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Jo, Kyung-Wook,Hong, Yoonki,Park, Jae Seuk,Bae, In-Gyu,Eom, Joong Sik,Lee, Sang-Rok,Cho, Oh-Hyun,Choo, Eun Ju,Heo, Jung Yeon,Woo, Jun Hee,Shim, Tae Sun The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.1
Background: We investigated the prevalence of latent tuberculosis infection (LTBI) among the health care workers (HCWs) and analyzed its risk factors in South Korea. Methods: A standard questionnaire regarding the baseline demographics and risk factors for LTBI was given to each participant and tuberculin skin test (TST), QuantiFERON-TB GOLD In-Tube (QFT-GIT) assay, and chest radiography were performed. Results: A total of 493 participants, 152 (30.8%) doctors and 341 (69.2%) nurses were enrolled in eight tertiary referral hospitals. The mean age of the subjects was 30.6 years old, and 383 (77.7%) were female. Of the 152 doctors, 63 (41.4%) and 36 (23.7%) were positive by TST and by QTF-GIT, respectively, and among the 341 nurses, 119 (34.9%) and 49 (14.4%) had positive TST and QFT-GIT results, respectively. Overall, the agreement between the two tests was 0.22 by the chance corrected proportional agreement rate (kappa coefficient) in 493 subjects. Experience of working in tuberculosis (TB)-related departments was significantly associated with positive LTBI test results by QFT-GIT assay, not by TST. In multivariate analysis, only age was independently associated with increased risk of a positive TST result, while age and experience of working in TB-related departments (odds ratio, 2.29; 95% confidence interval, 1.01-5.12) were independently associated with increased risk of a positive QFT-GIT result. Conclusion: A high prevalence of LTBI was found among South Korean HCWs. Considering the association between the experience of working in TB-related departments and high risk of LTBI, QFT-GIT may be a better diagnostic test for LTBI than TST in HCWs.
( Kyung Wook Jo ),( Yoon Ki Hong ),( Jae Seuk Park ),( In Gyu Bae ),( Joong Sik Eom ),( Sang Rok Lee ),( Oh Hyun Cho ),( Eun Ju Choo ),( Jung Yeon Heo ),( Jun Hee Woo ),( Tae Sun Shim ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.1
Background: We investigated the prevalence of latent tuberculosis infection (LTBI) among the health care workers (HCWs) and analyzed its risk factors in South Korea. Methods: A standard questionnaire regarding the baseline demographics and risk factors for LTBI was given to each participant and tuberculin skin test (TST), QuantiFERON-TB GOLD In-Tube (QFT-GIT) assay, and chest radiography were performed. Results: A total of 493 participants, 152 (30.8%) doctors and 341 (69.2%) nurses were enrolled in eight tertiary referral hospitals. The mean age of the subjects was 30.6 years old, and 383 (77.7%) were female. Of the 152 doctors, 63 (41.4%) and 36 (23.7%) were positive by TST and by QTF-GIT, respectively, and among the 341 nurses, 119 (34.9%) and 49 (14.4%) had positive TST and QFT-GIT results, respectively. Overall, the agreement between the two tests was 0.22 by the chance corrected proportional agreement rate (kappa coefficient) in 493 subjects. Experience of working in tuberculosis (TB)-related departments was significantly associated with positive LTBI test results by QFT-GIT assay, not by TST. In multivariate analysis, only age was independently associated with increased risk of a positive TST result, while age and experience of working in TB-related departments (odds ratio, 2.29; 95% confidence interval, 1.01-5.12) were independently associated with increased risk of a positive QFT-GIT result. Conclusion: A high prevalence of LTBI was found among South Korean HCWs. Considering the association between the experience of working in TB-related departments and high risk of LTBI, QFT-GIT may be a better diagnostic test for LTBI than TST in HCWs.
구성태,조명수,황재호,변기원,김경식,손인철 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1
In the present study, we aimed. to consider the name of twelve main Meridian in order to understand the concept of the Meridian system and to applicate acupuncture theory in the clinical field properly and fundamentally. We referred to several literatures on the matter and we found out that the name of present twelve Meridian was not settled until the period of Yellow Emperor's Classic. In the time of Yellow Emperor's Classic, the two theory of Internal Organ and Meridian system were combined and added new theory of 'WoonGi'. The general rule of combination is that the component of name of Meridian consist of 'Hand' or 'Foot', 'three Eum and Yang' and internal organ. The internal organ coupled with the root ki or middle ki of 'three Eum and Yang' and the 'Hand' or 'Foot' depend on the location of internal organ that belongs to meridian. The name of Twelve Meridian is a kind of system formed to analyze the two concepts organically and dynamically. One is material internal organ and the other is immaterial meridian system.
Resazurin(alarmar Blue™)을 이용한 효과적인 in vitro 항비듬력 즉정법
박병덕 ( Byeang Deog Park ),흥선영 ( Seon Young Hong ),정세규 ( Sekyoojeong ),조인식 ( In Sik Jo ),구형서 ( Hyeong Seo Gu ),한일민 ( Ii Min Han ),이상명 ( Sang Myeong Lee ),이완규 ( Wan Kyu Lee ) 대한화장품학회 1999 대한화장품학회지 Vol.25 No.3
Resazurin(alarmar Blue™)을 이용하여 in vitro 적으로 P. ovale의 최소 발육저지농도 (Minimum Inhibitory Concentration ; MIC)률 측정함으로써 여러 가지 조성의 항비듬제의 항비듬 효과를 측정하고자 하였다. 최적의 실험 조건을 결정하기 위한 기초 실험 결과, 약 2.6 X 105cfu/Mℓ 이상의 농도로 P. ovale가 주입되는 경우 alarmar Blue™ 흡광도의 변화률 정확하게 관찰할 수 있었고, alarmar Blue™ 자체의 희석 배율이 1:1 ~ 1:4 이며,16시간과 24 시간 배양을 하여야 비교적 정량적인 결과를 얻을 수 있었다. alarmar Blue™가 균체의 증식에 미치는 영향을 고찰하여 본 결과 1:1 의 희석 용액에서도 alarmar Blue™가 균체의 증식에 영향을 미치지 못함을 알 수 있었다. Zinc pyrithione과 Climbazole의 혼합계에서 항비듬 효과를 관찰하여 본 결과 일정 혼합비에서 효과적인 항비듬 효과를 관찰할 수 있었고, 현미경 관찰에 의한 MIC 측정 법과, SDDM(Skin-Disk Diffusion Method) 법에 의한 항비듬 효과와 비교하여 본 결과 유사한 경향성을 관찰할 수 있었다. 이상의 결과를 종합해 볼 때 alarmar Blue™를 사용한 in vitro 항비듬 효과 측정법은 시료나 배지의 탁도에 크게 영향을 받지 않으며, Micro-plate reader를 사용함으로써 많은 종류의 시료에 대한 결과를 빠르고 정확하게 얻을 수 있다는 장점을 가지고 있으므로, 향후 효율적인 in-vitro 항비듬 평가 방법으로 활용이 기대된다. We have tried to measure the anti-dandruff effect of the several kinds of formulations by determining the MIC values of the P. ovale which was determined by resazurin(alarmar Blue™). To get high reproducibility, it was suggested that about 2.6 X 105cfu/mℓ of P. ovale should be incubated with alarmar Blue™, optimum dilution ratio between alarmar Blue™ and PBS buffer should be 1:1 - 1:4, and oplimam incubation time should be 16 ~24 hours. Even though 1:1 diluted alarmar Blue™ was incubated with P. ovale,the metabolic activity of P. ovale was not inhibited by alarmar Blue™. The Minimum Inhibitory Concentration(MIC) values of several kinds of anti-dandruff formulation which were the mixture system between Zinc pyrithione and Climbazole make it possible to determine the optimal anti-dandruff formulation, which show similar results with that of microscopic MIC determination and that of SDDM(Skin-Disk Diffusion Method). It is expected that the anti-dandruff test method which uses alarmar Blue™ could be used as an effective in vitro test method because it was not so much affected by the turbidity of the broth and samples, and it can afford the MIC values of many samples within relatively short time by using microplate reader.
Gullian Barre Syndrome 患者 1例에 대한 症例報告
임승민,안정조,최영,조현경,김민상,유병찬,오병렬,김윤식,설인찬 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1
Gullian Barre Syndrome is an acute symmetric polyradiculoneuropathy that typically presents as a progressive flaccid paralysis. The pathology is believed to be caused by both cellular and humoral immune processes The possibility of death is 3-5% and About 20% of patients require mechanical ventilaton. Recently We have experienced a patient who had suspected Gullian Barre Syndrome for 60days, his condition weakness and pain was impoved through the herb and acupucture Therefore I reported it for the treatment.
신생아에 대한 가열 비 활동화한 B형 간염백신의 안전성과 면역성에 대한 임상적 관찰
전정식,이익준,심규식,정승연,정진우,최규용,조규홍,강진환,김승조,선희식,성인경,정규원,정환국,김부성 대한감염학회 1987 감염 Vol.19 No.4
A new heat-inactivated HBV vaccine has been evaluated for safety and immunogenicity in 157 newborn recipients. Three(Group 3M), one and a half(Group 1.5M), and one(Group 1M) μgm(HBsAgprotein) doses were given at 0,1 and 2 months.Three(Group 3W) and(Group 1W) μgm doses were also given at 0,1 and 2 weeks. All vaccine was administered intramuscularly in the thigh muscle. An adequate follow-up observation was possible during the period of 6 months after birth in 33, 26, 28, 34 and 36 infants in Groups 3M, 1.5M, 1M, 3W and 1W, respectively. Side effects were minor with limited local reaction at the site of adminisration. The 3W group produced seroconversion earliest and most rapidly, showing the highest rate of 60% and 70% at 1 and 2 months of age, resectively. However, at the age of 3 months, the highest seroconversion rate of 91.7% was observed in Group 1.5M, followed by 84.6% in Group 3W, 66.7% in Group 3M, 61.5% in Group 1M and 57.1% in Group 1W. At the age of 6 months, 87.5% of Group 3W, 80.8% of Group 1M, 80.4% of Group 1.5M, 83.3% of Group 3M infants showed seroconversion. However, a drop to 44.4% seroconversion was seen in Group 1W. There was no significant differences in seroconversion rates between Groups 3W, 1M, 1.5M and 3M at 6 months of age. There was also very little difference between these 4 Group regarding to the value of antibody response in terms of geometric mean titer. The vaccine was found to be safe and highly immunogenic for newborn infants. It can be concluded that 1.5M schedule is optimum for the immunization of newborn infants in immunogenicity and economy, while the 3W schedule can induce the earliest and most rapid seroconversion.
Regulatory Effects of Samul-tang on Axonal Recovery after Spinal Cord Injury in Rats
Lee, Ki-Tae,Kim, Yoon-Sik,Ryu, Ho-Ryong,Jo, Hyun-Kyeng,An, Jung-Jo,Namgung, Uk,Seol, In-Chan The Physiological Society of Korean Medicine and T 2006 동의생리병리학회지 Vol.20 No.5
In oriental medicine, Samul-tang (SMT) has been used for the treatment of cardiovascular diseases and neuronal disorders. Here, possible effects of SMT on axonal regeneration after the spinal cord injury were examined. SMT treatment induced increases in regeneration-related proteins GAP-43, cell division cycle 2 (Cdc2) and phospho-Erk1/2 in the peripheral sciatic nerves after crush injury. Increased levels of Cdc2 and phospho-Erk1/2 were observe mostly in the gray matter area and some in the dorsomedial white matter. These increases correlated with increased cell numbers in affected areas. Moreover, axons of corticospinal tract (CST) showed increased sprouting in the injured spinal cord when administrated with SMT compared with saline-treated control. Thus, the present data indicate that SMT may be useful for identifying active components and for therapeutic application toward the treatment of spinal cord disorders after injury.