혈중 콜레스테롤과 음독자실시도

최승필,권태욱,황주일,김세경 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

Objective: Several studies suggest that a low cholesterol concentration is associated with a greater than normal risk of mortality from suicide. The authors sought to determine whether a low cholesterol level is associated with a history of serious suicide attempts among drug ingested ED patients. Method: serum cholesterol levels of attempted suicide of 89 patients, aged 20-72 years, were obtained from the ED admission biochemical profiles. Results: The seriousness of suicide attempt was associated with low serum cholesterol concentration in all age subgroups. Conclusions: Low cholesterol concentration should be futher investigated as a potential biological marker of suicide risk.

Plyometric Training 박스의 높이 차이가 남자 핸드볼 선수의 점프력에 미치는 영향

장창현,김승권,한주욱 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

Twenty four male middle school and high school handball players were involved an adapted Plyometric Training program which was composed of depth jump and box jump, 3 days a week for B weeks. The jump ability factor before and after the training was analyzed, and the following conclusions were drawn 1. The group trained with higher box showed greater increase in their vertical jump ability than the group trained with lower box for both middle and high school players. 2. The group trained with higher box showed greater increase in their vertical running jump ability than the group trained with lower box for both Middle and high school players. 3. The group trained with higher box showed greater increase in the ability of staying in the air than the group trained with lower box for both middle and high school players. 4. The middle school players showed greater increase in the jump ability than the high school students.

Hypertension in Renal Diseases

( Kwon Wook Joo ) 대한전해질,혈압학회 2005 Electrolytes & Blood Pressure Vol.3 No.1

Poster Session : Innate Immunity ; Transcriptional regulation of the schlafen-2 gene in macrophages in response to TLR-triggered stimulation

( Wern Joo Sohn ),( Dong Bum Kim ),( Keun Wook Lee ),( Min Soo Kim ),( Sang Hoon Kwon ),( Young Hee Lee ),( Doo Sik Kim ),( Hyung Joo Kwon ) 한국생화학분자생물학회 (구 한국생화학회) 2007 생화학분자생물학회 춘계학술발표논문집 Vol.2007 No.-

Poster Session 1 : Genomics and Bioinformatics Proteomics Chemical Genetics / Genomics ; Effect of CpG-oligodeoxynucleotides as a immunomodulator in the skin of NC/Nga mice

( Hyung Joo Kwon ),( Hyun Sun Jin ),( Keun Wook Lee ),( Yang Soon Kim ),( Wern Joo Sohn ),( Doo Sik Kim ),( Tae Yoon Kim ) 한국생화학분자생물학회 (구 한국생화학회) 2004 생화학분자생물학회 춘계학술발표논문집 Vol.2004 No.-

증례 : 광방기에 의해 발생한 Chinese Herb Nephropathy 1예

이재욱 ( Jay Wook Lee ),손민정 ( Min Jung Sohn ),허남주 ( Nam Joo Heo ),주권욱 ( Kwon Wook Joo ),정윤철 ( Yoon Chul Jung ),이정상 ( Jung Sang Lee ),한진석 ( Jin Suk Han ) 대한내과학회 2006 대한내과학회지 Vol.71 No.2

본 증례의 환자는 근위부 신세뇨관 산증, 진행성 만성 신부전증, 세뇨관 위축 및 간질 섬유화 등 CHN에 잘 맞는 임상 증상 및 조직 소견을 보였고, 복용하던 한약재에서 AA가 검출되어 AA에 의한 CHN 또는 AAN으로 진단할 수 있었다. 이러한 환자의 신조직에서 AA-DNA adduct를 추가로 검출할 수 있다면 진단의 정확성을 더욱 높일 수 있을 것으로 보인다. Chinese herb nephropathy (CHN) is characterized by progressive tubulointerstitial nephritis and development of renal failure in a couple of years after diagnosis. Aristolochic acid (AA) is believed to be associated with the development of CHN. The authors report a case of CHN in which AA in the herb regimen was identified by high-performance liquid chromatography (HPLC). A 32-year-old female presented with nausea, vomiting and generalized weakness. She had been taking Chinese herbs for symptomatic care. Clinical and laboratory examinations revealed Fanconi syndrome, renal failure, and severe anemia. Renal biopsy showed severe tubulointerstitial nephritis with moderate tubular atrophy and interstitial fibrosis. She developed end-stage renal failure 4 months after diagnosis. The herb she had been taking was Aristolochia fangchi. HPLC technique was used to identify AA and to measure its concentration in the herb. From the clinical and laboratory data, the patient was diagnosed with CHN caused by aristolochic acid.(Korean J Med 71:224-228, 2006)

An Ultrasensitive, Selective, Multiplexed Superbioelectronic Nose That Mimics the Human Sense of Smell

Kwon, Oh Seok,Song, Hyun Seok,Park, Seon Joo,Lee, Seung Hwan,An, Ji Hyun,Park, Jin Wook,Yang, Heehong,Yoon, Hyeonseok,Bae, Joonwon,Park, Tai Hyun,Jang, Jyongsik American Chemical Society 2015 NANO LETTERS Vol.15 No.10

<P>Human sensory-mimicking systems, such as electronic brains, tongues, skin, and ears, have been promoted for use in improving social welfare. However, no significant achievements have been made in mimicking the human nose due to the complexity of olfactory sensory neurons. Combinational coding of human olfactory receptors (hORs) is essential for odorant discrimination in mixtures, and the development of hOR-combined multiplexed systems has progressed slowly. Here, we report the first demonstration of an artificial multiplexed superbioelectronic nose (MSB-nose) that mimics the human olfactory sensory system, leading to high-performance odorant discriminatory ability in mixtures. Specifically, portable MSB-noses were constructed using highly uniform graphene micropatterns (GMs) that were conjugated with two different hORs, which were employed as transducers in a liquid-ion gated field-effect transistor (FET). Field-induced signals from the MSB-nose were monitored and provided high sensitivity and selectivity toward target odorants (minimum detectable level: 0.1 fM). More importantly, the potential of the MSB-nose as a tool to encode hOR combinations was demonstrated using principal component analysis.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2015/nalefd.2015.15.issue-10/acs.nanolett.5b02286/production/images/medium/nl-2015-02286y_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl5b02286'>ACS Electronic Supporting Info</A></P>

정상인에서 옥시토신의 항이뇨 작용

주권욱,전은실,오윤규,김근호,한진석,김성권,이정상 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2

배 경 : 옥시토신은 바소프레신과 매우 유사한 구조의 호르몬으로서, 과거부터 항이뇨 효과가 있을 것으로 생각하였으나, 최근에야 체외실험을 통하여 옥시토신의 항이뇨 작용이 증명되었다. 인체에서도 옥시토신이 항이뇨 호르몬으로 작용할 가능성이 있지만 아직 분명하지 않다. 저자들은 정상인에게 옥시토신 또는 desmopressin(dDAVP)을 투여하여 인체에서 옥시토신의 항이뇨 효과를 직접적으로 검증하고자 하였다. 방 법: 신기능 장애의 증거가 없는 건강한 성인 남자 10명을 대상으로 기저상태와 옥시토신(20 mU/hour로 정주) 또는 dDAVP(2 μg을 피하 주사)를 투여한 후 2시간 동안 수집한 요에서 요량, 요 삼투질농도, 자유수분 청소율 등을 측정하였고, 요 전해질 배설의 변화를 함께 관찰하였다. 결 과 : 혈청 전해질이나 삼투질농도는 옥시토신 또는 dDAVP 투여 후에 기저상태에 비해 유의한 변화가 없었다. 2시간 요량은 기저상태 446±75 mL로부터, dDAVP 투여 후 92±9 mL로 감소하였고(p<0.05), 옥시토신 투여 후에는 289±53 mL로 변화하였다. 요 삼투질농도는 기저상태 223±25.0 mOsm/kg에서, dDAVP 투여 후 936±34 mOsm/kg 및 옥시토신 투여 후427±63 mOsm/kg로 모두 증가하였다(p<0.05). 자유수분 청소율은 기저상태 110±51 mL/2hour로부터, dDAVP 투여 후 -218±28 mL/2 hour, 옥시토신 투여 후 -57±51 mL/2 hour로 각각 감소하였다(p<0.05). 요나트륨분획배설율(FENa)을 포함한 다른 요 전해질 배설의 유의한 변화는 없었다. 결 론 : 옥시토신이 정상 성인 남자에서 요 삼투질농도의 증가 및 자유수분 청소율의 저하를유발함을 확인하였으며, 이는 옥시토신이 인체에서도 항이뇨 작용이 있음을 시사하는 결과이다. 그러나 생리적인 농도에서 옥시토신이 어떤 역할을 할 것인가와 그 작용기전은 앞으로 규명되어야 할 과제이다. Background : The antidiuretic action of oxytocin in human has been controversial. To investigate whether oxytocin directly acts on water balance in human, we evaluated the parameters of urinary concentration in response to administration of oxytocin in ten healthy male volunteers. Methods : Oxytocin was infused intravenously at a rate of 20 mU/hour for 2.5 hours and urine was collected during the last 2 hours of oxytocin infusion. Changes in urine volume, urine osmolality, excretions of urine electrolytes and free water clearance after the administrartion of oxytocin were compared with the baseline data. Results : The changes in the levels of serum electrolytes and osmolality after the administration of oxytocin were not significant compared with the baseline data. The volume of 2 hours' urine were 446±75 mL and 289±53 mL in the basal state and after the administration of oxytocin, respectively. The urine osmolality was increased significantly by the infusion of oxytocin(427±63 mOsm/kg) compared with that in the basal state(223±25 mOsm/kg)(p< 0.05). The free water clearance was 110±51 mL/2 hours in the basal state and decreased significantly to -57±51 mL/2 hours(p<0.05). Conclusion : We conclude that administration of oxytocin to normal men enhances urinary concentration, evidenced by increased urinary osmolality and decreased free water clearance. In human, oxytocin may play an important role in the regulation of renal water excretion as an antidiuretic hormone. (Korean J Nephrol 2002;21(2):251-258)

Pharmaceutical Evaluation of Genistein-loaded Pluronic Micelles for Oral Delivery

Kwon, Suk-Hyung,Kim, Sun-Young,Ha, Kyoung-Wook,Kang, Myung-Joo,Huh, Jin-Seo,Im, Tae-Jong,Kim, Yong-Min,Park, Young-Mi,Kang, Kyoung-Hoon,Lee, Sang-Kil,Chang, Jung-Yun,Choi, Young-Wook,Lee, Jae-Hwi 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9

The purpose of the present study was to determine whether Pluronic F127 polymeric micelles could improve the oral bioavailability of a poor water-soluble drug, such as genistein. Genistein is a phytoestrogen that has estrogenic activity. F127 triblock copolymer consists of $PEO_{100}-PPO_{65}-PEO_{100}$. Genistein was incorporated in the Pluronic F127 polymeric micelles by a solid dispersion method. The genistein release of genistein-loaded polymeric micelles was studied in vitro (in pH 1.2 and pH 6.8). And the oral bioavailabilities of genistein powder and genisteinloaded micelles were estimated at a dose of 4.0 mg/kg as genistein in rats. Drug loading amount and drug loading efficiency were 11.18% and 97.41%, respectively. The average size of the genistein-loaded polymeric micelles was 27.76 nm. And genistein release of the genistein-loaded polymeric micelles in vitro was 58% (pH 1.2) and 82% (pH 6.8). The bioavailability of genistein-loaded polymeric micelles was better than genistein powder. Consequently, Pluronic F127 polymeric micelles are an effective delivery system for the oral administration of genistein.

IgA 신병증에서 Haas의 조직학적 분류에 따른 임상적 예후

권영주,김형규,최창원,차대룡,김상욱,신진호,조원용,원남희,표희정,한상엽,조상경 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.1

Objectives:IgA nephropathy is a common type of primary glomerulonephritis and may present with a wide variety of histologic patterns on renal biopsy. IgA nephropathy may progress to end stage renal disease. But it is difficult to predict the prognosis of IgA nephropathy. Methods:In an attempt to identify prognostic indicators in this disease, the clinical data from 158 patients with IgA nephropathy were analyzed and compared to the pathologic subclassification proposed by Haas. Results: 1)The mean age of 158 patients with IgA nephropathy was 31.5 yrs(M:F=1:1.04) and there were 17 patients in subclass I, 5 patients in subclass II, 80 patients in subclass III, 34 patients in subclass IV, 22 patients in subclass V. 2)The significant correlation between renal survival rate and histologic subclass in 114 patients who were followed-up for more than 12 months was showed in order of I, II$gt;III, IV$gt;V. 3)Active crescents were a significant negative prognostic indicator in renal survival in subclass III, but not in subclass IV. 4) The presence of immune complex deposits in the glomerular capillary loops in addition to the deposits in mesangial areas was associated with poor prognosis in progression to end stage renal disease of IgA nephropathy 5)With a respect to clinical presentation, hypertension, serum creatinine of?1.5mg/dL, and proteinuria of?2.0g/day were significant negative prognostic indicators for renal survival but the presense of gross hematuria was not associated with increased renal survival rate by an univariate analysis. Conclusion:These results suggest that histologic subclassification proposed by Haas may be a useful prognostic indicator for the clinical outcome of IgA nephropathy, as well as the amount of proteinuria, serum creatinine level and hypertension at the time of initial renal biopsy.