제2형 당뇨병 환자에서 Voglibose와 Acarbose의 비교임상연구

정인경,정재훈,민용기,이명식,이문규,김광원,정윤이,박중열,홍성관,이기업 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.2

연구배경:아카보스와 보글리보스는 ­glucosidase inhibitors로써 비록 약리학적 작용이나 부작용에 있어서 두 약물간에 차이가 있다는 것은 잘 알려져 있으나 당뇨병 환자를 대상으로 아직 이에 대한 두 약물간에 직접적인 비교에 대해 연구된 바는 없었다. 이에 저자등은 국내 2형 당뇨병 환자에 대해 유효성과 부작용 발현에 대해 두 약제를 비교하고자 무작위법에 의한 위약 대조군의 이중 맹검법 연구를 시행하였다. 방법:시험 약제 투여 4주간의 관찰기를 설정하여 공복혈당의 변화가 30㎎/dL 이하이고, 식후 혈당이 200㎎/dL 이상인 환자로 기타 제외 기준에 해당하지 않은 환자 53명을 대상으로 하여 보글리보스 군(24명)과 아카보스 군(29명)으로 무작위로 나누었다. 치료기간은 총 8주로 하였으며, 4주간 간격으로 혈청학적 검사와 부작용을 분석하여 치료 효과가 부작용을 평가하였다. 결과:1)혈당 변화:보글리보스군은 식후 1시간 혈당이 치료 후 4주, 8주째 의미 있게 감소하였도, 아카보스군은 식후 1시간과 2시간 혈당이 치료 후 4주, 8주째 의미있게 감소하였다. 또한 관찰기 혈당에 대한 치료 4주째 감소량은 아카보스군에서 더 큰 경향을 보였으나, 치료 8주째에는 두 군 간의 강하정도에 의미있는 차이가 없었다(p=0.569). 2)인슐린 치의 변화:보글리스 군은 식후 1시간 인슐린 치가 치료 전에 비해 치료 4주, 8주째 감소하는 경향을 보였고, 공복 인슐린이나 식후 2시간 인슐린치는 치료전 후에 의미 있는 차이가 없었다. 아카보스군에서는 치료 전후로 공복 인슐린, 식후 1시간과 2시간 인슐린치에 의미 있는 차이를 보이지 않았다. 두약제 간에 치료 전과 치료 8주사이의 식후 2시간 인슐린의 감소량이 보글리보스 군에서 의미있게 높았다(p=0.040). 3)당화혈색소:보글리보스 군은 치료 전에 비해 치료후 당화혈색소가 감소하는 경향을 보였고, 아카보스군은 치료 전에 비해 의미있게 감소하였다. 당화혈색소 변화량은 두 군간에 의미 있는 차이는 없었다(p=0.412). 4)지질대사의 변화:중성지방, 콜레스테롤, 고밀도 진단백 콜레스테롤에 대해 두 군간에 의미 있는 차이는 없었다. 5)부작용:소화기계 부작용의 빈도는 치료 4주째 보글리보스 군에서 의미 있게 낮았으나(p=0.028), 치료 8주째 부작용의 빈도는 두 군간에 의미 있는 차이가 없었다(p=0.215). 결론:2형 당뇨병 환자에서 보글리보스와 아카보스의 두 약제의 임상적 유효성과 부작용발현에 대해 비교한 결과 치료 후 8 주 후 혈당강화효과는 두 약제간에 유사한 효과를 보였으나 보글리보스군에서 4주째의 초기 위장관 부작용이 적었다. Background : Acarbose and voglibose are alpha-glucosidase inhibitors. Although different pharmacological effects and adverse abdominal events associated with the two drugs have been reported, no study directly compared acarbose and voglibose in diabetes has been undertaken. To compare the pharmacological effects and gastrointestinal adverse events between two drugs, a randomized, placebo-controlled, double-bind study was performed in type 2 diabetes patients. Methods : The period of study was 12 weeks(observation period: 4 weeks; treatment period: 8 weeks). Fifty-three patients were randomized into two groups(the acarbose group: 24 patients; the voglibose group: 29 patients). The serum glucose, insulin, fructosamine, HbA_1c, cholesterol, triglyceride and the incidence of adverse events were measured. Results : 1) The reduction of glucose from before treatment to 4 weeks after treatment was significantly higher in the acarbose group, but the change before treatment and 8 weeks after treatment in the two groups was similar(p=0.569). 2) The insulin significantly decreased after voglibose treatment(p=0.040). 3) HbAa_1c level tended to decrease in voglibose group, and there was a significant decrease after acarbose treatment. However, the change in HbA_1c level before and after treatment was similar between the two groups(p=0.412). 4) The two drugs did not cause any other changes in the total, HDL-cholesterol and triglyceride. 5) The number of patients with gastrointestinal adverse events was significantly low 4 weeks after voglibose treatment (p=0.049), but the incidence in the two groups was similar after 8 weeks(p=0.215). Conclusions : Acarbose and voglibose significantly improved postprandial hyperglycemia in diabetes. The incidence of gastrointestinal adverse events was low 4 weeks after voglibose treatment(J Kor Diabetes 26:134~145, 2002).

하악골 골절수술에서 흡수성 골고정장치의 유용성

문재원,천지선,양정열 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Introduction: The mandible is one of frequent facial bone fracture due to anatomic configuration like the nose and zygoma. When the mandible fractures occured, displacement of segments developed by pulling of strong muscles. And so for reduction of fractured mandible, rigid fixation needs for prevention of displacement. Metal plates and screws are most appropriate device to obtain for prevention of displacement in case of mandible fracture. But metal devices are hampered by temperature sensitivity and interference with radio-graphic imaging, leading corrosion, inflammatory response, the effect of atrophy of cortical bone, the need for a subsequent operation for removal. To overcome drawbacks of metal rigid fixation devices, there had been a continuous research on the development of a bioabsorbable skeletal fixation system using polymers of polylactic and polyglycolic acid. Material and Method: One hundred sixty eight fractures of the mandible in 110 patients (84 male patients and 26 female patients) were treated by open reduction and internal fixation using bioabsorbable plates and screws (BiosorbFX^(R), Bionix Implants, Inc., Finland). The average age is 36.5 years old. Total number used absorbable devices and 972 (182 plates and 790 screws). Patients were evaluated during the follow-up period, which ranged from 1 to 30 months. Common fracture sites are para symphysis (26%), body (19%) and angle (18%) which are experienced. Intermaxillary fixation placed before operation but removed after internal fixation of absorbable devices. After 5 days from operation, temporomandibular joint movement are started. We encountered no significant intraoperative difficulties obtaining placement of the devices. Result: None of patients has been experienced any implant-related complication including fracture instability or relapse, or radiographic evidence of osteolysis except one case of delayed osteomyelitis and four cases of intraoral infections. Conclusion: Absorbable devices have many advantage, that are lower infection rates, satisfactory strength, no metallic irritation, no restrictive growth of the neurocranium in pediatric patients, only one surginal procedure. Absorbable devices have some problems, such as slow and expense. But we experienced good results using absorbable devices to mandible fracture, and these results indicate that the use of bioabsorbable implants can be considered routinely for the fixation of mandible fractures.

엄지손가락 과다증을 동반한 수열에서 이엽피판을 이용한 제 1 갈퀴막 공간의 재건

문재원,천지선,양정열 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Cleft hand is a rare disease that is characterized by absence of one or more digits, It was introduced by Abroise Pare in 1575. The cause of this is not identified yet. Polydactyly is defined as normally pentadactylous hand with excess digits, It was reported that the possible cause of polydactyly is increased folding of AER(apical ectodermal ridge). There are so rare cases that cleft hand is accompanied with preaxial polydactyly. We experienced a case of cleft hand with preaxial polydactyly. That case had narrowing of first web space and thumb polydactyly. Untilil now, there have been so many methods of reconstruction of web such as skin graft, z-plasty, dorsal and volar flap, etc. We reconstruct the first web with bilobed flap elevated from polydactylized thumb. As it has good results of functional and cosmetic properties, It's very useful to use accessory tissue from polydactylized finger such as our case.

저선량 감마선 조사가 왕겨의 항산화능에 미치는 영향

정석문,김정한,김동열,육홍선,변명우,이승철 慶南大學校 附設 基礎科學硏究所 2002 硏究論文集 Vol.16 No.-

왕겨에 200, 400, 600, 800 및 1000 Gy의 저선량의 감마선을 조사하여 항산화능의 변화를 관찰하였다. 총 페놀 화합물의 양은 무처리구의 경우 0.184 mM를 나타내었고, 200 Gy로 감마선을 조사하였을 때는 0.215 mM로 약간 증가함을 보였으나 이후 차츰 감소하였다. 전자 공여능은 무처리구에 비해 처리구의 경우 조사 선량별로 조금씩의 차이만 있을 뿐, 조사 선량에 대한 왕겨의 전자 공여능은 유의적인 큰 변화 없이 비슷한 활성을 보였다. Fe^2+-ions 킬레이팅 활성은 무처리구의 경우 68.25%를 나타내었으며, 200, 400, 600 및 800 Cy 에서는 각각 86.45, 85.61, 86.65 및 82.84%로서 무처리구보다는 증가함을 보였으나, 1000 Gy에서는 74.67%로 감소하였다. 지질 과산화 억제능은 무처리구에 비해 처리구는 약간의 증가를 보였으나 효과는 미비하였다. We studied the effect of small-dose of γ-irradiation to rice hull(RH) for its antioxidant ability. The RH was treated with 200, 400, 600, 800, and 1000 Gy of γ-ray at 70 Gy/min. Total phenol amount of unirradiated RH was 0,184 mM, after irradiation at 200 Gy it increased to 0,215 mM, while irradiation above 400 Gy up to 1000 Gy decreased that to unirradiated level. The electron donating ability of RH did not show significant change depend on irradiation. The chelating ability for Fe^2+ of unirradiated RH was 68.25 %, while that of 200, 400, 600 and 800 Gy irradiated RH showed 86.45, 85.61, 86.65 and 82.84 % respectively, but, 1000 Gy was decreased to 74.67 %. According to TBARS analyses, inhibition ability of lipid peroxidation by RH was not affected by γ-irradiation.

뇌혈류 측정 기기의 개발

김정래,김정열,김덕원,남문현 대한의용생체공학회 1989 의공학회지 Vol.10 No.1

In this paper, principles of Rheoencephalography(REG) was described and REG was designed and developed. Using the developed instrument, REG waveforms of the left and right brain, REG waveform changes by posture, were observed. It was found that REG waveforms could be observed noninvasively. REG can be easily applied for testing the effect of various drugs related to CBF(Cerebral blood flow) since it is quite senaitive to the relative changes of CBF. Various cerebral diseases can be diagnosed by analyzing the REG waveforms. The area of restricted cerebral blood vessels can be located by arranging the appropriate electrode configuration.

p-니트로톨루엔과 Fe(CO)_(5)로 부터의 p-톨루이딘 합성에 대한 상이동 촉매의 응용

박대원,문정열 부산대학교 1995 生産技術硏究所論文集 Vol.48 No.-

The application of phase transfer catalysts to the reduction of p-nitrotoluene by Fe(CO)_(5) has been investigated in this study. Quaternary ammonium salts and polyethylene glycols were used as phase transfer catalyst. The phase transfer catalytic system of p-nitrotoluene and Fe(CO)_(5) in organic solvent contacted with aqueous NaOH solution showed a good yield of p-toluidine at 1 atm and room temperature. Quaternary ammonium salt catalysts with larger alkyl group more hydrophilic counter anions showed higher conversion of p-nitrotoluene. Immobilization of PEG on various oxide supports was also performed in this work and γ-Alumina, having the largest specific surface area, showed the highest activity. 본 연구는 p-니트로톨루엔을 Fe(CO)_(5) 로 환원시켜 p-톨루이딘을 합성하는데 있어서 상이동 촉매의 특성을 고찰한 것이다. 상이동 촉매로는 4급 암모늄염과 폴리에틸렌글리콜을 사용하였고 p-니트로톨루엔과 Fe(CO)_(5)이 용해된 유기상과 NaOH 수용액상을 접촉시킨 상이동 촉매 반응은 상온, 상압에서 높은 수율로 p-톨루이딘을 합성할 수 있었다. 4급 암모늄염 촉매의 알칼기가 클수록 그리고 짝음이온의 친수성이 증가할수록 p-니트로톨루엔의 전화율이 증가하였다. PEG를 여러 가지 산화물 담체에 고정화시킨 경우 비표면적이 큰 γ-알루미나가 가장 높은 활성을 보여 주었다.

임피던스 방법을 이용한 뇌혈류량 측정기기의 개발(Ⅰ)

김덕원,김정래,송철규,김정열,남문현 대한의용생체공학회 1989 의공학회지 Vol.10 No.1

In this study, Rheoencephalography(REG) was designed and constructed. Using the constructed instrument cerebral blood flow(CBF) of left and right brain, CBF change by posture, and reproducibility were studied. Followings are important results. Relative CBF could be measured noninvasively and continuously. Since reproducibility of the constructed REG was found to be quite high (4 %), the accuracy of the instrument itself was proved. REG can be easily applied for testing the effect of drugs for the patients with cerebral vessel diseases since it is quite sensitive to the relative changes of CBF. Various cerebral diseases can be diagnosed by analyzing the REG waveforms. The area of restricted cerebral blood vessels can be located by arranging the electrode configuration. Comparative studies with the standard techniques of measuring CBF are needed to verify the accuracy of REG. Further studies on optimal electrode configuration and various artifacts are also necessary.

지난 2년간의 학회지 "신경정신의학" 심사 평가보고

김찬형,김세주,김도관,김성곤,박원명,송동호,박용천,이영문,오강섭,정영철,이상열,김주한,이동영,이헌정,함병주,김율리,김문두,김정진,이강욱,천근아,김재진,홍진표,홍승철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Fuzzy Compactness in the Usual Fuzzy Topological Space

Jeong-Yeol Choi(최정열),Ju-Ran Moon(문주란),Jae-Jeong Hwang(황재정) 한국지능시스템학회 1999 한국지능시스템학회논문지 Vol.9 No.2

Articles : Application of Quaternary Ammonium Salt as Catalyst in the Reaction of Glycidyl Methacrylate with CO2

( Jeong Yeol Moon ),( Jeong Gyu Yang ),( Sung Mi Jung ),( Dae Won Park ),( Jin Kook Lee ) 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.6

This study is related to the investigation of the characteristics of quaternary ammonium salt catalyst on the addition reaction of carbon dioxide and glycidyl methacrylate (GMA) to form (2-oxo-1,3-dioxolan-4-yl) methyl methacrylate (DOMA). Among the salts tested, the ones with higher alkyl chain length and with more nucleophilic counter anion showed a higher catalytic activity. The DOMA monomer was obtained in non polar solvent like toluene and cyclohexane, while poly (DOMA) could be directly obtained in aprotic dipolar solvent such as DMF. In order to facilitate recovery of catalyst, polymer-immobilized quaternary ammonium salt was prepared by copolymerization of styrene (ST), divinylbenzene (DVB) and vinyl benzene chloride (VBC). The catalyst with 2 wt% of DVB, 25 wt% of VBC and quaternized tributyl amine showed the highest catalytic activity, and its activity was maintained even up to 10 successive experimental runs.