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Jeon, Beom Su,Shin, Byung Ho,Huh, Beom Kang,Kim, Byung Hwi,Kim, Se-Na,Ji, Han Bi,Lee, Seung Ho,Kang, Soo Im,Shim, Jung Hee,Kang, So Min,Lee, Jae Chul,Lee, Kyu Sang,Heo, Chan Yeong,Choy, Young Bin Elsevier 2018 Journal of industrial and engineering chemistry Vol.63 No.-
<P><B>Abstract</B></P> <P>We propose silicone implants capable of the local, controlled release of a glucocorticoid drug, triamcinolone acetonide (TA), for the prevention of fibrosis. The shells of these silicone implants were coated with two different loading amounts of TA, which could release the drug in a sustained manner for 12 weeks. The drug-loaded implants were inserted into the subcutaneous space in living rats, and the tissues were biopsied at scheduled times during 12 weeks. For the drug-coated implants, the capsule thickness and collagen density decreased compared with those of the non-coated implant. Because of the effect of TA, inflammation and the expression of pro-inflammatory cytokines were downregulated, thereby decreasing the number of monocytes during acute inflammation. This effect in turn decreased the number of macrophages at the later stage of inflammation, leading to the expression of less TGF-β and consequently fewer fibroblasts and myofibroblasts. Our findings also revealed that with an appropriate dose control, skin and muscle atrophy, major side effects of TA, could be avoided while still effectively reducing fibrosis. Therefore, we conclude that the local, sustained release of an appropriate dose of a glucocorticoid drug can be a promising strategy for safely preventing fibrosis around silicone implants.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jeon Hak Rim,Chung Ho Kyoon,Lee Jun Yeob,Cho Kwang‐Hwi 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.7
Pyrido[3,4-d]pyrimidine (PyPm) was designed as a new acceptor of thermally activated delayed fluorescent (TADF) emitters and the potential of the new acceptor moiety for TADF properties was investigated. Time-dependent density functional theory calculation was performed to estimate TADF characteristics by comparing five isomers of PyPm-based TADF emitters. Geometries of the emitters were affected by the presence of hydrogen bonding depending on the substitution position of the phenyl linker in the donorphenyl linker-acceptor type backbone structure, which also influenced the molecular orbital distributions. The nature of the triplet excited state was also dependent on the substitution position of the phenyl linker and donor moiety in the molecular structure, and the substitution at 5 position of the PyPm provided small singlet-triplet energy gap and hybridized local and charge transfer triplet excited state for efficient reverse intersystem crossing. From the computational calculation results, it can be expected that PyPm would effectively work as an acceptor of TADF emitters.
Hwi-Seok Jung,Hong-Bin Jeon,Ik-Sung Jeon,Bum-Jun Lee,Hyun-Woo Yoo,Dong-Kuk Ahn,Dong-Ho Youn 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.5
Nitric oxide (NO), a diffusible gas, is produced in the central nervous system, including the spinal cord dorsal horn and the trigeminal nucleus, the first central areas processing nociceptive information from periphery. In the spinal cord, it has been demonstrated that NO acts as pronociceptive or antinociceptive mediators, apparently in a concentration-dependent manner. However, the central role of NO in the trigeminal nucleus remains uncertain in support of processing the orofacial nociception. Thus, we here investigated the central role of NO in formalin (3%)-induced orofacial pain in rats by administering membrane-permeable or -impermeable inhibitors, relating to the NO signaling pathways, into intracisternal space. The intracisternal pretreatments with the NO synthase inhibitor L-NAME, the NO-sensitive guanylate cyclase inhibitor ODQ, and the protein kinase C inhibitor GF109203X, all of which are permeable to the cell membrane, significantly reduced the formalin- induced pain, whereas the membrane-impermeable NO scavenger PTIO significantly enhanced it, compared to vehicle controls. These data suggest that an overall effect of NO production in the trigeminal nucleus is pronociceptive, but NO extracellularly diffused out of its producing neurons would have an antinociceptive action.
시분해 레이저 유도 백열법을 이용한 커먼레일 디젤 엔진 배기단 에서의 PM 측정
한휘영(Hwi-young Han),김규보(Gyu-Bo Kim),이종호(Jong-Ho Lee),조승완(Seung-wan Cho),정동수(Dong-Soo Jeong),장영준(Young-June Chang),전충환(Chung-Hwan Jeon) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.11
Recently, diesel vehicles are increased and their emission standards will become strict. Diesel exhaust contains numerous dangerous compounds expecially among them particle matter is a serious environmental pollutant and seriously hazardous for human health. Thousands of studies also have documented that particle matters are associated with respiratory and cardiovascular diseases and death. To understand soot formation and develop control strategies for soot emission, it is necessary to measure soot concentration and soot particle size in laboratory flames or practical engines. As a diagnostic to measure soot concentration laser induced incandescence has been used, and Time-Resolved laser induced incandescence has been used to determine soot particle size in flames and engines. In this work, the soot particle emission of turbochared 2.0 CRDI engine has been investigated within the raw exhaust gas and soot particles are measured in different engine loads.
Jung, Hwi-Seok,Jeon, Hong-Bin,Jeon, Ik-Sung,Lee, Bum-Jun,Yoo, Hyun-Woo,Ahn, Dong-Kuk,Youn, Dong-Ho The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.5
Nitric oxide (NO), a diffusible gas, is produced in the central nervous system, including the spinal cord dorsal horn and the trigeminal nucleus, the first central areas processing nociceptive information from periphery. In the spinal cord, it has been demonstrated that NO acts as pronociceptive or antinociceptive mediators, apparently in a concentration-dependent manner. However, the central role of NO in the trigeminal nucleus remains uncertain in support of processing the orofacial nociception. Thus, we here investigated the central role of NO in formalin (3%)-induced orofacial pain in rats by administering membrane-permeable or -impermeable inhibitors, relating to the NO signaling pathways, into intracisternal space. The intracisternal pretreatments with the NO synthase inhibitor L-NAME, the NO-sensitive guanylate cyclase inhibitor ODQ, and the protein kinase C inhibitor GF109203X, all of which are permeable to the cell membrane, significantly reduced the formalin-induced pain, whereas the membrane-impermeable NO scavenger PTIO significantly enhanced it, compared to vehicle controls. These data suggest that an overall effect of NO production in the trigeminal nucleus is pronociceptive, but NO extracellularly diffused out of its producing neurons would have an antinociceptive action.
확산화염에서 시분해 레이저 유도 백열법을 이용한 매연입자 크기와 화염 온도의 영향에 관한 연구
한휘영(Hwi-young Han),김규보(Gyu-Bo Kim),이종호(Jong-Ho Lee),조승완(Seung-wan Cho),정동수(Dong-Soo Jeong),장영준(Young-June Chang),전충환(Chung-Hwan Jeon) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6
An experimental investigation is reported about soot primary particle size and flame temperature in laminar ethylene diffusion flame. We use TIRE-LII(Time-resolved Laser Induced Incandescence) technique to measure soot primary particle size and rapid insertion method to measure flame temperature. LII(Laser Induced Incandescence) has wide applications for soot diagnostic. LII is the technique which heats the soot particle using a pulsed laser and detects the intense thermal emission from the particles. TIRE-LII uses the ratio of different two time at the LII temporal decay curve to decide the soot primary particle size. In this study, the measurement positions are 15,20,27.5,30㎜ height above the burner tip along the radial direction. Particle size was increased to 20㎜ and the decreased from 27.5㎜ to 30㎜. Central flame temperature was increased as going to the upper direction.
70세 이상의 고령에서 발생한 기관지 결핵의 임상적 특징
김휘종 ( Hwi Jong Kim ),김현식 ( Hyeon Sik Kim ),마정은 ( Jeong Eun Ma ),이승준 ( Seung Jun Lee ),함현석 ( Hyoun Seok Ham ),조유지 ( Yu Ji Cho ),정이영 ( Yi Yeong Jeong ),전경녀 ( Kyoung Nyeo Jeon ),김호철 ( Ho Cheol Kim ),이종덕 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.5
연구배경: 폐결핵의 발생은 연령이 증가함에 따라 그 빈도가 증가하는 것으로 알려져 있어 기관지 결핵의 발생률도 고령에서 증가할 것으로 생각된다. 본 연구는 70세 이상의 고령에서 발생한 기관지 결핵의 임상적 특징을 알아보고자 하였다. 방 법: 2003년 3월부터 2006년 6월까지 경상대학교병원에서 기관지 결핵으로 진단 받은 74명의 환자(남:여=12:62, 평균나이: 64.6±16.2세)를 대상으로 70세 이상 환자군과 70세 미만 환자군으로 나누어 임상적 특징을 후향적으로 조사하였다. 결 과: 1) 70세 이상의 환자는 41명(55%), 70세 미만의 환자는 33명(45%)이었다. 2) 양군 모두에서 가장 흔한 증상은 기침이었으며, 호흡곤란의 빈도는 70세 이상 환자군이 70세 미만 환자군보다 높았다(31.7% vs. 12.1%). 3) 기관지내시경 소견상 70세 이상의 환자군이 70세 미만의 환자군보다 건락성 괴사형의 비율은 낮았고(39% vs. 66.7%), 부종 충혈형은 상대적으로 높았다(53.7% vs. 27.2%)(p<0.05). 4) 병변의 위치는 기관 또는 주 기관지를 침범하는 경우가 70세 이상의 환자군이 70세 미만의 환자군보다 유의하게 많았다(9.7% vs. 30.3%). 5) 객담 및 기관지 세척액의 항산균 도말 양성률과 배양 양성률은 유의한 차이가 없었다. 결 론: 70세 이상의 고령에서도 기관지 결핵은 흔히 관찰할 수 있으며, 70세 미만의 기관지 결핵 환자와는 다른 몇 가지 임상양상을 보였다. Background: The possibility of developing pulmonary tuberculosis usually increases with increasing age. Therefore, the incidence of endobronchial tuberculosis in older people may increase. We evaluated the clinical characteristics in patients with endobronchial tuberculosis above the age of 70 years. Methods: We enrolled 74 patients (12 males and 62 females; mean age 64.6±16.2 years) that were diagnosed with endobronchial tuberculosis from March 2003 to July 2006 at Gyeongsang University Hospital. We retrospectively evaluated the clinical characteristics of endobronchial tuberculosis for patients 70 years or older (older group) and for patients below the age of 70 years (younger group). Results: The number of patients in the older group was 41 (55%). Cough was the most common symptom in the two groups of patients and dyspnea on exertion was more common in the older group of patients than in the younger group of patients (31.7% vs. 12.1%). The actively caesating type of disease was more common in the younger group of patients than in the older group of patients (66.7% vs. 39%). The edematous type of disease was more common in the older group of patients than in the younger group of patients (53.7% vs. 27.2%) (p<0.05). Tracheal and main bronchial involvement of lesions were more common for the younger group of patients than for the older group of patients (30.3% vs. 9.7%) (p<0.05). Conclusion: Endobronchial tuberculosis was commonly observed in patients older than 70 years and this group of patients had some clinical characteristics that were different from the younger group of patients. (Tuberc Respir Dis 2007;63:412-416)
비특이적인 어지럼증 환자에서 골도와 기도 경부전정유발근전위의 차이
Yong-Hwi An,Jung Ho Choi,Seung Yeon Jeon,Hyun Joon Shim 대한평형의학회 2022 Research in Vestibular Science Vol.21 No.4
Objectives: This study was performed to evaluate the difference of the cervical vestibular evoked myogenic potentials (cVEMP) stimulated by bone-conduction (BC) and air-conduction (AC) in patients with nonspecific dizziness. Methods: Twenty-eight dizzy patients (56 ears) and 15 subjects (30 ears) as normal control was enrolled. Responses of BC- and AC-cVEMP were recorded sequen-tially in both groups. cVEMP parameters including latencies, inter-latencies intervals, amplitudes, and interaural amplitude asymmetry were analyzed and compared. Results: Among the patients with nonspecific dizziness, AC-cVEMP responses were clearly detected in all 56 ears while BC-cVEMP responses were detected in 32 ears (57.1%). Amplitudes of BC-cVEMP were significantly smaller than those of AC-cVEMP in all patients with BC-cVEMP response. There was no difference in latencies, inter-latencies intervals, and interaural amplitude asymmetry ratios between BC- and AC-cVEMP. There was no significant difference in BC- and AC-cVEMP between the dizzy and control groups. Conclusions: BC-cVEMP is not clinically useful in comparison to AC-cVEMP for the evaluation of nonspecific dizziness. An effective stimulation tool for BC is necessary to provoke more reliable responses of BC-cVEMP.
데이터 증강을 통한 안전모 착용 여부 확인 객체 탐지 모델 성능 향상 연구
조재호 ( Jae-ho Cho ),이현준 ( Hyun-joon Lee ),전광휘 ( Gwang-hwi Jeon ),오민택 ( Min-taek Oh ),윤상범 ( Sang-bum Yoon ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.2
안전모 착용 여부를 확인하는 객체 탐지 모델을 물류 현장에서 활용하기 위해서는 안전모를 착용한 경우와 착용하지 않은 경우를 정확하게 탐지해야 한다. 하지만 학습 데이터가 안전모를 착용한 클래스와 착용하지 않은 클래스 간 불균형이 존재하는 경우 해당 데이터만으로는 태스크에 맞게 학습이 됐다고 보긴 힘들다. 본 연구는 데이터 증강 기법 적용 시 임의의 데이터에 증강을 적용하는 대신 상대적으로 적은 안전모를 착용하지 않은 클래스를 포함하는 이미지에 대하여 데이터 증강 기법을 적용하였다. 여러 데이터 증강 기법 중 Rotation, Gaussian Noise, 객체를 기준으로 한 Crop을 직접구현 및 적용하여 객체 탐지 모델인 YOLOv5의 성능을 효과적으로 높이며 더욱 강건한 모델을 개발하는 방법을 제안한다.