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Cordycepsmilitaris polysaccharide triggers apoptosis and G0/G1 cell arrest in cancer cells
Cheng Chen,Mei-LinWang,Chao Jin,Huijuan Chen,Shao-Hui Li,Shu-Ying Li,Xing-Fan Dou,Jun-Qiang Jia,Zhong-Zheng Gui 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.3
Although many studies have shown the antitumor properties of Cordyceps militaris (artificial cultivated from Bombyx mori pupa) polysaccharides, little is known regarding the mechanism of its effects. This study was conducted to determine the mechanism of antitumor effects of C. militaris polysaccharide extract by evaluating apoptosis rate and cell cycle progression status in human liver cancer cell SMMC-7721, stomach cancer cell BGC-823 and breast cancer cell MCF-7. Results showed that C. militaris polysaccharides inhibited proliferation of SMMC-7721, BGC-823 and MCF-7 cells with an IC50 of 192 ± 23.2 μg/mL, 237 ± 12.7 μg/mL and 165 ± 16.3 μg/mL, respectively. We also found that C. militaris polysaccharides at increasing concentrations induced apoptosis dose dependently in those cancer cells: apoptosis rates were 48.3%, 59.4% and 70.9% for SMMC-7721, 41.3% and 57.0%, 72.2% for BGC-823 and 61.3%, 66.9% and 80.6% for MCF-7 at 110, 156 and 323 mg/mL of C. militaris polysaccharides, respectively. C. militaris polysaccharides arrested SMMC-7721, BGC-823 and MCF-7 cells at G0/G1 and G2/M phases with corresponding decrease in S-phase. This study suggests that C. militaris polysaccharides may exert its antitumor effects in those cancer cells by suppressing its growth, arresting the G0/G1-phase, reducing DNA synthesis and inducing apoptosis.
( Huijuan Gao ),( Xin Li ),( Xiatian Chen ),( Deng Hai ),( Chuang Wei ),( Lei Zhang ),( Peifeng Li ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.10
Probiotics are live microorganisms that can be consumed by humans in amounts sufficient to offer health-promoting effects. Owing to their various biological functions, probiotics are widely used in biological engineering, industry and agriculture, food safety, and the life and health fields. Lactobacillus acidophilus (L. acidophilus), an important human intestinal probiotic, was originally isolated from the human gastrointestinal tract and its functions have been widely studied ever since it was named in 1900. L. acidophilus has been found to play important roles in many aspects of human health. Due to its good resistance against acid and bile salts, it has broad application prospects in functional, edible probiotic preparations. In this review, we explore the basic characteristics and biological functions of L. acidophilus based on the research progress made thus far worldwide. Various problems to be solved regarding the applications of probiotic products and their future development are also discussed.
Epidemiology of gynecologic cancers in China
Xiyi Jiang,Huijuan Tang,Tianhui Chen 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.1
Cancer has become a major disease burden across the globe. It was estimated that 4.29 million new incident cases and 2.81 million death cases of cancer would occur in 2015 in China, with the age-standardized incidence rate (ASIR) of 201.1 per 100,000 and age-standardized mortality rate (ASMR) of 126.9 per 100,000, respectively. For females, 2 of the top 10 most common types of cancer would be gynecologic cancers, with breast cancer being the most prevalent (268.6 thousand new incident cases) and cervical cancer being the 7th most common cancer (98.9 thousand new incident cases). The incidence and mortality of gynecologic cancers have been constantly increasing in China over last 2 decades, which become a major health concern for women. Survival rates of gynecologic cancers are generally not satisfactory and decrease along with advancing stage, though national data on survival are still not available. It is of great importance to overview on the epidemiology of gynecologic cancers, which may provide scientific clues for strategy-making of prevention and control, and eventually lowering the incidence and mortality rate as well as improving the survival rate in the future.
Atractylenolides (I, II, and III): a review of their pharmacology and pharmacokinetics
Mao Deng,Huijuan Chen,Jiaying Long,Jiawen Song,Long Xie,Xiaofang Li 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.7
Atractylodes macrocephala Koidz is a widelyused as a traditional Chinese medicine. Atractylenolides(-I, -II, and -III) are a class of lactone compounds derivedfrom Atractylodes macrocephala Koidz . Research intoatractylenolides over the past two decades has shown thatatractylenolides have anti-cancer, anti-infl ammatory, antiplatelet,anti-osteoporosis, and antibacterial activity; protectthe nervous system; and regulate blood glucose and lipids. Because of structural diff erences, both atractylenolide-I andatractylenolide-II have remarkable anti-cancer activities,and atractylenolide-I and atractylenolide-III have remarkableanti-infl ammatory and neuroprotective activities. Wetherefore recommend further clinical research on the anticancer,anti-infl ammatory and neuroprotective eff ects ofatractylenolides, determine their therapeutic eff ects, aloneor in combination. To investigate their ability to regulateblood glucose and lipid, as well as their anti-platelet, antiosteoporosis,and antibacterial activities, both in vitro andin vivo studies are necessary. Atractylenolides are rapidlyabsorbed but slowly metabolized; thus, solubilization studiesmay not be necessary. However, due to the inhibitory eff ectsof atractylenolides on metabolic enzymes, it is necessaryto pay attention to the possible side eff ects of combiningatractylenolides with other drugs, in clinical application. Inshort, atractylenolides have considerable medicinal valueand warrant further study.
Weidong Zhang,Jie Chen,Huijuan Zhang,Fengming Song 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.3
A rice diacylglycerol kinase (DGK) gene, OsBIDK1, which encodes a 499-amino acid protein, was cloned and characterized. OsBIDK1 contains a conserved DGK domain, consisting of a diacylglycerol kinase catalytic subdomain and a diacylglycerol kinase accessory subdomain. Expression of OsBIDK1 in rice seedlings was induced by treatment with benzothiadiazole (BTH), a chemical activator of the plant defense response, and by infection with Magnaporthe grisea, causal agent of blast disease. In BTH-treated rice seedlings, expression of OsBIDK1 was induced earlier and at a higher level than in water-treated control seedlings after inoculation with M. grisea. Transgenic tobacco plants that constitutively express the OsBIDK1 gene were generated and disease resistance assays showed that overexpression of OsBIDK1 in transgenic tobacco plants resulted in enhanced resistance against infection by tobacco mosaic virus and Phytophthora parasitica var. nicotianae. These results suggest that OsBIDK1 may play a role in disease resistance responses.
Synthesis and Enhanced Photocatalytic Activity of Black Porous Zr-doped TiO2 Monoliths
Jimin Du,Huiming Wang,Huijuan Chen,Menghe Yang,Xiaoling Lu,Hui Guo,Zhanmin Zhang,Tianwei Shang,Shujue Xu,Wenqi Li,Pianpian Wang,Imran Shakir 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.6
Black Porous Zr-doped TiO2 monoliths were successfully synthesized by a combined route including sol–gel method with polystyrene spheres as template followed by calcination at high temperature in the presence of oxygen. As-synthesized samples were then treated in hydrogen atmosphere at 500℃ for 6 h to obtain black Porous Zr-doped TiO2 monoliths. This as-synthesized black porous Zr-doped TiO2 composite showed relatively narrow bandgap compared to the pure anatase phase of TiO2, which may have its origin from the contributions from the Zr impurity and oxygen vacancies. The photocatalytic activity of the black porous Zr-doped TiO2 monolith was examined by carrying out the dye degradation on Rhodamine B under visible irradiation. Our experimental results indicate that black porous 0.9% Zr-doped TiO2 sample exhibits high photocatalytic activity with the photodecomposition of 95.25% under visible irradiation for 120 min.
Lingqin Shen,Hengbo Yin,Aili Wang,Xiufeng Lu,Changhua Zhang,Fen Chen,Yuting Wang,Huijuan Chen 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.3
Liquid phase dehydration of glycerol to acrolein catalyzed by Brønsted acidic ionic liquids (BAILs) usingsemi-batch reaction technique was investigated. For the BAILs catalysts, the acrolein yields were inan order of [Bmim]H2PO4 > [Bmim]HSO4 > [BPy]HSO4 > [PSPy]HSO4 > [N2224]HSO4 > [PSPy]H2PO4> [BPy]H2PO4 > [N2224]H2PO4. When [Bmim]H2PO4 and [Bmim]HSO4 were used as the catalysts at 270℃ with the molar ratio of catalyst to glycerol of 1:100, the acrolein yields were 57.4% and 50.8%,respectively, at complete conversion of glycerol. The BAILs with [Bmim] cation and moderate acidityfavored the formation of acrolein in liquid phase glycerol dehydration.