소아에서 간질발작의 임상양상과 뇌파검사의 관계

이승현(Seung Hyeon Lee),손동우(Dong Woo Son),은병욱(Byung Wook Eun),심소연(So Yeon Sim),최덕영(Deok Young Choi),선용한(Yong Han Sun),조강호(Kang Ho Cho0, 류 일(Eell Ryoo),전인상(In Sang Jeon0, 차 한(Hann Tchah) 대한소아신경학회 2009 대한소아신경학회지 Vol.17 No.2

목적:발작의 분류는 발작의 원인, 예후를 추정하거나 항경련제를 선택하는 데 있어 매우 중요하며 뇌파검사는 발작의 종류를 구분하고 적절한 치료를 하기 위해 시행하는 중요한 검사이다. 저자들은 소아에서 임상적 발작이 확실한 경우 간질발작의 임상양상과 뇌파검사 간의 일치 정도를 알아보고자 한다. 방법:2000년 1월 1일부터 2008년 9월 30일까지 1회 이상의 간질발작을 주소로 가천의대 길병원 소아청소년과에 방문한 환자 중 본원에서 처음으로 뇌파검사를 시행한 환자를 대상으로 하였다. 발작의 임상양상은 목격자와 본인의 설명을 기록한 의무기록지를 기준으로 하여 부분발작과 전신발작으로 분류하였고 뇌파검사는 발작간간질양방전을 기준으로 정상과 비정상으로 분류하였으며 각성과 수면상태 모두에서 시행하였다. 결과:총 461명의 환자의 뇌파검사 시의 평균 연령은 6.7세였고 남자는 247명, 여자는 214명이었다. 전체 환자에서 발작의 임상양상은 부분발작이 310명, 전신발작이 187명이었다. 각성뇌파검사에서 비정상은 158명으로 부분발작파가 118명, 전신발작파가 59명, 두 가지 발작파가 한 환자에서 나온 경우가 19명이었고, 수면뇌파검사에서는 비정상이 239명으로 부분발작파가 196명, 전신발작파가 77명, 두 가지 발작파가 한 환자에서 나온 경우가 34명이었으며 전체 환자에서는 비정상이 273명으로 부분발작파가 216명, 전신발작파가 97명, 두 가지 발작파가 한 환자에서 나온 경우가 40명이었다. 간질증후군은 전체 환자 중 90명에서 관찰되었다. 146명(41.5%)의 부분발작과 44명(23.4%)의 전신발작 및 79명(87.8 %)의 간질증후군이 뇌파소견과 일치하였다. 결론:영유아 및 소아에 있어 발작을 진단할 때에는 발작양상 분 아니라 정확한 뇌파소견을 세심하게 고려하여야 한다. Purpose:Electroencephalography(EEG) is an essential method carried out for classifying seizures and taking appropriate treatment. The aim of this study is to investigate the concordance between clinical findings of epileptic seizures and EEG in children. Methods:We enrolled 461 patients from those who visited Gil hospital from January 1, 2000 to September 30, 2008 with the chief complaint of epileptic seizure more than once and checked their first EEG at the same hospital. The clinical findings of seizure were based on the charts and interictal waking and sleep EEGs were done. Results:The mean age of the patients was 6.7 years old. 497 epileptic seizures occurred and its clinical finding included 310 of partial seizures and 187 of generalized seizures. In 315 waking EEG 158 were abnormal including 118 of partial seizures, 59 of generalized seizures and 19 of both seizures, in 431 sleep EEG 239 were abnormal including 196 of partial seizures, 77 of generalized seizures and 34 of both seizures, and in waking and/or sleep EEG 273 were abnormal including 216 of partial seizures, 97 of generalized seizures and 40 of both seizures. Epileptic syndromes were observed in 90 patients. 146(41.5%) of partial seizures, 44(23.4%) of generalized seizures, and 79(87.8%) of epileptic syndromes accorded with EEG. Conclusion:When diagnosing seizures in children, we must consider not only clinical findings but also accurate EEG findings.

미용사의 요통 경험에 영향을 미치는 요인

백승룡,남철현,배성욱,김성우,권현숙,이정옥,전연숙 慶山大學校 保健福祉硏究所 2002 保健福祉硏究 Vol.7 No.-

The purpose of this study is to analyze and grasp the actual lumbaginous condition and relevant factors of 1,182 beauty artists of beauty shops in 5 metropolitan cities, small-to-medium cities, and fishing or agrarian villages for 3 months from June 20 to September 25, 2000 through questionnaires. 1) They showed 61.0 percents in her twenties, 66.4 percents of unmarried women from all the female objects, 70 percents in high school graduates as educational background, 52.4 percents in metropolitan city as service place, 25.4 percents in smoking rate, 71.6 percents in drinking rate, 48.1 percents in general bed as condition of bedroom, 17.9 percents in exercising rate, 53.6 percents in 'little eating', 39.6 percents in two or three centimeters of heel, and 89.5 percents in hair as beauty-related professional field. 2) The rate of lumgaginous experience of beauty artists was 83.5 percents. They showed higher rate of 91 percents in the thirties and forties, 92 percents of the married, 93.9 percents in junior college graduates, 97.2 percents in higher economic classes, 88.7 percents in smokers, 85 percents in general bed, 89.3 percents in sleeping on one's face, 85 percents in swimming, 92 percents in stretch, 86.7 percents in 56 to 60 kilograms of weight, 89.7 percents in group O blood, 90.5 percents in experienced women of abortion, 97 percents in heel over 8 centimeters, 58.3 percents in 'feel much fatigue', 93.6 percents in inconvenient chair of beauty shop, and 89.4 percents in a lack of recess than other group. 3) The more women who have been experienced in lumbago, the higher their social treatment(p<0.01), income(p<0.001), working time(p<0.05), job potentiality(p<0.05), inner affinity(p<0.05), and job satisfaction of environment(p<0.001) were. Women who suffered much stress related to job environment(p<0.001), client(p<0.01), and their duty(p<0.01) showed high rate of lumbaginous experience. 4) In degree of lumbago by characteristic, there was the significant difference in age over 50-years-old, unmarried women, college graduates, service of small-medium cities, higher economic classes, smokers or drinkers, hot-floored room, sleeping with ransack, stretch or swimming, group A blood, fat body, experience of abortion, 6 to 7 centimeters of heel, convenient chair of beauty shop, insufficient recess, lumbago continued for one to the three months in comparison of other group. 5) There were variables of posture such as to place materials under one foot(p<0.001), to lay arm on armrest and desk(p<0.001), to pull materials near body while lifting them (p<0.05), to sometimes use anodyne(p<0.01), not to lift also light materials(p<0.001), to be inconvenient in sleeping(p<0.001), to be absent at job for two or three days(p<0.01). The degree of depression(p<0.001), had the significant effect on the degree of lumbago(32.7%). The results are as follows : Beauty artists have faced upon dangerous job environment to cause lumbago. The more the industrial society will be developed, the more their burden of service will be increased. In addition, the occupational stress and posture of beauty artists who showed high job satisfaction and high economical level became major factors which have had an effect on their lumbago. In conclusion, it is desirable for beauty-related organizations and professionals to positively develop program of health education with much concern as well as to lessen stress of beauty artists through education of job posture and rightful life in order to prevent lumbago of those beaut.

A qualitative study on the internal response of medical students during the transgender healthcare education: a focus on professional identity

Jeon Seung Yeon,Yoon Hyun Bae,Park Jee Eun,Lee Sun Young,윤정원 한국의학교육학회 2022 Korean journal of medical education Vol.34 No.4

Purpose: This qualitative study examined the inner response of medical students who participated in a transgender healthcare education program. The factors that effected the inner response were investigated in order to suggest strategies for improving the effectiveness of the transgender healthcare education program.Methods: The transgender healthcare education program consisted of 2 hours of lectures and 2 hours of clinical role-play over 3 weeks. Eight 4-year medical students in Seoul, South Korea, were selected considering gender, the route of admission to medical school, and religion. Each student was interviewed individually for approximately 30 minutes 3 times before, during, and after the educational program, and interviews were analyzed using thematic analysis.Results: By attending the transgender healthcare education program, students have shown three types of inner response—confusion, acceptance, and negotiation. The students’ personal identities and professional identities influenced these responses. In particular, students’ existing professional identities motivated them to learn about transgender healthcare and played a key role in resolving the discomfort that occurred during the educational program. Through the transgender healthcare education, students were able to reduce prejudice against transgender people, understand the unique medical needs of the transgender population and increase their self-efficacy related to transgender health care.Conclusion: The transgender healthcare education program allowed medical school students to acquire medical knowledge related to transgender patients and increase their cultural competence as future medical professionals. In addition, as the professional identity is critical in educating transgender healthcare, it should be considered thoroughly in order to effectively educate the medical students.

REVIEW : Open Access ; Hanwoo cattle: origin, domestication, breeding strategies and genomic selection

( Seung Hwan Lee ),( Byoung Ho Park ),( Aditi Sharma ),( Chang Gwon Dang ),( Seung Soo Lee ),( Tae Jeong Choi ),( Yeon Ho Choy ),( Hyeong Cheol Kim ),( Ki Jun Jeon ),( Si Dong Kim ),( Seong Heum Yeon 한국동물자원과학회(구 한국축산학회) 2014 한국축산학회지 Vol.56 No.2

Hanwoo (Korean cattle) is the native, taurine type of cattle breed of Korea and its history as a draft animal dates back to 5000 Years. In earlier times Hanwoo was used extensively for farming, transportation. Over the period of time, Hanwoo has changed to be meat type cattle. Full-scale production of Hanwoo as meat-type cattle has occurred since 1960s with the rapid growth of the Korean economy. Hanwoo is one of the most economically important species in Korea as it is a significant source of nutrition to the Korean people. Hanwoo beef is the most cherished food of Korea. One of the main goals of researchers is to increase the meat quality, quantity and taste of the beef. In this review we describe the origin, domestication of Hanwoo cattle and breeding program initiated from 1980’s. Moreover the advent of technological advancement had provided us a platform to perform genome wide selection on economic traits and its implementation into traditional breeding programs.

사람 눈에서 Transglutaminase 4의 발현과 분포양상

전연숙 ( Jeon Yeon Sug ) , 서승희 ( Seo Seung Hui ) , 김인규 ( Kim In Gyu ) , 위원량 ( Wi Won Lyang ) , 이진희 ( Lee Jin Hui ) 대한안과학회 2003 대한안과학회지 Vol.44 No.8

Hanwoo cattle: origin, domestication, breeding strategies and genomic selection

Lee, Seung-Hwan,Park, Byoung-Ho,Sharma, Aditi,Dang, Chang-Gwon,Lee, Seung-Soo,Choi, Tae-Jeong,Choy, Yeon-Ho,Kim, Hyeong-Cheol,Jeon, Ki-Jun,Kim, Si-Dong,Yeon, Seong-Heum,Park, Soo-Bong,Kang, Hee-Seol Korean Society of Animal Sciences and Technology 2014 한국축산학회지 Vol.56 No.1

Hanwoo (Korean cattle) is the native, taurine type of cattle breed of Korea and its history as a draft animal dates back to 5000 Years. In earlier times Hanwoo was used extensively for farming, transportation. Over the period of time, Hanwoo has changed to be meat type cattle. Full-scale production of Hanwoo as meat-type cattle has occurred since 1960s with the rapid growth of the Korean economy. Hanwoo is one of the most economically important species in Korea as it is a significant source of nutrition to the Korean people. Hanwoo beef is the most cherished food of Korea. One of the main goals of researchers is to increase the meat quality, quantity and taste of the beef. In this review we describe the origin, domestication of Hanwoo cattle and breeding program initiated from 1980's. Moreover the advent of technological advancement had provided us a platform to perform genome wide selection on economic traits and its implementation into traditional breeding programs.

통계기법을 활용한 공동주택 세대에서의 용도별 에너지사용량 분석 및 추정 - 급탕, 전기기기, 조명 에너지사용량을 중심으로 -

홍승연(Hong, Seung-Yeon),전서윤(Jeon, Seo-Yoon),송승영(Song, Seung-Yeong) 대한건축학회 2020 대한건축학회 학술발표대회 논문집 Vol.40 No.2

Based on the building physical factor, residential information and characteristics of device use, this study is analyzing the factors which influences the use of domestic hot water, Electric Appliances, and Lighting energy. The study is also proposing an energy consumption estimation model so that individuals could search for ways to reduce energy consumption. For analysis and estimation of energy consumption, we used statistical techniques such as correlation analysis, ANOVA and regression analysis. Correlation analysis and ANOVA help determine the factors affecting the use of domestic hot water, Electric Appliances, and Lighting energy. Regression analysis derived the estimation model. Some samples taken at random were used to verify the model.

발효유 산물인 LHFM의 인지기능 개선 효과

전용진(Yong-Jin Jeon),김준형(Jun-Hyeong Kim),이명재(Kim, Myong-Jae Lee),전우진(Woo-Jin Jeon),이승훈(Seung-Hun Lee),연승우(Seung-Woo Yeon),강재훈(Jae-Hoon Kang) 한국식품과학회 2012 한국식품과학회지 Vol.44 No.4

본 연구팀의 선행 연구 결과, L. helveticus IDCC3801의 발효유 주정 침전물이 BACE의 활성 억제를 통한 amyloid beta(Aβ) 생성 저해효과를 갖고 있음을 확인하였다(15). 이러한 결과를 바탕으로 L. helveticus IDCC3801의 발효유 주정 침전물의 산업화를 위한 공정 개선연구를 진행하였고, 대량생산을 통해 LHFM을 확보하였다. 본 연구는 LHFM의 인지기능 개선 기능성 입증 연구로써 Aβ 저해효과 외에 신경세포 보호효과 및 기억력 개선 효능을 확인하고 어떠한 작용 기전으로 개선 효과가 나타나는지 조사한 것으로 scopolamine으로 기억 손상을 유발한 mouse에서 학습 능력과 기억력 개선 효과, 신경세포 보호 효과, AChE 저해와 ACh 증가 효과 등을 평가하였다. LHFM은 신경세포 사멸을 유도하는 고농도의 glutamate가 존재하는 환경에서 농도 의존적으로 신경세포의 사멸을 억제하여 신경세포를 보호하였다. 또한 LHFM은 in vitro에서 농도 의존적으로 강력하게 AChE의 활성을 저해하였다. 이러한 in vitro 결과들을 근거로 scopolamine으로 기억 손상을 유발한 mouse에서 Morris water maze와 Y-maze 행동 시험을 통해 LHFM의 학습능력과 기억 개선 효과를 조사하였다. LHFM은 Morris water maze에서 실험 2일째부터 escape latency시간을 유의적으로 감소 시켰으며 5일째에서는 정상 mouse와 동등한 수준으로 감소되어 우수한 학습 효과를 보였다. 실험 6일째 platform을 치운 후 시행한 probe trial에서도 platform이 있던 위치에 머무는 회수가 scopolamine을 단독으로 처리한 것보다 유의적으로 높아 장기기억의 개선에도 효과가 있었다. Y-maze 시험에서도 LHFM은 scopolamine 단독 처리군과 비교하여 뚜렷하게 변경 행동력을 증가시켜 여러 행동 시험을 통해 LHFM의 인지기능 개선 효과를 확인하였다. 행동실험 후 hippocampus를 적출하여 ACh 및 AChE의 활성을 측정한 결과, donepezil과 마찬가지로 LHFM은 AChE의 활성을 유의적으로 억제하였으며 또한 ACh 함량도 증가시켰다. 결론적으로 LHFM은 신경세포 보호 효과와 신경전달물질인 ACh의 뇌 조직 내 농도를 높여 인지기능 개선 효과를 보이는 것을 확인하였다. Probiotics and their products, such as yogurt and cheese have been widely consumed in many countries with proven health benefits including anti-microbial activity and anti-diarrheal activity. LHFM (Lactobacillus helveticus-fermented milk) is a processed skim milk powder, fermented by a probiotics, L. helveticus IDCC3801. In the present study, we aimed to investigate the neuroprotective effects and the cognitive improvements of LHFM. LHFM itself did not show any cytotoxicity to the human neuroblastoma cell line, SH-SY5Y; however, it dose-dependently protected against glutamate-induced neuronal cell death. LHFM also attenuated scopolamine-induced memory deficit in Y-maze and Morriswater maze. In the analysis of hippocampus after a behavior test, LHFM significantly increased the acetylcholine level and also inhibited acetylcholine esterase activity. Therefore, the raised acetylcholine release partially contributes to the improvement of learning and memory by a treatment with LHFM. These results suggest that LHFM is an effective material for prevention or improvement of cognitive impairments caused by neuronal cell damage and central cholinergic dysfunction.

Wheel Balanced Cancer Therapy for Longer Than 21 Days Can Have a Positive Effect on the Survival of Patients with Stage IV Cancer

Jeon, Hyung-Joon,Kim, Jong-min,Cho, Chong-kwan,Lee, Yeon-weol,Yoo, Hwa-seung KOREAN PHARMACOPUNCTURE INSTITUTE 2015 Journal of pharmacopuncture Vol.18 No.3

Objectives: Correlations of the levels of the nonspecific inflammatory markers C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) and of the coagulation marker fibrinogen with the treatment period of wheel balanced cancer therapy were determined. Methods: Electronic charts of stage IV cancer patients hospitalized from February 1, 2008, to November 30, 2013, were reviewed retrospectively. Patients whose laboratory follow-up tests included at least two data points for at least one marker were included. Patients receiving chemotherapy or radiotherapy or having Eastern Cooperative Oncology Group (ECOG) levels exceeding 2 were excluded. Correlations of the markers with the length of treatment for treatment periods ${\geq}21$ and ${\leq}20$ days were determined by gender and whether or not surgery had been performed. Results: Analyses of the CRP and the ESR revealed a higher proportion of patients with stable marker levels than with increased or decreased levels. Also, only the ESR in female and the CRP in male groups had higher proportions of patients with stable marker levels than with increased or decreased levels. The ${\geq}21$ day group had a higher proportion of patients with stable CRP and ESR levels than the ${\leq}20$ days group. Only the ESR in female and the CRP in male groups had higher proportions of patients with stable marker levels in the ${\geq}21$ day than in the ${\leq}20$ day group. In addition, only the CRP in the surgery group and the ESR in the non-surgery group had higher proportions of patients with stable marker levels in the ${\geq}21$ day group than in the ${\leq}20$ day group. Conclusion: For stage IV cancer patients at hospitals that offer Korean medicine, more than 21 days of long-term wheel balanced cancer therapy (WBCT) should help maintain the CRP and the ESR levels and should have a favorable effect on the survival rate.

Lactobacillus Probiotic Protects Intestinal Epithelium From Citrobacter Rodentium-Induced Colitis in a TLR 2 and 4 Dependent Manner

Seung Hyun Ryu,Jong Hyung Park,Soo Young Choi,Seung Hoon Ham,Hee Yeon Jeon,Jin Il Park,Jun Young Kim,Yang Kyu Choi 한국실험동물학회 2015 한국실험동물학회 학술발표대회 논문집 Vol.2015 No.8