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- 저자 : Hyoung Il Son (검색결과 146 건)
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Minjung Chae,Eui-dong Son,Il-Hong Bae,조은경,Hyoung-June KIM,Ji-Yong Jung 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Lipin-1 is an Mg2+-dependent phosphatidate phosphatase (PAP1) that catalyzes a critical step in the synthesis of glycerophospholipids and is also a cotranscriptional regulator. The role of lipin-1 in the regulation of inflammatory responses has been extensively studied in various cell types but not in skin cells. In the present study, the function of lipin-1 in UVB-induced proinflammatory responses was assessed in normal human epidermal keratinocytes (NHEKs). UVB radiation downregulated lipin-1 expression. Lipin-1 inhibition was mediated by UVB-dependent sterol-response element binding protein-1 (SREBP-1) inhibition. The UVB-dependent inhibition of lipin-1 and SREBP-1 was mediated by AMPK activation. UVB-induced activation of JNK was dependent on AMPK activation and mediated lipin-1 inhibition. Prevention of UVB-mediated lipin-1 repression by introducing a lipin-1 expression vector stimulated IL-6 and IL-8 production, suggesting that lipin-1 inhibition attenuates UVB-induced IL-6 and IL-8 production. The downregulation of lipin-1 ameliorated UVB-induced NF-ĸB phosphorylation, which might be attributed to the suppression of UVB-induced accumulation of free fatty acids (FFAs). Pharmacological inhibition of PAP1 with propranolol suppressed UVB-induced production of IL-6 and IL-8 in NHEKs and reconstituted human skin models. Taken together, lipin-1 is downregulated by exposure to UVB radiation, which confers protection against UVB-induced proinflammatory responses; therefore, the inhibition of lipin-1 is a potential strategy for photoaging.
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장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4
Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.
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Two-Channel Control for Scaled Teleoperation
Hyoung Il Son,Doo Yong Lee 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
There is a trade-off between stability and performance in haptic control systems. In this paper, a stability and performance analysis is presented for a scaled teleoperation system in an effort to increase the performance of the system while maintaining the stability. The stability is quantitatively defined as a metric using Llewellyn’s absolute stability criterion. Position tracking and kinesthetic perception are used as the performance indices. The analysis is carried out using various scaling factors and impedances of human and environment. A two-channel position-position (PP) controller and a two-channel force-position (FP) controller are applied for the analysis and simulation.
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Haptic Feedback Cues Can Improve Human Perceptual Awareness in Multi-Robots Teleoperation
Hyoung Il Son,Lewis L. Chuang,Junsuk Kim,Heinrich H. B¨ulthoff 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10
The availability of additional force cues in haptic devices are often expected to improve control performance, over conditions that only provide visual feedback. However, there is little empirical evidence to show this to be true for the teleoperation control of remote vehicles (i.e., multiple unmanned aerial vehicles (UAVs)). In this paper, we show that force cues can increase one’s sensitivity in discerning the presence of obstacles in the remote multi-UAVs’ environment. Significant benefits, relative to a purely visual scenario, were achieved only when force cues were sufficiently amplified by large gains. In addition, force cues tended to provide stronger benefits when they were based on the UAVs’ velocity information.
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Effects of Imperfect Communication Network on Haptic Teleoperator’s Performance
Hyoung Il Son,Ayoung Hong,Heinrich H. Bulthoff,Dongjun Lee 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10
There is, practically, imperfect communication network (e.g., time delay and packet loss/switching) in haptic interaction (or teleoperation) systems. It is well known that such imperfect communication degrades teleoperator’s performance as well as stability. We hypothesis that as an imperfectness level in the communication network is increasing, the teleoperator’s performance is decreasing monotonically. In this paper, we verified the hypothesis via a human-centered evaluation of the teleoperator’s perceptual performance in terms of just noticeable difference (JND), point of subject equality (PSE), and perception time using two psychophysical experiments: experiment of packet separation time and experiment of packet loss. In the experiment of packet separation time, there were significant increases of JND and PSE as the packet separation time was increased. However, interestingly, there was no significant decrease of teleoperator’s perceptual performance in the experiment of packet loss although the packet loss rate was increased until 75 %. The experimental results clearly shows that the packet separation time affects on the teleoperator’s perceptual performance more than the packet loss rate.
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Hyoung Il Son,Jang Ho Cho,Bhattacharjee, Tapomayukh,Hoeryong Jung,Doo Yong Lee Institute of Electrical and Electronics Engineers 2014 IEEE transactions on industrial electronics Vol. No.
<P>This paper focuses on the human perception capabilities for haptic interaction with remote environments. The perception capabilities are compared for two well-known control methods with two kinds of haptic cues. Analytical and psychophysical methods are used to analyze the performance. The first control method aims at maximizing the transparency of the remote interactions (i.e., transparency-based method), whereas the second one aims at maximizing the detection and discrimination abilities of the human operator (i.e., perception-based method). For each of these two control methods, two kinds of haptic cues are studied, which use position and force cues from remote environments. Hybrid matrix formulation is employed, and it is analyzed in the frequency domain for these studies. Psychophysical experiments are then conducted for human-centered evaluation and comparison of the control methods. Analytical and experimental results clearly show that the perception-based method, when compared with the transparency-based method, enhances the human operator's perceptual capabilities of remote environments irrespective of force cues. For each of the two control methods, the force cues always contribute more to the increase in perceptual sensitivity when compared with the case of position cues.</P>
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A psychophysical evaluation of haptic controllers: viscosity perception of soft environments
Son, Hyoung Il,Jung, Hoeryong,Lee, Doo Yong,Cho, Jang Ho,Bü,lthoff, Heinrich H. Cambridge University Press 2014 Robotica Vol.32 No.1
<B>SUMMARY</B><P>In this paper, human viscosity perception in haptic teleoperation systems is thoroughly analyzed. An accurate perception of viscoelastic environmental properties such as viscosity is a critical ability in several contexts, such as telesurgery, telerehabilitation, telemedicine, and soft-tissue interaction. We study and compare the ability to perceive viscosity from the standpoint of detection and discrimination using several relevant control methods for the teleoperator. The perception-based method, which was proposed by the authors to enhance the operator's kinesthetic perception, is compared with the conventional transparency-based control method for the teleoperation system. The fidelity-based method, which is a primary method among perception-centered control schemes in teleoperation, is also studied. We also examine the necessity and impact of the remote-site force information for each of the methods. The comparison is based on a series of psychophysical experiments measuring absolute threshold and just noticeable difference for all conditions. The results clearly show that the perception-based method enhances both detection and discrimination abilities compare with other control methods. The results further show that the fidelity-based method confers a better discrimination ability than the transparency-based method, although this is not true with respect to detection ability. In addition, we show that force information improves viscosity detection for all control methods, as predicted from previous theoretical analysis, but improves the discrimination threshold only for the perception-based method.</P>
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