Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity

Yu Zhong Duan,Fang Lin Chen,An Mei Zhang,Bo Zhu,Jian Guo Sun,Qi Chao Xie,Zheng Tang Chen,Zheng Tang Chen 생화학분자생물학회 2014 BMB Reports Vol.47 No.1

Listeria monocytogenes Serovar 4a is a Possible Evolutionary Intermediate Between L. monocytogenes Serovars 1/2a and 4b and L. innocua

Jian Shun Chen,Ling Li Jiang,Xue Yan Chen,Xiao Kai Luo,Yang Chen,Ying Yu,Guo Ming Tian,Dong You Liu,Wei Huan Fang 한국미생물 · 생명공학회 2009 Journal of microbiology and biotechnology Vol.19 No.3

Comparison Study of the Band-gap Structure of a 1D-Photonic Crystal by Using TMM and FDTD Analyses

Jian-Bo Chen,Yan Shen,Wei-Xi Zhou,Yu-Xiang Zheng,Hai-Bin Zhao,Liang-Yao Chen 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.42

A variety of numerical methods has been developed to demonstrate the nature of photons propagating in an artificially-composed periodic structure. Differences will be generated by different kinds of numerical approaches. In this work, we carry out two types of numerical calculations, TMM (transfer matrix method) and FDTD (finite different time domain) calculations. In terms of the 1D-photonic crystal structures with two different structures, we illustrate the energy band spectra, and the results show dispersive characteristics for the optical transmission and reflection of the crystal material. Through a discussion of the mechanism, detailed comparison studies are preformed based on the different physical conditions. The results given in the work will help in better understanding the ways in which photons propagate in an artificially-composed periodic structure.

Use of an Artificial Neural Network to Construct a Model of Predicting Deep Fungal Infection in Lung Cancer Patients

Chen, Jian,Chen, Jie,Ding, Hong-Yan,Pan, Qin-Shi,Hong, Wan-Dong,Xu, Gang,Yu, Fang-You,Wang, Yu-Min Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12

Background: The statistical methods to analyze and predict the related dangerous factors of deep fungal infection in lung cancer patients were several, such as logic regression analysis, meta-analysis, multivariate Cox proportional hazards model analysis, retrospective analysis, and so on, but the results are inconsistent. Materials and Methods: A total of 696 patients with lung cancer were enrolled. The factors were compared employing Student's t-test or the Mann-Whitney test or the Chi-square test and variables that were significantly related to the presence of deep fungal infection selected as candidates for input into the final artificial neural network analysis (ANN) model. The receiver operating characteristic (ROC) and area under curve (AUC) were used to evaluate the performance of the artificial neural network (ANN) model and logistic regression (LR) model. Results: The prevalence of deep fungal infection from lung cancer in this entire study population was 32.04%(223/696), deep fungal infections occur in sputum specimens 44.05%(200/454). The ratio of candida albicans was 86.99% (194/223) in the total fungi. It was demonstrated that older (${\geq}65$ years), use of antibiotics, low serum albumin concentrations (${\leq}37.18g/L$), radiotherapy, surgery, low hemoglobin hyperlipidemia (${\leq}93.67g/L$), long time of hospitalization (${\geq}14$days) were apt to deep fungal infection and the ANN model consisted of the seven factors. The AUC of ANN model($0.829{\pm}0.019$)was higher than that of LR model ($0.756{\pm}0.021$). Conclusions: The artificial neural network model with variables consisting of age, use of antibiotics, serum albumin concentrations, received radiotherapy, received surgery, hemoglobin, time of hospitalization should be useful for predicting the deep fungal infection in lung cancer.

Analysis of Small Fragment Deletions of the APC gene in Chinese Patients with Familial Adenomatous Polyposis, a Precancerous Condition

Chen, Qing-Wei,Zhang, Xiao-Mei,Zhou, Jian-Nong,Zhou, Xin,Ma, Guo-Jian,Zhu, Ming,Zhang, Yuan-Ying,Yu, Jun,Feng, Ji-Feng,Chen, Sen-Qing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12

Background: : Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease mainly caused by mutations of the adenomatous polyposis coli (APC) gene with almost complete penetrance. These colorectal polyps are precancerous lesions that will inevitable develop into colorectal cancer at the median age of 40-year old if total proctocolectomy is not performed. So identification of APC germline mutations has great implications for genetic counseling and management of FAP patients. In this study, we screened APC germline mutations in Chinese FAP patients, in order to find novel mutations and the APC gene germline mutation characteristics of Chinese FAP patients. Materials and Methods: The FAP patients were diagnosed by clinical manifestations, family histories, endoscope and biopsy. Then patients peripheral blood samples were collected, afterwards, genomic DNA was extracted. The mutation analysis of the APC gene was conducted by direct polymerase chain reaction (PCR) sequencing for micromutations and multiplex ligation-dependent probe amplification (MLPA) for large duplications and/or deletions. Results: We found 6 micromutations out of 14 FAP pedigrees, while there were no large duplications and/or deletions found. These germline mutations are c.5432C>T(p. Ser1811Leu), two c.3926_3930delAAAAG (p.Glu1309AspfsX4), c.3921_3924delAAAA (p.Ile1307MetfsX13), c3184_3187delCAAA(p.Gln1061AspfsX59) and c4127_4126delAT (p.Tyr1376LysfsX9), respectively, and all deletion mutations resulted in a premature stop codon. At the same time, we found c.3921_3924delAAAA and two c.3926_3930delAAAAG are located in AAAAG short tandem repeats, c3184_3187delCAAA is located in the CAAA interrupted direct repeats, and c4127_4128 del AT is located in the 5'-CCTGAACA-3', 3'-ACAAGTCC-5 palindromes (inverted repeats) of the APC gene. Furthermore, deletion mutations are mostly located at condon 1309. Conclusions: Though there were no novel mutations found as the pathogenic gene of FAP in this study, we found nucleotide sequence containing short tandem repeats and palindromes (inverted repeats), especially the 5 bp base deletion at codon 1309, are mutations in high incidence area in APC gene,.

PERCEIVED RESIDENTIAL ENVIRONMENT QUALITY, PLACE ATTACHMENT, AND ENVIRONMENTAL SATISFACTION: THE COMPETING MODELS IN RURAL AND URBAN AREAS OF CHINA

Kangkang Yu,Ning (Chris) Chen,Xinkai Zhu,Jian Gao 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7

Level of urbanization in China has reached 53.73% in 2013, indicating a tremendous progress on the urbanization of China. On the other hand, the number of villages in China reduces by around one million from 3.6 million in 2000 to 2.7 million in 2010 (Zhang, 2014). Issues in both urban and rural areas of China appear, including the imbalance between increased population and limited resources in urban region, and more significantly, the increasing disparity between rural and urban areas. Chinese researchers interpret and analyse these matters from different perspectives. For instance, Zheng (2006) and Ma (2006) suggest the importance of the infrastructure construction and public service. Wu (2006) advises that the government should pay attention to the development of the secondary and tertiary industry. Wen (2005) proposes that the improvement of social institution and the recovery of social cultural environment are required to achieve sustainability in the urbanization process in China. Previous studies in environmental psychology put quality of life, attachment to place, and residence satisfaction at the center to understand the relationship between inhabitants and their neighborhood of residence. However, there are gaps in this research realm in both practice and theories. Firstly, very limited research studies this environmental psychology issue in China (e.g. Mao, Fornara, Manca, Bonnes, & Bonaiuto, 2015). Secondly, there are different opinions on the causal order between quality, attachment, and satisfaction. Research on the relationship between perceived residential environment quality (PREQ), place attachment, and environmental satisfaction has not reached a consensus. The debate on the direction of the causal relationship between perceived quality and satisfaction has been summarized by Bradya and Robertson (2001). They conclude that the quality to satisfaction causal order holds up well across diverse cultures. However, relevant debate is still ongoing. A number of research articles place satisfaction as an antecedent to attachment, e.g. Chen, Dwyer, and Firth (2014); Lee, Kyle, and Scott (2012); Ramkissoon and Mavondo (2015); etc. Some argue that place attachment is an indicator of satisfaction. Kyle et al. (2004) investigate the effect of place attachment on the perceived values of tourists and find that place attachment is an important factor explaining the variance of perceived values. This is supported by research e.g. Hwang, Lee, and Chen (2005); Prayag and Ryan (2012); Yuksel, Yuksel, Biljm (2010); etc. As to the relationship between perceived quality and attachment, the debate has not stopped. Through comparisons, Mesch and Manor (1996) conclude that the residents who give a higher evaluation of the social and natural environment may have greater place attachment. Brown, Perkins, and Brown (2003) also suggest that the residents who agree that the street environment is better would attach to this place. Sam, Bayram, and Bilgel (2012) have certified the relationship between residential environment quality and place attachment. Furthermore, Borrie and Roggenbuck (2001) and Walker and Ryan (2008) find that the connection between human beings and the nature environment would affect their affection toward the environment. It means that the closer the relationship with the nature environment is, the stronger the attachment would be, which in turn, enhances the intentions to protect the environment. This quality to satisfaction relationship is supported by other research such as Bonaiuto, Aiello, Perugini, Bonnes, and Ercolani (1999); Grisaffe and Nguyen (2011); Yu, Chen, and Chen (2015); etc. Nevertheless, a different opinion arguing that attachment to a place may affect one’s perception on the quality related to a place is emerging in tourism research (e.g. Neuvonen, Pouta, & Siev?nen, 2010). This paper takes the credit of quality → attachment → satisfaction causal order as the initial model and proposes three hypotheses as follows. H1a: One’s PREQ has a positive impact on his/her attachment to this place; H2a: One’s attachment to a place has a positive impact on his/her satisfaction to the environmental settings in this place; H3a: Place attachment in addition performs as a mediating role between PREQ and environment satisfaction.To be noted, the initial model has its theoretical basis as discussed above but is not necessarily the absolute optimal model. Relatively, this model provides more theoretical interpretation and practical implications in the specific research context: residential psychology in urban and rural areas of China. On this basis, this article further examines a competing model illustrating an alternative theoretical framework on the relationships between these three constructs (satisfaction → attachment → quality). Relatively, another group of hypotheses in this competing model is listed as follows. H1b: One’s attachment to a place has a positive impact on his/her PREQ; H2b: One’s satisfaction to the environmental settings in this place has a positive impact on his/her attachment to this place; H3b: Place attachment in addition performs as a mediating role between environment satisfaction and PREQ. A survey approach is employed and data are collected from several backgrounds. Dataset A (rural) is collected from three villages from Heilongjiang Province and two villages from Shandong Province in China from July to August 2014. The choices of the provinces, rural areas, and the sampling process are random. 490 valid questionnaires are included in the data analysis. Dataset B (urban) is collected via an online survey portal, which allows a nationwide sampling reach. In total 1368 online survey entries are recorded and 420 valid questionnaires are included, resulting in a valid rate of 30.7%. The measures for each construct are based on an extensive literature review. The measurement of perceived residential environment quality is from Sam, Bayram, & Bilgel’s (2012) development on the perception of residential environment. The measurement of place attachment in this study is adopted from Kyle, Graefe, and Manning’s (2005) and Chen, Dwyer, and Firth’s (2014) evaluation based place attachment dimensionality and scales. As for the scale of environmental satisfaction, Pelletier, Legault, and Tuson’s (1996) measure was applied. All the entire variables adopted multiple-item, 5-point Likert scales were adopted, where “1” indicated “strongly disagree” and “5” indicated “strongly agree”. After pre-testing the preliminary version of the survey instrument, a revised version was developed. This study adopts structural equation modeling (SEM) based on partial least squares (PLS) modeling given the small sample size and the explorative purpose of this study (Dijkstra & Henseler, 2015a). The software used was Smart PLS 3.0. The reliability and validity of the constructs were assessed. Cronbach’s alpha and the value of CR of each construct were found to exceed the cut-off value of 0.70 (Fornell & Larcker, 1981), except for adequacy of education which is close to 0.70 (only for Cronbach’s alpha but not for CR). Furthermore, the AVE of each construct exceeded the variance attributable to its measurement error cut-off value of 0.50 (Chin, 1998; Fornell & Larcker, 1981). In addition, heterotrait-monotrait ratio (HTMT) is recommended as a better method to test discriminant validity (Henseler, Dijkstra, Sarstedt, Ringle, Diamantopoulos, Straub, Ketchen, Hair, Hult, & Calantone, 2014). The result shows that there is neither value of the HTMT higher than the threshold of 0.85 nor confidence interval containing the value one, indicating that all the constructs exhibit satisfactory discriminant validity. The hypothesized effects in the theoretical model were tested by structural equation modeling (SEM). The first group of models tested the effect of perceived environmental quality on environmental satisfaction through place attachment i.e. initial model (Model A, Model B, Model C), while the second group of models tested the reverse effect of environmental satisfaction on perceived environmental quality through place attachment (Model D, Model E, Model F). Both the full model and the multi-group model were tested. The value of SRMR of the full model that tests either the effect of perceived environmental quality on environmental satisfaction (SRMR = 0.104, t = 41.826, p < 0.001) or the reversed effect (SRMR = 0.106, t = 37.736, p < 0.001) shows that the models fit the data quite well (Dijkstra & Henseler, 2015b). However, the former is little bit more significant. In this study, PREQI is found different impacts on place attachment and environmental satisfaction. This provides evidence to support a similar mechanism of studying residents’ psychology with SERVEQUAL model. However, the model testing is found significantly different between rural and urban samples, indicating a systematic difference in the psychology of rural and urban populations. Quality ? attachment ? satisfaction causal order is found significant and supported by both samples in this study. However, a reversed causal order model (satisfaction ? attachment ? quality) is also supported by the samples. Although the results may not be able to end the debate on alternative models between PREQ, place attachment, and environmental satisfaction, this paper provides empirical evidence from a specific context (urban and rural China) for further research. Specifically, PREQ has a significant impact on place attachment in both urban and rural areas in China. As for the impact of place attachment on environmental satisfaction as well as the indirect impact of PREQ on environmental satisfaction, the influence is more significant in cities of China compared to rural areas. This suggests in the urban areas in China, affective and emotional responses to their lives play an important role to residents. Local government in cities should balance between improving and maintaining quality of the environment and strengthening local residents’ psychological attachment to the place. Governments in rural areas, on the other hand, should lay great focus on the physical aspects of the environment including nature, health, education, commerce, and venture of the rural areas, to enhance residents’ living experience and satisfaction. Further, there are some limitations. Although this study attempts to clarify the framework of “perception-affection-attitude” in the field of environment management, considering the practical implications, the future study could bring the individuals’ behaviors or intentions into this model such as willingness-to-pay for environment-friendly products. It will also benefit from reviewing more literature on community-based social marketing.

Study of the Band-gap Structure of a 1D-photonic Crystal by Using Different Numerical Approaches

Liang-Yao Chen,Jian-Bo Chen,Yue-Rui Chen,Yan Shen,Wei-Xi Zhou,Jiu-Chun Ren,Yu-Xiang Zheng 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.56 No.4

Comparative studies between the transfer matrices method (TMM) and plane wave method (PWM) approaches have been performed on 1D photonics crystal under different conditions to show the differences between these two kinds of calculations. TMM is suitable for the design of 1D photonic crystal device with high precision and is in good agreement with experimental results, but is not suitable for the 2D and 3D photonic structures which are limited by the complicated boundary conditions at micro interfaces. The result based on the PWM approach to deal approximately with the photonic structure in approximation has not yet been strictly verified by experiment, not even for 1D photonic crystal structures. More efforts will be required to explore its validation under all physical conditions to enhance its application.

Association of Visit-to-Visit Variability of Blood Pressure with Cardiovascular Disease among Type 2 Diabetes Mellitus Patients: A Cohort Study

Zhe-Bin Yu,Die Li,Xue-Yu Chen,Pei-Wen Zheng,Hong-Bo Lin,Meng-Ling Tang,Ming-Juan Jin,Jian-Bing Wang,Kun Chen 대한당뇨병학회 2019 Diabetes and Metabolism Journal Vol.43 No.3

Background: Increasing evidence has shown that visit-to-visit variability (VVV) of blood pressure (BP) is associated with an increased risk of cardiovascular disease (CVD). The objective of this study was to evaluate the impact of VVV of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the risk of CVD among patients with type 2 diabetes mellitus (T2DM) in China. Methods: We conducted a retrospective cohort study of 10,163 T2DM patients who were not previously diagnosed with CVD from January 2008 to December 2012 in Ningbo, China. The VVV of BP was calculated using five metrics, including standard deviation (SD), coefficient of variation (CV), variation independent of mean, average real variability, and successive variability (SV) of measurements, obtained over a 24-month measurement period. Hazard ratios and 95% confidence intervals (CIs) were estimated by Cox proportional hazards regression models for the associations of variability in BP with risk of CVD. Results: A total of 894 CVD events were observed during a median follow-up of 49.5 months. The hazard ratio in the highest quintile of SD of SBP was 1.24 (95% CI, 1.01 to 1.52) compared with patients in the lowest quintile. The association between higher VVV of DBP and risk of CVD was not consistent across different metrics and sensitivity analyses. Conclusion: Higher VVV of SBP was associated with an increased risk of CVD, irrespective of the mean SBP level. Future studies are needed to confirm these findings.

Risk Factors for Anxiety in Major Depressive Disorder Patients

Li-Min Xin,Lin Chen,Zhen-Peng Ji,Suo-Yuan Zhang,Jun Wang,Yan-Hong Liu,Da-Fang Chen,Fu-De Yang,Gang Wang,Yi-Ru Fang,Zheng Lu,Hai-Chen Yang,Jian Hu,Zhi-Yu Chen,Yi Huang,Jing Sun,Xiao-Ping Wang,Hui-Chun 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.3

Objective: To analyze the sociodemographic and clinical factors related to anxiety in patients with major depressive disorder (MDD). Methods: This study involved a secondary analysis of data obtained from the Diagnostic Assessment Service for People with Bipolar Disorders in China (DASP), which was initiated by the Chinese Society of Psychiatry (CSP) and conducted from September 1, 2010 to February 28, 2011. Based on the presence or absence of anxiety-related characteristics, 1,178 MDD patients were classified as suffering from anxious depression (n=915) or non-anxious depression (n=263), respectively. Results: Compared with the non-anxious group, the anxious-depression group had an older age at onset (t=−4.39, p<0.001), were older (t=−4.69, p<0.001), reported more lifetime depressive episodes (z=−3.24, p=0.001), were more likely to experience seasonal depressive episodes (χ2=6.896, p=0.009) and depressive episodes following stressful life events (χ2=59.350, p <0.001), and were more likely to have a family history of psychiatric disorders (χ2=6.091, p=0.014). Their positive and total scores on the Mood Disorder Questionnaire (MDQ) and the 32-item Hypomania Checklist (HCL-32) (p<0.05) were also lower. The logistic regression analysis indicated that age (odds ratio [OR]=1.03, p<0.001), a lower total MDQ score (OR=0.94, p=0.011), depressive episodes following stressful life events (OR=3.04, p<0.001), and seasonal depressive episodes (OR=1.75, p=0.039) were significantly associated with anxious depression. Conclusion: These findings indicate that older age, fewer subclinical bipolar features, an increased number of depressive episodes following stressful life events, and seasonal depressive episodes may be risk factors for anxiety-related characteristics in patients with MDD.

Failure Mechanism of Single-layer Steel Reticular Domes with Reinforced Concrete Substructure Subjected to Severe Earthquakes

Chen Lu,Zhiwei Yu,Shuiming Li,Dagang Lu,Jian Liu 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.4

This paper performs the research on failure mechanism of single-layer steel reticulated domes with the reinforced concrete substructure subjected to sever earthquakes. Based on ABAQUS, this paper built user-defined material subroutines of the steel and the reinforced concrete, which took material non-linearity and the material damage accumulation into consideration. The failure mechanism of reticulated domes with reinforced concrete substructures under severe earthquakes is studied by the nonlinear dynamic response analysis. Three different failure modes of single-layer reticular domes with different sizes of reinforced concrete substructure are illustrated. Failure criterion is put forward to discriminate the failure modes and to estimate the critical load strength for single-layer reticular domes based on the structural damage theory. It has been found that reinforced concrete substructure has significant impact on the failure behaviors and the critical load of reticulated domes under seismic loads. It is essential to consider the influence of the reinforced concrete substructure upon the failure behaviors in the structural analysis and design process of reticular domes.