Extracellular Vesicles-Encapsulated miR-153-3p Potentiate the Survival and Invasion of Lung Adenocarcinoma

Hongli Cao,Ping Zhang,Hong Yu,Jianing Xi 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.6

Extracellular vesicles (EVs) play an essential role in the communication between cells and the tumor micro­environment. However, the effect of tumor-derived EVs on the growth and metastasis of lung adenocarcinoma (LUAD) remains to be explored. This study aimed to elucidate the role of miR-153-3p-EVs in the invasion and migration capabilities of LUAD cells and explore its mechanism through in vivo and in vitro experiments. We found that miR-153-3p was specifically and highly expressed in LUAD and its secreted EVs. Furthermore, the expression of BANCR was negatively regulated by miR-153-3p and identified as a target gene of miR-153-3p using luciferase reporter assays. Through further investigation, we found that the downregulation of BANCR activates the PI3K/AKT pathway and accelerates the process of epithelial-mesenchymal transition (EMT), which ultimately leads to the aggravation of LUAD. The orthotopic xenograft mouse model was established to illustrate the effect of miR-153-3p-EVs on LUAD. Animal studies showed that miR-153-3p-EVs accelerated tumor growth in mice. Besides, we found that miR-153-3p-EVs could damage the respiratory ability of mice and produce a mass of inflammatory cells around the lung tissue of mice. Nevertheless, antagomir-153-3p treatment could inhibit the deterioration of respiratory function and inhibit the growth of lung tumors in mice. In conclusion, our study reveals the potential molecular mechanism of miR-153-3p-EVs in the development of LUAD and provides a potential strategy for the treatment of LUAD.

Alveolar bone thickness around maxillary central incisors of different inclination assessed with cone-beam computed tomography

Yu-lou Tian,Fang Liu,Hong-jing Sun,Pin Lv,Yu-ming Cao,Mo Yu,Yang Yue 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.5

Objective: To assess the labial and lingual alveolar bone thickness in adults with maxillary central incisors of different inclination by cone-beam computed tomography (CBCT). Methods: Ninety maxillary central incisors from 45 patients were divided into three groups based on the maxillary central incisors to palatal plane angle; lingual-inclined, normal, and labial-inclined. Reformatted CBCT images were used to measure the labial and lingual alveolar bone thickness (ABT) at intervals corresponding to every 1/10 of the root length. The sum of labial ABT and lingual ABT at the level of the root apex was used to calculate the total ABT (TABT). The number of teeth exhibiting alveolar fenestration and dehiscence in each group was also tallied. One-way analysis of variance and Tukey’s honestly significant difference test were applied for statistical analysis. Results: The labial ABT and TABT values at the root apex in the lingual-inclined group were significantly lower than in the other groups (p < 0.05). Lingual and labial ABT values were very low at the cervical level in the lingual-inclined and normal groups. There was a higher prevalence of alveolar fenestration in the lingual-inclined group. Conclusions: Lingual-inclined maxillary central incisors have less bone support at the level of the root apex and a greater frequency of alveolar bone defects than normal maxillary central incisors. The bone plate at the marginal level is also very thin.

A New Method to Detect Glyphosate Resistant Soybean - PPM Method

Hong-yu Cao,Xiang-ju Li,Hai-lan Cui,Hong-bo Niu 한국잡초학회 2011 한국잡초학회 별책(학술대회 초록집) Vol.31 No.2

The comparative research about the evolutionary model of our naational corpotate competitiveness based on the judgment approach of different life cycle

CAO Yu,CHEN Xiao-hong,MA Yue-ru 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

The correct judgment of the stage at which a corporation stays is the premise of empirical research on the issue of a corporation in the life cycle perspective, this paper has put forward two methods, by which the evolutionary model of our national corporate competitiveness at different stage of life cycle has been verified with empirical research, one is acquired directly from questionare, the other is the employ of fuzzy-integrated judgment through setting up relative subjects. This has in one hand. proved the feasibility of different life cycle judgment approach adopted by this paper, and on the other hand, verified the reliability of conduction made by this paper on the evolutionary model of our national corporate competitiveness. The result reveals that the life cycle of our national corporations can all be assessed by these two methods. By these two methods, this paper has put forward the evolutionary model of our national corporate competitiveness at different stage of life cycle, which is of significant referential importance of the establishment of corporate competitive strategy

Topology Control for Increasing Connectivity in Cooperative Wireless Ad Hoc Networks

YU, Jieun,ROH, Heejun,CAO, Jun,PACK, Sangheon,LEE, Wonjun,DU, Ding-Zhu,HONG, Sangjin (Stephen) The Institute of Electronics, Information and Comm 2010 IEICE TRANSACTIONS ON COMMUNICATIONS - Vol.93 No.4

<P>We propose a novel topology control scheme that reduces the transmission power of nodes and increases the network connectivity, based on the fact that Cooperative Communication (CC) technology can bridge disconnected networks. Simulation results demonstrate that our scheme greatly increases the connectivity for a given transmission power, compared to other topology control schemes.</P>

Crack Resistance and Strength Properties of Red Clay Modified with Lignocellulose and Guar gum

Hong-Yuan Fu,Guang-Tao Yu,Qian-Feng Gao,Ling Zeng,Shuo-Peng Cao 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.10

Desiccation cracking is a common problem of red clay under wet and dry conditions. The presence of cracks could reduce soil strength properties, which is the major reason for shallow failure of red clay slopes. This study aims to propose some additives to improve the crack resistance as well as the strength of red clay. To this end, three natural fibers and three natural gels were primarily selected to modify red clay. Desiccation crack tests were conducted to identify the best fiber and gel in terms of crack resistance. Then, direct shear tests and uniaxial tensile tests were performed on the soil specimens modified by the best fiber and gel to determine the optimal dosages regarding strength improvements. The results demonstrated that natural gels reduced the crack resistance of red clay, while natural fibers could enhance the crack resistance. Lignocellulose was the best additive in improving the crack resistance of red clay, and the modified effect was positively correlated with the fiber dosage. Adding 1.5% lignocellulose into red clay could reduce the crack rate from 2.19% to 0.30%, with a reduction of 0.86 times. The tensile strength, shear strength and its parameters of lignocellulose-modified red clay showed a trend of increasing first and then decreasing with increasing lignocellulose dosage. At the optimal lignocellulose dosage of 0.75%, the shear strength and tensile strength were increased by 44.63% and 18.21%, respectively. The strength of red clay modified by both lignocellulose and guar gum was positively correlated with the dosage of guar gum, and the desirable dosage of guar gum was 1.0%. In engineering practice, the wet red clay mixed with 0.75% lignocellulose and grass seeds can be employed as planting soil and is sprayed uniformly onto the slope surface after excavation using a spraying planting machine. To further improve the strength of the planting soil, 1.0% guar gum solution can be sprayed on the soil surface. The findings could provide useful guidance for the protection of red clay slopes.

복합재 튜브를 이용한 고속 열차의 에너지 흡수장치에 대한 실험 및 수치해석 연구

장홍규 ( Hong Kyu Jang ),신재환 ( Jae Hwan Shin ),손유나 ( Yu Na Shin ),김천곤 ( Chun Gon Kim ),( Cao Son Nguyen ) 한국복합재료학회 2011 Composites research Vol.24 No.1

본 논문에서는 복합재료 튜브를 이용한 고속 열차의 에너지 흡수장치에 대한 실험 및 수치 해석에 관한 연구를 수행하였다. 논문의 목적은 에너지 흡수장치에 대한 최적의 적층(lay-up) 형태를 알아내는 것으로, quasi static method를 이용한 네 가지 적층 형태에 대한 실험을 수행 하였다: [0/45/90/-45]4, [0]16, [0/90]8, [0/30/-30]5. 실험을 위해 초기 파괴 시작점을 생성하고, 일정 방향으로 진행되는 파괴를 만들기 위해 베벨 엣지(bevel edge)와 노치 엣지(notch edge)의 두 가지 트리거링 방법을 이용하였다. 저속 충돌실험 결과 [0/45/90/-45]4의 적층 형태가 다른 방법과 비교해서 가장 좋은 에너지 흡수 결과를 보여주었다. 수치해석을 위해 LS-DYNA 프로그램의 변수 분석(parametric analysis)을 통해 가장 적합한 복합재료의 quasi static 실험 시뮬레이션 방법 연구를 수행하였다. 움직이는 벽이 복합재 튜브에 저속 충돌하는 모델을 가정하여 해석을 수행하였으며, 실험값과 수치해석 결과의 비교를 통해 비슷한 경향을 보임을 확인 하였다. 특히 TFAIL과 mass scaling factor를 조절하며 수행하는 변수 분석은 LS-DYNA에서 복합재 튜브의 quasi static 실험을 시뮬레이션 하는 능력과 한계를 보여준다. This paper presents an experimental and numerical study on composite tubes for the energy absorber of the high-speed train. The purpose of the experimental study is to find out which lay-up is the best lay-up for the energy absorber. Four lay-ups were tested using quasi static method: [0/45/90/-45]4, [0]16, [0/90]8, [0/30/-30]5. Two triggering methods were used to create initial damage and guarantee the progressive collapse mode: bevel edge and notch edge. As a result, [0/45/90/-45]4 lay-up was find out the best lay-up among the laminates being tested. In the numerical study, a parametric analysis was done to find out the most proper way to simulate the quasi static test of a composite tube using LS-DYNA program. A single composite tube was modeled to be crashed by a moving wall. Comparison between simulation and experiment was done. Reasonable agreement between experiment and analysis was obtained. Dealing with parameter TFAIL and the mass scaling factor, this parametric study shows the ability and the limitation of LS-DYNA in modeling the quasi static test for the composite tube.

High-accuracy electrohydraulic control system for the position and orientation of the primary mirror for a large telescope

Li Yu-Xia,Wang Jian-Li,Guo Peng-Fei,Li Hong-Wen,Cao Yu-Yan 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.79 No.7

Due to variations in gravity, temperature, and external disturbances, the optical axes of a telescope’s primary mirrors can shift and, consequently, become misaligned with the light path. Such misalignment significantly reduces image quality; thus, the position and orientation of primary mirror (POPM) control systems must maintain the optical axis in an ideal position. Therefore, in this paper, we proposes a novel high-accuracy electrohydraulic control system for the position and orientation of the primary mirror (POPM) of a large telescope. To this end, a POPM control system with five electrohydraulic partitions is adopted, and a mathematical model of the POPM is derived. In addition, a mathematical model of each partition of the electrohydraulic system is derived for the telescope controller design. A linear active disturbance rejection controller (LADRC) and a sliding mode controller (SMC) are adopted in each electro-hydraulic partition to ensure positioning accuracy. Experiments are carried out on 4 and 1.2 m large telescopes. The corresponding results show that by both keeping constant and varying the elevation of the large telescopes, the position error of the primary mirror can be limited to less than 1 μm, and the orientation of the primary mirror can be maintained with an error of less than 0.05 arcsec, even in the presence of external disturbances. This control accuracy can guarantee both the inalterability of the optical axis of the primary mirror and the possibility to adjust the light according to the requirement in order to obtain high-resolution images.

中国政府与华人高技术新移民

?宏(Liu Hong),曹善玉(Cao Shan Yu) 전남대학교 글로벌디아스포라연구소 2011 전남대학교 세계한상문화연구단 국제학술회의 Vol.2011 No.2

As knowledge based economy has become increasingly globalized, the competition for talent has intensified. In order to attract more highly skilled new Chinese migrants return to work in their homeland, the Chinese government has initiated a series of policies since the 1980s. This paper investigates these policies and mechanisms and the responses from the new migrants. It suggests that a new immigrant policy combining with horizontal and vertical approaches should be employed to accommodate burgeoning trend of global circulation of brains.

Mucin2 is Required for Probiotic Agents-Mediated Blocking Effects on Meningitic E. coli-Induced Pathogenicities

Jing Yi Yu,Xiao Long He,Santhosh Puthiyakunnon,Liang Peng,Yan Li,Li Sha Wu,Wen Ling Peng,Ya Zhang,Jie Gao,Yao Yuan Zhang,Swapna Boddu,Min Long,Hong Cao,Sheng He Huang 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.10