Carboxymethyl Flavonoids and A Monoterpene Glucoside from Selaginella moellendorffii

Hong-Sheng Wang,Ling Sun,Yue-Hu Wang,Ya-Na Shi,Gui-Hua Tang,Fu-Wei Zhao,Hong-Mei Niu,Chun-Lin Long,Ling Li 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.8

A new dihydroflavone, 5-carboxymethyl-7,4'-dihydroxyflavonone (1), and its glucoside 5-carboxymethyl-7,4'-dihydroxyflavonone-7-O-β-D-glucopyranoside (2), and one new monoterpene glucoside, (4Z,6E)-2,7-dimethyl-8-hydroxyocta-4,6-dienoic acid 8-O-β-D-glucopyranoside (3), were isolated from the whole plants of Selaginella moellendorffii. Their structures were determined by spectroscopic methods and chemical transformation. Compound 2 was evaluated for the ability to enhance glucose consumption in normal and insulin-resistant L6 muscle cells induced by high concentrations of insulin and glucose. Glucose consumption in insulin-resistant cells (but not in normal cells) was increased 15.2 ± 3.3% (p < 0.01) by compound 2 at a concentration of 0.1 μM in the presence of insulin (1 nM).

Separation of arenols from a low-temperature coal tar by liquid-liquid extraction

Hua-Shuai Gao,Zhi-Min Zong,Zheng Yang,Dao-Guang Teng,Xiu-Hua Sun,Li Yan,Xian-Yong Wei,Qing-Jie Guo,Tian-Sheng Zhao,Hong-Cun Bai 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.5

Low-temperature coal tar (LTCT) is a sticky liquid mixture produced mainly from coal pyrolysis, which contains various value-added chemicals (VACs). Liquid-liquid extraction is considered as one of the green and effective ways to explore the organic composition and separate the VACs from LTCT. Herein, petroleum ether, methanol, and carbon disulfide were used to extract arenols from a LTCT. As a result, the relative content and absolute content of arenols extracted from the LTCT are ca. 96.3% and 85.9%, respectively. Among them, p-cresol is predominant, accounting for 22.2%. The isolated contents of arenols are up to 84.6%. Moreover, a kilogram-scale operation was carried out under the same conditions, which offers a potential application in industrial production.

Phytochemistry and pharmacology of natural prenylated flavonoids

Hua-Wei Lv,Qiao-Liang Wang,Meng Luo,Meng-Di Zhu,Hui-Min Liang,Wen-Jing Li,Hai Cai,Zhong-Bo Zhou,Hong Wang,Sheng-Qiang Tong,Xing-Nuo Li 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.4

Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain enriched the structural diversity of flavonoids and increased their bioactivity and bioavailability. Prenylated flavonoids show a wide range of biological activities, such as anti-cancer, anti-inflammatory, neuroprotective, anti-diabetic, anti-obesity, cardioprotective effects, and anti-osteoclastogenic activities. In recent years, many compounds with significant activity have been discovered with the continuous excavation of the medicinal value of prenylated flavonoids, and have attracted the extensive attention of pharmacologists. This review summarizes recent progress on research into natural active prenylated flavonoids to promote new discoveries of their medicinal value.

Structural health monitoring of innovative civil engineering structures in Mainland China

Li, Hong-Nan,Li, Dong-Sheng,Ren, Liang,Yi, Ting-Hua,Jia, Zi-Guang,LI, Kun-Peng Techno-Press 2016 Structural monitoring and maintenance Vol.3 No.1

This paper describes the backgrounds, motivations and recent history of structural health monitoring (SHM) developments to various types of engineering structures. Extensive applications of SHM technologies in bridges, high-rise buildings, sport avenues, offshore platforms, underground structures, dams, etc. in mainland China are summarily categorized and listed in tables. Sensors used in implementations, their deployment, damage identification strategies if applicable, preliminary monitoring achievements and experience are presented in the lists. Finally, existing problems and promising research efforts in civil SHM are discussed, highlighting challenges and future trends.

Prognostic Significance of GSTP1, XRCC1 and XRCC3 Polymorphisms in Non-small Cell Lung Cancer Patients

Ke, Hong-Gang,Li, Jun,Shen, Yi,You, Qing-Sheng,Yan, Yu,Dong, Han-Xuan,Liu, Jun-Hua,Shen, Zhen-Ya Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Aim: Individual differences in chemosensitivity and clinical outcome in non-small cell lung cancer (NSCLC) patients treatment with platinum-based chemotherapy may be due to genetic factors. Our study aimed to investigate the prognostic role of GSTP1, XRCC1 and XRCC3 in NSCLC patients treated with chemotherapy. Methods: A total of 460 cases were consecutively selected from The Affiliated Hospital of Nantong University between Jan. 2003 to Nov. 2006, and all were followed-up until Nov. 2011. Genotyping of GSTP1 Ile105Val, XRCC1 Arg194Trp, XRCC1 Arg399Gln and XRCC3 Thr241Met was conducted by duplex polymerase-chain-reaction with confronting-two-pair primer methods. Results: Patients with GSTP Val/Val exhibited a shorter survival time, and had a 1.89 fold greater risk of death than did those with the IIe/IIe genotype. For XRCC1 Arg194Trp, the variant genotype Trp/Trp was significantly associated with a decreased risk of death from NSCLC when compared with the Arg/Arg. Individuals carrying XRCC1 399Gln/Gln genotype had a longer survival time, with a lowered risk of death from NSCLC. Conclusion: This study indicated that GSTP1 Ile105Val, XRCC1 Arg194Trp and XRCC1Arg399Gln genes have a role in modifying the effect of platinum-based chemotherapy for NSCLC patients in a Chinese population. Our findings provide information for therapeutic decisions for individualized therapy in NSCLC cases.

Articles : Medicinal Chemistry ; Highly efficient polymer supported phase-transfer catalysts containing hydrogen bond inducing functional groups

( Qing Hua Shi ),( Yeon Ju Lee ),( Mi Jeong Kim ),( Mi Kyung Park ),( Kyoung Yim Lee ),( Hong Rui Song ),( Mao Sheng Cheng ),( Byeong Seon Jeong ),( Hyeung Geun Park ),( Sang Sup Jew ) 영남대학교 약품개발연구소 2008 영남대학교 약품개발연구소 연구업적집 Vol.18 No.-

Association of Lipoprotein-Associated Phospholipase A_2 with Characteristics of Vulnerable Coronary Atherosclerotic Plaques

Yu-Sheng Liu,Qing-Hua Lu,Xiao-Bo Hu,Hong-Zhuan Li,Wei-Dong Jiang,Xin Wang,Hao Lin,Ai-Qiong Qin,Yong-Mei Wang,Tong Zhao,Zhao-Qiang Dong,Mei Zhang 연세대학교의과대학 2011 Yonsei medical journal Vol.52 No.6

Purpose: Lipoprotein-associated phospholipase A2 (Lp-PLA_2) is an inflammatory enzyme expressed in atherosclerotic plaques. We investigated the association of circulating Lp-PLA_2 with characteristics of vulnerable coronary atherosclerotic plaques. Materials and Methods: We recruited 113 patients with either unstable angina (UA, n=59) and stable angina (SA, n=54) by coronary angiography. Thirty-six healthy subjects served as controls. Intravascular ultrasound (IVUS) was used to evaluate the characteristics of coronary atherosclerotic plaque, and serum Lp-PLA2 concentration was measured as well. Results: Lp-PLA_2 concentration was significantly higher in both UA and SA patients [(396±36) μg/L and (321±39) μg/L, respectively]compared with the controls [(127±49) μg/L, p<0.01], and higher in UA than SA group. IVUS findings showed that remodeling index (RI) (0.91±0.15 vs. 0.85±0.11, p=0.005) and eccentricity index (EI) (0.73±0.16 vs. 0.65±0.22, p=0.039) were larger in UA than in SA group, and fibrous caps were thicker in SA than UA group [(0.91±0.23) mm vs. (0.63±0.21) mm, p=0.032]. Moreover, Lp-PLA_2 correlated positively with EI (r=0.439, p<0.01) and RI (r=0.592, p<0.05) in UA group. There was an inverse relationship between Lp-PLA_2 and fibrous cap thickness in both UA (r=-0.587, p<0.001) and SA (r=-0.318, p<0.05) groups. The independent risk factors in UA group were Lp-PLA_2 (OR=1.055, 95% CI: 1.03-1.08, p=0.013), LDL-cholesterol (OR=0.032, 95% CI: 0.00-0.05, p=0.041) and fibrous cap thickness (OR=0.008, 95% CI: 0.00-0.45, p=0.019). Lp-PLA_2 was strongly associated with both EI and fibrous cap thickness in both groups. Conclusion: Serum level of Lp-PLA_2 is associated with both eccentricity index and fibrous cap thickness in both UA and SA groups. Elevated levels of circulating Lp-PLA_2 might to be a strong risk factor and more serious for unstable angina than stable angina.

Reviews on innovations and applications in structural health monitoring for infrastructures

Li, Hong-Nan,Yi, Ting-Hua,Ren, Liang,Li, Dong-Sheng,Huo, Lin-Sheng Techno-Press 2014 Structural monitoring and maintenance Vol.1 No.1

The developments and implementations of the structural health monitoring (SHM) system for large infrastructures have been gradually recognized by researchers, engineers and administrative authorities in the last decades. This paper summarizes an updated review on innovations and applications in SHM for infrastructures carried out by researchers at Dalian University of Technology. Invented sensors and data acquisition system are firstly briefly described. And then, some proposed theories and methods including the sensing technology, sensor placement method, signal processing and data fusion, system identification and damage detection are discussed in details. Following those, the activities on the standardization of SHM and several case applications on specific types of structure are reviewed. Finally, existing problems and promising research efforts in the field of SHM are given.

Characterizations of Ag-catalyzed ZnO nanostructures prepared by vapor–solid mechanism

Su-Hua Yang,Pao-Chih Chen,Sheng-Yu Hong 한국물리학회 2009 Current Applied Physics Vol.9 No.2

This paper presents the synthesis and field emission characteristics of zinc oxide (ZnO) nanostructures grown on Ag-deposited Si substrate by using the vapor–solid (VS) mechanism. The morphology of the ZnO nanostructures was related to source and substrate temperatures. Nanowhiskers, nanotips and well-aligned nanorods were grown at substrate temperatures of 620, 650 and 680℃, respectively. A strong bluish-green photoluminescence (PL) indicated that the nanostructures had many surface defects correlated with oxygen vacancies. Field emission analyses showed that the turn-on fields of ZnO nanowhiskers, nanotips and well-aligned nanorods were 4.5, 5.8 and 6.1 V/㎛, respectively. The high emitter density and high aspect ratio of the well-aligned nanorods resulted in an enhancement in emission current density. Furthermore, the field emission stability of the well-aligned nanorods was better than that of the nanowhiskers and nanotips. The emission current densities of the ZnO nanowhiskers, nanotips and well-aligned nanorods, measured after continuous operation for 6 h, were approximately 2.05, 4.68 and 20.5 μA/㎠, respectively. This paper presents the synthesis and field emission characteristics of zinc oxide (ZnO) nanostructures grown on Ag-deposited Si substrate by using the vapor–solid (VS) mechanism. The morphology of the ZnO nanostructures was related to source and substrate temperatures. Nanowhiskers, nanotips and well-aligned nanorods were grown at substrate temperatures of 620, 650 and 680℃, respectively. A strong bluish-green photoluminescence (PL) indicated that the nanostructures had many surface defects correlated with oxygen vacancies. Field emission analyses showed that the turn-on fields of ZnO nanowhiskers, nanotips and well-aligned nanorods were 4.5, 5.8 and 6.1 V/㎛, respectively. The high emitter density and high aspect ratio of the well-aligned nanorods resulted in an enhancement in emission current density. Furthermore, the field emission stability of the well-aligned nanorods was better than that of the nanowhiskers and nanotips. The emission current densities of the ZnO nanowhiskers, nanotips and well-aligned nanorods, measured after continuous operation for 6 h, were approximately 2.05, 4.68 and 20.5 μA/㎠, respectively.

Online damage detection using pair cointegration method of time-varying displacement

Cui Zhou,Hong-Nan Li,Dong-Sheng Li,You-Xin Lin,Ting-Hua Yi 국제구조공학회 2013 Smart Structures and Systems, An International Jou Vol.12 No.3

Environmental and operational variables are inevitable concerns by researchers and engineers when implementing the damage detection algorithm in practical projects, because the change of structural behavior could be masked by the conditions in a large extent. Thus, reliable damage detection methods should have a virtue of immunity from environmental and operational variables. In this paper, the pair cointegration method was presented as a novel way to remove the effect of environmental variables. At the beginning, the concept and procedure of this approach were introduced, and then the theoretical formulation and numerical simulations were put forward to illustrate the feasibility. The jump exceeding the control limit in the residual indicates the occurrence of damage, while the direction and magnitude imply the most potential damage location. In addition, the simulation results show that the proposed method has strong ability to resist the noise.