고양이에서의 선천성 요추 기형의 평가

오이세,안지영,최호정,이영원 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2008 動物醫科學硏究誌 Vol.15 No.1

A 2-month old female siamese cat was presented with dyschezia and abdominal distention. On the abdominal radiographic view, the body of 5th lumbar was wider than the other lumbar vertebral bodies and 7th lumbar fused with sacrum. 5, 6, and 7th caudal lumbar vertebrae was fused with each other Based on the radiographic findings, this case was diagnosed as butterfly vertebra at 5th lumbar vertebra block vertebra of 7th lumar and sacrum, block vertebra of 5, 6, and 7th caudal lumbar vertebra. During 16 months, this cat did not have specific clinical sign associated lumbar vertebral deformity.

말티즈 견에서 발생한 골육증

안지영,오이세,최호정,이영원 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2008 動物醫科學硏究誌 Vol.15 No.1

A 15-years old, castrated male Maltese dog presented a right hind limb lameness. On the radiographs of a right hind limb, a cortical and medullary bone lysis along the medial lesion of the proximal tibia was identified. The histophathologic examination after bone biopsy showed inflammatory cells in the cortex of the bone. So this patient was diagnosed as osteomyelitis of the right proximal tibia. After 6 months, this patient was amputated the right hind limb, because of the finding of the pulmonary metastasis with the thoracic radiography and computed tomography. The histophathologic examination after amputation was identified osteopoid substance and poorly differentiated osteoblast. Based on the history, physical examination, radiographic, and histopathologic findings, this case was diagnosed as osteosarcoma of the proximal tibia.

Alpha-fetoprotein 생산성 담낭암종 -1 증례 보고-

오영하,강행지,이헝근,홍은경,김용일,이중달 대한병리학회 1996 Journal of Pathology and Translational Medicine Vol.30 No.5

슬관절 손상과 동통의 보존적 치료

빈성일,남태석,안지현,정광환,Bin Seoung-I1,Nam Tae-Seok,Ahn Ji-Hyun,Jung Kwang-Whan 대한정형외과스포츠의학회 2004 대한정형외과스포츠의학회지 Vol.3 No.2

슬관절 손상과 동통의 치료 방법은 크게 보존적 치료와 수술적 치료로 나눌 수 있다. 보존적 치료로도 충분한 경우에도 과도한 수술적 치료를 시행하는 것을 볼 수 있는데, 이는 여러가지 면에서 바람직하지 않다. 따라서 손상의 기전을 명확히 알고 치료 방법을 선택하여 야 하겠다. 여기에서는 슬관절 손상 환자에서 손상 기전을 알아보고, 치료에 있어 보존적인 방법에 대해 알아보고자 한다. Treatment of knee injury and pain consists of conservative and surgical treatment. Although conservative treatment is suffice in many cases, surgical treatment is performed which is not necessary. Therefore, thorough knowledge of injury mechanism and selection of treatment modalities are required. Injury mechanism and conservative treatment of knee injury patients will be discussed.

정신분열병환자의 뇌량에 대한 신경병리적 고찰 : 확산텐서영상(Diffusion Tensor Image)기법의 적용

이경진,신용욱,하태현,이종민,김인영,김선일,문원진,정은철,박해정,오정은,박지영,강경훈,권기원,권준수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4

Objectives : Diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue. It is particularly useful for evaluating white matter abnormalities. In this paper, we investigated the neuropathology of the corpus callosum in patients with schizophrenia through the new methods, diffusion tensor imaging. Methods : Diffuse tensor imaging was performed in 19 schizophrenic patients and 26 healthy controls. One complementary measure, fractional anisotropy (FA), which is considered to be sensitive indices of axonal integrity, was obtained from regions of interest in the five areas of the corpus callosum. Neuropsychological measurement also underwent for measurement of frontal lobe function in two groups. Results : There were no significant differences of FA in the DTI measures for either the schizophrenic patients compared with controls. FA was significantly decreased in women compared with men. Neuropsychological measurements such as Wisconsin card sorting test were correlated with FA of patients with schizophrenia. Conclusion : FA measures revealed no differences between schizophrenia and controls. The findings suggest that the structural integrity of white matter in patient with schizophrenia was not disrupted. The results are discussed in relation to previous studies reporting positive and negative findings. It is concluded that further studies using DTI in larger samples, improved and standardized methods of data acquisition and analysis are needed.

Application of acid mine drainage for coagulation/flocculation of microalgal biomass

Salama, El-Sayed,Kim, Jung Rae,Ji, Min-Kyu,Cho, Dong-Wan,Abou-Shanab, Reda A.I.,Kabra, Akhil N.,Jeon, Byong-Hun Elsevier 2015 Bioresource technology Vol.186 No.-

<P><B>Abstract</B></P> <P>A novel application of acid mine drainage (AMD) for biomass recovery of two morphologically different microalgae species with respect to AMD dosage, microalgal cell density and pH of medium was investigated. Optimal flocculation of <I>Scenedesmus obliquus</I> and <I>Chlorella vulgaris</I> occurred with 10% dosage of AMD at an initial pH 9 for both 0.5 and 1.0g/L cell density. The flocculation efficiency was 89% for <I>S</I>. <I>obliquus</I> and 93% for <I>C</I>. <I>vulgaris</I>. Zeta potential (ZP) was increased from −10.66 to 1.77 and −13.19 to 1.33 for <I>S</I>. <I>obliquus</I> and <I>C</I>. <I>vulgaris</I>, respectively. Scanning electron microscope with energy-dispersive X-ray of the microalgae floc confirmed the sweeping floc formation mechanism upon the addition of AMD. Application of AMD for the recovery of microalgae biomass is a cost-effective method, which might further allow reuse of flocculated medium for algal cultivation, thereby contributing to the economic production of biofuel from microalgal biomass.</P> <P><B>Highlights</B></P> <P> <UL> <LI> AMD contains high amount of Fe(II)/Al(III) ions which are natural flocculants. </LI> <LI> Sweeping microalgal floc formation was the dominant mechanism in this study. </LI> <LI> AMD can be an efficient coagulant/flocculant for low-cost microalgae harvesting. </LI> </UL> </P>

Interactions Between Innate Immunity Genes and Early-Life Risk Factors in Allergic Rhinitis

Seo, Ju-Hee,Kim, Hyung Young,Jung, Young-Ho,Lee, Eun,Yang, Song-I,Yu, Ho-Sung,Kim, Young-Joon,Kang, Mi-Jin,Kim, Ha-Jung,Park, Kang Seo,Kwon, Ji-Won,Kim, Byung-Ju,Kim, Hyo-Bin,Kim, Eun-Jin,Lee, Joo-Shi The Korean Academy of Asthma, Allergy and Clinical 2015 Allergy, Asthma & Immunology Research Vol.7 No.3

<P><B>Purpose</B></P><P>Allergic rhinitis (AR) is a common chronic disease. Many factors could affect the development of AR. We investigated early-life factors, such as delivery mode, feeding method, and use of antibiotics during infancy, which could affect the development of AR. In addition, how interactions between these factors and innate gene polymorphisms influence the development of AR was investigated.</P><P><B>Methods</B></P><P>A cross-sectional study of 1,828 children aged 9-12 years was conducted. Three early-life factors and AR were assessed by a questionnaire. Skin prick tests were done. Polymorphisms of <I>TLR4</I> (rs1927911) and <I>CD14</I> (rs2569190) were genotyped.</P><P><B>Results</B></P><P>Use of antibiotics during infancy increased the risk of AR (aOR [95% CI] 1.511 [1.222-2.037]) and atopic AR (aOR [95% CI], 1.565 [1.078-2.272]). There were synergistic interactions between caesarean delivery, formula feeding, and use of antibiotics in the rate of atopic AR (aOR [95% CI], 3.038 [1.256-7.347]). Additional analyses revealed that the risk for the development of AR or atopic AR subjects with the <I>TLR4</I> CC genotype were highest when all the 3 early-life factors were present (aOR [95% CI], 5.127 [1.265-20.780] for AR; 6.078 [1.499-24.649] for atopic AR). In addition, the risk for the development of AR or atopic AR in subjects with the <I>CD14</I> TT genotype were highest when all the 3 early-life factors were present (aOR [95% CI], 5.960 [1.421-15.002] for AR; 6.714 [1.440-31.312] for atopic AR).</P><P><B>Conclusions</B></P><P>Delivery mode, feeding method, and use of antibiotics during infancy appeared to have synergistic interactions in the development of AR. Gene-environment interactions between polymorphism of innate genes and early- life risk factors might affect the development of AR.</P>

Assessment of patient safety and the efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin in a high-volume liver transplantation center

I-Ji Jeong,Shin Hwang,Dong-Hwan Jung,Gi-Won Song,Gil-Chun Park,Chul-Soo Ahn,Deok-Bog Moon,Ki-Hun Kim,Tae-Yong Ha,Hea-Seon Ha,Jung-Ja Hong,In-Ok Kim,Sung-Gyu Lee 한국간담췌외과학회 2019 Annals of hepato-biliary-pancreatic surgery Vol.23 No.2

Backgrounds/Aims: This study intended to evaluate patient safety and efficiency of facility utilization following simplified ultra-rapid intravenous infusion of hepatitis B immunoglobulin (HBIG) in recipients of hepatitis B virus-associated adult liver transplantation (LT), who visited our outpatient clinic. Methods: Our simplified ultra-rapid infusion protocol was to directly infuse 50 ml volume of 10,000 IU HBIG for 20-25 minutes on an ambulatory basis. The incidence of adverse side-effects and the efficiency of facility utilization were assessed retrospectively. Results: A total of 1,513 patients received 12,472 sessions of HBIG infusion according to simplified ultra-rapid infusion method. Of these, 1,172 patients were converted from conventional ultra-rapid infusion method, and received 8,352 sessions of HBIG infusion for 18 months (mean 7.1 times; 4.8 times per year). The remaining 341 de novo patients received 4,120 sessions of HBIG infusion for 18 months (mean 12.1 times; 8.1 times per year). None of these patients experienced any adverse side-effects following the simplified ultra-rapid infusion. The maximal capacity of HBIG infusion sessions at the injection facility of our outpatient clinic was increased from 65-70 sessions to 80 sessions, after introduction of simplified ultra-rapid infusion method. Mean trough anti-HBs titer was lower, and mean interval of HBIG infusion was longer in the combination therapy group compared with HBIG monotherapy group. Conclusions: Our high-volume study indicates that in nearly all LT recipients, rapid infusion of highly purified HBIG within 30 minutes was well-tolerated. This suggests that it would be reasonable to perform simplified ultra-rapid infusion protocol widely for patient convenience.

Long-term patency and complications of ringed polytetrafluoroethylene grafts used for middle hepatic vein reconstruction in living-donor liver transplantation

I-Ji Jung,Shin Hwang,Tae Yong Ha,Gi Won Song,Dong-Hwan Jung,Chul-Soo Ahn,Deok-Bog Moon,Ki-Hun Kim,Gil-Chun Park,Young-In Yoon,Yo-Han Park,Hui-Dong Cho,Jae-Hyun Kwon,Yong-Kyu Chung,Sang-Hyun Kang,Sung 대한이식학회 2020 Korean Journal of Transplantation Vol.34 No.1

Background: Homologous vein allografts are adequate for reconstruction of the middle hepatic vein (MHV) in living-donor liver transplantation (LDLT). However, supply is a matter of concern. To replace homologous vein allografts, polytetrafluoroethylene (PTFE) grafts were used. This study aimed to assess the long-term patency rates and complications of PTFE grafts used for MHV reconstruction of LDLT in a high-volume liver transplantation center. Methods: We analyzed the patency rates of PTFE-interposed MHV in 100 LDLT recipients and reviewed complications including PTFE graft migration. Results: The mean age was 53.5±5.4 years and male to female ratio was 73:27. Primary diagnoses were hepatitis B virus infection (n=71) and other (n=28). Mean model for endstage liver disease score was 16.2±8.3. V5 reconstruction was performed as either single anastomosis (n=85) or double anastomoses (n=14). No V5 reconstruction was required in one patient. V8 reconstruction was performed as single anastomosis, double anastomoses, and no reconstruction in 75, 0, and 25 patients, respectively. During a mean follow-up of 6 years, three recipients required early MHV stenting within 2 weeks. After 3 months, there were no episodes of congestion-associated infarct, regardless of MHV patency. Patency rates of PTFE-interposed MHV were 54.0%, 37.0%, and 37.0% at 1, 3, and 5 years, respectively. Unwanted PTFE graft migration occurred in two recipients, and the actual incidence was 2% at 5 years. Conclusions: PTFE grafts combined with small-artery patches demonstrated acceptably high short- and long-term patency rates. Since the risk of unwanted migration of PTFE graft is not negligibly low, lifelong surveillance is necessary to detect unexpected rare complications.

Purification and Properties of Novel Calcium-binding Proteins from Streptomyces coelicolor

Chang, Ji-Hun,Yoon, Soon-Sang,Lhee, Sang-Moon,Park, I-Ha,Jung, Do-Young,Park, Young-Sik,Yim, Jeong-Bin The Microbiological Society of Korea 1999 The journal of microbiology Vol.37 No.1

Two novel calcium-binding proteins, named CAB-I and CAB-II, have been isolated from Streptomyces coelicolor. Purification of the calcium-binding proteins involved heat treatment, fractionation with ammonium sulfate, acid treatment, anion exchange and hydrophobic interaction column chromatography, FPLC gel filtration, and preparative isoelectric focusing. A chelex competitive assay and 45Ca autoradiography verified the calcium-binding ability of the proteins. The major band CAB-II has an apparent molecular weight of 26,000 determined by SDS-polyacrylamide gel electrophoresis and 340,000 determined by gel filtration. The isoelectric point of this molecule showed the acidic nature of the molecule. N-terminal amino acid sequence analysis shows homology to rat Ca2+/calmodulin-dependent protein kinase-II (CAB-II) and yeast phosphoprotein phosphatase (CAB-I).