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Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions
Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8
Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.
Echocardiography에 의한 力道 選手 및 마라톤 選手의 左心室 構造와 機能에 관한 硏究
朴哲浩,金榮俊 東亞大學校附設스포츠科學硏究所 1990 스포츠科學硏究論文集 Vol.8 No.-
This study used echocardiography to reveal the function and structure of left ventricle for the subjects of marathoners, weight-lifters and a control group. The following shows the results. 1. Marathoners and weight-lifters had greater systolic and diastolic left ventricular internal dimension and volume than a control group, but there was no significance among the groups in left ventricular posterior wall or interventrcular septum. 2. Marathoners and weight-lifters showed little significance in the absolute values of systolic and diastolic internal dimension, left ventricular posterior wall, and interventricular septum, whereas weight-lifters increased in left ventricular internal dimension per body surface area more than marathoners. 3. Weight-lifters had a shorter pre-ejection period time than other groups, while left ventricular ejection time was significantly longer in marathoners and weight-lifters. Also, marathoners took greater total electro mechanical systolic time and ratio of pre-ejection period time to ejection time than others. 4. Marathoners showed lower ejection fraction, shortening fraction, and percentage of systolic wall thickness but with no conceivable significance. It also took significantly greater end-systolic posterior wall stress and lower mean endocardial systolic velocity than weight-lifters and control group.
李相于,朴哲浩,辛尙根,金榮俊 東亞大學校附設스포츠科學硏究所 1991 스포츠科學硏究論文集 Vol.9 No.-
The purpose of this study was focused on the degree of work intensity and optimal race pace in rowing for Korean national male and female rowers. The items in physique were body height and body weight. Body density was estimated from the sum of two skinfold using the regressional equations suggested by Nagamine et al.(1972). Percent fat was calculated by Brozek et al.(1963) formular. Somatotype was calculated by Health-Carter(1981) anthropometric somatotype method. Maximal oxygen uptake measurements were continued while the work load increased by a uniform amount each 40m/4min for male and 30m/4min for female on the treadmill ergometer. The grade was constant at 0% and the initial speeds were 160m/min for male rowers and 120m/min for female rowers. Heart rate was recorded continuously all through the experiment of actual rowing by using telemetering method(Hart Check 108 System). Oxygen uptake in percent of maximal oxygen uptake(% of VO₂max) of the actual rowing was calculated from the equation of relationship between heart rate and oxygen uptake obtained during exhaustive running test on the treadmill. Heart rates during the exercise of actual rowing was measured on 8 male and 4 female Korean national rowers. Blood lactate concentration measurements were used autoclix Lancet Method after actual rowing exercise for 8 male rowers. Also, eleven male rowers and six female rowers volunteered as subjects in this study. The results obtained are summarized as follows. 1. The means for the percent fat of the Korean national male and female rowers were 12.1±1.09% and 18.4±3.50, respectively. 2. The means for Health-Carter somatotype of the Korean national male and female rowers were 2.8-4.5-2.9 of balanced mesomorph and 4.2-3.4-2.9 of mesoendomorph, respectively. 3. The means for the maximal oxygen uptake(VO₂max) of the Korean national male and female rowers were 5.30±0.607ℓ/min(65.6㎖/㎏/min) and 3.22±0.148ℓ/min(48.1㎖/㎏/min), respectively. 4. The means for the heart rate of national male and female rowers by actual rowing exercise were 171.3±10.44bpm ad 172.9±8.35bpm, respectively. 5. The means for the heart rate in percent of maximal heart rate(%VO₂max) of national male and female rowers by actual rowing exercise were 88.6±8.12% HRmax(81.7±11.12%VO₂max) and 88.2±5.38%HRmax(88.8±5.77%VO₂max), respectively. 6. The means for the RMR(Mets) of national male and female rowers by actual rowing exercise were 17.2±2.59RMR(15.4±2.12Mets) and 13.5±1.95RMR(12.2±1.44Mets), respectively. 7. The means for the pitch rate of national male and female rowers by actual rowing exercise were 31∼33 stroke/min and 29∼31 stroke/min, respectively. 8. In actual 2,000m rowing exercise, blood lactate concentration was 6.74±0.854mM/ℓ on goal in-point and 7.07±0.989mM/ℓ on 5 minutes after recovery in male rowers.
( Choel Kyu Park ),( Hyun Wook Kang ),( Tae Ok Kim ),( Ho Seok Ki ),( Eun Young Kim ),( Hee Jung Ban ),( Byeong Kab Yoon ),( In Jae Oh ),( Yoo Deok Choi ),( Yong Soo Kwon ),( Yoo Il Kim ),( Sung Chul 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.2
Paclitaxel has been widely used for treating many solid tumors. Although colonic toxicity is an unusual complication of paclitaxel-based chemotherapy, the reported toxicities include pseudomembranous colitis, neutropenic enterocolitis and on rare occasions ischemic colitis. Genexol-PM(R), which is a recently developed cremophor-free, polymeric micelle-formulated paclitaxel, has shown a more potent antitumor effect because it can increase the usual dose of paclitaxel due to that Genexol-PM(R) does not include the toxic cremophor compound. We report here on a case of a 57-year-old man with advanced non-small cell lung cancer and who developed ischemic colitis after chemotherapy with Genexol-PM(R) and cisplatin. He complained of hematochezia with abdominal pain on the left lower quadrant. Colonoscopy revealed diffuse mucosal hemorrhage and edema from the sigmoid colon to the splenic flexure. After bowel rest, he recovered from his symptoms and the follow-up colonoscopic findings showed that the mucosa was healing. Since then, he was treated with pemetrexed monotherapy instead of a paclitaxel compound and platinum.
PROTO-MODEL OF AN INFRARED WIDE-FIELD OFF-AXIS TELESCOPE
Kim, Sang-Hyuk,Pak, Soo-Jong,Chang, Seung-Hyuk,Kim, Geon-Hee,Yang, Sun-Choel,Kim, Myung-Sang,Lee, Sung-Ho,Lee, Han-Shin The Korean Astronomical Society 2010 Journal of The Korean Astronomical Society Vol.43 No.5
We develop a proto-model of an off-axis reflective telescope for infrared wide-field observations based on the design of Schwarzschild-Chang type telescope. With only two mirrors, this design achieves an entrance pupil diameter of 50 mm and an effective focal length of 100 mm. We can apply this design to a mid-infrared telescope with a field of view of $8^{\circ}{\times}8^{\circ}$. In spite of the substantial advantages of off-axis telescopes in the infrared compared to refractive or on-axis reflective telescopes, it is known to be difficult to align the mirrors in off-axis systems because of their asymmetric structures. Off-axis mirrors of our telescope are manufactured at the Korea Basic Science Institute (KBSI). We analyze the fabricated mirror surfaces by fitting polynomial functions to the measured data. We accomplish alignment of this two-mirror off-axis system using a ray tracing method. A simple imaging test is performed to compare a pinhole image with a simulated prediction.
( Gheun-Ho Kim ),( Bum Soon Choi ),( Dae Ryong Cha ),( Dong Hyun Chee ),( Eunah Hwang ),( Hyung Wook Kim ),( Jae Hyun Chang ),( Joong-Kyung Kim ),( Jung Woo Noh ),( Kwon Wook Joo ),( Sang Choel Lee ) 대한신장학회 2014 Kidney Research and Clinical Practice Vol.33 No.1
Background: In many countries, nephrologists follow clinical practice guidelines for mineral bone disorders to control secondary hyperparathyroidism (SHPT) associated with abnormal serum calcium (Ca) and phosphorus (P) levels in patients undergoing maintenance hemodialysis (MHD). The Kidney Disease Outcomes Quality Initiative (KDOQI) Guidelines have long been used in Korea, and this study was undertaken to investigate the current status of serum Ca and P control in MHD patients. Methods: Data were collected from a total of 1,018 patients undergoing MHD without intercurrent illness, in 17 hemodialysis centers throughout the country. Serum levels of Ca, P, and intact parathyroid hormone (iPTH) were measured over 1 year, and the average values were retrospectively analyzed. Results: Serum levels of Ca, P, and the Ca×P product were 9.1±0.7mg/dL, 5.3±1.4mg/dL, and 48.0±13.6mg2/dL2, respectively. However, the percentages of patients with Ca, P, and Ca × P product levels within the KDOQI guideline ranges were 58.7%, 51.0%, and 70.7%, respectively. Of the 1,018 patients, 270 (26.5%) had iPTH >300pg/mL (uncontrolled SHPT), whereas 435 patients (42.7%) showed iPTH <150pg/mL. Patients with uncontrolled SHPT had significantly higher values of serum Ca, P, and Ca×P product than those with iPTH ≤300pg/mL. Conclusion: Despite the current clinical practice guidelines, SHPT seems to be inadequately controlled in many MHD patients. Uncontrolled SHPT was associated with higher levels of serum Ca, P, and Ca × P product, suggestive of the importance of SHPT management.
Park, Choel-Kyu,Kang, Hyun-Wook,Kim, Tae-Ok,Ki, Ho-Seok,Kim, Eun-Young,Ban, Hee-Jung,Yoon, Byeong-Kab,Oh, In-Jae,Choi, Yoo-Deok,Kwon, Yong-Soo,Kim, Yoo-Il,Lim, Sung-Chul,Kim, Young-Chul,Kim, Kyu-Sik The Korean Academy of Tuberculosis and Respiratory 2010 Tuberculosis and Respiratory Diseases Vol.69 No.2
Paclitaxel has been widely used for treating many solid tumors. Although colonic toxicity is an unusual complication of paclitaxel-based chemotherapy, the reported toxicities include pseudomembranous colitis, neutropenic enterocolitis and on rare occasions ischemic colitis. $Genexol-PM^{(R)}$, which is a recently developed cremophor-free, polymeric micelle-formulated paclitaxel, has shown a more potent antitumor effect because it can increase the usual dose of paclitaxel due to that $Genexol-PM^{(R)}$ does not include the toxic cremophor compound. We report here on a case of a 57-year-old man with advanced non-small cell lung cancer and who developed ischemic colitis after chemotherapy with $Genexol-PM^{(R)}$ and cisplatin. He complained of hematochezia with abdominal pain on the left lower quadrant. Colonoscopy revealed diffuse mucosal hemorrhage and edema from the sigmoid colon to the splenic flexure. After bowel rest, he recovered from his symptoms and the follow-up colonoscopic findings showed that the mucosa was healing. Since then, he was treated with pemetrexed monotherapy instead of a paclitaxel compound and platinum.