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OsSPL13 controls grain size in cultivated rice
Si, Lizhen,Chen, Jiaying,Huang, Xuehui,Gong, Hao,Luo, Jianghong,Hou, Qingqing,Zhou, Taoying,Lu, Tingting,Zhu, Jingjie,Shangguan, Yingying,Chen, Erwang,Gong, Chengxiang,Zhao, Qiang,Jing, Yufeng,Zhao, Y Nature Publishing Group, a division of Macmillan P 2016 Nature genetics Vol.48 No.4
<P>Although genetic diversity has a cardinal role in domestication, abundant natural allelic variations across the rice genome that cause agronomically important differences between diverse varieties have not been fully explored. Here we implement an approach integrating genome-wide association testing with functional analysis on grain size in a diverse rice population. We report that a major quantitative trait locus, GLW7, encoding the plant-specific transcription factor OsSPL13, positively regulates cell size in the grain hull, resulting in enhanced rice grain length and yield. We determine that a tandem-repeat sequence in the 5'UTR of OsSPL13 alters its expression by affecting transcription and translation and that high expression of OsSPL13 is associated with large grains in tropical japonica rice. Further analysis indicates that the large-grain allele of GLW7 in tropical japonica rice was introgressed from indica varieties under artificial selection. Our study demonstrates that new genes can be effectively identified on the basis of genome-wide association data.</P>
Xiaohui Huang,Lizhen Gao 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.4
Based on the Reynolds-averaged Navier-Stokes (RANS) method, the standard k-ε turbulence model was used to simulate the effects of the side ratio (SR: building depth/building width, SR = 0.5, 1.0, 1.5, and 2.0, respectively) of isolated buildings on the flow field and pollutant of ethylene dispersion under unstable temperature stratification and neutral conditions. The results showed that under unstable temperature stratification, the updraft on the leeward side of the building caused the high temperature gas to flow upward and the temperature gradient to drop. Compared with the neutral condition, the length of the recirculation zone was shorter, and with the decrease in SR, the vortex in the recirculation zone became larger and more stable. Because the pollution source was located on the leeward side of the building, the pollutant gas was concentrated in the area between the pollution source and the leeward side of the building. The near-ground concentration of pollutants under unstable temperature stratification was lower than that under neutral conditions, and with the decrease in SR, the near-ground axis concentration decreased while the width of the pollutant plumes increased.
Synthesis and Bioactivity of Quercetin Aspirinates
Lu, Chenjuan,Huang, Feng,Li, Zexin,Ma, Jinshuo,Li, Huanhuan,Fang, Lizhen Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
Hybrids of some natural compounds are promising to obtain new leads with good biological activities for drug discovery. Three quercetin aspirinates were synthesized by esterification of the 3-and 7-hydroxyl groups of quercetin with aspirin. Biological activities of these quercetin aspirinates were initially screened and showed better cytotoxic activities against tumor cell lines HL-60 and HepG2 and less scavenging activity against DPPH than the quercetin respectively.
Synthesis and Bioactivity of Quercetin Aspirinates
Chenjuan Lu,Feng Huang,Zexin Li,Jinshuo Ma,Huanhuan Li,Lizhen Fang 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
Hybrids of some natural compounds are promising to obtain new leads with good biological activities for drug discovery. Three quercetin aspirinates were synthesized by esterification of the 3-and 7-hydroxyl groups of quercetin with aspirin. Biological activities of these quercetin aspirinates were initially screened and showed better cytotoxic activities against tumor cell lines HL-60 and HepG2 and less scavenging activity against DPPH than the quercetin respectively.
Kai Wen,Baiqing Xiong,Yongan Zhang,Zhihui Li,Xiwu Li,Shuhui Huang,Lizhen Yan,Hongwei Yan,Hongwei Liu 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.3
In the present work, the infl uence of various retrogression treatments on hardness, electrical conductivity and mechanicalproperties of a high Zn-containing Al–Zn–Mg–Cu alloy is investigated and several retrogression regimes subjected to a samestrength level are proposed. The precipitates are qualitatively investigated by means of transmission electron microscopy(TEM) and high-resolution transmission electron microscopy techniques. Based on the matrix precipitate observations, thedistributions of precipitate size and nearest inter-precipitate distance are extracted from bright-fi eld TEM images projectedalong ⟨110⟩ Al orientation with the aid of an imaging analysis and an arithmetic method. The results show that GP zonesand η′ precipitates are the major precipitates and the precipitate size and its distribution range continuously enlarge with theretrogression regime expands to an extent of high temperature. The nearest inter-precipitate distance ranges obtained arequite the same and the average distance of nearest inter-precipitates show a slight increase. The infl uence of precipitates onmechanical properties is discussed through the interaction relationship between precipitates and dislocations.
Xiaokang Yu,Jinsheng Liang,Jiarui Xu,Xingsong Li,Shan Xing,Huilan Liu,Wan-Li Liu,Dongdong Liu,Jianhua Xu,Lizhen Huang,Hongli Du 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4
Purpose: Breast cancer is the most commonly occurring cancer among women worldwide, and therefore, improved approaches for its early detection are urgently needed. As microRNAs (miRNAs) are increasingly recognized as critical regulators in tumorigenesis and possess excellent stability in plasma, this study focused on using miRNAs to develop a method for identifying noninvasive biomarkers. Methods: To discover critical candidates, differential expression analysis was performed on tissue-originated miRNA profiles of 409 early breast cancer patients and 87 healthy controls from The Cancer Genome Atlas database. We selected candidates from the differentially expressed miRNAs and then evaluated every possible molecular signature formed by the candidates. The best signature was validated in independent serum samples from 113 early breast cancer patients and 47 healthy controls using reverse transcription quantitative real-time polymerase chain reaction. Results: The miRNA candidates in our method were revealed to be associated with breast cancer according to previous studies and showed potential as useful biomarkers. When validated in independent serum samples, the area under curve of the final miRNA signature (miR-21-3p, miR-21-5p, and miR-99a-5p) was 0.895. Diagnostic sensitivity and specificity were 97.9% and 73.5%, respectively. Conclusion: The present study established a novel and effective method to identify biomarkers for early breast cancer. And the method, is also suitable for other cancer types. Furthermore, a combination of three miRNAs was identified as a prospective biomarker for breast cancer early detection.