Oral Administration of Novel Oriental Medicine, KIOM-C, Protect against Influenza Virus

Jin Yeul Ma, Eun Ha Kim, Jun Han Lee, Min-Suk Song, Yun Hee Baek, Young Ki Choi 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

The influenza virus is an important respiratory risk affecting humans, and effective treatments are needed. Some oriental medicines are currently applied for treatment of common colds as well as influenza infection. Previous studies have reported that the therapeutic properties of MA-128 are effective for treatment of psoriasis antiasthmatic and atopic dermatitis. In this study, we investigated the therapeutic properties of the novel herbal medicine, MA-128, for treatment of influenza virus infection by oral administration. MA-128 is an active natural biological compound from herbal-marine origin. The results showed that oral administration of MA-128 in mice could confer a survival benefit against Type A influenza virus infection. Daily oral administration of MA- 128 resulted in delayed death in infected mice for three days against mouse adapted H3N2 (A/Philippines/2/82). However, it protected more than 60% of mice from lethal infection of 2009 pandemic H1N1 (A/Korea/CJ01/2009) influenza virus. In addition, lung viral titers were significantly reduced at seven days post infection (~100 times) compared with mock-treated mice and viruses were cleared at 9 dpi only in the MA-128 treated groups. This study demonstrated the potential of the novel herbal medicine, MA-128, as an herbal remedy against influenza A viruses.

Monoamine Oxidase 의 활성 변화에 의한 기미론 연구

黃今熙,마진열,金仁洛 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

To explain the theory of KIMI which is the theory of therapeutics in oriental medicine, the monoamine oxidase(MAO) activities were determined in the brain and liver of mouse which was orally adminstered cold and hot drugs, and forced swimming in cold and hot water. The MAO plays a central role in the metabolism of many amines including the neurotransmetter monoamines. MAO is a flavoprotein found exclusively in the mitochondrial outer membrane, occuring in the MAO-A and MAO-B subtypes. MAO-A deaminates serotonin and noradrenaline, whereas MAO-B prefers penylethylamine and benzylamine as substrates. Serotonin is important neurotransmetter for the control of body temperature. Coptis japonica Makino was selected as the cold drug, and Radix Aconiti lateralis preparata was as the hot drug. Coptis japonica Makino elevated the MAO-A activity which was increased by cold stress, whereas it inhibited the MAO-B activity which was increased by cold stress. Coptis japonica Makino elevated the MAO-A activity which was decreased by heat stress, whereas it inhibited the MAO-B activity which was increased by heat stress. Radix Aconiti lateralis preparata inhibited the MAO-A activity which was increased by cold stress, whereas it inhibited the MAO-B activity which was increased by heat stress.

E-Mobile System을 이용한 국립공원 관리시스템 설계

오세진,안상렬,변희섭,마호섭 경상대학교 농과대학 부속연습림 2001 演習林硏究報告 Vol.- No.11

In this paper, we developed a design model for integral administration of national parks using E-Mobile system, which combined Geographical Information System(GIS) and Geographical Positioning System()GPS . This E-Mobile system will contribute to the systematic administration in the national parks by recording geographical information of the national parks by GIS, as well as an individual route guide within the parks by GPS with satellites. Finally, this paper will considerably contribute to the systematic and integral organization of the national parks organization by the newly developed E-Mobile system.

SDS-PAGE를 이용한 우리나라 벼 유전자원의 저장단백질 특성평가

이석영,강희경,이정로,마경호,박용진 한국국제농업개발학회 2003 韓國國際農業開發學會誌 Vol.15 No.4

벼 종실의 단백질 함량 및 조성은 식미에서 매우 중요한 형질로서, 우리나라 벼 유전자원의 종실 단백질 조성의 특성을 평가하고자 재래종 벼 390점, 샤레 46점 및 앵미 105점을 공시하여 SDS-PAGE방법으로 조사한 결과는 다음과 같다. 1. 우리나라 벼 유전자원의 단백질 패턴은 60kD 및 13kD의 단배질 분포에 따라 총 24개형으로 구분되었다. 2. 저장 단백질 중 60kD의 밴드패턴에 의한 분석에 의하면 앵미 및 샤레벼의 63%, 재래종의 91%, 육성종 100%가 진한 밴드패턴을 보였다. 3. 저장단백질 13kD밴드의 패턴에 의해 6가지 형태로 구분되었으며, 대부분의 accessions은 13kD-a 및 13kD-b사이에 추가적인 밴드가 관찰되었다. Protein contents and their composition are very important in controlling rice quality. A total of 633 rice (Oryza sativa L.) varieties/lines consisting of 390 landraces, 46 Share and 105 Red rice weedy type collection, and 92 improved varieties were analyzed for endosperm storage protein evaluation using single seed of each accession. Proteins were separated by the Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE). The 24 different types were developed based on the polypeptide banding patterns of 60kD and 13kD proteins. In the 60kD polypeptide banding pattern, almost 63% of Red rice and Share collection showed thick band intensity, while 91.1% of landraces and 100% of improved varieties had weak band intensity. Six types were discriminated at the near 13kD polypeptide by the intensity and migration mode. Most of accessions had two bands at prolamin of 13kD-a and 13kD-b, but one band was detected between 13kD-a and 13kD-b of the 21 accessions of the Red rice collection and five improved varieties.

The Impact of the Buyer Participation in CSR Activities on a Supply Chain

Jin-Hee Ma,Young-Hyo Ahn,Seok-Beom Choi 한국유통과학회 2018 유통과학연구 Vol.16 No.3

Purpose - This study aims to investigate whether the buyer s participation in CSR activities can affect the informal cooperation and relationship beyond formal cooperation and relationship. Research design, data, and methodology - We defined the research model and selected variables(monitoring and contracts by the buyer, formal cooperation & relationship, and informal cooperation & relationship). After completing the questionnaire, we analyzed 319 manufacturing companies. Prior to the hypothesis testing, Exploratory factor analysis(EFA) and confirmatory factor analysis(CFA) were conducted to check for discriminant validity and convergent validity. Results - The stronger the buyer monitoring on the company s CSR activities, the more positive it affects the formal business cooperation. On the other hand, strong buyer monitoring did not affect formal business relationships. Therefore, even if buyers monitoring of CSR activities is strong, it does not mean that the formal business relationship is improved, but it means that it is possible to improve the formal business cooperation. Conclusions - This study shows that the stronger the buyer monitoring on the supplier s CSR activities, the more positive it affects formal cooperation. It also demonstrates that formal business cooperation between the supplier and the buyer, that is, sharing goals and works for CSR activities, has a positive effect on relationships based on emotional exchange and commitment.

Location Efficiencies of Host Countries for Strategic Offshoring Decisions Amid Wealth Creation Opportunities and Supply Chain Risks

Jin-Hee Ma,Young-Hyo Ahn 한국무역학회 2021 Journal of Korea trade Vol.25 No.3

Purpose - Offshoring has emerged as one of the major trends in international trade and has become one of the strategies for achieving competitiveness in the global market. In spite of this, the expected gains of offshoring can be offset by hidden costs and risks, such as those associated with the COVID-19 andemic, the trade war between the USA and China, and the ongoing trade dispute between Korea and Japan. To obviate such business failure and prevent critical business blunders, offshoring strategies that efficiently consider both risk elements and potential wealth creation are urgently need. The first purpose of this study is to contribute to the development of more advanced offshoring strategies to help host countries select the best locations to manage supply chain risks and create unique value. The second purpose is to specifically analyze the current status of Korea and provide Korean companies with implications to be considered when deciding whether to offshore or re-shore. Design/methodology - A Network DEA model was applied to measure the comparative location efficiency of national competencies for offshoring strategy from perspectives of wealth creation opportunities (profitability and marketability) and supply chain risk management. The location efficiencies are compared among a total 70 countries selected from the Global Competitiveness Index (GCI) and globally attractive locations outlined by Kearney (2017). For the secondary analysis of efficiency, a t-test examining the nature of competitive advantage and the level of sophistication in production processes was implemented in three divisions. We then analyzed differences in offshoring performance in terms of the identified national traits. Moreover, Tobit regression analysis is conducted to investigate the correlation between value-added business activities and each divisional efficiency, seeking to determine how each degree of value-added business activity influences the increase in offshoring productivity. Findings - Regarding overall location efficiency for offshoring performance, only the USA and Italy were identified as being efficient as host countries for offshoring, under circumstances of advanced development, such as productivity and risk management. Korea ranks 13th among 70 countries. The determinants of national competitiveness depend on national traits (the nature of competitive advantage and business sophistication). Countries with labor/resource advantages and labor-intensive industries are more competitive in terms of marketability than others. In contrast, countries with strong technology-intensive industries benefit offshoring companies, particularly in the technology sector, with the added advantage of supply chain risk management. As the perception of a value chain is broader in a country, it can achieve both production sophistication and competitive advantages such as marketability and SCRM. Originality/value - Existing studies focus on offshoring effectiveness from a company perspective. This paper contributes to comparing country efficiency in producing core competencies related to an offshoring strategy and also segments countries into three performance-based considerations associated with the global offshoring market. It also details Korea s position as an offshoring location according to national efficiency and competency.

A Novel Herbal Medicine KIOM-MA Exerts an Anti-Inflammatory Effect in LPS-Stimulated RAW 264.7 Macrophage Cells

Oh, You-Chang,Cho, Won-Kyung,Jeong, Yun Hee,Im, Ga Young,Kim, Aeyung,Hwang, Youn-Hwan,Kim, Taesoo,Song, Kwang Hoon,Ma, Jin Yeul Hindawi Publishing Corporation 2012 Evidence-based Complementary and Alternative Medic Vol.2012 No.-

<P>KIOM-MA was recently reported as a novel herbal medicine effective for atopic dermatitis and asthma. In this study, we have demonstrated the inhibitory effect of KIOM-MA on proinflammatory mediator produced in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. KIOM-MA significantly inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) as well as nitric oxide (NO) and prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>). Consistent with the inhibitory effect on PGE<SUB>2</SUB>, KIOM-MA suppresses the LPS-induced migration of macrophages and gelatinase activity and the expression of matrix metalloprotease-9 (MMP-9) in a dose-dependent manner. Additionally, KIOM-MA showed a strong suppressive effect on the inflammatory cytokines production such as tumor necrosis factor-<I><I>α</I></I> (TNF-<I><I>α</I></I>) and interleukin-6 (IL-6). We also found that KIOM-MA inhibits the activation of nuclear factor-<I><I>κ</I></I>B (NF-<I><I>κ</I></I>B) and represses the activity of extracellular signal-regulated kinase (ERK), p38, and c-Jun NH<SUB>2</SUB>-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs). Taken together, we elucidated the mechanism of anti-inflammatory effect of KIOM-MA using RAW 264.7 cells stimulated by LPS.</P>

Highly self-diffused Sn doping in α-Fe₂O₃ nanorod photoanodes initiated from β-FeOOH nanorod/FTO by hydrogen treatment for solar water oxidation

Ma, Haiqing,Mahadik, Mahadeo A.,Park, Jin Woo,Kumar, Manish,Chung, Hee Suk,Chae, Weon Sik,Kong, Gi Won,Lee, Hyun Hwi,Choi, Sun Hee,Jang, Jum Suk The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.47

<P>In this study, we present an advanced strategy of low-temperature hydrogen annealing combined with high- temperature quenching in air for activating α-Fe2O3 nanorod photoanodes to boost the photoelectrochemical performance. We report that various low-temperature annealing conditions (340, 360, 380, and 400 °C) under hydrogen gas flow convert β-FeOOH into magnetite (Fe3O4) as well as introduce Sn<SUP>4+</SUP> diffusion from FTO substrates to its surface. Furthermore, high-temperature quenching (800 °C) resulted in the phase change of magnetite (Fe3O4) into hematite (α-Fe2O3) and self Sn<SUP>4+</SUP> doping into the hematite lattice. Thus, the hydrogen-assisted thermally activated hematite photoanode achieved a photocurrent density of 1.35 mA cm<SUP>−2</SUP> at 1.23 V <I>vs.</I> RHE and 1.91 mA cm<SUP>−2</SUP> at 1.4 V <I>vs.</I> RHE, which is 70% and 80% higher than that of directly quenched hematite at 800 °C. These combined two step strategies provide new insight into high Sn-self doping for α-Fe2O3 photoanodes and allow for further development of more efficient solar water oxidation systems.</P>

한국, 일본, 글로벌 택배기업의 효율성 및 생산성 비교 분석

Jin-Hee Ma,Young-Hyo Ahn 한국유통과학회 2016 유통과학연구 Vol.14 No.3

Purpose – The parcel delivery service(courier) industry all over the world has been expanding its market so far, but its growth has been declining in recent years. In this situation, most parcel delivery companies are having trouble with managing themselves because of the pressure from the customer to increase service level and decrease the rate. The purpose of this study is to provide ways to improve competitive advantages of the parcel delivery service industry by evaluating the multi-period operating efficiency of Korea, Japan and global service providers. Research design, data, and methodology – The data for the period of 2011 to 2014 were collected from the annual reports published by parcel delivery companies. In this study, we analyze the marketability (revenue), profitability (operating profits), and management conditions (net profits) of parcel service companies by combining information on human resources (number of employees) and material resources (total assets and equity). Therefore, the number of employees, total assets, and equity are selected as input variables, and revenue, operating profits, and net profits as the output variables. In this study, DEA (Data Envelopment Analysis) is used to measure the comparative efficiency and MPI (Malmquist Productivity Index) is used to analyze the trend of change of the efficiency for a multi-year period. Results – The operational efficiency scores of medium-sized parcel delivery companies in Korea are higher than other larger competitors such as Korean, Japan and Global larger companies. As of 2014, Logen(1.878) was found to be the most efficient parcel delivery enterprise, followed by KGB (1.224), and Kyoungdong(1.002). Otherwise, Hanjin(0.235), CJ(0.262), Hyundai Logistics(0.657), DHL(0.611), UPS(0.766), FedEx(0.498), TNT(0.350), Yamato(0.762) and Sagawa(0.520), larger sized companies, were done inefficiently. The productivity of parcel delivery companies is influenced by endogenous factors as well as exogenous ones such as changes in business environment and technological advances. Conclusions – Korean medium-sized companies have relatively high efficiency scores in operation. That is why they still survive the competitive market in Korea where market restructuring on the industry has been expected to be conducted for many years. The reason why medium-sized couriers had higher efficient scores than larger couriers is that most of couriers spend more operating expenses versus unit price of delivery which is the amount of money that is needed in order to send a package by parcel service. So the delivery unit price must be taken into account by all the expenses associated with the cost of fuel, labor and maintenance expenses for facilities, etc. therefore, the unit price must be increased to strengthen business competitive power. In order for the industry to have more competitive advantage, the companies need to make profits by increasing demand volume and raising the delivery rate to provide high-quality delivery service to customers. And both endogenous and exogenous change must take precedence in order to strengthen their competitiveness.

Sustainable GSCM Practices - CSR Governance of Chinese Companies and Their Performances in a Green Supply Chain

마진희(Ma, Jin-Hee),케이서 파룩 다(Qaiser Farooq Dar),안영효(Ahn, Young-Hyo) 한국물류학회 2020 물류학회지 Vol.30 No.4

중국은 세계 경제의 제조 동력원으로서 전 세계 공급망에서 산업적인 역할이 매우 크다. 중국 내 제조업의 비중과 역할이 커짐에 따라 중국 제조기업은 환경에 대한 사회적 책임을 피할 수 없게 되었다. 따라서 본 연구의 목적은 환경보호적 측면에서 중국 제조업체가 상생의 기회를 얻을 수 있도록 동기 부여와 실무적인 시사점을 제시하는 데 있다. 이를 위해 중국 제조기업을 대상으로 설문조사를 실시하였고 이 중 296부를 채택하여 조사데이터로 활용하였다. 구조방정식 모델링을 통해 첫째, 녹색 공급망 하에 관행(녹색 협력과 생산)과 기업의 성과(환경보호, 재무성과 및 품질개선)와의 연관성과 둘째, 사회적 책임을 기반으로 한 운영방식이 녹색 공급망 내 관행을 통해 성과에 미치는 조절효과, 셋째로 녹색 공급망 하의 관행과 성과 간 관계에 환경규제가 미치는 매개효과를 분석하였다. 연구결과, 중국 제조기업의 녹색 협력은 환경 보호성과 뿐 아니라 재무성과 및 품질개선에도 영향을 주는 것으로 나타났다. 그러나 녹색 생산은 모든 기업성과에 부정적인 영향을 미치는 것으로 나타나 중국 제조기업의 녹색 생산방식의 전반적인 개선이 필요할 것으로 판단된다. 기업의 사회적 책임을 강화한 운영방식(가버넌스)은 녹색 생산과 협력을 실행함에 따라 성과가 개선되는데 직접적인 영향을 주는 것으로 나타났다. 즉, 기업이 사회적 책임을 강조하고 이를 운영방식의 기반으로 채택할 경우, 환경보호 성과 및 기업 재무 및 품질 성과를 개선하는데 녹색 협력 및 생산의 효과가 커질 수 있다. 반면에 환경규제는 녹색 협력을 통한 성과개선에 간접적으로 부정적인 효과를 주는 것을 알 수 있다. 따라서 환경보호를 목적으로 기업 간 협력관계를 통해 기업의 성과를 높이는데 환경규제가 악영향을 줄 수 있다는 것이다. 본 연구는 중국 제조기업의 녹색 공급망 관리 및 사회적 책임의 현재 수준을 알아보고 녹색 공급망 관리 하의 실무적 관행이 환경보호뿐 아니라 기업 재무/품질 성과에 영향을 미친다는 사실을 확인하였다는데 의의가 있다. 이를 통해 중국 제조기업이 환경친화적 운영방식을 채택하는데 긍정적인 동기 부여를 하고자 한다. The aim of this study is to provide motivation and practical implication for Chinese manufacturing companies to achieve their win-win opportunities in a global supply chain. Structural equation modeling has been applied to test hypothesis about GSCM practices (green cooperation and production) association with corporate performances (environment protection, financial and quality improvement), moderation effect of CSR relational governance on the asso ciation between GSCM practices and performances and mediation effect of environmental regulation on basic hypothesis by using survey data collected from 296 Chinese manufacturing companies. This study shows that green cooperation of Chinese manufacturing companies affects their financial and quality improvement as well as environmental protection, while green production affects negatively their overall performances. CSR governance moderates the effect of GSCM practices on performance improvement. CSR relational governance can be beneficial for GSCM practices to improve environmental and economy performances. There exists negative mediation effect of environmental regulation on overall performances through green cooperation. Environmental regulation can be detrimental for green cooperation to bring environmental and economy performances. This study contributes to understand current level of GSCM practices in China and CSR relational governance and identify that GSCM practices provide motivations for Chinese manufacturers to achieve the win-win opportunities in a global supply chain.