RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      • 좁혀본 항목

      • 좁혀본 항목 보기순서

        • 원문유무
        • 음성지원유무
          • 원문제공처
          • 등재정보
          • 학술지명
          • 주제분류
          • 발행연도
          • 작성언어
          • 저자

        오늘 본 자료

        • 오늘 본 자료가 없습니다.
        더보기
        • 무료
        • 기관 내 무료
        • 유료
        • SCIESCOPUSKCI등재

          Review : Liver Transplantation

          ( Deok Bog Moon ), ( Sung Gyu Lee ) The Editorial Office of Gut and Liver 2009 Gut and Liver Vol.3 No.3

          Liver transplantation has become a lifesaving procedure for patients who have chronic end-stage liver disease and acute liver failure. The satisfactory outcome of liver transplantation has led to insufficient supplies of deceased donor organs, particularly in East Asia. Hence, East Asian surgeons are concentrating on developing and performing living-donor liver transplantation (LDLT). This review article describes an update on the present status of liver transplantation, mainly in adults, and highlights some recent developments on indications for transplantation, patient selection, donor and recipient operation between LDLT and deceased-donor liver transplantation (DDLT), immunosuppression, and long-term management of liver transplant recipients. Currently, the same indication criteria that exist for DDLT are applied to LDLT, with technical refinements for LDLT. In highly experienced centers, LDLT for high-scoring (>30 points) Model of End-Stage Liver Disease (MELD) patients and acuteon- chronic liver-failure patients yields comparably good outcomes to DDLT, because timely liver transplantation with good-quality grafting is possible. With increasing numbers of liver transplantations and longterm survivors, specialized attention should be paid to complications that develop in the long term, such as chronic renal failure, hypertension, diabetes mellitus, dyslipidemia, obesity, bone or neurological complications, and development of de novo tumors, which are highly related to the immunosuppressive treatment. (Gut and Liver 2009;3:145-165)

        • SCIESCOPUSKCI등재

          ORiginal Article : Hypocholesterolemia in Patients with an Amebic Liver Abscess

          ( Maria S Flores ), ( Adriana Obregon Cardenas ), ( Eva Tamez ), ( Elba Rodriguez ), ( Katiushka Arevalo ), ( Isela Quintero ), ( Rolando Tijerina ), ( Francisco Bosques ), ( Luis Galan ) The Editorial Office of Gut and Liver 2014 Gut and Liver Vol.8 No.4

          Background/Aims: Many parasites induce changes in the lipid profiles of the host. Cholesterol increases the virulence of Entamoeba histolytica in animal models and in vitro culture. This study aimed to determine, in patients with an amebic liver abscess, the correlation between cholesterol and other features, such as the size and number of abscesses, standard hematological and serum chemistry profiles, liver tests, and duration of hospital stay. Methods: A total of 108 patients with an amebic liver abscess and 140 clinically healthy volunteers were investigated. Cholesterol and triglycerides were measured in the sera. The data from medical observations and laboratory tests were obtained from the clinical records. Results: A total of 93% of patients with an amebic liver abscess showed hypocholesterolemia not related to any of the studied parameters. Liver function tests correlated with the size of the abscess. The most severe cases of amebic liver disease or death were found in patients whose cholesterol levels continued to decrease despite receiving antiamebic treatment and hospital care. Conclusions: Our results show that the hypocholesterolemia observed in patients with an amebic liver abscess is not related to any of the clinical and laboratory features analyzed. This is the first study relating hypocholesterolemia to severity of hepatic amebiasis. (Gut Liver 2014;8:415-420)

        • SCIESCOPUSKCI등재

          ORiginal Article : Prediction of Advanced Fibrosis in Nonalcoholic Fatty Liver Disease; An Enhanced Model of BARD Score

          ( Tae Hoon Lee ), ( Seung Hye Han ), ( Ju Dong Yang ), ( Donghee Kim ), ( Monjur Ahmed ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.3

          Background/Aims: The BARD score is a model to detect advanced liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients. The aims of this study were to identify additional factors and then to build an enhanced version of the BARD score. Methods: One hundred seven patients with biopsy proven NAFLD were enrolled retrospectively. Logistic regressions were performed to identify independent risk factors for advanced liver fibrosis (stage 3 or 4). An enhanced model of the BARD score (BARDI score) was built and evaluated with a receiver operating characteristic (ROC) curve. Results: In multivariate analysis, age (odds ratio [OR], 0.89; p=0.04), aspartate aminotransferase/alanine aminotransferase ratio (OR, 1.73; p<0.01), and international normalized ratio (INR) (OR, 8.85; p<0.01) were independently significant factors. The BARDI score was created by adding the INR to the BARD. The area under the ROC curve of the BARDI score was significantly larger than that of the BARD score (0.881 vs 0.808, p<0.01). A BARDI score of 3 or more showed a positive predictive value (PPV) of 51.0% and a negative predictive value (NPV) of 96.0%. Conclusions: The BARDI score had an improved PPV over the BARD score and maintained an excellent NPV. Further study is warranted for its external validation and comparison with other models. (Gut Liver 2013; 7:323-328)

        • SCIESCOPUSKCI등재

          Original Article : Decreased Hepatic Nerve Fiber Innervation in Patients with Liver Cirrhosis

          ( Soon Woo Nam ), ( Hyun Joo Song ), ( Su Jung Back ), ( Tae Hun Kim ), ( Se Hyun Cho ), ( Joon Yeol Han ), ( Kwon Yoo ), ( Young Suk Lee ), ( Kyu Won Chung ) The Editorial Office of Gut and Liver 2007 Gut and Liver Vol.1 No.2

          Background/Aims: Hepatic nerve innervation plays important roles in hepatic metabolism and hemodynamic mechanisms. We compared the distribution patterns of hepatic nerves between normal livers and two liver diseases to elucidate the effects of liver disease on the distribution of hepatic nerves. Methods: Tissue specimens were obtained by ultrasonography-guided needle biopsies from 10 normal controls, 74 patients with chronic hepatitis (CH), and 35 patients with liver cirrhosis (LC). The obtained specimens were immunohistochemically stained using antibodies for S-100 protein and α-smooth-muscle actin (α-SMA). The degree of the expression in liver tissues was quantified by manual counting of positively stained nerve fibers under light microscopy. The serum hyaluronic acid level was assayed in all subjects to evaluate hepatic fibrosis. Electron microscopy examinations were also performed. Results: The hepatic nerve innervation was significantly lower in LC than in normal controls, as indicated by S-100 protein staining. α-SMA and hyaluronic acid levels were higher in LC and CH than in normal controls. Electron microscopy revealed that unmyelinated nerve fiber bundles in the intralobar connective tissue coursed in the vicinity of hepatic triads. Conclusions: These results suggest that hepatic nerve innervation can be decreased by hepatic inflammatory responses and/or fibrotic changes in LC patients. Further study is needed to clarify this observation. (Gut and Liver 2007; 1:165-170)

        • SCIESCOPUSKCI등재

          Original Article : Ischemia-Modifi ed Albumin Levels in Children with Chronic Liver Disease

          ( Murat Cakir ), ( Suleyman Caner Karahan ), ( Ahmet Mentese ), ( Elif Sag ), ( Umit Cobanoglu ), ( Tugcin Bora Polat ), ( Erol Erduran ) The Editorial Office of Gut and Liver 2012 Gut and Liver Vol.6 No.1

          Background/Aims: Ischemia-modifi ed albumin (IMA) levels have been shown to correlate with the severity of liver failure in adults. However, the role of IMA levels has not been evaluated in children with chronic liver disease (CLD). We analyzed the clinical significance of IMA levels in children with CLD. Methods: Thirty-three children with CLD and 33 healthy children were included in the study. Blood was collected to analyze biochemical parameters, oxidant status, and IMA. Liver biopsies were re-evaluated for liver fibrosis; severe fibrosis (SF) was defi ned as fi brosis stage ≥4. Results: The IMA and and IMA to albumin ratios (IMARs) were signifi cantly higher in children with CLD than in those without (IMA: 0.545±0.095 vs 0.481±0.062, p=0.003; IMAR: 0.152±0.046 vs 0.126±0.018, p=0.04). The IMAR was positively correlated with the pediatric end-stage liver disease score (p=0.03, r=0.503) and fibrosis score (p=0.021, r=0.400). Patients with SF had higher IMARs compared to patients with mild fi brosis (0.181±0.056 vs 0.134±0.025, p=0.003). The area under the receiver operation curve (AUROC) for predicting SF was 0.78 (p=0.006). Using a cutoff ratio value of 0.140, the sensitivity and specificity were 84% and 70%, respectively. The AUROC for predicting the need for liver transplantation and/or death was 0.82 (p=0.013). With a cutoff value of 0.156, the sensitivity and specifi city was 83% and 82%, respectively. Kaplan-Meier analysis revealed increased morbidity and/or mortality in the group with an IMAR>0.156 (50% vs 4.3%, p=0.005). Conclusions: IMARs have been shown to provide important clues in predicting the fi brosis stage of the disease and determining the outcome in children with CLD. (Gut Liver 2012;6:92-97)

        • SCIESCOPUSKCI등재

          ORiginal Article : Endoscopic Management of Bile Leakage after Liver Transplantation

          ( Dongwook Oh ), ( Sung Koo Lee ), ( Tae Jun Song ), ( Do Hyun Park ), ( Sang Soo Lee ), ( Dong Wan Seo ), ( Myung Hwan Kim ) The Editorial Office of Gut and Liver 2015 Gut and Liver Vol.9 No.3

          Background/Aims: Endoscopic retrograde cholangiopancreatography (ERCP) can be an effective treatment for bile leakage after liver transplantation. We evaluated the efficacy of endoscopic treatment in liver transplantation in patients who developed bile leaks. Methods: Forty-two patients who developed bile leaks after liver transplantation were included in the study. If a bile leak was observed on ERCP, a sphincterotomy was performed, and a nasobiliary catheter was then inserted. If a bile leak was accompanied by a bile duct stricture, either the stricture was dilated with balloons, followed by nasobiliary catheter insertion across the bile duct stricture, or endoscopic retrograde biliary drainage was performed. Results: In the bile leakage alone group (22 patients), endoscopic treatment was technically successful in 19 (86.4%) and clinically successful in 17 (77.3%) cases. Among the 20 patients with bile leaks with bile duct strictures, endoscopic treatment was technically successful in 13 (65.0%) and clinically successful in 10 (50.0%) cases. Among the 42 patients who underwent ERCP, technical success was achieved in 32 (76.2%) cases and clinical success was achieved in 27 (64.3%) cases. Conclusions: ERCP is an effective and safe therapeutic modality for bile leaks after liver transplantation. ERCP should be considered as an initial therapeutic modality in post-liver transplantation patients. (Gut Liver 2015;9:417-423)

        • KCI등재후보SCOPUS

          Case Report : Pulmonary Arteriovenous Malformation in Cryptogenic Liver Cirrhosis Associated with Turner`s Syndrome

          ( Ji Hoon Kim ), ( Young Kul Jung ), ( Eun Seok Jeong ), ( Yeon Seok Seo ), ( Hyung Joon Yim ), ( Jong Eun Yeon ), ( Jae Jeong Shim ), ( Kwan Soo Byun ), ( Chang Hong Lee ) The Editorial Office of Gut and Liver 2010 Gut and Liver Vol.4 No.2

          Turner`s syndrome is a genetic disorder of the sex chromosomes (e.g., 45,X or 45,X/46,XX) that manifests as various congenital anomalies. Despite its numerous extragonadal manifestations and frequent accompanying abnormalities in liver function tests, liver cirrhosis associated with Turner`s syndrome has not been reported in Korea. Moreover, pulmonary arteriovenous malformations (PAVMs) have rarely been reported in association with liver cirrhosis, but there have been no reports of PAVMs occurring in cryptogenic liver cirrhosis associated with Turner`s syndrome. We report a case of PAVM that occurred in cryptogenic liver cirrhosis associated with Turner`s syndrome. (Gut Liver 2010;4:258-261)

        • SCIESCOPUSKCI등재

          Review : NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications

          ( Geoffrey C. Farrell ), ( Derrick Van Rooyen ), ( Lay Gan ), ( Shivrakumar Chitturi ) The Editorial Office of Gut and Liver 2012 Gut and Liver Vol.6 No.2

          While non-alcoholic fatty liver disease (NAFLD) is highly prevalent (15% to 45%) in modern societies, only 10% to 25% of cases develop hepatic fibrosis leading to cirrhosis, end-stage liver disease or hepatocellular carcinoma. Apart from pre-existing fibrosis, the strongest predictor of fibrotic progression in NAFLD is steatohepatitis or non-alcoholic steatohepatitis (NASH). The critical features other than steatosis are hepatocellular degeneration (ballooning, Mallory hyaline) and mixed infl ammatory cell infi ltration. While much is understood about the relationship of steatosis to metabolic factors (over-nutrition, insulin resistance, hyperglycemia, metabolic syndrome, hypoadiponectinemia), less is known about infl ammatory recruitment, despite its importance for the perpetuation of liver injury and fi brogenesis. In this review, we present evidence that liver infl ammation has prognostic signifi cance in NAFLD. We then consider the origins and components of liver infl ammation in NASH. Hepatocytes injured by toxic lipid molecules (lipotoxicity) play a central role in the recruitment of innate immunity involving Toll-like receptors (TLRs), Kupffer cells (KCs), lymphocytes and neutrophils and possibly infl ammasome. The key pro-infl ammatory signaling pathways in NASH are nuclear factor-kappa B (NF-κB) and c-Jun N-terminal kinase (JNK). The downstream effectors include adhesion molecules, chemokines, cytokines and the activation of cell death pathways leading to apoptosis. The upstream activators of NF-κB and JNK are more contentious and may depend on the experimental model used. TLRs are strong contenders. It remains possible that infl ammation in NASH originates outside the liver and in the gut microbiota that prime KC/TLR responses, infl amed adipose tissue and circulating infl ammatory cells. We briefl y review these mechanistic considerations and project their implications for the effective treatment of NASH. (Gut Liver 2012;6:149-171)

        • SCIESCOPUSKCI등재

          Original Article : Biliary Stricture after Adult Right-Lobe Living-Donor Liver Transplantation with Duct-to-Duct Anastomosis: Long-Term Outcome and Its Related Factors after Endoscopic Treatment

          ( Jae Hyuck Chang ), ( In Seok Lee ), ( Jong Young Choi ), ( Seung Kyoo Yoon ), ( Dong Goo Kim ), ( Young Kyoung You ), ( Ho Jong Chun ), ( Dong Ki Lee ), ( Myung Gyu Choi ), ( In Sik Chung ) The Editorial Office of Gut and Liver 2010 Gut and Liver Vol.4 No.2

          Background/Aims: Biliary stricture is the most common and important complication after right-lobe living- donor liver transplantation (RL-LDLT) with duct-to-duct biliary anastomosis. This study evaluated the efficacy and long-term outcome of endoscopic treatment for biliary stricture after LDLT, with the aim of identifying the factors that influence the outcome. Methods: Three hundred and thirty-nine adults received RL-LDLTs with duct-to-duct biliary anastomosis between January 2000 and May 2008 at Kangnam St. Mary`s Hospital. Endoscopic retrograde cholangiography (ERC) was performed in 113 patients who had biliary stricture after LDLT. We evaluated the incidence of post-LDLT biliary stricture and the long-term outcome of endoscopic treatment for biliary stricture. The factors related to the outcome were analyzed. Results: Biliary strictures developed in 121 (35.7%) patients, 95 (78.5%) of them within 1 year of surgery. The mean number of ERCs performed per patient was 3.2 (range, 1 to 11). The serum biochemical markers decreased significantly after ERC (p<0.001). Stent insertion or stricture dilatation during ERC was successful in 90 (79.6%) patients. After a median follow-up period of 33 months from the first successful treatment with ERC, 48 (42.5%) patients achieved treatment success and 12 (10.6%) patients remained under treatment. The factors related to the outcome of endoscopic treatment were nonanastomotic stricture and stenosis of the hepatic artery (p=0.016). Conclusions: Endoscopic treatment is efficacious and has an acceptable long-term outcome in the management of biliary strictures related to RL-LDLT with duct-to-duct biliary anastomosis. Nonanastomotic stricture and stenosis of the hepatic artery are correlated with a worse outcome of endoscopic treatment. (Gut Liver 2010;4:226-233)

        • SCIESCOPUSKCI등재

          ORiginal Article : Comparative Study of Shear Wave Velocities Using Acoustic Radiation Force Impulse Technology in Hepatocellular Carcinoma: The Extent of Radiofrequency Ablation

          ( Ji Oung Kang ), ( Hee Jin Kwon ), ( Jin Han Cho ), ( Jong Young Oh ), ( Kyung Jin Nam ), ( Seong Kuk Yoon ), ( Myong Jin Kang ), ( Sung Wook Lee ), ( Sang Yeong Han ) The Editorial Office of Gut and Liver 2012 Gut and Liver Vol.6 No.3

          Background/Aims: The purpose of this study was to as-sess the value of acoustic radiation force impulse (ARFI) for predicting the extent of radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) by correlating the elastic-ity of HCC and peritumoral parenchyma (as measured by ARFI) with the extent of ablation determined by computed tomography (CT). Methods: From September 2009 to June 2011, 158 patients underwent RFA ablation for HCC (single, ≤3 cm). We evaluated the data of a total of 38 prospectively enrolled patients who underwent both ARFI imaging and contrast-enhanced CT after one session of 12 minutes of RFA without a change in needle position. The ARFI imaging indices, including the mean shear wave velocity (SWV) of HCC, mean SWV of the peritumoral parenchyma and tumor size, were evaluated to determine the statistical correlation with RFA extent after one session of 12 minutes of RFA. Results: A stiffer liver parenchyma in patients with cirrhosis results in a smaller ablation zone. Conclusions: SWV of ARFI in liver parenchyma was well correlated with RFA extent. After evaluating the correlation between ARFI and RFA extent, we suggest that the SWV in liver parenchyma might be a non-invasive supplementary tool for predicting the extent of RFA. (Gut Liver 2012;6:362-367)

        맨 위로 스크롤 이동