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      • Performance of woodchip biofilters to treat piggery stormwater

        Cheng, Jing,Park, Kisoo,Yuan, Qingke,Kim, Youngchul 한국방재학회 2015 한국방재학회 학술발표대회논문집 Vol.14 No.-

        Biofilters are widely used for treating various types of wastewater and also recently in controlling non-point source (NPS) pollution including piggery stormwater. Gravels are common substrates employed in this type of biofilters. In this study, three parallel woodchip based biofilters with different thickness of woodchip layer were constructed and operated for about 300 days in 2013. Sampling was conducted every 2 days. The water temperature, pH, electric conductivity (EC), turbidity and DO were measured in situ. Other water quality parameters were analyzed in accordance with the Standard Methods for the Examination of Water and Wastewater (APHA et al. 1995). On one hand, with less woodchip media packed in the biofilter, better removal of TN, TP, NH4-N, TCOD was achieved. On the other hand, almost all NO3-N were removed regardless of the thickness of woodchip. In addition, with deeper thickness of woodchip media in the biofilter, more increased alkalinity and released organic matters were observed at the effluent. Alkalinity is important in biological nitrogen processes, especially in the reactions of ammonia transformation into nitrate (nitrification). Organic matters released from woodchip served as the carbon source to derive denitrification. It seems that only small amount of the woodchip were sufficient to achieve nice removal of nitrogen and phosphorus. Therefore, the amount of the woodchip could be a key in designing a woodchip biofilter.

      • SCIESCOPUS

        Probabilistic determination of initial cable forces of cable-stayed bridges under dead loads

        Cheng, Jin,Xiao, Ru-Cheng,Jiang, Jian-Jing Techno-Press 2004 Structural Engineering and Mechanics, An Int'l Jou Vol.17 No.2

        This paper presents an improved Monte Carlo simulation for the probabilistic determination of initial cable forces of cable-stayed bridges under dead loads using the response surfaces method. A response surface (i.e. a quadratic response surface without cross-terms) is used to approximate structural response. The use of the response surface eliminates the need to perform a deterministic analysis in each simulation loop. In addition, use of the response surface requires fewer simulation loops than conventional Monte Carlo simulation. Thereby, the computation time is saved significantly. The statistics (e.g. mean value, standard deviation) of the structural response are calculated through conventional Monte Carlo simulation method. By using Monte Carlo simulation, it is possible to use the existing deterministic finite element code without modifying it. Probabilistic analysis of a truss demonstrates the proposed method' efficiency and accuracy; probabilistic determination of initial cable forces of a cable-stayed bridge under dead loads verifies the method's applicability.

      • SCIESCOPUSKCI등재

        Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging rats by inhibiting TGF-β/p38/MK2 signaling pathway

        Cheng, Jing,Ren, Chaoyang,Cheng, Renli,Li, Yunning,Liu, Ping,Wang, Wei,Liu, Li The Korean Society of Pharmacology 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.2

        Aging is the process spontaneously occurred in living organisms. Cardiac fibrosis is a pathophysiological process of cardiac aging. Mangiferin is a well-known C-glucoside xanthone in mango leaves with lots of beneficial properties. In this study, rat model of cardiac fibrosis was induced by injected with 150 mg/kg/d D-galactose for 8 weeks. The age-related cardiac decline was estimated by detecting the relative weight of heart, the serum levels of cardiac injury indicators and the expression of hypertrophic biomakers. Cardiac oxidative stress and local inflammation were measured by detecting the levels of malondialdehyde, enzymatic antioxidant status and proinflammatory cytokines. Cardiac fibrosis was evaluated by observing collagen deposition via masson and sirius red staining, as well as by examining the expression of extracellular matrix proteins via Western blot analysis. The cardiac activity of profibrotic TGF-β1/p38/MK2 signaling pathway was assessed by measuring the expression of TGF-β1 and the phosphorylation levels of p38 and MK2. It was observed that mangiferin ameliorated D-galactose-induced cardiac aging, attenuated cardiac oxidative stress, inflammation and fibrosis, as well as inhibited the activation of TGF-β1/p38/MK2 signaling pathway. These results showed that mangiferin could ameliorate cardiac fibrosis in D-galactose-induced aging rats possibly via inhibiting TGF-β/p38/MK2 signaling pathway.

      • KCI등재후보

        DEMO: Deep MR Parametric Mapping with Unsupervised Multi-Tasking Framework

        Jing Cheng,Yuanyuan Liu,Yanjie Zhu,Dong Liang 대한자기공명의과학회 2021 Investigative Magnetic Resonance Imaging Vol.25 No.4

        Compressed sensing (CS) has been investigated in magnetic resonance (MR) parametric mapping to reduce scan time. However, the relatively long reconstruction time restricts its widespread applications in the clinic. Recently, deep learningbased methods have shown great potential in accelerating reconstruction time and improving imaging quality in fast MR imaging, although their adaptation to parametric mapping is still in an early stage. In this paper, we proposed a novel deep learningbased framework DEMO for fast and robust MR parametric mapping. Different from current deep learning-based methods, DEMO trains the network in an unsupervised way, which is more practical given that it is difficult to acquire large fully sampled training data of parametric-weighted images. Specifically, a CS-based loss function is used in DEMO to avoid the necessity of using fully sampled k-space data as the label, thus making it an unsupervised learning approach. DEMO reconstructs parametric weighted images and generates a parametric map simultaneously by unrolling an interaction approach in conventional fast MR parametric mapping, which enables multi-tasking learning. Experimental results showed promising performance of the proposed DEMO framework in quantitative MR T1ρ mapping.

      • KCI등재

        Influence of FeSe doping on superconducting properties of MgB2 by hybrid microwave method

        Cheng Cheng,Zhenjie Feng,Qing Li,Xu Wang,Chuan Yu,Hao Chu,Ya Yang,Changqin Liu,Yiming Cao,Zhe Li,Jingzhe Chen,Chao Jing,Shixun Cao,Jincang Zhang 한국물리학회 2017 Current Applied Physics Vol.17 No.11

        The effect of FeSe doping on the physical properties of MgB2 is studied. Bulk samples of the FeSe doped MgB2 with weight ratio x ðFeSe : MgB2Þ ¼ 0%; 3%; 7% and 10% were prepared by hybrid microwave method. It is proved that FeSe is not stable together with MgB2. Fe2þ enters into MgB2 lattice, some Mg2þ and Se2『 are combined into the new impurity compound MgSe. The superconducting transition temperature (Tc) slightly decreased with increasing doping content of FeSe from R-T and M-T curves, which results from the substitution of Mg2þ by Fe2þ in the MgB2 lattice. The Jc increase slightly with the FeSe doping content increasing from 3 wt % to 10 wt %, which results from the increasing MgSe impurity pinning centers.

      • Up-regulation of Thy-1 Promotes Invasion and Metastasis of Hepatocarcinomas

        Cheng, Bian-Qiao,Jiang, Yi,Li, Dong-Liang,Fan, Jing-Jing,Ma, Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

        Increasing evidence has revealed that thy-1 was a potential stem cell marker of liver cancer, but no data have been shown on how thy-1 regulates the pathophysiology of liver cancer, such as proliferation, apoptosis, invasion and migration. We previously demonstrated that thy-1 was expressed in about 1% of hepg2 cells, thy-1+hepg2 cells, but not thy-1-, demonstrating high tumorigenesis on inoculation $0.5{\times}10^5$ cells per BACA/LA mouse after 2 months. In the present study, our results showed that higher expression of thy-1 occurs in 72% (36/50 cases) of neoplastic hepatic tissues as compared to 40% (20/50 cases) of control tissues, and the expression of thy-1 is higher in poorly differentiated liver tumors than in the well-differentiated ones. In addition, thy-1 expression was detected in 85% of blood samples from liver cancer patients, but none in normal subjects or patients with cirrhosis or hepatitis. There was a significant negative correlation between thy-1expression and E-cadherin expression (a marker of invasion and migraton), but not between thy-1 expression and AFP expression in all the liver cancer and blood samples. We further investigated the relationship between thy-1 and E-cadherin in liver cancer hepg2 cell line which was transfected with pReceiver-M29/thy-1 eukaryotic expression vector followed by aspirin treatment. Lower expression of E-cadherin but higher expressions of thy-1 were detected in hepg2 cells transfected with pReceiver-M29/thy-1. Taken together, our study suggested that thy-1 probably regulates liver cancer invasion and migration.

      • KCI등재

        Optimal Design and Dynamic Control of Construction Dewatering with the Consideration of Dewatering Process

        Cheng-hua Shi,Cheng-yong Cao,Ming-feng Lei,Li-min Peng,Jing Jiang 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.4

        Design optimization of construction dewatering has important values in protecting the surrounding environment and reducing the engineering cost. The existing dewatering design methods are mostly based on the optimization of pumping rate needed to maintain a stable water level, while the drop and rise of water level are not considered in the estimation of pumping rate and dewatering time. The dynamics process of construction dewatering is taken into account in this article. The method for calculating the total water yield and dewatering time from the initial groundwater level to the target water level is established. Then, the design optimization of well group dewatering is provided with the consideration of total water yield and dewatering time in dynamic dewatering process. Finally, the method for the calculation of total water yield and dewatering time when dewatering regions change is derived. The proposed method can realize design optimization and dynamic control of dewatering as the dewatering regions and water level changes in construction. The reliability of this method is verified in on-site engineering applications.

      • KCI등재

        Investigation of Proteomic Responses of Streptomyces lydicus to Pitching Ratios for Improving Streptolydigin Production

        Jing-Sheng Cheng,Xiao-Min Lv,Ying-Jin Yuan 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.5

        Streptomyces lydicus has been reported to produce antibiotic streptolydigin. Pitching ratios play crucial roles in primary and secondary metabolism of Streptomyces bacteria. The higher pitching ratio (30%, v/v)significantly enhanced the levels of streptolydigin products in S. lydicus. Proteome analysis revealed that betaglucosidase and UTP-glucose-1-phosphate uridylyltransferase were up-regulated to accelerate the starch hydrolyzation at the high pitching ratios. Enhancement in the levels of UDPN-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase and glycine cleavage system aminomethyltransferase were involved in the conversion of amino acids into secondary metabolites. Additionally, the expression levels of PfkA2, PfkA3, Zwf2, SucD, GalE1, GatB, TktA1 and ThcA, associated with glycolysis, pentose phosphate pathway, TCA cycle and amino acid metabolism, were dramatically elevated at high pitching ratios, which play important roles in the enhanced streptolydigin production in S. lydicus E9. Interestingly, the levels of proteins (glutamine synthetase I, glutamate synthase subunit beta and glutamine synthetase) were down-regulated with the increases of pitching ratios and fermentation progress,revealing that pitching ratio altered the glutamine synthetase levels and consequently regulated the streptolydigin production of S. lydicus E9. The up-regulation of proteins (eg, aldehyde dehydrogenase and alkyl hydroperoxide reductase) was involved in the redox-based regulation network triggered by an imbalance of the intracellular cell redox homeostasis and by crosstalk with secondary metabolism at the higher pitching ratio. These results settle new insights into physiological facts of S. lydicus E9 in responses to pitching ratios and will eventually improve the antibiotic production schemes in industry.

      • KCI등재후보

        Characteristics of Reactively Sputtered Niobium Nitride Thin Films as Diffusion Barriers for Cu Metallization

        Cheng-Lin Huang,Chih-Huang Lai,Po-Hao Tsai,Hsing-An Huang,Jing-Cheng Lin,Chiapyng Lee 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.5

        NbN films were prepared by radio frequency reactive magnetron sputtering and then employed as diffusion barriers between Cu and Si. The microstructure of the NbN films was an assembly of very small columnar crystallites with a cubic structure. To investigate the properties as diffusion barriers, we performed metallurgical reactions of Cu/NbN0.8/Si, Cu/Nb/Si and Cu/TaN0.7/Si for comparisons. The sheet resistance increased dramatically after annealing above 750°C for Cu/NbN0.80/Si, and above 500°C for both Cu/Nb/Si and Cu/TaN0.7/Si. The interfaces were deteriorated seriously and formation of Cu3Si was observed when the sheet resistance was significantly increased. The diffusion coefficient of Cu in NbN barrier films was estimated by using the change of resistance (ΔRs/Rs %). Compared with TaN0.7, NbN0.8 films possess larger grain size and lower Cu diffusion coefficient. Our results suggest that the NbN film can be used as a diffusion barrier for Cu metallization as compared to the well-known TaN film.

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