척수압박으로 발현된 급성 골수성 백혈병에 동반된 과립구성 육종 1 례

윤상준,김영곤,김희종,박유환,정춘해,김양수,김태균,박영진,전호종 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

저자들은 척수압박으로 하지마비를 보인 환자에서 수술 후에 급성 백혈병에 동반된 과립구성 육종으로 진단된 환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Granulocytic sarcoma(GS) is an uncommon tumor composed of immature cells of the granulocytic series. Most case of GS occur in the course of acute leukemia and the blast crisis of chronic leukemia, Rarely, however, it may present before leukemia becomes clinically apparent. It may also occur in patients with myeloproliferative disoders. GS has been reported that it occurs in 3% to 9% of patients with acute myelogenous leukemia(AML) and the incidence of GS is reported to be higher in patients with t(8;21). GS occurs relatively commonly in africa and has been reported to affect 10-25% of black children presenting with AML. This is very rare case of granulocytic sarcoma with AML(FAB M5) presented with spinal cord compression which was supported by decompression laminectomy.

분말충진방법과 가공정도에 따른 Ag/BSCCO 초전도선재의 특성

지봉기,김태우,김정호,김중석,주진호 成均館大學校 科學技術硏究所 1998 論文集 Vol.49 No.1

We evaluated the effects of processing variables on interface irregularity. microstructure. and resultant Jc of BSCCC superconductor tape. For the tapes made by PIT technique. the degree of interface irregularity was varied with powder packing methods and forming process variables. It was observed that the degree of interface irregularity of the tape by CIP method was more reduced. compared to that of the tape by ram method. In addition. the degree of interface irregularity was promoted with decreasing the dimension of tape during forming process. As the dimension of wire/tape were changed from diameter of 3.25mm to thickness of 200㎛ during forming process. Jc value was observed to be increased by 10 times. It was likely that the improvenment of Jc was mainly result from the enhanced texturing of 2223 grain. Microstructural investigation showed the degree of texturing was degraded by the existence of both second phases and interface irregularity. If the interface was flat, larger grain size and better texturing near interface were developed compared to those inside superconducting core, The improvements of microstructure near interface may be result of reaction between Ag and superconductor phase.

체외형 자동 제세동기(AED)와 심전도계(ECG)를 위한 통신 프로토콜의 설계 및 사용자 인터페이스 구현

김남훈,권희중,권호열,나학록 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.A

In this paper, we studied Automated External Defibrillator and Electro- Cardiogram System. Proposed System, CU-EX1, is a PC-based AED/ECG system that manages the data acquired by Paramedic CU-ER1. The system controls the transfer of data from the Paramedic CU-ER1 and the storage of the data in a local host computer. Patient data could be entered as soon as the rescue data is stored in a local computer. The system also displays the data on a local computer and facilitates review of rescue events.

상아모세포 관련 유전자, OD314의 발현과 기능 연구 : OD314

김두현,김흥중,정문진,손호현,박주철 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.4

Odontoblasts are responsible for the formation and maintenance of dentin. They are known to synthesize unique gene products including dentin sialophosphoprotein (DSPP). Another unique genes of the cells remain unclear. OD314 was isolated from the odontoblasts/pulp cells of rats and partially characterized as an odonto-blast-enriched gene (Dey et al., 2001). This study aimed to elucidate the biological function of OD314, relating to odontoblast differentiation and dentinogenesis. After determining the open reading frame (ORF) of OD314 by transient transfection analysis using green fluorescent protein (GFP) expression vector, mRNA in-situ hybridization, immunohistochemistry, reverse transcription-polymerase chain reaction (RT-PCR) and western analysis were performed. The results were as follows: 1. In in-situ hybridization, OD314 mRNAs were expressed in odontoblasts of developing coronal and root pulp. 2, OD314 was a novel protein encoding 154 amino acids, and the protein was mainly expressed in cyto-plasm by transient transfection analysis. 3. Mineralized nodules were associated with multilayer cell nodules in the culture of human dental pulp cells and first detected from day 21 using alizarin-red S staining. 4. In RT-PCR analysis, OD314, osteocalcin (OC) and DSPP strongly expressed throughout 28 days of culture. Whereas, osteonectin (ON) mRNA expression stayed low up to day 14, and then gradually decreased from day 21. 5. Western blots showed an approximately 17 kDa band. OD314 protein was expressed from the start of culture and then increased greatly from day 21. In conclusion, OD314 is considered as an odontoblast-enriched gene and may play important roles in odontoblast differentiation and dentin mineralization.

자가 말초혈액 조혈모세포 이식술의 임상적용

김혁,안명주,오석중,이영열,김인순,정태준,최일영,오미란,임호준,이항,김신규 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.1

Responses to chemotherapy correlate with the increased dose of chemotherapeutic agents in some cancers, e.g. breast cancer, Ewing's sarcoma, Hodgkin's disease(HD) and non-Hodgkin's lymphoma(NHL), then for the improvement of the chemotherapy responsiveness, high-dose chemotherapy(HDCT) was proposed. But, it's application was limited due to complications, especially bone marrow suppression. HDCT and succeeding autologous peripheral blood stem cell transplantation(APBSCT) was introduced to overcome this problem. This study was designed to determine the clinical pictures including clinical parameters and the responsiveness of HDCT followed by APBSCT in Hanyang University Hospital. Ten patients were enrolled. They were 8 adults (3 breast cancers, 3 multiple myelomas, 1 HD, 1 NHL) and 2 children (1 acute myelogenous leukemia (AML), 1 neuroblastoma). Mobilization chemocherapy(MCT) followed by Granulocyte Colony Stimulating Factor(G-CSF) was administered to mobilize stem cells from bone marrow to peripheral blood. The stem cells were collected by using CS-3000 and cryopreserved at -196℃ with programmed controlled rate freezer as the mixture with 10% dimethyl sulfoxide(DMSO). HDCT was administered and cryopreserved peripheral stem cells were infused on day 0 as planned. Patients' mean age was 41 years old. After induction chemotherapy three patients achieved complete response and 5 partial response. The median time for bone marrow recovery after MCT was 11.5 days for neutrophil(〉500/㎣) and 4.8 days for platelet(〉20,000/㎣). There were three cases of neutropenic fever and one case of gingivitis. After HDCT with APBSCT, one patient was converted partial response to complete response, and one patient achieved complete response after HDCT without induction chemotherapy. The median time for bone marrow recovery was 12.7 days for neutrophil(〉500/㎣) and 14.7 days for platelet(〉20,000/㎣). Eight patients developed neutropenic fever and required systemic antibiotics. Transfusion was required 1.6 pints for packed red cell and 23.4 pints for platelet concentrates. Toxicity consisted mainly of vomiting, diarrhea, and mucositis which were mild. HDCT with APBSCT can be performed safely with minimal complications. For the evaluation of the exact role of HDCT with APBSCT in malignant diseases, further studies are required as a large scale of patients and lung-term follow up.

SOL-GEL法에 依한 LAS系 結晶化유리의 製造에 있어서 租成比유리의 特性에 미치는 影響

김봉걸,양중식,조훈성,권창오,박경호 慶熙大學校 材料科學技術硏究所 1990 材料科學技術硏究論集 Vol.3 No.-

The purpose of this study is to investigate into the physical properties of Li₂O-Al₂O₃-nSiO₂ (LAnS) system of crystallized glass prepared by sol-gel method according to the composition ratio of LAnS. In order to find the crystallization temperature as well as the state of crystalline, differential thermal analysis and X-ray diffraction analysis were examined. The results obtained are as follows : 1. Gelling time became longer as increasing the composition ratio of SiO₂ and also found that it became faster as increasing the additive amount of water. Also, additive amount of water required for the gellation was above four times of the theoretical amount of water required hydrolysis. 2. Surface area and mean pore size became larger as increasing the composition ratio of SiO₂ and for LA4S dried gel, surface area was 331.1m^(2)/g, mean pore size distributed about 5nm and 30-50nm. 3. The crystallization temperature is high as increasing the composition ratio of SiO₂ and for LA4S, crystallization temperature is 800℃. Also, LA4S formed at 800℃ for the crystalline phase of β-eucryptite and at 900℃ for crystalline phase of β-spodumene.

외상으로 인한 후복막 유건종 제거술 후 신경인성 통증의 재활치료

김기찬,정호중 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Desmoid tumors are infrequent and histologically benign fibrous neoplasms originating from the musculoaponeurotic structures throughout the body. These tumors are found in areas of previous traumatic or surgical scarring. The compartment syndrome is considered a true emergency condition. The internal pressure rises so high that local circulation is cut off and the affected muscle dies. The local increased pressure can also damage associated nerves resulting in a loss of both power and sensation. Lumbosacral plexopathy is characterized by intense pain in one or both legs, associated with motor and sensory deficits. Proper medications including topiramate with physical therapy and psychological modalities are critical to successful outcome of the management for neuropathic pain. We experienced a case of rehabilitation for lumbosacral plexopathy and compartment syndrome following excision of retroperitoneal desmoid tumor due to trauma in 9 year-old child.

단지양 근위축증(Monomelic Amyorophy) 3례 : 증례 보고 Case Report

김기찬,정호중,정상욱,정흥채,조근열 고신대학교 의학부 1999 高神大學校 醫學部 論文集 Vol.14 No.1-2

Monomelic amyotrophy is a rare form of motor neuron disease which is insidious onset in the second and fourth decades, male preponderance, sporadic occurrence, wasting and weakness confined to one limb, and absence of involvement of the cranial nerves, cerebrum, brain, stem, and sensory system. Symptoms and signs often progress for several years before spontaneously arresting. Neurologic findings and electrophysiologic studies are only useful for the diagnosis of monomelic amyotrophy and other laboratory testing are frequently normal or nonspecific. We reported three cases of typical monomelic amyotrophy with review of the articles.

단순남성임균성 요도염에 대한 Clavulanatepotentiated Amoxycillin(CPA)의 치료효과

김성호,김중환,허훈,김영태 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.1

At the Venerel Disease Clinic of Choong-Ku Public Health Center in Seoul 103 patients with uncomplicated gonococcal urethritis were allocated randomly into one of 2 treatment regimens and 101 male patients were followed. All 51 patients, including PPNG infections, treated with clavulante-potentiated amoxycillin, 375 mg, PO, t.i.d for 5 days recovered (100%). Two (4%) of 50 patients treated with clavulanate-potentiated amoxycillin, 3.25g, PO plus probvenecid, 1g, PO failed to recover. These cases were 2 of 25 Penicillinase Producing Neisseria gonorrhoeae (PPNG) infections (failure rate of 8%) and all 25 non-PPNG infections recovered (100%). The antibiotics susceptibility pattern of pre-and post-treatment isolates from these cases did not give conclusive evidence of reinfection and the patients denied having has sexual intercourse during the follow up period. The fact that these treatment failure cases showed negative culture on the first follow up (at 24 hours) and positive result on the second follow up at 3rd post treatment day suggests that test of cure culture at 24 hours after treatment is not the optimal time. It is suggested that both of these clavulanate-potentiated amoxycillin regimens have simiarly good effect with minimal side effects in the treatment of gonococcal urethritis and , because of high rate of PPNGs among circulating N.gonorrhoeae, they can be recommended as the first line treatment for gonorrhoea in Korea.

김치용 간절임 배추의 저장에 관한 연구 : Ⅱ. 젖산, Calcium Chloride, 저장온도가 저장중 간절임 배추의 품질에 미치는 영향

김윤숙,김중만,백승화,문정옥,황호선,김인숙 圓光大學校 1987 論文集 Vol.21 No.2

배추를 다듬기 하는데 발생한 폐기량은 7.5∼14% (w/w)이었고 10±2℃에서 30일간 방치한 경우 약 17∼25% 발생하였다. 간절임 배추의 pH값은 저장온도가 낮을수록, 염도가 높을수록 높았으나 calcium chloride 첨가가 절임배추의 pH값의 변화에는 영향을 주지 않았다. 유리당의 함량변화는 최소 약 4% 수준에서 산의 함량과는 반비례적으로 변화하여 저장 90일에는 소금농도가 낮고 저장온도가 높은 경우 적게 감소되었다. 균수변화에서 세균과 효모는 전 기간을 통해 증가한 반면, 곰팡이는 감소하였다. 한편 산의 첨가와 CaCl? 첨가시 소금으로만 절인 경우보다 세균과 효모는 낮은 속도로 증가했다. 저장중 경도는 온도가 낮고 염도가 높으며 젖산을 첨가한 경우 다소 높게 유지됐고, CaCl? 첨가의 경우 잎과 줄기에서 월등히 높았다. 휘발산과 불휘발산의 함량변화에서 온도가 낮고 염도가 높은경우 불휘발산의 함량이 낮았는데 특히 젖산 첨가시 불휘발산의 증가를 억제하는 것으로 나타났다. flavor score 는 저온과 고염도 젖산첨가시 유리하였다. This study was to investigate the effects of storage temperature, lactic acid and calcium chloride addition about the pH values, sugar content, firmness, volatile and nonvolatile acidity, microbial counts and flavor of the salted chinese cabbages during storage (90 days), and trim loss of chinese cabbages during the trimming of raw and storaged (30 days) chinese cabbages. The waste rate was in the course of trimming of raw chinese, cabbages was 7.5-14(w/w). The proportion of trim loss was highly correlated to sunshine duration, temperature, humidity and handling for the storage. Free sugar was decreased fast and much in the case of high temperature and low level sodium chloride in comp rison of low temperature and high sodium chloride, but ?? and lactic acid did not affect its changes. Time to reach the lowest pH values were fast in the case of high temperature and low salt content. Lactic acid affected inital pH value (4.38-4.57) and constant pH value in each case was increased at low salt content, at high temperature, and then the pH values were slowly increased when volatile acidity was increased. Firmness was high in the case of addition of lactic acid and calcium chloride, low temperature, high sodium chloride concentration. Especially, calcium chloride addition remarkably showed high firmness. Flavor score was high in the case of low storage temperature, high yeast counts were slowly increased in spite of low temperature and high salt content, but mold counts were slightly increased during all period Lactic acid, low temperature and high sodium chloride were effective to inhibit the growth of microorganisms. Volatile and nonvolatile acidity was increased during all storage period ; however, lactic acid and low temperature storage inhibited their increase. To conclude, quality of salted chinese cabbages was effective at low temperature storage, lactic acid and calcium chloride addition, and high salt concentration.