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윤상준,송혜향 한국보건통계학회 2000 한국보건정보통계학회지 Vol.25 No.2
Two different drugs or two different formulations of the same drug are called bioequivalent if they are absorbed into the blood and became available at the drug action site at about the same rate and concentration. Bioequivalence trials aim to demonstrate that two different drugs or two diferent formulations of the same drug do not differ by more than a prespecified clinically irrelevant amount. In bioequivalence studies, C_max(maximum concentration) and A∪C(area under the blood level curve) serve as the primary pharmacokinetic characteristics of absorption. We explain in this paper equivalence tests of ration hypothesis under the assumption that the distributions of C_max and A∪C data are log-normal or normal. We compare sample size determination of three bioequivalence tests of Schuirmann(1981, 1987), Anderson and Hauck(1983) and Sasabuchi(1980, 1988). We present more simple approach of sample size determination of Sasabuchi(1980, 1988). When the original data are log-normally distributed, sample sizes determined by Schuirmann's and Anderson and Hauck's test are similar if the difference of the two location parameters becomes small. When the original data are normally distributed, sample sizes determined by Sasabuchi's test and Schuirmann's test is smallest among all if the ratio of two population means is, respectively, less than and greater than unity. There is no sample size difference between the method suggested in this paper which is based on Sasabuchi's test and Hauschke's one.
윤상준,최영완,옥성해,공순철,윤영설,구민주,박상현 대한전자공학회 2004 電子工學會論文誌-SD (Semiconductor and devices) Vol.41 No.03
Microwave characteristics of ridge type CPW traveling-wave(TW) electroabsorption modulator and photodetector are affected by the thickness of intrinsic layer, width of guiding layer, and the separation of signal and ground electrodes. These factors are determined effective index of microwave and characteristic impedance due to changing of capacitance(C) and inductance(L) of device. However, conventional equivalent circuit of TW-structure is approximated to microstrip and CPW transmission line by distribution of electric and magnetic fields, respectively. In this paper, we analyzed microwave characteristics of TW-structure and found more accurate value of C and L by using finite difference time domain (FDTD) method. These values are adopted circuit element of equivalent circuit. Microwave characteristics obtained by the FDTD and equivalent circuit model show good agreement. 릿지 형태 CPW 진행파형 전계 흡수 광 변조기와 광 검출기의 구조에 있어서 마이크로파의 특성은 도파관을 형성하는 진성 영역의 폭, 두께, 신호전극과 접지 전극사이의 거리의 영향을 받게 된다. 이러한 요소들은 소자에 존재하는 캐패시턴스(C)와 인덕턴스(L)의 크기를 변화시키게 되며 마이크로파의 유효 굴절률과 특성 임피던스를 결정하게 된다. 하지만 기존의 논문들은 전계와 자계의 분포에 따라 마이크로스트립과 CPW로 각각 근사화하여 해석했다. 본 논문에서는 FDTD를 이용해 릿지 형태 CPW 진행파형 구조의 마이크로파 특성을 분석하고 C와 L의 정량적인 값을 구했으며 이를 등가회로의 회로 소자로써 적용 시켰다. 등가회로에서 구해진 마이크로파의 특성은 FDTD 결과와 거의 일치함을 보였다.
Determination of the Energy Barrier and Spin Torque Efficiency Based on Telegraph Noise
윤상준,Sang-Cheol Yoo,최석봉,민병철 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.10
The spin torque (ST) efficiency and energy barrier of domain wall (DW) depinning are investigatedby analyzing the telegraph noise in nanostructured ferromagnetic Pt/Co/Pt films. The telegraphnoise is generated by applying both a magnetic field and an electric current, whose forces on theDW oppose each other. Cumulating the DW depinning probability experimentally revealed thatthe DW depinning was governed by a single energy barrier, whose height was estimated to be about1.0 × 10−19 J. The ST efficiency at the pinning site is estimated to be −4.6 × 10−14 T·m2/A. The present analysis technique provides an alternative way to determine the ST efficiency in theshort-current-pulse-driven DW motion at a single energy barrier.