거주자 감성을 위한 주거환경 평가도구 개발 연구

강혜은,이윤희,연태경,장지혜,이연숙 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The purpose of this study was to develop the evaluation instrument for sensible aspects of housing environment. In terms of importance of sensibility which people persceive their housing environment, researches on the sensible environment has been done in several academic fields. However, evaluation tool for sensible aspects of housing environment has not existed until now. Therefore, there is a need to develop evaluation tool to measure the fit between dwelling environment and human sensibility. For this purpose, this study reviewed literatures and test results about ergonomics and human factors according to five senses. Based on keywords about five senses and housing environment, a checklist was developed.

학문 분야별 감성의 적용사례 분석 연구

장지혜,이윤희,연태경,강혜은,이연숙 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The purpose of this study was to analyze application cases of human sensibility in various fields. Nowadays in various fields human sensibility and ergonomic have been studied using variety of methods. Studies on human sensibility have been widely carried in various field such as design and making instruments, selling products and marketing skills even if environmental design fields and human interface by computers. The results have been well applied in of industry. Therefore, understanding rationality. Through this study, ways of creating and measuring environment to improve our living quality, and living places can be developed. From such a viewpoint, this study did the following; First, it reviewed the literatures of studies and results of the tests for application of human sensibility in various field, and organized contents of studies and measurement tools which were used in the studies or tests. Second, it summarized the measurement methods of human sensibility according to three parts; physiological measurement, psychological measurement, and physical measurement. This study was expected to braden the sight on research methodologies and relevant applicable areas.

Sulfadimethoxine 투여에 의해 유발된 갑상선 증식성 병변에 나타난 피막 섬유화의 병리학적 특성

김혜성,손화영,조성환,최종윤,윤원기 충남대학교 수의과대학 동물의과학연구소 2001 動物醫科學硏究誌 Vol.9 No.-

Sulfadimethoxine (SM) is one of the anti-thyroid (goitrogenic) agents and has a thyroid tumor promoting effects. In this study, we analyzed the pathology of SM induced thyroid proliferative lesions to see if these lesions showed any distinctive features. Five-week-old male F344 rats were given a single subcutaneous injection of N-bis(2-hydroxypropyl)nitrosamine (DHPN: 2800㎎/㎏, body weight). Starting one week thereafter, SM (1000 ppm in drinking water) was administered for 12 weeks. All animals were autopsied and histopathological observation of the thyroids was perfomed. Thyroid follicular proliferative lesions were induced in all rats treated with SM. In addition, the formation of thick perithyroidal fibrous capsule and pleomorphic follicles within the capsule were observed. These pleomorphic follicles showed invasive figure in some area, especially around follicular adenomas and adenocarcinomas. This confuses adenoma with adenocarcinoma. However, pleomorphic follicles were also observed in the area without adenomas and adenocarcinomas. Therefore, we suggest that it should be careful to diagnose adenoma and adenocarcinoma in the presence of the invasive lesions in surrounding fibrous tissue, especially SM induced thyroid lesion.

전국 단위 감시체계의 현황과 전망

강성규,안연순,지영구,김형옥,하미나,권호장,백남종,김성아,홍윤철,김재용,강대희,정혜선,하은희 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

감국(Chrysanthemum indicum L.) 추출물이 H<SUB>2</SUB>O<SUB>2</SUB>로 유도한 산화적 스트레스에서 MC3T3-E1 조골세포 기능에 미치는 영향

윤지혜(Jee Hye Yun),황은선(Eun-Sun Hwang),김건희(Gun-Hee Kim) 한국식품과학회 2012 한국식품과학회지 Vol.44 No.1

감국 에탄올 추출물이 H<SUB>2</SUB>O<SUB>2</SUB>로 유도한 산화적 스트레스 상황에서 MC3T3-E1 조골세포의 증식 및 분화, ROS 생성 및 염증 매개성 cytokine인 TNF-α 생성 등에 미치는 영향을 분석하였다. H<SUB>2</SUB>O<SUB>2</SUB>로 유도한 산화적 스트레스 상황에서 감국 에탄올 추출물은 30-100 μg/mL 농도 범위에서 조골세포의 증식을 유의적으로 증가시켰다. 또한, 감국 에탄올 추출물 200 μg/mL 농도에서 ALP 활성이 약 1.5배 유의적인 증가를 나타냈다. 그러나 collagen 합성에는 유의적 차이를 보이지 않았다. Mineralization 측정에서는 200 μg/mL 농도에서 대조군에 비해 유의적 증가를 보였다. H<SUB>2</SUB>O<SUB>2</SUB>로 유도한 산화적 스트레스 상황에서 감국 에탄올 추출물이 intracellular ROS 생성에 미치는 영향을 측정해본 결과, 30 μg/mL 농도에서 antioxidant인 trolox 20 μM과 유사한 ROS 생성수준을 나타내어 유사한 항산화 효과를 보였으며, 그 이상의 농도에서는 더 높은 항산화 효과를 나타냈다. H<SUB>2</SUB>O<SUB>2</SUB>로 유도한 산화적 스트레스 상황에서 조골세포의 collagen 및 ALP의 합성을 억제하고 파골세포로의 분화 증강과 골흡수를 촉진시키는 것으로 알려진 TNF-α 생성정도를 측정한 결과, 감국 에탄올 추출물 처리에 의해 농도 의존적으로 생성이 감소되었으며, 200 μg/mL 농도에서 대조군 대비 89% 수준을 나타내어 유의적 차이를 보였다. 이상의 결과를 통해 감국 에탄올 추출물은 H<SUB>2</SUB>O<SUB>2</SUB>로 유도된 산화적 스트레스 상황에서 세포 내 ROS 생성과 염증매개 cytokine인 TNF-α 생성을 감소시킴으로써 조골세포 손상과 활성 감소를 억제하고, 증식과 분화를 촉진시키는 효과가 있는 것을 확인할 수 있었다. 따라서 감국 에탄올 추출물의 골다공증 예방을 위한 식물성 에스트로젠(phytoestrogen) 및 항산화 소재로의 이용 가능성이 있을 것으로 사료된다. Chrysanthemum indicum L. (Asteraceae) is a traditional herbal medicine that has been used for the treatment of inflammation, hypertension, and respiratory diseases due to its strong antagonistic activity against inflammatory cytokines. The effects of Chrysanthemum indicum L. Extract (CIE) for increasing cell growth, alkaline phosphatase (ALP) activity, and collagen content were totally inhibited, suggesting that the effect of CIE might be partly involved with estrogen activity. Furthermore, the protective effects of CIE on the response of osteoblasts to oxidative stress were evaluated. Osteoblastic MC3T3-E1 cells were incubated with hydrogen peroxide and/or CIE, and markers of osteoblast function and oxidative damage were examined. CIE significantly increased cell survival, ALP activity, and calcium deposition, and decreased the production of Reactive Oxygen Species (ROS) and Tumor Necrosis Factor-α (TNF-α) in osteoblasts. Taken together, these results indicate that the enhancement of osteoblast function by CIE may prevent osteoporosis and inflammatory bone diseases.

어린이 기호식품 품질인증을 위한 영양 및 위생기준 설정에 대한 연구

윤지혜(Jee Hye Yun),조순덕(Sun-Duk Cho),김서영(Seo Young Kim),이은주(Eun Ju Lee),박혜경(Hye Kyung Park),김명철(Myung Chul Kim),김건희(Gun-Hee Kim) 한국식품영양과학회 2008 한국식품영양과학회지 Vol.37 No.5

본 연구는 어린이 기호식품 품질인증제도를 위한 영양ㆍ위생기준안 제안을 통해 어린이 먹거리 안전관리의 체계적 수행을 위한 기반 마련을 목적으로 수행되었다. 어린이 기호식품의 품질인증을 위한 영양ㆍ위생기준안 제안을 위해, 초등학교 주변 어린이 기호식품의 실태조사 자료와 위해가능성이 제기된 성분관련 문헌고찰을 통해 영양위해성분을 선정하고, 선정된 성분의 기준치 설정을 위한 EU 및 영국, 미국, 캐나다, WHO, Codex 등 국외의 어린이식품관련 기준치 혹은 유사기준, 관련 법령 등에 대한 선행사례 자료를 수집하여 고찰하였다. 이를 바탕으로 한국인 영양섭취기준과 식품 등의 표시기준, 식품공전, 식품의약품안전청 연구결과 보고 등을 참조하여 어린이 기호식품 중 가공식품에 대한 영양ㆍ위생 기준안을 마련하였다. 제안된 영양ㆍ위생 기준 항목 중 영양기준은 열량, 당, 지방, 나트륨이며, 위생기준으로는 식품첨가물(타르색소, 카페인)과 aflatoxin B₁, Staphylococcus aureus, Bacillus cereus, Salmonella spp.의 미생물수준으로 하였다. 제안된 어린이 기호식품 품질인증 기준안의 「저」, 「중」, 「고」 영양기준치 설정의 현실성을 살펴보고자 시중에서 유통 중인 어린이 기호가공식품 242종을 대상으로 시뮬레이션을 실시해 본 결과, 당, 지방, 나트륨의 「저」 기준치 적용 시에는 조사대상 전체제품 중 0.4%에 해당하는 제품만 포함되었고, 「중」 기준치 적용 시에는 최대 22.3%가 해당되었다. 「중」 기준치에 1회 분량 당 열량 200 ㎉ 이하로 제한한 열량기준을 추가 적용한 결과는 17.8%에 해당되는 제품이 기준범위 내에 포함되는 것으로 나타났다. 따라서 품질인증제도의 실효성을 높이기 위해서는 「중」 기준 적용 등의 기준 완화가 필요하며 해당식품 유형이 유가공품과 음료류에 한정되는 결과를 보이므로, 품질인증대상 확대와 제조업체의 참여도를 높이는 측면에서는 각각의 식품유형에 따른 ‘개별 기준치’ 마련이 필요할 것으로 생각된다. 식품유형에 따른 개별 기준치 범위 조정 및 설정을 확립하기 위해서는 추후 체계적인 보완연구가 수행되어야할 것으로 사료된다. The purpose of this study is to arrange for the systematic execution of safety control in children's foods through nutrition and hygiene standard suggestions and guidelines for quality certification system in children's preferable food. Aiming to achieve this objective, the study researched the present status of children's preferable food sold near elementary schools, elicited the hazards and problems of those foods and selected nutritional and hygienic hazard components in those foods. To suggest the standards and guidelines for quality certification in children's preferable food, the study referred to sundry records, surveyed the practical cases of relevant policies and standards at home and abroad. We studied the standard of nutrition for the quality certification in those foods for sugar, fat, sodium, and additives (tar color: red No. 2 in a ban on use, caffeine), microorganism (aflatoxin B1 (㎍/㎏) and pathogenic bacteria (Staphylococcus aureus, Bacillus cereus, Salmonella spp.), which are the nutrients that may hamper health when taken in a large amount, and the standard for a diet restricted to under 200 kcal per one serving size. Results of distribution of processed foods (242 samples) by nutrition standards were as follows. In case of all ‘low’ level in total sugar, total fat and sodium, 0.4% of total samples was possible to be certified, In case of all ‘medium’ level in total sugar, total fat and sodium, maximumly 22.3% of total samples was possible to be certified. In case of all medium level in nutrients and ≤200 ㎉/serving, 17.8% of total samples was possible to be certified. Certified food types was milk products and beverages.

한국인의 혈청 아디포넥틴과 당뇨병 진단기준 설정에 관한 연구

지선하(Sun Ha Jee),이희연(Hee Yeon Lee),이선주(Sun Ju Lee),윤지은(Ji Eun Yun),지은정(Eun Jung Jee),송혜윤(Hye Yun Song),김상연(Sang Yeun Kim),박정용(Jungyong Park),김현숙(Hyon-Suk Kim) 한국역학회 2007 Epidemiology and Health Vol.29 No.2

  Background: As indicators of obesity, waist circumference (WC), body mass index (BMI), and adiponectin are well known risk factor for diabetes mellitus. The objectives of this study were to measure the independent association between these obesity indicators and diabetes and to examine the combined effect of these indicators on diabetes in a Korean population.   Methods: The WC, BMI, and serum adiponectin were measured in 6,505 healthy Koreans and were classified into tertile groups for men and women. The independent and combined associations of the obesity indicators with diabetes were measured using logistic regression analyses. Diabetes was defined as fasting serum glucose greater than 126㎎/dL or taking medication.   Results: Levels of adiponectin were inversely associated with BMI and WC and directly associated with age and high density lipoprotein cholesterol (HDL) cholesterol (P<0.001). After adjusting for age, WC, and other lifestyle factors, low levels of adiponectin were associated with an increased prevalence of diabetes. Further adjustment for HDL cholesterol and triglyceride attenuated this association in both men and women. The best cut-off value of adiponectin in terms of identifying the presence of diabetes was 5.5㎍/㎖ with a sensitivity and specificity of 46.7% and 63.9% for men and 9.5㎍/㎖ with a sensitivity and specificity of 68.2% and 55.2 for women.   Conclusions: These results suggest that adiponectin was associated with diabetes. The association was independent of WC and was partly modified by HDL and triglyceride. There were no effect modifications of adiponectin with WC on diabetes.

혈청 아디포넥틴 측정 키트(AdipoMark)의 개발과 심혈관질환 위험요인과의 관련성 연구

지선하(Sun Ha Jee),이승복(Seungbok Lee),민성식(Sungsik Min),박정용(Jungyong Park),김현숙(Hyon-Suk Kim),김상연(Sang Yeun Kim),윤지은(Ji Eun Yun),이선주(Sun Ju Lee),지은정(Eun Jung Jee),이희연(Hee Yeon Lee),송혜윤(Hye Yun Song) 한국역학회 2007 Epidemiology and Health Vol.29 No.2

  Purposes: To develop a rapid, sensitive, qualitative ELISA-kit for serum adiponectin and examine correlation with adiponectin and cardiovascular risk factors.   Methods: On the base of monoclonal antibodies against adiponectin, apply indirect ELISA to study the performance parameter of the kit. The correlation was examined between adiponectin and cardiovascular risk factors including waist circumference, body mass index, triglyceride, and HDL cholesterol.   Results: The limited concentration of detection of the ELISA-kit was 1㎍/㎖. Linearity with R&D system and AdipoGen with this ELISA-kit was acceptable: the linear equation with R&D system was y=1.0116x+0.4629 (R2=0.97) and linear equation with AdipoGen was y=0.9562x+1.1961 (R2=0.93), respectively. The average recovery rate of the ELISA-kit ranged 92 to 104%. The correlation coefficient of waist circumference with adiponectin was -0.2276 (p<0.0001) among men and -0.2328 (p<0.0001) among women.   Conclusion: This ELISA-kit was quick, sensitive, and stable and can be used to determine adiponectin in serum.

P146 Factors associated with severity of alopecia areata

( Hye Rin You ),( Sang Yub Kim ),( Sook Jung Yun ),( Jee-bum Lee ),( Seong Jin Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Alopecia areata is the most common cause of localized, nonscarring alopecia. Unfortunately, there are few data regarding clinical features and epidemiology of alopecia areata in Korean patients. Objectives: This study strived to investigate the differences in clinical profiles according to disease severity and to determine risk factors for severe alopecia areata. Methods: A total of 1137 patients from 2006 to 2015 were analyzed retrospectively. Patients were subdivided into two groups: mild-to-moderate and severe alopecia areata. The groups were compared on the basis of age of onset, duration, sex, family history, comorbid disorders including autoimmune diseases, nail changes, and laboratory test results. Results: 883 patients were in the mild-to-moderate alopecia areata group and 254 patients were in the severe group. Average onset age was 30.77±17.66 years and 30.60±16.75 years in the mild-to-moderate and severe groups, respectively. Disease duration was statistically longer in the severe group. Male sex, nail changes, and thyroid diseases were more common in the severe group. Hypertension, diabetes mellitus, dyslipidemia, atopic dermatitis, and family history did not differ between groups. Of the serologic values, only alkaline phosphatase was considerably differing between groups. Male sex, presence of nail changes, and disease duration greater than one year were identified as significant ri Conclusion: This is the largest case analysis in Korean patients with alopecia areata