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난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화
이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3
Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.
락탐화합물의 고리 확장 연구 : 입체 선택성과 Mechanism에 관한 연구 Study of Stereoselectivity and Mechanism
하진렬,최경민,김지아,원태진,신동수,이민주,안철진 昌原大學校 基礎科學硏究所 2002 基礎科學硏究所論文集 Vol.14 No.-
The ring expansion chemistry is one of the most important methods to prepare five-and six-membered heterocylic compounds. We have studied about γ-lactam ring expansion with stereoselectivity from β-lactam derivative. To do this chemistry, proton of N-benzyl group in β-lactam derivatives is eliminated by LDA and make carbanion.This anion make unstable 4-membered lactam intermediate, and then the ring is opened by homo clevage or hetero cleavage for releasing ring strain, followed by recyclization to one carbon to make γ-lactam ring with stereoselectivity in β-, γ- positions.
β-Lactam 유도체의 N(1)-C(4) 위치에 한 개의 탄소를 도입한 입체 선택적 고리확장에 관한 연구
하진렬,오선주,김지아,신동수,안철진 昌原大學校 基礎科學硏究所 2003 基礎科學硏究所論文集 Vol.15 No.-
The base induced ring opening of β -1actam derivatives with LDA gave γ-lactam derivatives stereoselectively. The γ -1actam derivatives were formed stereoselectively depending on β-3 substituent of B-lactam derivatives.
Kim, Ji Yeun,Kwon, Jung Hyun,Ahn, So Hyun,Lee, Sang Il,Han, Young Shin,Choi, Young Ok,Lee, Soo Young,Ahn, Kang Mo,Ji, Geun Eog Blackwell Publishing Ltd 2010 Pediatric allergy and immunology Vol.21 No.2
<P>Kim JY, Kwon JH, Ahn SH, Lee SI, Han YS, Choi YO, Lee SY, Ahn KM, Ji GE. Effect of probiotic mix (<I>Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus</I>) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial.Pediatr Allergy Immunol 2010: 21: e386–e393.© 2009 John Wiley & Sons A/S</P><P>Controversy exists regarding the preventive effect of probiotics on the development of eczema or atopic dermatitis. We investigated whether supplementation of probiotics prevents the development of eczema in infants at high risk. In a randomized, double-blind, placebo-controlled trial, 112 pregnant women with a family history of allergic diseases received a once-daily supplement, either a mixture of <I>Bifidobacterium bifidum</I> BGN4, <I>B. lactis</I> AD011, and <I>Lactobacillus acidophilus</I> AD031, or placebo, starting at 4–8 wks before delivery and continuing until 6 months after delivery. Infants were exclusively breast-fed during the first 3 months, and were subsequently fed with breastmilk or cow’s milk formula from 4 to 6 months of age. Clinical symptoms of the infants were monitored until 1 yr of age, when the total and specific IgE against common food allergens were measured. A total of 68 infants completed the study. The prevalence of eczema at 1 yr in the probiotic group was significantly lower than in the placebo group (18.2% vs. 40.0%, p = 0.048). The cumulative incidence of eczema during the first 12 months was reduced significantly in probiotic group (36.4% vs. 62.9%, p = 0.029); however, there was no difference in serum total IgE level or the sensitization against food allergens between the two groups. Prenatal and postnatal supplementation with a mixture of <I>B. bifidum</I> BGN4, <I>B. lactis</I> AD011, and <I>L. acidophilus</I> AD031 is an effective approach in preventing the development of eczema in infants at high risk of allergy during the first year of life.</P>
Ahn, Ji Young,Kim, Whi Dong,Kim, Jae Hyun,Kim, Ji Hoon,Lee, Jae Keun,Kim, Jong Man,Kim, Soo H. Hindawi Limited 2011 Journal of nanomaterials Vol.2011 No.-
<P>We demonstrate a simple and viable method for controlling the energy release rate and pressurization rate of nanoenergetic materials by controlling the relative elemental compositions of oxidizers. First, bimetallic oxide nanoparticles (NPs) with a homogeneous distribution of two different oxidizer components (CuO and Fe2O3) were generated by a conventional spray pyrolysis method. Next, the Al NPs employed as a fuel were mixed with CuO-Fe2O3bimetallic oxide NPs by an ultrasonication process in ethanol solution. Finally, after the removal of ethanol by a drying process, the NPs were converted into energetic materials (EMs). The effects of the mass fraction of CuO in the CuO-Fe2O3bimetallic oxide NPs on the explosive reactivity of the resulting EMs were examined by using a differential scanning calorimeter and pressure cell tester (PCT) systems. The results clearly indicate that the energy release rate and pressurization rate of EMs increased linearly as the mass fraction of CuO in the CuO-Fe2O3bimetallic oxide NPs increased. This suggests that the precise control of the stoichiometric proportions of the strong oxidizer (CuO) and mild oxidizer (Fe2O3) components in the bimetallic oxide NPs is a key factor in tuning the explosive reactivity of EMs.</P>
Ahn, Byung-Soo,Kim, Seong-Kyu,Kim, Ha Neul,Lee, Ji-Hye,Lee, Ji-Hwan,Hwang, Deog Sang,Bae, Hyunsu,Min, Byung-Il,Kim, Sun Kwang Hindawi Publishing Corporation 2014 Evidence-based Complementary and Alternative Medic Vol.2014 No.-
<P>Activation of spinal glial cells plays a crucial role in the pathogenesis of neuropathic pain. An administration of oxaliplatin, an important anticancer drug, often induces acute neuropathic cold hypersensitivity and/or mechanical hypersensitivity in patients. Gyejigachulbu-tang (GBT), a herbal formula comprising<I> Cinnamomi Cortex, Paeoniae Radix, Atractylodis Lanceae Rhizoma, Zizyphi Fructus, Glycyrrhizae Radix, Zingiberis Rhizoma, </I>and<I> Aconiti Tuber</I>, has been used in East Asia to treat various pain symptoms, especially in cold patients. This study investigated whether and how GBT alleviates oxaliplatin-induced cold and mechanical hypersensitivity in rats. The behavioral signs of cold and mechanical hypersensitivity were evaluated by a tail immersion test in cold water (4°C) and a von Frey hair test, respectively. The significant cold and mechanical hypersensitivity were observed 3 days after an oxaliplatin injection (6 mg/kg, i.p.). Daily oral administration of GBT (200, 400, and 600 mg/kg) for 5 days markedly attenuated cold and mechanical hypersensitivity. Immunoreactivities of glial fibrillary acidic protein (GFAP, astrocyte marker) and OX-42 (microglia marker) in the spinal dorsal horn were significantly increased by an oxaliplatin injection, which were restored by GBT administration. These results indicate that GBT relieves oxaliplatin-induced cold and mechanical hypersensitivity in rats possibly through the suppression of spinal glial activation.</P>
Ahn, Ji Young,Moon, Kook Joo,Kim, Ji Hoon,Lee, Sang Hyun,Kang, Jae Wook,Lee, Hyung Woo,Kim, Soo Hyung American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.2
<P>We fabricated solid and mesoporous TiO<SUB>2</SUB> nanoparticles (NPs) with relatively large primary sizes of approximately 200 nm via inorganic templates for aero-sol–gel and subsequent aqueous-washing processes. The amount of dye molecules adsorbed by the internal pores in the mesoporous TiO<SUB>2</SUB> NPs was increased by creating the nanopores within the solid TiO<SUB>2</SUB> NPs. Simultaneously, the light-scattering effect of the mesoporous TiO<SUB>2</SUB> NPs fabricated by this approach was secured by maintaining their spherical shape and relatively large average size. By precisely accumulating the fabricated solid or mesoporous 200 nm diameter TiO<SUB>2</SUB> NPs on top of a conventional 25 nm diameter TiO<SUB>2</SUB> NP-based underlayer, we could systematically examine the effect of the solid and mesoporous TiO<SUB>2</SUB> NPs on the photovoltaic performance of dye-sensitized solar cells (DSSCs). Consequently, the stacking architecture of the mesoporous TiO<SUB>2</SUB> NP-based overlayer, which functioned as both a light-scattering and dye-supporting medium, on top of a conventional solid TiO<SUB>2</SUB> NP-based underlayer in a DSSC photoelectrode (i.e., double-layer structures) was found to be very promising for significantly improving the photovoltaic properties of conventional solid TiO<SUB>2</SUB> NP single-layer-based DSSCs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-2/am4041866/production/images/medium/am-2013-041866_0009.gif'></P>
Ahn, Ji Young,Kim, Ji Hoon,Kim, Jong Man,Lee, Deug Woo,Park, Jong Kweon,Kim, Soo Hyung American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.10
<P>We demonstrated that the size and morphology of an oxidizer have strong effects on the propulsion forces of nano-Al-based propellants. Enhanced propulsion forces could be obtained through the creation and addition of various oxidizer nanoparticles and nanowires in nano-Al-based propellants.</P>