chul,Choi, Se-Young,Kim, Eunjoon The Society 2010 The Journal of neuroscience Vol.30 No.45
<P>PSD-95 (postsynaptic density-95) is thought to play important roles in the regulation of dendritic spines and excitatory synapses, but the underlying mechanisms have not been fully elucidated. TANC1 is a PSD-95-interacting synaptic protein that contains multiple domains for protein-protein interactions but whose function is not well understood. In the present study, we provide evidence that TANC1 and its close relative TANC2 regulate dendritic spines and excitatory synapses. Overexpression of TANC1 and TANC2 in cultured neurons increases the density of dendritic spines and excitatory synapses in a manner that requires the PDZ (PSD-95/Dlg/ZO-1)-binding C termini of TANC proteins. TANC1-deficient mice exhibit reduced spine density in the CA3 region of the hippocampus, but not in the CA1 or dentate gyrus regions, and show impaired spatial memory. TANC2 deficiency, however, causes embryonic lethality. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory, and implicate TANC2 in embryonic development.</P>
Seho Kweon,Jun‑Hyuck Lee,양성빈,박성진,Laxman Subedi,Jung‑Hyun Shim,Seung‑Sik Cho,Jeong Uk Choi,Youngro Byun,박주호,박진우 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Despite the effectiveness of glucagon-like peptide-1 agonist (GLP-1A) in the treatment of diabetes, its large molecular weight and high hydrophilicity result in poor cellular permeability, thus limiting its oral bioavailability. To address this, we developed a chimeric GLP-1A that targets transporter-mediated endocytosis to enhance cellular permeability to GLP-1A by utilizing the transporters available in the intestine, particularly the apical sodium-dependent bile acid transporter (ASBT). Methods In silico molecular docking and molecular dynamics simulations were used to investigate the binding interactions of mono-, bis-, and tetra-deoxycholic acid (DOCA) (monoDOCA, bisDOCA, and tetraDOCA) with ASBT. After synthesizing the chimeric GLP-1A-conjugated oligomeric DOCAs (mD-G1A, bD-G1A, and tD-G1A) using a maleimide reaction, in vitro cellular permeability and insulinotropic effects were assessed. Furthermore, in vivo oral absorption in rats and hypoglycemic effect on diabetic db/db mice model were evaluated. Results In silico results showed that tetraDOCA had the lowest interaction energy, indicating high binding affinity to ASBT. Insulinotropic effects of GLP-1A-conjugated oligomeric DOCAs were not different from those of GLP-1A-Cys or exenatide. Moreover, bD-G1A and tD-G1A exhibited improved in vitro Caco-2 cellular permeability and showed higher in vivo bioavailability (7.58% and 8.63%) after oral administration. Regarding hypoglycemic effects on db/db mice, tD-G1A (50 μg/kg) lowered the glucose level more than bD-G1A (50 μg/kg) compared with the control (35.5% vs. 26.4%). Conclusion GLP-1A was conjugated with oligomeric DOCAs, and the resulting chimeric compound showed the potential not only for glucagon-like peptide-1 receptor agonist activity but also for oral delivery. These findings suggest that oligomeric DOCAs can be used as effective carriers for oral delivery of GLP-1A, offering a promising solution for enhancing its oral bioavailability and improving diabetes treatment.
Choi, Hoseok,Lee, Jeyeon,Park, Jinsick,Lee, Seho,Ahn, Kyoung-ha,Kim, In Young,Lee, Kyoung-Min,Jang, Dong Pyo IOP 2018 Journal of neural engineering Vol.15 No.1
<P> <I>Objective</I>. In arm movement BCIs (brain–computer interfaces), unimanual research has been much more extensively studied than its bimanual counterpart. However, it is well known that the bimanual brain state is different from the unimanual one. Conventional methodology used in unimanual studies does not take the brain stage into consideration, and therefore appears to be insufficient for decoding bimanual movements. In this paper, we propose the use of a two-staged (effector-then-trajectory) decoder, which combines the classification of movement conditions and uses a hand trajectory predicting algorithm for unimanual and bimanual movements, for application in real-world BCIs. <I>Approach</I>. Two micro-electrode patches (32 channels) were inserted over the dura mater of the left and right hemispheres of two rhesus monkeys, covering the motor related cortex for epidural electrocorticograph (ECoG). Six motion sensors (inertial measurement unit) were used to record the movement signals. The monkeys performed three types of arm movement tasks: left unimanual, right unimanual, bimanual. To decode these movements, we used a two-staged decoder, which combines the effector classifier for four states (left unimanual, right unimanual, bimanual movements, and stationary state) and movement predictor using regression. <I>Main results</I>. Using this approach, we successfully decoded both arm positions using the proposed decoder. The results showed that decoding performance for bimanual movements were improved compared to the conventional method, which does not consider the effector, and the decoding performance was significant and stable over a period of four months. In addition, we also demonstrated the feasibility of epidural ECoG signals, which provided an adequate level of decoding accuracy. <I>Significance</I>. These results provide evidence that brain signals are different depending on the movement conditions or effectors. Thus, the two-staged method could be useful if BCIs are used to generalize for both unimanual and bimanual operations in human applications and in various neuro-prosthetics fields.</P>