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Thirteen-week Repeated Dose Toxicity and Genotoxicity Studies of Sophorae radix
Ji-Ran You,Jeong-Hwan Che,Seung-Hyun Kim,Euna Kwon,Eun-Young Cho,Jung-Hee Yoon,Yun-Soon Kim,Chang-Gil Kang,Hye-Jeong Jeong,Jung Ki Kim,Ja-June Jang,Hee-Chan Kim,Young-Tae Kim,Hyeon-Hoe Kim,Byeong-Cheo 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-
OB-25 : Development of a prediction model of probability of successful vaginal delivery
( Ji Yeon You ),( Hye Ran Lee ),( Sook Young Woo ),( So Yeon Yoon ),( Ye Ri Lee ),( Jung Joo An ),( Suk Joo Choi ),( Cheong Rae Roh ),( Jong Hwa Kim ),( Soo Young Oh ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Prediction of successful vaginal delivery in laboring women is clinically assessed by obstetricians depending on various factors associated with labor progression and maternal demographic characteristics. In this study, we tried to generate a prediction model based on these factors that can provide the arithmetical chance of successful vaginal delivery in real time for laboring women. We collected the clinical information from 1661 consecutive singleton pregnancies delivered at term from January 2008 to June 2009. The clinical information including maternal age, body mass index (BMI), gestational age at admission, parity, presence of labor induction, hourly cervical dilatation, time at examination, mode of delivery, and staff in charge was reviewed. Logistic regression analysis and generalized estimating equation were used to generate a prediction model. By the logistic regression analysis, we found that maternal age, BMI, gestational age at admission, parity, presence of induction, and hourly cervical dilatation were significant variables associated with successful vaginal delivery (p<0.05), but staff in charge were not (p=0.342). Using these independent variables, a prediction model that can provide the arithmetical chance of successful vaginal delivery in real time was generated. Areas under the receiver-operating characteristic curves of this prediction model was 0.94. Our prediction model could be used to provide the arithmetical chance of successful vaginal delivery in real time for laboring women.
( Ji Hun Kim ),( Jeong Won Jang ),( Chan Ran You ),( Si Young You ),( Mun Kyung Jung ),( Jin Hwan Jung ) The Editorial Office of Gut and Liver 2009 Gut and Liver Vol.3 No.3
It is known that neutropenia caused by combination pegylated interferon plus ribavirin therapy for hepatitis C virus (HCV) infection is well tolerated and carries a negligible risk of infection. Neutropenic enterocolitis is encountered most frequently in patients with hemato- oncologic diseases who are undergoing intensive chemotherapy. However, little information exists regarding this life-threatening event in the setting of HCV therapy. We present here an unusual case of fatal neutropenic enterocolitis in a cirrhotic patient receiving combination therapy for HCV infection. This is the first report of a death from neutropenic enterocolitis associated with treatment for chronic HCV infection. The present case suggests that caution should be exercised when continuing HCV therapy in neutropenic patients with advanced fibrosis, and the decision to maintain such therapy should be balanced against the potential for serious adverse events. (Gut and Liver 2009;3:218-221)
소아 천식환아에서 흡입용 fluticasone 및 tulobuterol의 병합치료와 두 배 용량 흡입용 fluticasone 치료의 효과 및 안전성 비교에 대한 다기관 연구
전유훈 ( You Hoon Jeon ),양현종 ( Hyeon Jong Yang ),유영 ( Young Yoo ),김영호 ( Young Ho Kim ),정지태 ( Ji Tae Jeong ),이혜란 ( Hae Ran Lee ),편복양 ( Bok Yang Pyun ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2009 소아알레르기 및 호흡기학회지 Vol.19 No.2
목적: 소아 천식 치료에서 흡입용 스테로이드의 용량을 증가시키는 것과 기존 용량의 흡입용 스테로이드에 기관지 확장제인 tulobuterol을 추가하는 것을 효과와 안전성 면에서 비교해 보고자 하였다. 방법: GINA 가이드라인에 따라 2단계(경증지속성) 천식으로 진단받고 하루 50-100 μg의 저용량 흡입용 스테로이드(fluticasone)로 유지치료를 받고 있는 4-8세의 소아천식 환자 중에서 step-up 치료를 고려하는 53명을 대상으로 하였다. 이들을 무작위로 기존의 흡입용 fluticasone용량(50-100 μg/일)에 tulobuterol (Hokunalin(R) patch 1 mg)을 추가한 군 (Flt+Hk군)과 흡입용 fluticasone을 두 배 용량(100-200 μg/일)으로 늘린 군 (Flt군)으로 나누었다. 이들을 각각 4주간 치료하였으며 이후 치료의 효과와 부작용을 보기 위해 추적관찰하였다. 두 군에서 치료시작전과 치료 4주 후의 천식 증상 점수의 변화, 일중 최대호기유속의 변화, 야간 증상으로 잠을 깬 횟수, 증상완화제의 사용 횟수를 비교하였고 치료에 대한 보호자의 전체적인 만족도, 이상 반응의 횟수를 조사하였다. 결과: 추적관찰이 된 환자는 Flt+Hk 군, Flt군 각각 24명이었다. 치료시작전과 치료 4주 후 두 군간의 전체적인 천식증상점수 변화는 Flt+Hk 군에서 -0.01±0.24 , Flt 군에서 -0.05±0.17로 두 군 간에 통계적으로 유의한 차이는 없었다.(P=0.54) 아침 최대호기유속의 평균변화와 저녁 최대호기유속의 평균 변화는 통계적으로 큰 차이를 보이지 않았다.(P=0.83, P=0.83) 야간 증상으로 잠을 깬 횟수나 증상완화제의 사용 횟수, 치료에 대한 보호자의 전체적인 만족도도 두 군 간에 차이가 없었다.(P=0.17, P=0.32, P=0.63) 치료 중의 이상증상의 경험 빈도 역시 통계학적으로 유의한 차이를 보이지 않았다.(P=1.00) 결론: 소아천식환아에서 흡입용 fluticasone propionate및 tulobuterol의 병합치료는 두 배 용량의 흡입용 fluticasone propionate 단독치료만큼 효과가 있으며 안전성도 비슷한 것으로 나타났다. 스테로이드 치료에 대한 거부감이나 잠재적 부작용에 대한 두려움을 가지고 있는 환자에서 흡입용 스테로이드의 용량을 늘리는 치료에 대한 대체치료로 tulobuterol의 병합치료를 고려할 수 있겠다. Purpose: We aim to compare the effectiveness and safety of fluticasone propionate (Flt) plus tulobuterol (Hk) versus high-dose Flt alone in controlling asthma in children. Methods: Fifty three children aged 4 to 8 years, who were diagnosed with mild persistent asthma and underwent maintenance therapy with a low dose of inhaled corticosteroid (Flt) of 50-100 μg/day were randomized to receive Flt plus Hk (Hokunalin(R) patch 1 mg, Abbott Japan, Tokyo, Japan), or Flt alone at twice the dosage. Patients underwent new treatment for 4 weeks. Asthma symptom scores, mean changes in morning and evening peak expiratory flow (PEF), the frequency of night awakenings, the use of reliever medication, caregiver`s overall satisfaction and safety were evaluated and compared in each group. And they were followed-up again 4 week after treatment course for the evaluation of treatment-emergent adverse event (TEAE). Results: No significant difference was found between the groups in terms of mean changes in the morning and evening PEF, the frequency of night awakening, the use of rescue medication and caregiver`s overall satisfaction (P=0.83, P=0.83, P=0.17, P=0.32 and P=0.63). Furthermore, no statistically significant difference was observed between 2 groups in the incidence of any TEAE (P=1.00). Conclusion: This study demonstrated that a combination of Flt and Hk was as effective as a high-dose Flt therapy in the management of mild persistent asthma in children. The results of this study suggest that tulobuterol add-on therapy can be considered as a reasonable substitute to an increase in the dosage of steroid in the patients with steroid-phobia and it might be used to reduce the risk of high dose steroid therapy. [Pediatr Allergy Respir Dis(Korea) 2009;19:125-136]