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박인근 ( Inkeun Park ),강병욱 ( Byung Woog Kang ),고수진 ( Su-jin Koh ),김경하 ( Kyoung Ha Kim ),김세현 ( Se Hyun Kim ),김찬규 ( Chan Kyu Kim ),김호영 ( Ho Young Kim ),박권오 ( Kwonoh Park ),박세훈 ( Se Hoon Park ),오성용 ( Sung Y 대한내과학회 2017 대한내과학회지 Vol.92 No.2
The management of advanced prostate cancer has evolved rapidly. Androgen deprivation therapy, via surgical or medical castration, is the first-line therapy for hormone-naive metastatic prostate cancer. For approximately a decade, docetaxel-based chemotherapy was the only approved agent to show a survival benefit for castration-resistant prostate cancer. However, over the last 5 years, significant advances in the field have led to the approval of several new agents with different mechanisms of action, such as the new androgen pathway inhibitors abiraterone and enzalutamide, a new cytotoxic agent, cabazitaxel, and new bone-seeking agents such as radium-223, which have all been associated with improved quality of life and pain palliation and an increase in survival. However, there has been no Korean treatment guideline for metastatic prostate cancer which is developed based on thorough search for relevant articles, including recently developed agents, and adequate review and assessment of evidences, and thus, a guideline adequate for domestic circumstance is eagerly needed. Experts from the Genitourinary Oncology Committee of the Korea Cancer Study Group developed clinical recommendations for the treatment of metastatic prostate cancer based on 19 key questions. The Korean Association for Clinical Oncology, the Korean Prostate Society, the Korean Urological Oncology Society, and the Korean Society of Pathologists reviewed and endorsed the guidelines. These are the first Korean treatment guidelines developed specifically for metastatic prostate cancer. (Korean J Med 2017;92:124-141)
Inkeun Park,Jae Lyun Lee 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.4
After cisplatin-based chemotherapy became the standard treatment for metastatic urothelial cancer (mUC), very little progress has been made in the treatment landscape of this condition until recently. With increased knowledge about the molecular biology of mUC and advances in the field of cancer immunobiology, there has been an explosion in the number of clinical trials for mUC, and systemic treatment of mUC is rapidly changing. Despite the availability of several novel therapeutic agents, cisplatin-based cytotoxic chemotherapy remains the standard, first-line treatment option. Immune checkpoint inhibitors (ICIs), including programmed death-1 and programmed death ligand-1 inhibitors, are preferred second-line treatment options that are also used in first-line cisplatin-ineligible settings. For patients with actionable fibroblast growth factor receptor 2 (FGFR2) or FGFR3 genomic alterations, erdafitinib can be considered after platinum-based treatment. Enfortumab vedotin, a monoclonal antibody targeting nectin-4 conjugated to monomethyl auristatin E, has been approved for patients who do not respond to both cytotoxic chemotherapy and ICIs. In this review, we address the clinical trial data that have established the current standard treatments and ongoing clinical trials of various agents with different mechanisms as well as provide a brief overview of current practice guidelines and recommendations in patients with mUC.
Park, Heui Joo,Kim, Yeong-chun,Moon, Heejong,Park, Minwon,Yu, Inkeun The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.3
Degradation due to delamination occurs frequently in the high temperature superconductors (HTS) coil of rotating machines made with 2nd generation (2G) HTS wire, and the authors have observed other similar cases. Since an HTS field coil for a rotating machine is required to have stable current control and maintain a steady state, co-winding techniques for insulation material and epoxy resin for shape retention and heat transfer improvement are applied during coil fabrication. However, the most important limiting factor of this technique is delamination, which is known to be caused by the difference in thermal expansion between the epoxy resin and 2G HTS wire. Therefore, in this study, the experimental results of mixing the ratio of epoxy resin and alumina ($Al_2O3$) filler were applied to the fabrication of small and large test coils to solve the problem of degradation. For the verification of this scheme, eight prototypes of single pancake coils with different shapes were fabricated. They showed good results. The energization and operation maintenance tests of the stacked coils were carried out under liquid neon conditions similar to the operation temperature of an MW-class rotating machine. In conclusion, it was confirmed that the alumina powder mixed with epoxy resin in an appropriate ratio is an effective solution of de-lamination problem of 2G HTS coil.
Skull Metastasis of Gastric Gastrointestinal Stromal Tumor Successfully Managed by Surgery
Park, Inkeun,Chung, Dong Hae,Yoo, Chan Jong,Shin, Dong Bok The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.1
Gastrointestinal stromal tumors (GISTs) are rare, but are the most common mesenchymal neoplasm of the gastrointestinal tract. The most common sites of metastasis are liver and peritoneum, while bone metastasis is rare. We report on a patient with skull metastasis after seven years of treatment with imatinib for metastatic GIST. She underwent metastasectomy consisting of craniectomy with excision of the mass, and cranioplasty and continued treatment with imatinib and sunitinib, without evidence of cranial recurrence. She died of pneumonia sepsis one year after metastasectomy. Skull metastasis of GIST is a very rare presentation, and an aggressive multidisciplinary approach should be considered whenever possible.
Heui Joo Park,Yeong-chun Kim,Heejong Moon,Minwon Park,Inkeun Yu 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.3
Degradation due to delamination occurs frequently in the high temperature superconductors (HTS) coil of rotating machines made with 2nd generation (2G) HTS wire, and the authors have observed other similar cases. Since an HTS field coil for a rotating machine is required to have stable current control and maintain a steady state, co-winding techniques for insulation material and epoxy resin for shape retention and heat transfer improvement are applied during coil fabrication. However, the most important limiting factor of this technique is delamination, which is known to be caused by the difference in thermal expansion between the epoxy resin and 2G HTS wire. Therefore, in this study, the experimental results of mixing the ratio of epoxy resin and alumina (Al2O3) filler were applied to the fabrication of small and large test coils to solve the problem of degradation. For the verification of this scheme, eight prototypes of single pancake coils with different shapes were fabricated. They showed good results. The energization and operation maintenance tests of the stacked coils were carried out under liquid neon conditions similar to the operation temperature of an MWclass rotating machine. In conclusion, it was confirmed that the alumina powder mixed with epoxy resin in an appropriate ratio is an effective solution of de-lamination problem of 2G HTS coil.
Prognosis of HER2 overexpression in small T1N0M0 breast cancer: A single center experience in Korea
( Jihong Bae ),( Hee Kyung Ahn ),( Kwan Il Kim ),( Heung Kyu Park ),( Yong Soon Chun ),( Young Saing Kim ),( Inkeun Park ),( Junshik Hong ),( Sun Jin Sym ),( Jinny Park ),( Eun Kyung Cho ),( Jae Hoon 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Introduction: A role of adjuvant treatment in patients with T1abN0M0 human epidermal growth factor receptor 2 (HER2)-positive breast cancer remains controversial. In this study, we investigated the prognosis of pT1abN0M0 breast cancer according to HER2 and hormone-receptor status. Methods: We retrospectively reviewed consecutive 536 patients diagnosed with T1a-cN0M0 breast cancer between 2003 and 2012 in a single center. Invasive disease free survival (IDFS), distant recurrence free survival (DRFS), and overall survival (OS) were estimated and compared by Kaplan-Meier method and log-rank test. Results: With a median estimated potential follow-up of 53 months, 5-year IDFS rate was 96.1% (92.3% in T1abN0, 97.3% in T1cN0), DRFS rate 98.3% (97.6% in T1abN0, 98.5% in T1cN0), and OS rate 98.4% (97.6% in T1abN0, 98.6% in T1cN0). Among 142 patients with T1abN0M0, IDFS in HER2 (+) disease (n=31, 5-year IDFS rate 73.2%, 5-year DRFS rate 96.3%) was significantly inferior to those with HR (+)/HER2 (-) disease (n=63, 5-year IDFS rate 98.4%, no distant recurrence has occurred during follow-up period) or TN (n=14, no recurrence has occurred during follow-up period). IDFS in HER2 (+) T1abN0 disease was not significantly different by HR status (5-year IDFS rate 64.1% in HR (+) HER2 (+) vs. 40.0% in HR (-) HER2 (+), p=0.104). Conclusions: In Korean patients with T1abN0M0 breast cancer, HER2 overexpression was associated with worse IDFS.
Min Young Baek,Hee Kyung Ahn,Kyu Ree Park,Hwa-Sun Park,Shin Myung Kang,Inkeun Park,Young Saing Kim,Junshik Hong,Sun Jin Sym,Jinny Park,Jae Hoon Lee,Dong Bok Shin,Eun Kyung Cho 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.1
Background/Aims: We investigated the time taken for patients with metastatic non-small cell lung cancer (NSCLC) to develop brain metastases (BM), as well as their subsequent overall median survival following diagnosis, considering the epidermal growth factor receptor (EGFR) mutational status. Methods: We retrospectively investigated the medical records of 259 patients diagnosed with advanced NSCLC from January 2010 to August 2013, who were tested for EGFR mutations. The time from the diagnosis of advanced NSCLC to the development of BM and the overall median survival after BM development (BMOS) were evaluated and compared by EGFR mutational status. Results: Sixty-seven patients (25.9%) developed BM. Synchronous BM occurred more often in patients with EGFR mutation type (MT) (n = 20, 27.4%) compared with EGFR wild type (WT) (n = 27, 14.5%, p < 0.009). The median BM-OS was significantly longer in patients with EGFR MT than in those with EGFR WT (25.7 months vs. 3.8 months, p < 0.001), and a similar trend was noticed for patients with synchronous BM (25.7 months for EGFR MT vs. 6.8 months for EGFR WT, p < 0.001). However, in patients with metachronous BM development, the difference in BM-OS between patients with EGFR MT (14.6 months) and EGFR WT (2.5 months) did not reach statistical significance (p = 0.230). Conclusions: Synchronous BM was more common in NSCLC patients with EGFR MT than in those with EGFR WT. However, EGFR mutations were associated with significantly longer median BM-OS, especially when the brain was the first metastatic site.
손인근(Inkeun Son),박상준(Sangjoon Park),김용철(Yongchul Kim) 국방로봇학회 2024 국방로봇학회 논문집 Vol.3 No.1
We have been witnessing innovative improvements in unmanned autonomous robot technologies and also facing enlarged their applications in the military. Even at Ukraine-Russia war, AI(artificial intelligence)-enhanced platforms have been being operated. It is very noteworthy that there are concerns about manipulating AI technologies even though AI is still in the early stage of growth. To dispel the constantly raised fears, a few nations have announced military AI principles and following guidelines. They intended to convince their credibility in developing and operating AI capabilities in military operations. However, the main object is to show the reliability of current AI systems, which are mainly based on weak AI and so can not execute beyond on-the-loop of human interventions. This paper is to deal with following AI issues that will be publicly agendicized when AI-enhanced platforms with limited autonomy are operated in battle field. Even unmanned autonomous robots have constrained autonomy, there must be ethical challenges in real operation environments. Thus, we make an issue of military ethical challenges and propose directions for future manned and unmanned team systems and following AI ethics.