Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

전방 불안정성 견관절에서 이두박근의 근전도 활동성

김승호,하권익,김현숙,김선우,박종혁,김영민 대한견.주관절학회 2000 大韓肩.주關節學會誌 Vol.3 No.2

Anti‑inflammatory effect of Rosa laevigata extract on in vitro and in vivo model of allergic asthma via the suppression of IgE and related cytokines

Seung‑Hyeon Lee,Seung‑Han Choi,In‑Seung Lee,Yumi Kim,Eun‑Jin An,Hyeung‑Jin Jang 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.2

Backgrounds Exposure to a toxic stress environment leads to excessive inflammatory reactions and induces allergic asthma resulting in airway hyper-responsiveness. We investigated whether Rosa laevigata Michx. (RL) exhibits anti-inflammatory effects related allergic asthma in both an in vitro and in vivo studies. Methods To investigate the preventive effect of RL, A549 cells were pretreated with non-toxic doses of RL (500, 1000 μg/ mL) and induced by epidermal growth factor (EGF) (10 ng/mL). First, we evaluated cytotoxicity via a MTT assay. The inhibitory effects of NF-κB activity and COX-2 expression were confirmed by a western blot assay. In the in vivo study, BALB/c mice were challenged with regard to ovalbumin via an intraperitoneal injection of RL (50, 100 mg/kg) and were killed to collect bronchoalveolar lavage fluid, lung tissues and blood serum. The number of inflammatory cells, the secretion of IgE and related cytokines were monitored by ELISA and multiplex assays. Results RL significantly suppressed NF-κB activity and COX-2 expression levels in EGF-induced A549 cells. In a chronic inflammation mice model, pretreatment of RL attenuated allergic airway inflammation by reducing inflammatory cells, the secretion of IgE and related cytokines in a dose-dependent manner. Conclusions The results of this study present the possibility of RL as a therapeutic agent for allergic asthma patients via the suppression of IgE and related cytokines.

Autophagy 매개체인 LC3로 인한 Aβ 신경 독성의 증가

이승아;이현정;김도희;김옥현 박지애;김대진;정윤희;김경용;김성수;이원복 중앙대학교 의과대학 의과학연구소 2012 中央醫大誌 Vol.37 No.1/2

Autophagy is a highly regulated cellular mechanism that results in the bulk degradation process and which seems to be implicated in a variety of physiological and pathological conditions relevant to Alzheimer's disease (AD). Also, it has been suggested that the large part of autophagy is mediated by Light Chains 3 (LC3). Despite research suggesting an association between AD and autophagy, many issues remain to be addressed. To determine the relevance between autophagy and AD, we evaluated amyloid beta (Aβ) toxicity either in SH-SY5Y cells transfected with only EGFP or the cells exogeneously transfected with EGFP-LC3, mediating autophagy easily by overexpressed LC3. Without treatment of Aβ, the cell viabilities were quietly similar in both kinds of cells. The cell viability was decreased significantly in LC3 overexpressed cells. Consistently, more increased oxidative stress was detected in LC3 overexpressed cells. These results suggest that autophagy enhanced Aβ toxicity by way of increasing oxidative stress at least in part. This study will be of help to understand the role of autophagy in neurodegenerative diseases.

Mo¨nckeberg 중막 석회화로 인해 초기자궁내막암이 진행성 자궁내막암으로 판독되었던 1례

김승만,배철성,김동훈,김정란,이현경,윤혜원 동국대학교 경주대학 1997 東國論集 Vol.16 No.1

Mo¨nckeberg 중막 석회화는 크거나 중간크기의 근육성 동맥(large and medium-sized muscular arteries)의 중막(media)에 노화와 관련되어 퇴행성 과정인 윤상석회화가 특징적으로 나타나는 동맥경화증의 일종으로, 근본적으로 폐쇄성 죽상경화증(occlusive atherosclerosis)과는 다른 과정으로 동맥의 관강(lumen)을 막는 경우는 드물어 상대적으로 임상적 의의는 적거나 거의 없다. 저자들은 Mo¨nckeberg 중막 석회화때문에 초음파 및 컴퓨터 단층촬영에 의한 병기결정에 혼란을 초래하였던 초기 자궁내막암 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The Mo¨nckeberg medial calcification is aging change rather than disease entity. The Mo¨nckeberg medial calcification involve muscular arteries of limb, head, and genital track and cause fibrosis change associated with hyalinization and fine basophilic staining, suggesting early calcification with little or no clinical significance but is demonstrable on roentgenograms as regular and diffuse radiopaque shadow under intima. We experienced one case of mis-staging of early endometrial cancer due to the Mo¨nckeberg medial calcification therefore, we report this case with a brief review of the literature of the Mo¨nckeberg medial calcification.

원발성 폐암 환자의 생존율에 관한 보고

김현태,이상무,어수택,박춘식,정성환,허승재,남충희,강창희,김용훈 순천향대학교 1994 논문집 Vol.17 No.4

We analysed 404 patients with primary lung carcinoma who were treated at Soonchunhyang University Hospital from July, 1985 to september, 1993 in order to investigate the survival rate and epidemiolgical properties of primary lung cancer. They were 330 males and 74 females. The most prevalent decade was seventh. In terms of cell type, the squamous cell was 225 patients (55%), and adenocarcinoma, small cell, mixed type was 21%, 19%, 4%, respectively. Among non-small cell lung carcinoma, stage Ⅲa was the most prevalent one(92%). In case of small cell carcinoma, the limited stage was 64%. The 12-, 24-, 36- month survival rate of total patients was 57%, 31%, 22%, respectivley and median sruvival time was 15 months. The 36-month survival rate tended to be longer in non-small cell lung carcinoma than that of small cell lung cancer, but there was no difference between two groups, statistically. In non-small cell carcinoma, The 36-month survival rate and meidan survival time were longer in the stage Ⅰ and Ⅱ than those of Ⅲa, Ⅲb, Ⅳ (80% versus 38%, 22%, 0%, p<0.05). According to involvement of lymph node, the 36-month survival rate was longer in NO and N1 than those of N2, N3 (61.9%, 48.7% versus 17.7%, 17.3%, p<0.05). In small cell carcinoma, The 36-month survival rate and median survival rate were higher and longer in limited stage than those of extensive stage(16.1% and 13 month vs 10% and 8 month, p<0.05). In conclusion, we report here the incidence of primary lung carcinoma and the survival rate of paients with primary lung carcinoma who were treated in Soonchunhyang University Hospital.

自然과 調和를 이룬 光山區의 文化觀光資源 開發 推進方向

김승현 조선대학교 지역사회발전연구원 2003 地域發展硏究 Vol.8 No.1

Gwangsan-gu is called the hidden place for Gwangju with its beautiful scenery. We must develop this inherited natural resources for the rest place of residents and the cultural sightseeing points with pro-environmental plans. Especially, Mt Udoong. Mt youngjun and Hwangyong river must be developed for the rest place of domestic and foreign tourists, preservation of the local history and the cultural resources. It will contribute to the enhancement of the life quality of residents and the personal income. By doing so, Gwangsan will take a firm root as a central city in the Korean South-west zone, coexisting cities and rural districts.

한국 엘리트 마라톤 선수들의 기질 특성에 관한 연구

김익겸,유승희,김복현 경희대학교 체육과학연구소 1999 體育學論文集 Vol.27 No.-

According to the research of Korean marathoners of Psychological characteristic, it can be conclusion follow this: 1.Korean marathoners have ambivert characteristic that it appears both extrovert and introvert as well as in the middle of both characteristic. 2.Look at the low of neuropsychiatric tendency, Korean marathoners are not easily shaken by emotion. 3.According to the temperament, most of marathoners belong to choleric temperament and sanguine temperament, and it can find good marathoners is located on the border of others temperament. According to the psychological Index of Korean marathoners, in order to develope high work ability in marathon, it recovers that extreme characteristic is not advisable whether extrovert and introvert or neuropsychiatric tendency index and temperament.

노인 입원 환자의 질병 양상과 의료이용 실태

김현주,홍성철,이상이,김명주,황승욱 대한노인병학회 2003 대한노인병학회지 Vol.7 No.4

고속직렬 인터페이스를 이용한 분산제어 시스템 설계에 관한 연구

김승연,박광현 大田工業大學 1991 한밭대학교 논문집 Vol.8 No.2

분산된 다양한 공정이나 대규모 공정제어시스템에 데이타전송을 위하여 사용되는 종래의 병렬버스 방식에는 여러가지 제한적요소가 내재해 있다. 본 논문에서는, IBM 호한 PC-AT를 호스트컴퓨터로 하고, dDCM 320 아나로그 1/0보드, dDCM 335 디지탈 1/0보드, PCX344 마스터 인터페이스보드 등으로 구성되는 고속직렬 인터페이스를 이용하여 계층적인 간단한 분산제어 시스템을 구현하였다. 또한, 입증된 데이타 링크프로토콜인 IBM 표준프로토콜 SDLC를 이용하여, SDLC 프로토콜의 중요기능인 Zero Bit Insertion/deletion 기능을 확인검증하였다. 이 논문에 제안된 고속직렬 인터페이스를 이용한 분산제어 시스템은 병렬버스방식의 단일제 어시스템보다 효율적임이 실증되었다. There are several limitations inherent in traditional parallel-bus mode used for the data transmission in the large scaled and various distributed process control system. In this paper, simple hierachical distributed control system is implemented with using a high-speed parallel interface consists of the IBM compatible PC -AT as host computer, dDCM 320 analog I/O board, dDCM 335 digital I/O board, and so forth. Moreover, the Zero bit inserion/deletion function which is important function of the SDLC protocol is verified using the proven protocol, SLDC of IBM. The distributed Control system with high-speed serial interface which is presented in this paper is testified in efficiency, comparing to a single control system with parallel-bub mode.