http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Synthesis of oleyl-4[<sup>131</sup>I]-iodobenzoate for long-term cell trafficking
Jeon, Hak Rim,Lee, Woonghee,Oh, Jieun,Lee, Yong Jin,Yoo, Jeongsoo Korean Society of Radiopharmaceuticals and Molecul 2018 Journal of radiopharmaceuticals and molecular prob Vol.4 No.2
Great efforts are currently devoted to the development of new approaches for the labeling of cells using appropriate radionuclides. While fluoride-18 and copper-64 have been extensively studied as short-term and intermediate-term trafficking agents, iodide was studied less intensely. Here, we report a new cell labeling agent labeled with $^{131}I$, $[^{131}I]$oleyl-4-iodobenzoate ($[^{131}I]$OIB) for long-term cell trafficking. A precursor of $[^{131}I]$OIB was obtained in two steps, with the yield of 35%. The radiochemical yield of $[^{131}I]$OIB was over 50%. While $[^{131}I]$OIB could label different cells, L6 cells showed the highest cell-labeling efficiency. The $[^{131}I]$OIB-labeled L6 cells were imprinted into a rat heart, and then monitored noninvasively for 2 weeks by gamma camera imaging. We conclude that $[^{131}I]$OIB is a good candidate molecule for a long-term cell trafficking agent.
Synthesis of oleyl-4[131I]-iodobenzoate for long-term cell trafficking
Hak Rim Jeon,Jeong soo Yoo,Woonghee Lee,Jieun Oh,Yong Jin Lee 대한방사성의약품학회 2018 Journal of radiopharmaceuticals and molecular prob Vol.4 No.2
Great efforts are currently devoted to the development of new approaches for the labeling of cells using appropriate radionuclides. While fluoride-18 and copper-64 have been extensively studied as short-term and intermediate-term trafficking agents, iodide was studied less intensely. Here, we report a new cell labeling agent labeled with 131I , [131I]oleyl-4-iodobenzoate ([131I]OIB) for long-term cell trafficking. A precursor of [131I]OIB was obtained in two steps, with the yield of 35%. The radiochemical yield of [131I]OIB was over 50%. While [131I] OIB could label different cells, L6 cells showed the highest cell-labeling efficiency. The [131I]OIB-labeled L6 cells were imprinted into a rat heart, and then monitored noninvasively for 2 weeks by gamma camera imaging. We conclude that [131I]OIB is a good candidate molecule for a long-term cell trafficking agent.
Jeon Hak Rim,Chung Ho Kyoon,Lee Jun Yeob,Cho Kwang‐Hwi 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.7
Pyrido[3,4-d]pyrimidine (PyPm) was designed as a new acceptor of thermally activated delayed fluorescent (TADF) emitters and the potential of the new acceptor moiety for TADF properties was investigated. Time-dependent density functional theory calculation was performed to estimate TADF characteristics by comparing five isomers of PyPm-based TADF emitters. Geometries of the emitters were affected by the presence of hydrogen bonding depending on the substitution position of the phenyl linker in the donorphenyl linker-acceptor type backbone structure, which also influenced the molecular orbital distributions. The nature of the triplet excited state was also dependent on the substitution position of the phenyl linker and donor moiety in the molecular structure, and the substitution at 5 position of the PyPm provided small singlet-triplet energy gap and hybridized local and charge transfer triplet excited state for efficient reverse intersystem crossing. From the computational calculation results, it can be expected that PyPm would effectively work as an acceptor of TADF emitters.
배추흰나비 (Pieris rapae L.)의 초기 용시기에 따른 Leucine의 대사
Jeon, Jin-Seon,Choe, Rim-Soon,Park, Choon-Keun,Kim, Hak-Ryul The Korean Society for Integrative Biology 1979 동물학회지 Vol.22 No.1
배추흰나비(Pieris rapae L.)의 용시기 (pupal stage)의 큐티를 형성 및 경화에 따른 leucine의 대사를 규명하기 위하여 $^3H-leucine$ 또는 $^14C-tyrosine$을 용화직후 혈림프에 주입시켰다. 혈림프내의 leucine은 탈피후 3시간 동안에 걸쳐 큐티를 단백질 합성에 관여하였고 또한 혈림프, 지방체, 장 및 큐티클 사이를 자유로이 이동하였는데 이것은 leucine대사에서 지방체 및 장이 혈단백질의 합성 및 저장에 관여하고 있다는 자료를 암시하여 준다. To determine the metabolism of leucine during the cuticle formation and the sclerotization process in Pieris rapae L., $U-^3$H-leucine or $U-^4$C-tyrosine is injected into the haemolymph of newly molted pupa through dorsal cuticle of heart area. The results show that leucine as a common amino acid participates in the synthesis of cuticle protein over the first 3 hr after ecdysis. It is also shown that leucine in the haemolymph at ecdysis is freely being moved between major internal organs during the short time period post-ecdysis, providing the evidence for some involvements including haemolymph protein synthesis and storage of fat body and gut in metabolism of leucine.
양친성 그래프트 공중합체의 탄소나노튜브 분산제로의 이용
김종학(Jong Hak Kim),전하림(Ha Rim Jeon),안성훈(Sung Hoon Ahn),지원석(Won Seok Chi) 한국고분자학회 2011 폴리머 Vol.35 No.6
탄소나노튜브(CNT)는 뛰어난 전기적, 물리적인 특성으로 인해 차 세대 소재로서 관심을 끌어 왔다. 그러나 탄소나노튜브들 사이에는 본질 적으로 강한 소수성 상호작용이 내재하여 불규칙한 결합체를 생성하기 때 문에 다양한 분야로의 응용이 어려웠다. 본 연구에서는 양친성 가지형 공 중합체, poly(vinyl chloride)-graft-poly(oxyethylene methacrylate), PVC-g-POEM를 합성하였고 극성 용매에서 단일벽 탄소나노튜브를 분 산시킬 수 있는 용이한 방법을 제시하였다. PVC-g-POEM는 원자전달 라디칼중합(ATRP)으로 중합되었고 gel permeation chromatography (GPC)와 1H NMR spectroscopy를 통해 성공적인 합성되었음을 확인하 였다. 단일벽 탄소나노튜브는 분산제인 PVC-g-POEM와의 친화력으로 인해 극성 용매 dimethylsiloxane(DMSO)에서 균일하게 분산되었으며 transmission electron microscopy(TEM) 분석으로 단일벽 탄소나노튜 브와 PVC-g-POEM의 상호작용으로 생성된 나노복합체의 분산 형태를 관찰하였다. 또한 용매증발 과정을 거쳐 우수한 균질성을 보이는 freestanding 나노복합체 막을 제조하였다. Carbon nanotubes (CNTs) draw attention as promising materials due to their excellent electrical and mechanical properties. However, the intrinsic strong interaction between CNTs presents a challenge to their use in various applications. Here, we present a facile method to disperse single-walled carbon nanotubes (SWCNTs) in a polar solution using a graft copolymer, poly(vinyl chloride)- graft-poly(oxyethylene methacrylate), PVC-g-POEM. The graft copolymer was synthesized via atom transfer radical polymerization (ATRP), as confirmed by gel permeation chromatography (GPC) and 1H NMR spectroscopy. The SWCNTs were uniformly dispersed in a polar solvent such as dimethylsiloxane (DMSO) using PVC-g-POEM as a dispersant, due to interaction between CNT and the graft copolymer, as revealed by transmission electron microscopy (TEM) analysis. Upon removal of the solvent, free standing nanocomposite films with good homogeneity were obtained.
Kim, Sunho,Jeon, Hak Rim,An, Chee-Hong,An, Byeong-Seon,Yang, Cheol-Woong,Lee, Hoo-Jeong,Weon, Byung Mook Elsevier 2017 Materials letters Vol.193 No.-
<P><B>Abstract</B></P> <P>This study proposes a chemical treatment using 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU), a well-known catalyst and non-nucleophilic base, to improve the conductivity of Ag nanowires (NWs)-networked transparent conductive films by removing the surface oxide of the wires. Upon DBU treatment, the sheet resistance of the films drops immediately and significantly, confirming its effectiveness for surface oxide reduction. Scanning and transmission electron microscopy analyses disclose that the wires do not show any sign of damage even after 1h-long exposure, an important benefit over other chemicals such as ammonia. We apply the method to excessively-oxidized Ag NWs via O<SUB>2</SUB> plasma and Cu NWs to further investigate the effectiveness of the method, confirming that the DBU treatment is an effective route to remove the surface oxide.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The chemical treatment using DBU improves the conductivity of Ag NWs films. </LI> <LI> The DBU treatment removes the surface oxide without harming the wires. </LI> <LI> The DBU treatment is effective in treating Cu NWs to some extent. </LI> </UL> </P>