http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Wei-dong Wang,Li-hua Zhang,Jia-Yan Ni,Xiong-ying Jiang,Dong Chen,Yao-ting Chen,Hong-liang Sun,Jiang-hong Luo,Lin-feng Xu 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.4
Objective: To meta-analytically compare combined transarterial chemoembolization (TACE) plus radiofrequency ablation (RFA) and surgical resection (SR) for the treatment of hepatocellular carcinoma (HCC) within the Milan criteria. Materials and Methods: PubMed, Medline, Embase, and Cochrane Library were searched for studies comparing these two therapies that were published between January 2006 and August 2017. Overall survival rate (OS), recurrence-free survival rate (RFS), major complications and the average length of hospital stay were compared between these two therapies. Metaanalytic pooled odds ratio (OR) was calculated using TACE plus RFA as the base category. Results: Seven case-control studies and one randomized trial were identified. Meta-analytic results revealed that, compared with SR, TACE plus RFA had significantly higher 1-year OS (OR for survival = 0.50, p = 0.009) and lower major complications (OR = 1.88, p = 0.02) after therapy. Three studies reported on the length of hospital stay. The average length ± standard deviation reported in individual studies for SR and TACE plus RFA groups was 19.8 ± 8.4 days and 7.4 ± 2.2 days, respectively; 18.7 ± 4.9 days and 11.5 ± 6.9 days, respectively; and 16.6 ± 6.7 days and 8.5 ± 4.1 days, respectively (p < 0.0001 for all studies). Three or 5-year OS and 1-, 3-, or 5-year RFS did not significantly differ between the two therapies. Conclusion: Combined TACE plus RFA may be an alternative to SR for the treatment of patients with HCC within Milan the criteria. Non-randomized design in most of the original studies was a limitation.
Centrifuge Model Tests and Numerical Simulations of the Landslide Evolution Process
Han-Dong Liu,Jia-Xing Chen,Wen-Xi Han,Ye Wu,Dong-Dong Li 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.6
Centrifuge model tests and numerical simulations were performed to study the landslide evolution process and failure mechanism. A TLJ-500 geotechnical centrifuge was used for the experiments and landslide deformation and stress was monitored using high-precision differential displacement sensors and earth pressure micro-sensors. Discrete element numerical simulations were performed using PFC2D based on the experimental results. The findings show that the landslide evolution process can be divided into three stages: 1) compaction and consolidation; 2) uniform deformation; and 3) accelerated deformation and failure. The numerical simulation results verify the distinct stage characteristics of the landslide evolution process. According to the migration of microscopic soil mass particles within the landslide, stage 3) can be further divided into a deformation development stage and instability and failure stage. The simulation displacement monitoring curves and displacement map show distinct deformation characteristics and displacement indicators from stages 2) to 3) and from the deformation development stage to the instability and failure stage. The experimental and numerical results reveal the landslide failure mechanism: the upper part of the landslide thrusts and slides; the middle part squeezes; the lower part collapses; and shear plane penetration leads to landslide failure.
Luo Xiao-Jing,He Ming-Ming,Liu Jia,Zheng Jia-Bo,Wu Qi-Nian,Chen Yan-Xing,Meng Qi,Luo Kong-Jia,Chen Dong-Liang,Xu Rui-Hua,Zeng Zhao-Lei,Liu Ze-Xian,Luo Hui-Yan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Esophageal squamous cell carcinoma (ESCC) is one of the most life- and health-threatening malignant diseases worldwide, especially in China. Long noncoding RNAs (lncRNAs) have emerged as important regulators of tumorigenesis and tumor progression. However, the roles and mechanisms of lncRNAs in ESCC require further exploration. Here, in combination with a small interfering RNA (siRNA) library targeting specific lncRNAs, we performed MTS and Transwell assays to screen functional lncRNAs that were overexpressed in ESCC. TMPO-AS1 expression was significantly upregulated in ESCC tumor samples, with higher TMPOAS1 expression positively correlated with shorter overall survival times. In vitro and in vivo functional experiments revealed that TMPO-AS1 promotes the proliferation and metastasis of ESCC cells. Mechanistically, TMPO-AS1 bound to fused in sarcoma (FUS) and recruited p300 to the TMPO promoter, forming biomolecular condensates in situ to activate TMPO transcription in cis by increasing the acetylation of histone H3 lysine 27 (H3K27ac). Targeting TMPO-AS1 led to impaired ESCC tumor growth in a patient-derived xenograft (PDX) model. We found that TMPO-AS1 is required for cell proliferation and metastasis in ESCC by promoting the expression of TMPO, and both TMPO-AS1 and TMPO might be potential biomarkers and therapeutic targets in ESCC.
AC4E: An Access Control Model for Emergencies of Mission-Critical Cyber-Physical Systems
( Dong Chen ),( Guiran Chang ),( Jie Jia ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.9
Access control is an essential security component in protecting sensitive data and services from unauthorized access to the resources in mission-critical Cyber-Physical Systems (CPSs). CPSs are different from conventional information processing systems in such that they involve interactions between the cyber world and the physical world. Therefore, existing access control models cannot be used directly and even become disabled in an emergency situation. This paper proposes an adaptive Access Control model for Emergences (AC4E) for mission-critical CPSs. The principal aim of AC4E is to control the criticalities in these systems by executing corresponding responsive actions. AC4E not only provides the ability to control access to data and services in normal situations, but also grants the correct set of access privileges, at the correct time, to the correct set of subjects in emergency situations. It can facilitate adaptively responsive actions altering the privileges to specific subjects in a proactive manner without the need for any explicit access requests. A semiformal validation of the AC4E model is presented, with respect to responsiveness, correctness, safety, non-repudiation and concurrency, respectively. Then a case study is given to demonstrate how the AC4E model detects, responds, and controls the emergency events for a typical CPS adaptively in a proactive manner. Eventually, a wide set of simulations and performance comparisons of the proposed AC4E model are presented.
Antimycobacterial Activity of Fusaric Acid from a Mangrove Endophyte and its Metal Complexes
Jia-Hui Pan,Yi Chen,Yu-Hong Huang,Yi-Wen Tao,Jun Wang,Yan Li,Yi Peng,Tao Dong,Xiao-Min Lai,Yong-Cheng Lin 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7
Due to the increasing prevalence of multidrug-resistant Mycobacterium tuberculosis, there is an urgent need for new antituberculosis drugs that have novel mechanisms of action. As part of our ongoing search for antimycobacterial metabolites from mangrove endophytes, chemical analysis of the active extract of a strain of Fusarium sp. was performed, which led to the isolation of fusaric acid as the predominant constituent. A variety of metal complexes of fusaric acid were prepared. Antimycobacterial assays showed that Cadmium (II) and Copper (II) complexes exhibited potent inhibitory activity against the M. bovis BCG strain [minimum inhibitory concentration (MIC) = 4 μg/mL] and the M. tuberculosis H37Rv strain (MIC = 10 μg/mL), respectively. This is the first report of the antimycobacterial activity of the mangrove Fusarium metabolite and its coordinating metal complexes.
Jia Chen,Jianhua Shao,Chunchao Zhao,Jie Shen,Ziling Dong,Wenyan Liu,Min Zhao,Judi Fan 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.6
Three new neolignans, fordianoles A-C (1–3),characterized as (7S,8R)-4-hydroxy-3,30,50-trimethoxy-80,90-dinor-8,40-oxyneolignan-7,70,9-triol, (7R,8R)-4-hydroxy-3,30,50-trimethoxy-80,90-dinor-8,40-oxyneolignan-7,70,9-triol, and (7R,8R)-4-hydroxy-3,30,50-trimethoxy-8,40-oxyneolignan-7,9,90-triol-70-one, together with an unusual c-lactone,3-(3,4-dihydroxyphenyl)-4-pentanolide (4), andtwenty-five known compounds (5–29) were isolated fromthe aerial parts of Viburnum fordiae Hance. Their structuresincluding absolute configurations were determined byspectroscopic and chemical methods. Among them, compounds6, 7, 11–15, 17–28 were isolated from the Viburnumgenus for the first time. The anti-inflammatory and antioxidantactivities of all compounds were evaluated in vitro. Compounds 15, 19, 20 and 29 showed significant inhibitoryactivity on NO production in RAW264.7 cells stimulated byLPS with IC50 values ranging from 8.60 to 13.92 lM. Meanwhile, compounds 1–4, 15, 19, 20, 22, 23, 25, 26 and29 exhibited varying antioxidant activities through DPPH,ABTS free radical scavenging and FRAP assays.
Dong Li,Yunzhou Chen,Jialin Jia,Haiyang He,Wei Shi,Jianghua Yu,Jun Ma 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-
Effects of hydrothermal parameters on morphology, crystal structure, light absorption, separation efficiencyof photo-generated charge carriers, and photocatalytic removal of Bisphenol A (BPA) of Ti-basedTiO2 nanomaterials were systematically investigated. Through changing hydrothermal parameters,TiO2 nanobelts, TiO2 nanosheets and TiO2 nanowires were prepared. With increasing NaOH concentration,hydrothermal temperature, and hydrothermal time, more TiO2 with (101) crystal plane grew onTi substrate, resulting in higher crystallinity. The UV-light absorption enhanced with increasing NaOHconcentration, but decreased with improving hydrothermal temperature, hydrothermal time, and HClconcentration. Variation of UV-light absorption was mainly affected by morphology, and UV-light absorptionof TiO2 nanomaterials with different morphologies was arranged in order ofnanobelts > nanosheets > nanowires. The hydrothermal growth of TiO2 nanomaterials on Ti plate conformedto Ostwald ripening mechanism. Variation trend of photo-generated current was consistent withthat of BPA degradation, they both first increased and then decreased within investigated range. The optimalNaOH concentration, hydrothermal temperature, hydrothermal time, and HCl washing concentrationwere 1 M, 170℃, 28 h, and 0.1 M, respectively. Under this condition, Ti-based TiO2 nanosheets exhibitedthe highest BPA removal efficiency (92.7%), which was due to highly ordered nanosheet structure, goodcrystallinity, appropriate UV-light absorption and high separation efficiency of electron-hole pairs.
Jia Nan Zhang,Bo Zhi Chen,Mohammad Ashfaq,Xiao Peng Zhang,Xin Dong Guo 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.65 No.-
Hyaluronic acid (HA) has many applications in human medicine and cosmetic industry. This study describes the fabrication and evaluation of cross-linked HA (cHA) based microneedles (HA-cHA-MNs) for anti-ageing treatment. The results suggested that the increasing content of cHA gel particles decrease the mechanical properties of MNs. The in-vitro degradation profile and in-vivo epidermal expansion in mice were also carried out. The data suggested that the proportion of cHA particles decreased the rate of MNs degradation. The prepared HA-cHA-MNs have prolonged effectiveness with high swelling retention time or epidermal expansion time in mice up to 6 days or more.