현대(現代) 한국사회(韓國社會)에 적합한 한의학(韓醫學) "치미병(治未病)"방법(方法)에 대한 모색(摸索)

류정아 ( Jeong Ah Lyu ),장우창 ( Woo Chang Jang ),백유상 ( You Sang Baik ),정창현 ( Chang Hyun Jeong ) 대한한의학원전학회(구 대한원전의사학회) 2011 대한한의학원전학회지 Vol.24 No.4

In present-day Korea, a climatic change is causing various changes to the life of people and their body. The climate is more and more warm, so the internal environment of people`s body is exchanging to warm. The climatic change`s range is big and the speed is fast. So the harmony of human body is being destroyed and the human body`s adaptation ability is becoming low. At this condition, diseases more frequently occur. So doctor must expect the occur of diseases and practice early treatment. And in present-day Korea, a life environmental change is being advanced. The life environmental change is causing big changes to the people`s body and having influences to the occur of diseases. To this problem, doctor must expect and practice early treatment. This thesis would like to interpret about present-day Korea`s climatic changes and life environmental changes in Korean Medicine point of view, and try to present the method of Korean Medicine early treatment. And comment on present-day Korea`s early treatment method especially on health supplement or functional food and vaccination.

폐경 후 여성의 심혈관질환 예방을 위한 식사중재에 대한 준수도(adherence) 평가

정경아,김상연,우정익,장유경 漢陽大學校 韓國生活科學硏究所 2001 韓國 生活 科學 硏究 Vol.- No.19

The purpose of this study is to assess the adherence to dietary intervention for prevention of coronary heart disease (CHD) in postmenopausal women by observing changes of antioxidant vitamins and fatty acid composition in dietary intake and seam level. The subjects with hypercholesterolemia (TC≥240mg/dl) were treated with one of hormone replacement therapy (HRT group), dietary intervention (DIET group) or combination of hormone replacement therapy and dietary intervention (HRT+DIET group) for 12 weeks. The results were as followed. Mean daily nutrient intakes were not significantly changed in the HRT group, but were significantly changed in the DIET group and the HRT+DIET group. Especially, dietary vitamin A and E intakes were increased from less than 75% to more than 90% of RDA for Korean in the two groups. With changes of dietary intakes, serum vitamin A and E levels were also significantly increased in the DIET group and tended to increase in the HRT+DIET group. Dietary fatty acid composition was also not significantly changed in the HRT group, but was significantly chanced in the DIET group and the HRT+DIET group. With changes of dietary fatty acid composition, serum phospholipid fatty acid composition was significantly changed in the DIET group and the HRT+DIET group although there was tendency of returning to initial value after 12 weeks. Judging from changes in serum phospholipid fatty acid composition, subjects' adherence to dietary intervention tended to decrease after 12 weeks. However, the changes of antioxidant vitamins and fatty acid composition in dietary intake were compatible with the changes of those in serum level, and we can conclude that dietary intervention was adhered quite well by subjects.

논문 : 배당의 미래이익 예측력과 외국인투자자

강태구 ( Tae Goo Kang ),이창우 ( Chang Woo Lee ),남혜정 ( Hye Jeong Nam ) 명지대학교 금융지식연구소 2013 금융지식연구 Vol.11 No.3

본 연구는 배당의 미래이익 예측력이 외국인 투자자들의 지분율에 따라 어떻게 달라지는지 검증하였다. 일반적으로 배당지급은 기업의 미래이익을 예측하는 데 유용한 정보로 여겨지고 있으나, 이에 대한 실증연구결과들은 혼재되어 있다. 또한 배당의사결정과 관련된 연구들은 투자자들의 배당선호현상에 따라 기업의 배당의사결정이 영향을 받고 있음을 제시하고 있으며, 특히 우리나라의 경우, 배당의사결정에 외국인투자자가 미치는 영향이 매우 높게 나타나고 있다. 이는 특정투자자집단의 배당요구가 높은 경우, 기업의 배당의사결정이 미래이익에 대한 사적정보의 전달수단이기 보다는 단기적으로 배당에 대한 투자자들의 요구를 반영한 결과로 나타날 수 있음을 보여준다. 나아가 이러한 배당의사결정은 배당의 미래이익 예측력을 낮게 만들 것으로 예측된다. 본 연구는 배당의 미래이익 예측력을 재검증하고, 나아가 외국인지분율에 따라 배당의 미래이익예측력이 달라지는지 검증하였다. 먼저, 배당의 미래이익 예측연구들은 자기자본이익률(ROE)의 평균회귀(mean reverting)현상과 배당증가 또는 배당감소가 이익변화에 미치는 비대칭적 영향을 고려하고 있으나, 이익변화에 영향을 미치는 여러 가지 변수들을 통제하지 않고 있다. 따라서 본 연구는 선행연구에서 제시되고 있는 기업규모(SIZE), 성장성(SGR), 부채비율(LEV), 그리고 연도더미를 추가하여, 이를 통제하고 난 후에도 배당의 미래이익예측력이 여전히 존재하는지 검증하였다. 둘째, 배당의 미래이익 예측력이 기업의 배당의사결정에 영향을 미치는 특정집단에 의하여 달라지는지 검증하였다. 2000년부터 2007년까지 배당지급을 한 6,720 기업-년 표본을 대상으로 분석한 결과, 기본 모형뿐만 아니라 여러 통제변수를 포함한 모형에서도 우리나라 기업들의 배당변화는 미래 1년 뒤의 이익변화와 유의한 양의 관계를 나타냈으나, 미래 2년 뒤의 이익변화와는 유의하지 않았다. 또한 이익변화에 영향을 미치는 변수들을 추가한 모형의 설명력(R2=0.46)이 기본모형의 설명력(R2=0.28)보다 급격히 증가함을 알 수 있었다. 그러나 이러한 관계는 외국인지분율을 통제할 경우, 유의하지 않게 나타났다. 이는 기업의 배당의사결정이 미래전망에 근거하여 이루어지기보다는 특정투자자집단의 배당요구를 반영하는 수단으로 사용되고 있음을 보여준다. 즉 우리나라의 경우, 배당의사결정이 외국인투자자들의 배당요구를 반영하여 이루어짐을 알 수 있다. 본 연구는 대부분의 선행연구들이 외국인투자자와 배당성향간의 동시적인 관계에 대한 결과들을 제시한 반면에, 외국인투자자가 우리나라 기업들의 배당의사결정에 미치는 영향과 함께 배당의 미래이익예측력의 관점에서 살펴보았다는 점에 의의가 있다. This paper investigates whether the dividend payout predicts future earnings and the predictability varies depending on the proportion of investors. Specifically, this paper examines the effect of foreign investors on the relationship between dividend change and the predictability of future earnings in Korean firms. Reasoning from the hypothesis that dividend changes convey new information about a firm`s future profitability, a dividend increase is seen as a positive signal about the firm`s future earnings and profitability. However, the results from prior studies are controversial. Some papers have suggested that dividend changes would mean different things depending on a firm`s dividend policy and the motives behind its managers` decision to pay dividends. In addition, a firm`s governance is considered as one of important factors that affects dividend policy. In the Korean security market, foreign investors owned about 38% of the stock in 2007. As the percentage of foreign ownership had grown, many researchers have analyzed the effect of this ownership on dividend policy. However, prior studies found mixed results and have focused on the association between foreign investors and the level of the dividend or dividend change. They also suggest that predictability of dividend on future earnings is influenced by applied assumption on earnings and other factors like governance as well. We revisit the dividend signaling issue in the light of the catering theory of dividends suggested by Baker and Wurgler (2004). Lintner (1956) argued that managers unwilling to change payout ratio without any important change on the firm`s future performance. Won and Kim (1992) report that managers are more likely to be concerned about the internal factors such as net income, divisible surplus, predicted future performance, and the shareholders` preference for dividend policy. More importantly, several studies suggest that the foreign investors have a significant effect on the Korean market. Park (2004) reports that foreign investors` participation in firms generally pushes up the dividend payments while pulling down investments made in facilities no matter which industry a company is in. Sul and Kim (2006) show that those companies whose majority shareholders are foreign investors tend to pay higher dividends than others whose majority shareholders are domestic investors. In contrast to negative effect of foreign investor, there are empirical studies claiming positive impact of foreign investor in Korean market. Ahn, Shin, and Chang (2005) suggest that foreign investors prefer firms with lower information asymmetry. The study also shows that foreign investors can effectively monitor the management of firm in lessening information asymmetry. Similarly, Park and Lee (2006) suggest that foreign investors` participation in investment of domestic firms can help them make more efficient management decision by improving their corporate governance. Thus, Park and Lee claim that it is problematic to generalize the negative role of foreign investors in the Korean market. Based on this argument, we predict that if foreign investors play an effective monitoring role in a dividend policy, dividend change for firms with higher level of foreign investors is a good indicator in predicting future earnings than for firms with lower level of foreign investors. However, if foreign investors play a negative role in dividend decision process, predictability of dividend decreases. We test this prediction by using the modified model with several control variables that can affect earnings changes. Using 6,720 observations from 1993 to 2007, we find that the dividend change predicts future earnings for next one year relative to the dividend change year. Specifically, the coefficient on RDIV is 0.045 (t=6.85) and this indicates the dividend increases is a good indicator in predicting future earnings. When it comes to model specification, adjusted R2 of modified model is greater than that of the basic model, which means that the modified model is well specified in explaining earnings changes. The result of the effect of foreign investors on predictability of dividend is not significant. This finding implies that managers, on average, decide to pay dividend as a response to demand from foreign investors.

대장암종에서 암관련 유전자들의 Promoter Methylation과 암종 발생 및 진행과의 관게에 대한 연구

정동준,이정은,민영기,조성우,백무준,양승하,김의한,김창진 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The colorectal corcinoma is one of the most common malignant tumor in Korea and its carcinogenic mechanism has not been elucidated exactly yet. So far, the most common carcinogenic mechanism has been known to be multiple genetic changes. But, the CpG island hypermethylation has been revealed to be one of the most important carcinogenic mechanism second to the genetic changes. The epigenetic changes characteristically imprint and transfer to the next generation without changes of nucleotide sequences. When the CpG island of promoter or 5'- exon 1 of a specific gene is methylated by DNA methyltrasferases (DNMTs), the gene expression is inhibited. Carcinogenic mechansisms by promoter methylation has been well known, but the progression of the cancer has not been elucidated yet. The molecular researches on the carcinogenic mechanisms largely depended on the tumor tissue containing various components of cell, due to difficulties in harvesting pure homogeneous tumor cells. Promoter methylatonof the cancer related genes as APc, hMLH2, p16, DAP-K and MGMT in 50 cases of sporadic colorectal carcinoma was studied. The pure normal colorectal epithelial cells, and cancer cells from superficial and deep invasive portion were harvested respectively by laser captured microdissection(LCM), and DNA was extracted from them. The promoter methylation was studied by methylation specific poymerase reaction (MSP) after bisulfite modification of the DNA and the expression of the genes by immunohistochemistry. The results suggests that promoter methylation of the cancer related genes are closely related with the colorectal carcinogenesis and it occurrs from early phase of carcinogenesis, progressing constantly to the late stage. And the promoter methylation of normal epithelial cells increased by age. The p15, known to be the genes related to hematologic malignancy, was closely related to the colorectal carcinoma as well.

십이지장 결핵 2예의 내시경적 고찰

장린,박충기,민영일,장영운,우정택,방익수,최학림,장주희 대한소화기내시경학회 1985 Clinical Endoscopy Vol.5 No.1

Today, the duodenal tuberculosis is a very rare disease. Final diagnosis of duodenal tuberculosis is difficult due to inconsistent symptoms and nonspecific duodenal lesions. We found 2 cases of duodenal tuberculosis by gastrascopy. In gastroscopic findings, there were undetermined ulcers and irregular nodular mucosal changes.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

Low-level Green and Red Laser Treatment of Shaochong (HT9)·Dadun (LR1) and Shaohai (HT3)·Yingu (KI10) Acupoints in a Rat Model of Focal Cerebral Ischemia

Na, Chang-Su,Kim, Wang-In,Jang, Ho-Sun,Youn, Dae-Hwan,Moon, Young-Min,Jeong, Sung-Ho,Cheon, Min-Woo The Korean Institute of Electrical and Electronic 2015 Transactions on Electrical and Electronic Material Vol.16 No.2

Low level laser therapy (LLLT) has facilitated an improvement in acupuncture treatment. In this study, we stimulated Shaochong (HT9), Dadun (LR1), Shaohai (HT3), and Yingu (KI10) acupoints with pulsed laser diodes 532 nm [green laser] and 658 nm [red laser] in rats with induced middle cerebral artery occlusion(MCAO). The animals were divided into 6 groups: intact control; MCAO control without LLLT; LLLT with red laser at HT9·LR1 and HT3·KI10 (RR); LLLT with green laser at HT9·LR1 and HT3·KI10 (GG); LLLT with green laser at HT9·LR1 and red laser at HT3·KI10 (GR); and LLLT with red laser at HT9·LR1 and green laser at HT3·KI10 (RG). We evaluated the immunohistochemical changes in the hippocampal CA1 region, and complete blood count changes. Compared to the MCAO control group, the RG group showed a significant decrease in Bax and cytochrome c levels in the hippocampus, and a significant increase in hemoglobin level, hematocrit, total white blood cell, neutrophil, lymphocyte, monocyte, and erythrocyte counts.

Original Article : Morphologic Characteristics of the Outer Retina in Cone Dystrophy on Spectral-domain Optical Coherence Tomography

( Soo Chang Cho ),( Se Joon Woo ),( Kyu Hyung Park ),( Jeong Min Hwang ) 대한안과학회 2013 Korean Journal of Ophthalmology Vol.27 No.1

Purpose: To investigate the morphologic changes in the outer retina of patients with cone dystrophy, using spectral-domain optical coherence tomography (SD-OCT). Methods: The medical records of 15 cone dystrophy patients examined from January 2007 to January 2012 were reviewed retrospectively. All patients underwent ophthalmic evaluation including best-corrected visual acuity (BCVA), color vision testing, fundus examination, full-field standard electroretinography (ERG), multifocal (mf) ERG, and SD-OCT. Qualitative and quantitative SD-OCT data and ERG responses were analyzed and compared among the patient categories and the normal control group. Results: There were 4 major categories of SD-OCT findings, based on the status of the ellipsoid portion of the photoreceptor inner segment (ISe), outer segment (OS) contact cylinder, and retinal pigment epithelium (RPE) layer. Category 0 showed no structural abnormalities. Category 1 showed foveal ISe loss and obscurity of the border between the ISe band and the external limiting membrane (ELM). Category 2 showed foveal thinning and focal foveal ISe disruption with an intact ELM. Category 3 showed foveal thickening and perifoveal disruption of the ISe layer. Category 1 to 3 showed OS contact cylinder layer absence and RPE thickening. The patients in category 0 tended to be younger (mean, 10.0 years) than those in categories 1 to 3 (mean, 17.6 years), although this difference was not statistically significant. Category 1 to 3 patients exhibited statistically significant thinning of the central retina and outer nuclear layer and thickening of the RPE layer relative to the category 0 and normal control group. There was a significant correlation between the central foveal thickness and BCVA in the patients with cone dystrophy. ERG and mfERG responses did not differ significantly among the different cone dystrophy categories. Conclusions: The morphologic features of cone dystrophy as revealed by SD-OCT, could be categorized as either normal or 1 of 3 different types of outer retinal changes. The presence of normal retinal structures in young cone dystrophy patients with functional impairment (category 0) indicates that electrophysiologic studies are superior to current imaging modalities for the early diagnosis of cone dystrophy. The characteristic SDOCT findings in cone dystrophy patients may aid in differential diagnosis and be useful for future research on the pathology of cone dystrophy.

Genome-Wide Analysis of DNA Methylation before- and after Exercise in the Thoroughbred Horse with MeDIP-Seq

Gim, Jeong-An,Hong, Chang Pyo,Kim, Dae-Soo,Moon, Jae-Woo,Choi, Yuri,Eo, Jungwoo,Kwon, Yun-Jeong,Lee, Ja-Rang,Jung, Yi-Deun,Bae, Jin-Han,Choi, Bong-Hwan,Ko, Junsu,Song, Sanghoon,Ahn, Kung,Ha, Hong-Seok Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.3

Athletic performance is an important criteria used for the selection of superior horses. However, little is known about exercise-related epigenetic processes in the horse. DNA methylation is a key mechanism for regulating gene expression in response to environmental changes. We carried out comparative genomic analysis of genome-wide DNA methylation profiles in the blood samples of two different thoroughbred horses before and after exercise by methylated-DNA immunoprecipitation sequencing (MeDIP-Seq). Differentially methylated regions (DMRs) in the pre-and post-exercise blood samples of superior and inferior horses were identified. Exercise altered the methylation patterns. After 30 min of exercise, 596 genes were hypomethy-lated and 715 genes were hypermethylated in the superior horse, whereas in the inferior horse, 868 genes were hypomethylated and 794 genes were hypermethylated. These genes were analyzed based on gene ontology (GO) annotations and the exercise-related pathway patterns in the two horses were compared. After exercise, gene regions related to cell division and adhesion were hypermethylated in the superior horse, whereas regions related to cell signaling and transport were hypermethylated in the inferior horse. Analysis of the distribution of methylated CpG islands confirmed the hypomethylation in the gene-body methylation regions after exercise. The methylation patterns of transposable elements also changed after exercise. Long interspersed nuclear elements (LINEs) showed abundance of DMRs. Collectively, our results serve as a basis to study exercise-based reprogramming of epigenetic traits.

Which Environmental Factors Caused Lammas Shoot Growth of Korean Red Pine?

Lee, Chang-Seok,Song, Hye-Gyung,Kim, Hye-Soo,Lee, Bit-Na-Ra,Pi, Jeong-Hoon,Cho, Yong-Chan,Seol, Eun-Sil,Oh, Woo-Seok,Park, Sung-Ae,Lee, Seon-Mi The Ecological Society of Korea 2007 Journal of Ecology and Environment Vol.30 No.1

Lammas growth, a rare phenomenon for Korean red pine (Pinus densiflora), occurred in 2006. Lammas shoots showed higher frequency and longer length in Seoul's hotter urban center than in urban boundary or suburban forest sites. Frequency and length showed a close correlation with urbanization density and vegetation cover expressed in NDVI. Air temperature in the late summer of 2006 was more than $1^{\circ}C$ higher than an average year. Of the predominant environmental signals that modulate bud flush, only temperature changed significantly during the year. Differences in temperature between the urban centers, urban boundaries and suburban forests correlated with varying land-use density. The rise in temperature likely spurred lammas growth of the Korean red pine. Symptoms of climate change are being detected throughout the world, and its consequences will be clearer in the future. Considerate interest in the responses of ecological systems to the variable changes is required to prepare for unforeseeable crises. Monitoring of diverse ecological phenomena at Long Term Ecological Research sites could offer harbingers of change.