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- 저자 : Cheng-yong Cao (검색결과 13 건)
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Cheng-yong Cao,Cheng-hua Shi,Ming-feng Lei,Li-min Peng,Ruxue Bai 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.8
Hongmian Road goes under Jihe highway by the way of tunnel in Shenzhen City, Guangdong Province, China. The tunnel hassome special characteristics such as shallow depth, large span, soft soil, busy traffic, and long distance under-crossing the operatinghighway, thus there is great difficulty and risk during its construction. A series of in-situ tests were conducted to reveal deformationcharacteristics during tunneling beneath the existing highway by the double-side-drift method (DSDM). The results show that initialconstruction method and measures can't meet the safety requirement of tunnel construction, and the level of risk is extremely high, sothe construction method need to be timely adjusted. By comprehensive analysis, the double-side-drift optimum method (DSDOM) isput forward, on the basis of which a series of optimum measures also have been put forward, such as reasonable constructionmethods, the suitable length of bench and excavation, soil reinforcement measures on tunnel face, optimizing construction process,closing primary support in time and speeding up the construction of secondary lining. Then the feasibility of this optimizedconstruction method and measures are verified by the numerical simulations. Finally, from feedbacks of monitoring results, theoptimum method and measures have been proved to be reasonable and feasible, and they can guarantee a successful pass beneath theoperating highway.
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Cheng-hua Shi,Min Long,Cheng-yong Cao,Guangcheng Long,Ming-feng Lei 대한토목학회 2017 KSCE JOURNAL OF CIVIL ENGINEERING Vol.21 No.4
Reactive Powder Concrete (RPC) has ultra-high strength, toughness and durability. Review studies were focused on the mechanical properties of RPC material and RPC beam. In this paper, the bearing features of RPC columns under eccentric compression with different section dimensions, reinforcement ratios, and conditions of with and without steel fibres were determined through large eccentric compression test of 22 RPC columns. The distribution patterns of stresses over the section of the RPC columns under large eccentric compression were determined under cracking loads. A simple analytical method for the cracking loads was also established. Test results revealed that the thickness ratio of elastic tensile region and the whole tensile region can be 0.4 (with steel fibres) or 0.5 (without steel fibres) when calculating the cracking loads. The tensile stress on the RPC columns showed an isosceles triangle distribution in the tensile region. A simple analytical method for calculating the ultimate loads of RPC columns under large eccentric compression was set up. Test results revealed that the equivalence coefficient of the RPC column in tensile regions can be 0.6 (with steel fibres) or 0.4 (without steel fibres). The method deduced in this paper can be used to design the RPC column under large eccentric compression.
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Cheng-hua Shi,Cheng-yong Cao,Ming-feng Lei 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.5
The ground movement induced by the construction of shield tunnels affects the safety of nearby underground pipes and aboveground structures. Therefore, the reliable prediction of ground movement is important. In this paper, a model describing the interaction between soil and an EPB shield used in tunnels is presented, based on the classical elastic theory of Mindlin. In this model, the changing location of the working shield is considered. The equations describing the ground deformation around the tunnel caused by the additional force on the shield working surface and the frictional force between the outer surface of the shield and the surrounding soil are derived. The ground deformation caused by ground loss due to shield tunnel construction is derived using stochastic medium theory. Finally, this model is applied to two running tunnels, and the sensitivity of the ground deformation to the calculation parameters is discussed.
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Cheng-hua Shi,Cheng-yong Cao,Ming-feng Lei,Li-min Peng,Jing Jiang 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.4
Design optimization of construction dewatering has important values in protecting the surrounding environment and reducing the engineering cost. The existing dewatering design methods are mostly based on the optimization of pumping rate needed to maintain a stable water level, while the drop and rise of water level are not considered in the estimation of pumping rate and dewatering time. The dynamics process of construction dewatering is taken into account in this article. The method for calculating the total water yield and dewatering time from the initial groundwater level to the target water level is established. Then, the design optimization of well group dewatering is provided with the consideration of total water yield and dewatering time in dynamic dewatering process. Finally, the method for the calculation of total water yield and dewatering time when dewatering regions change is derived. The proposed method can realize design optimization and dynamic control of dewatering as the dewatering regions and water level changes in construction. The reliability of this method is verified in on-site engineering applications.
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Effect of TLR4 and B7-H1 on Immune Escape of Urothelial Bladder Cancer and its Clinical Significance
Wang, Yong-Hua,Cao, Yan-Wei,Yang, Xue-Cheng,Niu, Hai-Tao,Sun, Li-Jiang,Wang, Xin-Sheng,Liu, Jing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Background/Aim: Toll-like receptor 4 (TLR4) and B7-H1, both normally expressed restricted to immune cells, are found to be aberrantly expressed in a majority of human tumors and may play important roles in regulation of tumor immunity. It has been shown that urothelial bladder cancer (UBC) patients can manifest tumoral immune escape which may be a potential critical factor in tumor pathogenesis and progression. However, so far, the mechanisms of UBC-related immune escape have not been clarified. The aim of this study was to investigate the effect of TLR4 and B7-H1 on immune escape of UBC. Methods: Bladder cancer T24 cells were pre-incubated with LPS and co-cultured with tumor specific CTLs. CTL cytotoxicity and apoptosis rates were measured by MTT assay and flow cytometry, respectively. The effects of an ERK inhibitor on B7-H1 expression and CTL cytotoxicity against T24 cells were also evaluated. In addition, TLR4, B7-H1 and PD-1 protein expression was analyzed by immunohistochemistry in 60 UBC specimens and 10 normal urothelia. Results: TLR4 activation protected T24 cells from CTL killing via B7-H1 overexpression. However PD98059, an inhibitor of ERK, enhanced CTL killing of T24 cells by reducing B7-H1 expression. TLR4 expression was generally decreased in UBC specimens, while B7-H1 and PD-1 were greatly overexpressed. Moreover, expression of both B7-H1 and PD-1 was significantly associated with UICC stage and WHO grade classification. Conclusions: TLR4 and B7-H1 may contribute to immune escape of UBC. Targeting B7-H1 or the ERK pathway may offer new immunotherapy strategies for bladder cancer.
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Spectral Research on an AlGaAs Epitaxial Material for a Terahertz Quantum-cascade Laser
Zhi-Yong Tan,Jun-Cheng Cao 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.8
The spectral properties of a series of AlGaAs epitaxial films were studied by using a Fourier transform infrared spectrometer with an 80-degree grazing incidence reflection unit. The AlAslike transversal optical phonon was obviously observed in the spectra, but the longitudinal optical phonon was obscured in the transmission spectra. The variation curves for the transversal optical phonon energy were acquired from the two kinds of spectra and were compared with each other and with the early results. A comparison of the results show that the grazing incidence reflection spectrum is better in reflecting the AlAs-like phonon energy of an AlGaAs epitaxial film and could be a supplementary means in the characterization of the material for a terahertz quantum-cascade laser.
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A Systemic Analysis of S-1 Regimens for Treatment of Patients with Colon Cancer
Zhang, En,Cao, Wei,Cheng, Chong,Huo, Bin-Liang,Wang, Yong-Heng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Background: Fluorouracil-based regimens have been widely accepted and recommended in the guidelines for treating patients with early or advanced staged colon cancer, although results are controversial. Here we performed a systemic analysis to evaluate the impact of S-1 based regimens on response and survival of patients with colon cancer. Methods: Clinical studies evaluating the impact of S-1 based regimens on response and survival of patients with colon cancer were identified using a predefined search strategy. Summary response rates (RRs) to treatment were calculated. Results: Six clinical studies which including 227 patients with advanced colorectal cancer were considered eligible for inclusion. Two studies were conducted using combination of S-1 and Oxaliplatin, and four studies featured S-1 and irinotecan. Systemic analysis showed that, in all patients, pooled RRs was 43.17%. Major adverse effects were hematological toxicities, gastrointestinal disturbance, neurosensory toxicity. No treatment related death occurred. Conclusion: This systemic analysis suggests that S-1 based regimens, both with oxaliplatin or irinotean are associated with acceptable response and toxicity in patients with colon cancer.
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( Chun Fang ),( Tong Cao ),( Ying Shan ),( Ye Xia ),( Yong Ping Xin ),( Chang Yong Cheng ),( Houhui Song ),( John Bowman ),( Xiao Liang Li ),( Xiang Yang Zhou ),( Wei Huan Fang ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.1
Listeria monocytogenes is a foodborne pathogen of considerable genetic diversity with varying pathogenicity. Initially, we found that the strain M7 was far less pathogenic than the strain Lm850658 though both are serovar 4a strains belonging to the lineage III. Comparative genomic approaches were then attempted to decipher the genetic basis that might govern the strain-dependent pathotypes. There are 2,761 coding sequences of 100% nucleotide identity between the two strains, accounting for 95.7% of the total genes in Lm850658 and 92.7% in M7. Lm850658 contains 33 specific genes, including a novel 20K prophage whereas strain M7 has 130 specific genes, including two large prophages (38K and 44K). To examine the roles of these specific prophages in pathogenicity, the 20K and 38K prophages were deleted from their respective strains. There were virtually no differences of pathogenicity between the deletion mutants and their parent strains, although some putative virulent factors like VirB4 are present in the 20K region or holin-lysin in the 38K region. In silico PCR analysis of 29 listeria genomes show that only strain SLCC2540 has the same 18 bp integration hotspot as Lm850658, whereas the sequence identity of their 20K prophages is very low (21.3%). The 38K and 44K prophages are located in two other different hotspots and are conserved in low virulent strains M7, HCC23, and L99. In conclusion, the 20K and 38K prophages of L. monocytogenes serovar 4a strains Lm850658 and M7 are not related to virulence but contribute to genetic diversity.
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Terahertz Computed Tomorgraphy with a Quantum Cascade Laser and a Quantum-well Photodetector
Tao Zhou,Li Gu,Zhi-Yong Tan,Jun Cheng Cao 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.2
In this letter, a terahertz (THz) tomography system based on a quantum cascade laser (QCL)and a quantum-well photodetector (QWP) is demonstrated. The QCL provides a relatively high power (a few microwatts) in a continuous-wave mode at 3.9 THz as a light source, and the QWP provides a narrow response range from 3 to 7 THz with a calibrated peak response of 0.5 A/W under background-limited performance. We employ the widely-used filtered back projection (FBP)and algebraic reconstruction algorithms for terahertz tomography technology. The reconstructed cross-sectional image of a sample has successfully revealed the internal and the external structures with a resolution of around 1.5 mm. This experiment demonstrates that the terahertz QCL and the photodetector are potentially useful for terahertz tomography applications.
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