Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [99mTc] TRODAT-1

Tsung-Hua Lu(Tsung-Hua Lu),Shih-Hsien Lin(Shih-Hsien Lin),Huai-Hsuan Tseng(Huai-Hsuan Tseng),Yen Kuang Yang(Yen Kuang Yang),Nan Tsing Chiu(Nan Tsing Chiu),Po See Chen(Po See Chen) 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4

Objective: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. Methods: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [99mTc] TRODAT-1. Results: The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD. Conclusion: The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.

Harm Avoidance is Correlated with the Reward System in Adult Patients with Attention Deficit Hyperactivity Disorder: A Functional Magnetic Resonance Imaging Study

Tsung-Hua Lu(Tsung-Hua Lu),Shih-Hsien Lin(Shih-Hsien Lin),Mei Hung Chi(Mei Hung Chi),Ching-Lin Chu(Ching-Lin Chu),Dong-Yu Yang(Dong-Yu Yang),Wei Hung Chang(Wei Hung Chang),Po See Chen(Po See Chen),Yen 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Objective: Hypoactivity in the reward system among patients with attention deficit hyperactivity disorder (ADHD) is a well-known phenomenon. Whether the activity in the reward pathway is related to harm avoidance, such as in sensitivity to punishment, is unclear. Evidence regarding the potential difference between ADHD patients and controls in terms of this association is scarce. Methods: Event-related functional magnetic resonance imaging was conducted on subjects performing the Iowa gambling test. Fourteen adults with ADHD and 14 controls were enrolled in the study. Results: Harm avoidance was found to be positively correlated with the activities of the bilateral orbitofrontal cortex and right insula in individuals with ADHD. A group difference was also confirmed. Conclusion: Understanding the roles of harm avoidance and brain activation during risk tasks is important.

Impact of a Glyphosate-Tolerant Soybean Line on the Rhizobacteria, Revealed by Illumina MiSeq

( Gui-hua Lu ),( Yin-ling Zhu ),( Ling-ru Kong ),( Jing Cheng ),( Cheng-yi Tang ),( Xiao-mei Hua ),( Fan-fan Meng ),( Yan-jun Pang ),( Rong-wu Yang ),( Jin-liang Qi ),( Yong-hua Yang ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.3

The global commercial cultivation of transgenic crops, including glyphosate-tolerant soybean, has increased widely in recent decades with potential impact on the environment. The bulk of previous studies showed different results on the effects of the release of transgenic plants on the soil microbial community, especially rhizosphere bacteria. In this study, comparative analyses of the bacterial communities in the rhizosphere soils and surrounding soils were performed between the glyphosate-tolerant soybean line NZL06-698 (or simply N698), containing a glyphosate-insensitive EPSPS gene, and its control cultivar Mengdou12 (or simply MD12), by a 16S ribosomal RNA gene (16S rDNA) amplicon sequencing-based Illumina MiSeq platform. No statistically significant difference was found in the overall alpha diversity of the rhizosphere bacterial communities, although the species richness and evenness of the bacteria increased in the rhizosphere of N698 compared with that of MD12. Some influence on phylogenetic diversity of the rhizosphere bacterial communities was found between N698 and MD12 by beta diversity analysis based on weighted UniFrac distance. Furthermore, the relative abundances of part rhizosphere bacterial phyla and genera, which included some nitrogen-fixing bacteria, were significantly different between N698 and MD12. Our present results indicate some impact of the glyphosate-tolerant soybean line N698 on the phylogenetic diversity of rhizosphere bacterial communities together with a significant difference in the relative abundances of part rhizosphere bacteria at different classification levels as compared with its control cultivar MD12, when a comparative analysis of surrounding soils between N698 and MD12 was used as a systematic contrast study.

论东亚文化圈三国汉字文化产业的发展现状, 开发方向与完善对策

LU JING HUA,곽다예 동북아시아문화학회 2022 동북아 문화연구 Vol.1 No.72

Chinese Culture Circle is the world with Chinese characteries as media and has the same value system. Chinese culture circle of East Asia refers to the countries and of east Asia such as China, Korea, Japan, Vietnam and so on, This paper mainly focus on and conduct analysis and research on China, South Korea, and Japan, three representative countries in the East Asian Chinese character circle. It is committed to combining the experience advantages of the cultural industries of these three countries to propose a Chinese character cultural industry. The targeted countermeasures will make a contribution to promoting the development of the Chinese character culture industry in practice in the vast number of countries in the East Asian cultural circle. Although China, South Korea, and Japan in the East Asian cultural circle are all belong to the field of Chinese character culture and have many similarities in culture, there are great differences in the way of using Chinese characters. Therefore, for the development of the Chinese character culture industry, countries in the Chinese character culture circle should make efforts in four aspects. In view of the above policies, efforts should be made for the revitalization and development of the Chinese character culture industry according to the actual situation of each country. Humans have language, and language is the most basic information. Since modern times, some Chinese scholars have followed Saussure's erroneous theory. It is hoped that from now on, China and all countries in the East Asian Chinese character culture circle can fundamentally continue to establish and further strengthen the character confidence and even cultural confidence in our East Asian script circle. Lu Jianming believes that global integration makes language an intangible resource that plays an increasingly important role in national economy and security.

魏秀仁及其相关人物考证与《花月痕》新解

???(Hua Xiaochen),?薇(LU Wei) 동아인문학회 2020 동아인문학 Vol.50 No.-

The interpretation of Hua Yue Hen has long been confined to the text itself, while the research about the author, the real life of related figures, and the social context is insufficient. Based upon the historical materials about Wei Xiuren’s life experiences and the social context in which the book was written, this paper aims to probe the gist of the novel and the author’s motive from a humanist perspective. Furthermore, a defense of the novel is included from some of its criticisms.

The Tense and Aspect System of Chinese, English and Korean : Focusing on the present, the past and the future

Lu, Jing-Hua 대한중국학회 2016 중국학 Vol.57 No.-

There are grammatical markers of tense that are obligatory in English and Korean, ho wever, these grammatical temporal forms are absent in Chinese. Although it is uncontrov ersial that Chinese does not morphologically encode tense, there are several other ways in which temporal information can be encoded (Smith&Erbaugh, 2005). Chinese is an aspect system language which marks aspect. On the contrast, English is a tense system languag e which marks tense. In our review of languages considered in this study, the main focus will be on aspect system and tense system which are illustrated by Chinese, English and Korean. The author will illustrate that the tense and aspect system of Chinese is different from that of Korean and English. Our argument in this paper focuses on three categories which can be referred to as the present, past and future. In chapter one, the motive of re search that difference of aspect and tense expression in Chinese, English and Korea was introduced and the course of this research was mentioned. A contrasting study was conducted in chapter two. As for contrasting the characteristics of three languages, the author hope that this paper would help to learn Chinese, English or Korean easily.

miR-424-5p regulates apoptosis and cell proliferation via targeting Bcl2 in nucleus pulposus cells

Lu Hua-tuo,Xu Yong-qing,Wang Hai,Zhang Xu-lin 한국통합생물학회 2020 Animal cells and systems Vol.24 No.3

Background: miRNAs play an important role in the pathogenesis of intervertebral disc degeneration (IDD). The role and the underlying mechanism of miR-424-5p in human nucleus pulposus (NP) are still unknown. We aimed to explore the role of miR-424-5p in IDD. Methods: Real-time PCR was used to detect the expression of miR-424-5p and Bcl2 in IDD tissues and idiopathic scoliosis tissues. Human NP cells were used in our study. MTT and Hoechst apoptosis assays were used to detect the proliferation and apoptosis of NP cells, respectively. Western blotting assays were used to detect the expression levels of Bcl-2, cleaved caspase-3, cleaved caspase-9, caspase-3 and caspase-9 in degenerative NP cells. A luciferase reporter assay was applied to confirm the relationship between miR-424-5p and Bcl2. Results: Our results showed that the expression of miR-424-5p was increased and Bcl2 was decreased in degenerative NP cells. miR-425-5p expression was negatively correlated with Bcl2 expression in IDD tissues. Suppression of miR-424-5p using an inhibitor increased Bcl2 expression at both the mRNA and protein levels, and it promoted cell viability and inhibited apoptosis. Furthermore, the levels of cleaved caspase-3 and cleaved caspase-9 were downregulated in miR-424-5p-silenced NP cells. Interestingly, we found that silencing miR-424- 5p increased p62 expression at both the mRNA and protein levels. Finally, a luciferase reporter assay verified the binding of the miR-424-5p and the 3’UTR of Bcl2. Conclusion: These results suggested that silencing miR-424-5p suppressed NP cell apoptosis by upregulating Bcl2. Therefore, miR-424-5p might be a novel target for IDD therapies.

韩语汉字词与汉语词汇词义的对比研究

LU JING HUA,정성임 동북아시아문화학회 2018 동북아 문화연구 Vol.1 No.56

Although Chinese and Korean belong to different language families, Korea is one of the countries in the East Asian Chinese cultural circle, the development of language is deeply influenced by Chinese characters. In Korean vocabulary system, we know that Korean vocabulary is divided into three types: intrinsic words, Chinese characters, and foreign words, while 70% of the total Korean vocabulary are Chinese characters. This paper will focus on the meaning of comparison between Korean Chinese Characters and Chinese words. Furthermore, we will analyze the similarities and differences between Korean Chinese Characters and Chinese words. Finally, the problems in the teaching of Chinese vocabulary to Korean students will be summarized. This paper is divided into four sections. The first section is a comparative analysis of Korean Chinese Characters and Chinese vocabulary. It mainly expounds the similarities and differences between Chinese vocabulary and Korean Chinese Characters. In the second section, combining with the practical experience of the author's teaching work, the application and teaching methods of Chinese teaching to Korean students will be discussed through the methods of classification and comparison. The third section is the conclusion of this paper. Problems existing in the teaching of Korean Chinese words will be summarized. We hope to promote the teaching of Chinese characters, provide practical reference and some help for Chinese learners in Korean. Moreover, for the deep study, we will prepare the paper about Korean Chinese Characters and Chinese Words focusing on the grammar. We hope to promote the teaching of Chinese characters, and provide some help for Chinese learners in Korean.

Risk Assessment of Secondary Primary Malignancies in Nasopharyngeal Carcinoma: A Big-Data Intelligence Platform-Based Analysis of 6,377 Long-term Survivors from an Endemic Area Treated with Intensity-Modulated Radiation Therapy during 2003-2013

Lu-Lu Zhang,Guo-Hong Li,Yi-Yang Li,Zhen-Yu Qi,Ai-Hua Lin,Ying Sun 대한암학회 2019 Cancer Research and Treatment Vol.51 No.3

Purpose The incidence, risk factors and survival impact of secondary primary malignancies (SPMs) among survivors of nasopharyngeal carcinoma (NPC) treated with definitive intensity-modulated radiation therapy (IMRT) with or without chemotherapy are poorly characterized. Materials and Methods Consecutive patients (n=6,377) from the big-data intelligence platform at Sun Yat-sen University Cancer Center, China (in a high-incidence area) with newly diagnosed non-metastatic pathologically proven non-keratinizing undifferentiated NPC treated with IMRT±chemotherapy between January 2003 and June 2013 were retrospectively analyzed. Cumulative incidence of SPMs was calculated using the Kaplan-Meier method. Cox proportional hazards model was used to identify potential risk factors for SPMs and assess whether SPMs affect overall survival. Results Of the 6,377 patients, 189 (3.0%) suffered SPMs (median follow-up, 62 months). One-, 2-, 3-, 4-, and 5-cumulative risks of SPMs were 0.4%, 0.9%, 1.6%, 2.2%, and 2.6%, respectively. Latency from start of IMRT to SPMs diagnosis was 37 months (range, 6 to 102 months). In patients with SPMs, 14.3% suffered SPMs within 1 year post-IMRT: 1-3 years, 38.1%; 3-5 years, 33.9%; and > 5 years, 13.7%. Lung cancer was the most common SPM (50/6,377, 0.78%). Multivariate analysis demonstrated sex (male, 64% increase), age (! 50 years, 68% increase), and smoking history (41% increase) were significant risk factors for SPMs, and SPMs were associated with poorer overall survival. Conclusion This large cohort study confirms SPMs a dreadful complication for long-term survivors of NPC treated with IMRT. SPMs negatively impact overall survival in NPC. Close follow-up is recommended for older male survivors with a smoking history.

The Economic and Political System of Hong Kong Special Administrative Region

Lu, Jing-Hua(여정화) 경성대학교 인문과학연구소 2016 인문학논총 Vol.42 No.-

홍콩특별행정구(香港特别行政区)는 홍콩섬(香港島, 향항도)과 주룽반도(九竜半島, 구룡반도), 신제(新界, 신계)와 그 밖의 230개의 부속도서로 구성되어 있는 중국의 특별행정구이다. 1840년 아편 전쟁 이후 영국에 의해 점령 된 홍콩은 중국과 영국의 여러 번의 논의 후 1997년 드디어 중국에 반환과 함께 중국홍콩특별행정구가 수립되었다. 홍콩은 중국의 영토이다. 그러나 1941년에 일본이 홍콩을 점령한 뒤 1945년에 다시 해방되었으며 국공내전으로 인해 영국에 다시 점령되었다. “기본법”, “영국-중국 공동 선언”, “일국양제”에 따라 홍콩은 1997년 7월 1일부터 2047년 6월 30일까지 50년간 외교와 국방을 제외한 고도의 자치권이 인정되는 특별행정구의 지위를 유지하도록 되어있다. 지금까지 중국 국내에서 가장 높은 수준의 자율성을 보유하고 있다. 본 논문은 홍콩특별행정구의 중국 반환 20주년에 맞춰 ‘일국양제’의 특징과 시사점을 분석했으며 학계의 많은 관심을 이끌기 위해, 특히 홍콩의 경제와 정치 구조에 대한 분석을 했다. 이러한 독특한 특성은 매우 시의성이 높으며 한국과 다른 체제제도를 유지하는 중국을 이해하는데 도움을 주는 내용으로 구성되어 있다. Hong Kong is China"s territory since ancient times, which have been occupied by Britain after the Opium War of 1840. Since 1979, China and the United Kingdom have began to discuss the issue about Hong Kong several times. In accordance with the Basic Law, the Sino-British Joitnt Declaration and one country and two systems principle, New Territories, New Kowloon and other areas in Hongkong officially handed over to China in July 1, 1997. Comparing with other provinces, Hong Kong Special Administrative Region has a high degree of autonomy. Since the system of Hongkong Special Administrative Region is an innovative system of national political system, this paper just make a preliminary analysis on the political and economic structure of the Hong Kong Special Administrative Region, in order to arouse many academics" attention that continue to explore this rich system constitute, distinctive characteristics of power relations and structure power. The institutional practice of Hong Kong has unique status on the national governance system and governance modernization.