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Propylthiouracil에 의한 중증 급성간염 1예
임종주,심미령,이명수,김태현,오석규,안선호,박무림,김남호,박병현,조성구 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2
PTU에 의한 간염의 발생은 매우 드물게 발생하는 것으로 알려져 있으나 저자들은 Graves씨 병으로 진단 받고 propylthiouracil 투여를 받고있던 환자에서 중증의 급성 간염이 발생한 1예를 경험하였기에 보고하는 바이다. Propylthiouracil is widely used to treat patients with hyperthyroidism. This drug has been associated with severe hepatotoxicity rarely. We presented the case of jaundice and profound liver dysfunction from a 23-year old woman treated with propylthiouracil for hyperthyroidism. Viral, metabolic, and autoimmune liver disease could be excluded and liver biopsy revealed a pattern of acute hepatitis. After discontinuing the drug, there was a progressive resolution of hepatic symptoms and decrease in biochemical data of the liver. Despite propylthiouracil induced hepatitis in rare case, patients receiving propylthiouracil are exposed to develope severe hepatotoxicity. Therefore it might be advisable to monitor level of the transaminase on regular base from patients receiving propylthiouracil.
전형적인 DISIDA scan 소견의 Rotor 증후군 1예
황의태,염동한,권지혜,임종주,최창수,김태현,김학철 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2
만성의 비용혈성 직접형 고빌리루빈혈증은 Rotor 증후군과 Dubin-Johnson 증후군의 특징적인 소견으로, Rotor 증후군은 드문 양성 유전성 질환이며, Dubin-Johnson 증후군과 감별을 필요로 한다. 본 저자들은 황달을 주소로 내원한 26세 남자 환자에서 고빌리루빈혈증에 대한 검사를 시행하여 담도폐쇄 소견없이 간담도 스캔상 전형적인 Rotor 증후군의 소견 즉, 강한 심장 배후방사능이 지속되면서, 간담도계의 조영은 지연 촬영에서도 관찰되지 않으며 신장으로의 배설이 계속 관찰되는 특징적인 소견과 정상 간조직 검사 결과로 Rotor 증후군으로 진단한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Chronic nonhemolytic conjugated hyperbilirubinemia characterizes both Rotor and Dubin-Johnson syndromes. Rotor syndrome is a rare, benign familial disorder and needs to be differentiated from Dubin-Johnson syndrome. Cholescintigraphy is a simple and informative procedure for the diagnosis, which can differentiate Rotor syndrome from Dubin-Johnson syndrome. A 26-year-old man was admitted due to asymptomatic persistent jaundice. Physical examination revealed icteric sclera without hepatosplenomegaly. Laboratory findings showed increased serum bilirubin with direct bilirubinemia. Markedly decreased hepatic uptake and poor visualization of the gallbladder and biliary tract were shown in ^(99m)Tc-DISIDA scan. Histology of the liver showed no diagnostic abnormality without pigmentation. But, we report a case of Rotor syndrome that showed characteristic cholescintigraphic findings with normal urinary total coproporphyrin excretion.
위암세포주에서 Recombinant Human Interferon-r와 Adriamycin의 투여순서가 항암효과에 미치는 영향
홍원선,손영숙,김창민,강윤구,이춘택,김유철,임영혁,남현석,이진오,강태웅 大韓免疫學會 1993 大韓免疫學會誌 Vol.15 No.-
Numerous previous studies, both in vitro and in vivo, have demonstrated that the cytotoxicity can be enhanced by the combination of chemotherapeutic agent and interferons(IFNs) in various types of cancer cells. We have previously reported that combined treatment of MKN-45, human gastric adenocarcinoma cells, with adriamycin(ADM) and recombinant human interferon-r(rh-IFN-r) increased in the cytotoxicity. In this study, the effects of combination timing of rh-IFN-r and ADM on the cytotoxicity against MKN-45 were investigated using MTT assay. MKN-45 was treated with rh-IFN-r and ADM in vitro on three schedules : Treat A ; rh-IFN-r and ADM were treated simultaneously, Treat B ; rh-IFN-r was treated 24 hours after the treatment with ADM, Treat C ; rh-IFN-r was treated for 72 hours and followed by the treatment with ADM. The survival of MKN -45 was inhibited by ADM dose-dependently. 102 and 103U/ml of rh-IFN-r significantly inhibited the survival of MKN-45(% survival : 35.1 ±-1.2% and 34.4 ±1.1% in Treat A and 42.5 ± 2.1% and 45.9-±2.5% in Treat C, respectively). However no difference in the survival was observed between 102 and 103U/ml of rh-IFN-r. Combined treatment with rh-IFN-r and ADM significantly augmented the cytotoxicity at low concentrations of ADM. Combined effects of rh-IFN-r and ADM were evaluated using IC30(,ag/ml) to ADM. IC30s of MKN-45 in Treat A, B and C at 102 U/ml of rh -IFN-r _ were 0.019 -?- 0.003, 0.045 :I:0.001 and 0.054 ± 0.012, respectively, while IC30 of MKN-45 treated with ADM alone was 0.052±0.004. IC30s of MKN-45 in ADM alone group, Treat A, Treat B and Treat C at 103U/ml of rh-IFN-r were 0.047 ±0.003, 0.004 -±0.001, 0.031 ±0.004 and 0.056 0.008, respectively. These results indicate IC30s of Treat A and B were significantly lower than those of ADM alone(p<0.05) and IC30s of Treat A was significantly lower than those of Treat B(p <0.01). IC30s of Treat C, however, were not different from those of ADM alone. From these results demonstrating that cytotoxic effects were increased by the combination of rh-IFN-r and ADM in the order, Treat A > Treat B> Treat C, it can be concluded that the simultaneous administration of rh-IFN-r and ADM may be the most effective method to combine these two therapeutic modalties.
내독소에 의한 급성폐손상에서 Protein Kinase C의 역할
김현태 ( Hyeon Tae Kim ),박춘식 ( Choon Sik Park ),진병원 ( Byung Won Jin ),김용훈 ( Yong Hoon Kim ),문승혁 ( Seung Hyug Moon ),기신영 ( Sin Young Kee ),주재학 ( Jae Hak Ju ),박태응 ( Tae Eung Park ),임건일 ( Keon Il Im ),정성환 ( 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.2
복막염이 동반되지 않으면서 복막투석 도관에 증식한 진균 (Alternaria species)
신도현 ( Sin Do Hyeon ),안상미 ( An Sang Mi ),임선교 ( Im Seon Gyo ),정희선 ( Jeong Hui Seon ),김명성 ( Kim Myeong Seong ),신규태 ( Sin Gyu Tae ),이위교 ( Lee Wi Gyo ),임현이 ( Im Hyeon I ),길혜련 ( Gil Hye Lyeon ),김흥수 ( Kim He 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.3
Visible fungal colonization on peritoneal dialysis catheter is a rare complication and it was not reported yet in Korea. We here report a case of Alternaria spp. colonization on peritoneal dialysis catheter without peritonitis. A 58-year-old man on continuous ambulatory peritoneal dialysis for 2 years, noticed 3..4 mm sized two black-brown immobile fungal colonization plaque on peritoneal catheter lumen (15 cm distal from catheter exit site). The dialysate effluent was clear and culture for fungus and bacteria was negative. Peritoneal catheter was removed and culture from the plaque revealed saprophytic fungus, Alternaria species. The catheter removal alone was sufficient for the treatment. He is on hemodialysis thereafter. (Korean J Nephrol 2004;23(3):523-527)
컨볼루션 신경망(CNN)을 이용한 폭발물 성분 용량별 분류 성능 평가에 관한 연구
이창현,조성윤,권기원,임태호,Lee, Chang-Hyeon,Cho, Sung-Yoon,Kwon, Ki-Won,Im, Tae-Ho 한국인터넷정보학회 2022 인터넷정보학회논문지 Vol.23 No.4
본 논문은 컨볼루션 신경망(CNN)을 이용하여 폭발물 성분의 용량별로 분류할 때의 성능을 평가하는 연구이다. 기존의 폭발물 분류 방식 중에 IMS 증기 탐지기 방식은 폭발물의 농도가 사용자가 장비에서 설정한 임계치를 넘어야만 폭발물의 존재 여부를 판단한다. IMS 증기 탐지기는 폭발물이 존재하더라도 임계치를 넘지 않는 양이면 폭발물이 존재하지 않는다고 판단하는 문제가 있다. 따라서 폭발물 성분의 농도가 임계치를 넘지 않는 양일 때에도 폭발물 성분을 검출하는 방안이 필요하다. 이에 따라 본 논문에서는 폭발물 시계열 데이터를 Gramian Angular Field(GAF) 알고리즘으로 이미지화를 진행한 후 이미지와 영상처리뿐만 아니라 시계열 데이터 처리에도 뛰어난 성능을 보이는 딥러닝 모델인 컨볼루션 신경망(CNN)으로 직접 label을 설정해서 지도학습을 진행한 결과 폭발물 성분의 농도가 임계치를 넘지 않는 양일 때에도 폭발물 성분이 존재한다고 판단함과 동시에 폭발물 성분의 종류와 폭발물 성분의 농도의 양을 같이 판단할 수 있는지 성능평가를 진행했다. This paper is a study to evaluate the performance when classifying explosive components by capacity using a convolutional neural network (CNN). Among the existing explosive classification methods, the IMS steam detector method determines the presence or absence of an explosive only when the explosive concentration exceeds the threshold set by the user. The IMS steam detector has a problem of determining that even if an explosive exists, the explosive does not exist in an amount that does not exceed the threshold. Therefore, it is necessary to detect the explosive component even when the concentration of the explosive component does not exceed the threshold. Accordingly, in this paper, after imaging explosive time series data with the Gramian Angular Field (GAF) algorithm, it is possible to determine whether there are explosive components and the amount of explosive components even when the concentration of explosive components does not exceed a threshold.
Im, Hyeon-Gyun,Jeong, Seonju,Jin, Jungho,Lee, Jaemin,Youn, Doo-Young,Koo, Won-Tae,Kang, Sin-Bi,Kim, Hyo-Joong,Jang, Junho,Lee, Daewon,Kim, Han-Ki,Kim, Il-Doo,Lee, Jung-Yong,Bae, Byeong-Soo Nature Publishing Group 2016 NPG Asia Materials Vol.8 No.-
<P>Here, we propose crystalline indium tin oxide/metal nanowire composite electrode (c-ITO/metal NW-GFRHybrimer) films as a robust platform for flexible optoelectronic devices. A very thin c-ITO overcoating layer was introduced to the surface-embedded metal nanowire (NW) network. The c-ITO/metal NW-GFRHybrimer films exhibited outstanding mechanical flexibility, excellent optoelectrical properties and thermal/chemical robustness. Highly flexible and efficient metal halide perovskite solar cells were fabricated on the films. The devices on the c-ITO/AgNW- and c-ITO/CuNW-GFRHybrimer films exhibited power conversion efficiency values of 14.15% and 12.95%, respectively. A synergetic combination of the thin c-ITO layer and the metal NW mesh transparent conducting electrode will be beneficial for use in flexible optoelectronic applications.</P>