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Liu Xiaoyi,Wei Qinglv,Yang Chenyue,Zhao Hongyan,Xu Jie,Mobet Youchaou,Luo Qingya,Yang Dan,Zuo Xinzhao,Chen Ningxuan,Yang Yu,Li Li,Wang Wei,Yu Jianhua,Xu Jing,Liu Tao,Yi Ping 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional regulation, in ovarian cancer, is poorly understood. In this study, we revealed that the RNA methyltransferase NSUN2 facilitates mRNA m5C modification and forms a positive feedback regulatory loop with the transcription factor E2F1 in ovarian cancer. Specifically, NSUN2 promotes m5C modification of E2F1 mRNA and increases its stability, and E2F1 binds to the NSUN2 promoter, subsequently reciprocally activating NSUN2 transcription. The RNA binding protein YBX1 functions as the m5C reader and is involved in NSUN2-mediated E2F1 regulation. m5C modification promotes YBX1 phase separation, which upregulates E2F1 expression. In ovarian cancer, NSUN2 and YBX1 are amplified and upregulated, and higher expression of NSUN2 and YBX1 predicts a worse prognosis for ovarian cancer patients. Moreover, E2F1 transcriptionally regulates the expression of the oncogenes MYBL2 and RAD54L, driving ovarian cancer progression. Thus, our study delineates a NSUN2-E2F1-NSUN2 loop regulated by m5C modification in a manner dependent on YBX1 phase separation, and this previously unidentified pathway could be a promising target for ovarian cancer treatment.
Jianhua Liu,Haihui Pu,Dejin Yin,Bin Gao,Hongyue Gao,Haitao Dai 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.56 No.4
An analytical method was applied for quantitative determinations of the initial rate coefficients of diffusion and reaction for a photo-curable recipe in holographic photo-polymerization. The results showed that the initial diffusion rate kept within small discrepancy despite an order of magnitude difference in the curing light power, while corresponding differences were found for the decay constants of diffusion and reaction in the curing process. Polymerization kinetics was analyzed for both curing and post curing processes.
Liu, Jianhua,Liu, Futain,He, Jiankun,Chen, Hui Korean Society of Earth and Exploration Geophysici 2000 지구물리 Vol.3 No.4
본 연구는 동지나 분지에서의 지각변형, 3차원적 지진파 속도 분포 및 화산암 원소의 지화학적 추적을 통하여, 분지의 지체구조적 및 대륙의 지체동역학적인 해석을 목적으로 수행되었다 This research was carried out in order to give some reasonable solutions on basin tectonics and on continental geodynamics, which are approached by using integrative researches on crustal deformation, 3-D seismic velocity reconstruction and geochemical tracing of volcanic rocks in the eastern China basin system.
An Efficient Complex Event Processing Algorithm based on NFA_HTS for Massive RFID Event Stream
Jianhua Wang,Jun Liu,Jun Liu,Lianglun Cheng 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.2
Massive event stream brings us great challenges in its volume, velocity, variety, value and veracity. Picking up some valuable information from it often faces with long detection time, high memory consumption and low detection efficiency. Aiming to solve the problems above, an efficient complex event detection method based on NFA_HTS (Nondeterministic Finite Automaton_Hash Table Structure) is proposed in this paper. The achievement of this paper lies that we successfully use NFA_HTS to realize the detection of complex event from massive RFID event stream. Specially, in our scheme, after using NFA to capture the related RFID primitive events, we use HTS to store and process the large matched results, as a result, our scheme can effectively solve the problems above existed in current methods by reducing lots of search, storage and computation operations on the basis of taking advantage of the quick classification and storage technologies of hash table structure. The simulation results show that our proposed NFA_HTS scheme in this paper outperforms some general processing methods in reducing detection time, lowering memory consumption and improving event throughput.
Liu, Jianhua,Walker, Bright,Tamayo, Arnold,Zhang, Yuan,Nguyen, Thuc‐,Quyen WILEY‐VCH Verlag 2013 Advanced functional materials Vol.23 No.1
<P><B>Abstract</B></P><P>Substitution of the heteroatoms in the aromatic end‐groups of three diketopyrrolopyrrole containing small molecules is investigated to evaluate how such substitutions affect various physical properties, charge transport, and the performance in bulk heterojunction solar cells. While the optical absorption and frontier orbital energy levels are insensitive to heteroatom substitution, the materials' solubility, thermal properties, film morphology, charge carrier mobility, and photovoltaic performance are altered significantly. Differences in material properties are found to arise from changes in intra‐ and intermolecular interactions in the solid state caused by heteroatom substitution, as revealed by the single crystal structures of three compounds. This study demonstrates a systematic investigation of structure–property relationships in conjugated small molecules.</P>
Chengcheng Liu,Zhifeng Liu,Lei E,Yabin Li,Jianhua Han,Yun Wang,Zhichao Liu,Jing Ya,Xuhuang Chen 대한금속·재료학회 2012 ELECTRONIC MATERIALS LETTERS Vol.8 No.5
TiO2 nanotubes with an inner diameter of 4-6 nm were synthesized by hydrothermal treatment method. TiO2nanotubes/nanoparticles composite films were fabricated as a dye-sensitized solar cells work electrode using TiO2 nanotubes and TiO2 nanoparticles as precursor. The structure of composite films has a remarkable influence on the final performance of the cell due to high surface area, fast electron transfer, enhanced light-scattering and light-harvesting, simultaneously. I-V characteristic measurement indicates an enhanced efficiency by 27%as compared to TiO2 nanotubes film.
Constant Output Power Control Methods for Variable-Load Wireless Power Transfer Systems
Xu Liu,Lindsay Clare,Xibo Yuan,Jun Wang,Chonglin Wang,Jianhua Liu 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.2
This study proposes a comprehensive mathematical model that includes coil-system circuit and loss models for power converters in wireless power transfer (WPT) systems. The proposed model helps in understanding the performance of WPT systems in terms of coil-to-coil efficiency, overall efficiency, and output power capacity and facilitates system performance optimization. Three methods to achieve constant output power for variable-load systems are presented based on system performance analysis. An optimal method can be selected for a specific WPT system by comparing the efficiencies of the three methods calculated with the proposed model. A two-coil 1 kW WPT system is built to verify the proposed mathematical model and constant output power control methods. Experimental results show that when the load resistance varies between 5 and 25 Ω, the system output power can be maintained at 1 kW with a maximum error of 6.75% and an average error of 4%. Coil-to-coil and overall efficiencies can be maintained at above 90% and 85%, respectively, with the selected optimal control method.
Douglas-Peucker-Based Accelerated Similarity Measures for Massive AIS Trajectories
Kai WANG,Ryan Wen LIU,Yan LI,Maohan LIANG,Yi LIU,Jianhua WU,Jingxian LIU 국제이네비해양경제학회 2017 International Journal of e-Navigation and Maritime Vol.8 No.1
With the rapid development of the global economy, transport safety and security have become the key issues in maritime transportation all over the world. In practical applications, the Automatic Identification System (AIS)-based measurement of similarities between different vessel trajectories plays an important role in improving maritime transportation, e.g., maritime navigation, maritime supervision and management. However, the received AIS datasets are usually composed of a large amount of redundant information which could significantly increase the computational complexity. To deal with this problem, a Douglas-Peucker (DP)-based calculation method is introduced in this paper to accurately compress the spatio-temporal AIS trajectories while preserving the main geometrical structures. Based on the compressed trajectories, it is able to accelerate the Dynamic Time Warping (DTW) algorithm for the measurement of similarities between different vessel trajectories. In particular, the combination of DP and DTW has the capacity of significantly reducing the computational cost and guaranteeing the accuracy of similarity measures. The experimental results have demonstrated the superior performance of the proposed method in terms of computational cost and accuracy of similarity measures.
Xiaokang Yu,Jinsheng Liang,Jiarui Xu,Xingsong Li,Shan Xing,Huilan Liu,Wan-Li Liu,Dongdong Liu,Jianhua Xu,Lizhen Huang,Hongli Du 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4
Purpose: Breast cancer is the most commonly occurring cancer among women worldwide, and therefore, improved approaches for its early detection are urgently needed. As microRNAs (miRNAs) are increasingly recognized as critical regulators in tumorigenesis and possess excellent stability in plasma, this study focused on using miRNAs to develop a method for identifying noninvasive biomarkers. Methods: To discover critical candidates, differential expression analysis was performed on tissue-originated miRNA profiles of 409 early breast cancer patients and 87 healthy controls from The Cancer Genome Atlas database. We selected candidates from the differentially expressed miRNAs and then evaluated every possible molecular signature formed by the candidates. The best signature was validated in independent serum samples from 113 early breast cancer patients and 47 healthy controls using reverse transcription quantitative real-time polymerase chain reaction. Results: The miRNA candidates in our method were revealed to be associated with breast cancer according to previous studies and showed potential as useful biomarkers. When validated in independent serum samples, the area under curve of the final miRNA signature (miR-21-3p, miR-21-5p, and miR-99a-5p) was 0.895. Diagnostic sensitivity and specificity were 97.9% and 73.5%, respectively. Conclusion: The present study established a novel and effective method to identify biomarkers for early breast cancer. And the method, is also suitable for other cancer types. Furthermore, a combination of three miRNAs was identified as a prospective biomarker for breast cancer early detection.