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Jeong Heo,Yoon Jun Kim,Sung Wook Lee,Youn-Jae Lee,Ki Tae Yoon,Kwan Soo Byun,Yong Jin Jung,Won Young Tak,Sook-Hyang Jeong,Kyung Min Kwon,Vithika Suri,Peiwen Wu,Byoung Kuk Jang,Byung Seok Lee,Ju-Yeon Ch 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.4
Background/Aims: Despite the availability of direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection in Korea, need remains for pangenotypic regimens that can be used in the presence of hepatic impairment, comorbidities, or prior treatment failure. We investigated the efficacy and safety of sofosbuvir–velpatasvir and sofosbuvir–velpatasvir–voxilaprevir for 12 weeks in HCV-infected Korean adults. Methods: This Phase 3b, multicenter, open-label study included 2 cohorts. In Cohort 1, participants with HCV genotype 1 or 2 and who were treatment-naive or treatment-experienced with interferon-based treatments, received sofosbuvir–velpatasvir 400/100 mg/day. In Cohort 2, HCV genotype 1 infected individuals who previously received an NS5A inhibitor-containing regimen ≥ 4 weeks received sofosbuvir–velpatasvir–voxilaprevir 400/100/100 mg/day. Decompensated cirrhosis was an exclusion criterion. The primary endpoint was SVR12, defined as HCV RNA < 15 IU/mL 12 weeks following treatment. Results: Of 53 participants receiving sofosbuvir–velpatasvir, 52 (98.1%) achieved SVR12. The single participant who did not achieve SVR12 experienced an asymptomatic Grade 3 ASL/ALT elevation on day 15 and discontinued treatment. The event resolved without intervention. All 33 participants (100%) treated with sofosbuvir–velpatasvir–voxilaprevir achieved SVR 12. Overall, sofosbuvir–velpatasvir and sofosbuvir–velpatasvir–voxilaprevir were safe and well tolerated. Three participants (5.6%) in Cohort 1 and 1 participant (3.0%) in Cohort 2 had serious adverse events, but none were considered treatment-related. No deaths or grade 4 laboratory abnormalities were reported. Conclusions: Treatment with sofosbuvir–velpatasvir or sofosbuvir–velpatasvir–voxilaprevir was safe and resulted in high SVR12 rates in Korean HCV patients.
경기도 성남시, 인천시, 강원도 강릉시, 충북 청원군 강수의 화학적 성분에 관한 비교 연구
박국태,문경언,허정구,홍현복 한국환경과학회 1995 한국환경과학회지 Vol.4 No.3
A comparative study on the chemical compositions of precipitations from February 1993 to April 1993 in Sungnam city of Kyunggi province, Inchon city, Kangneung city of Kangwon province, and Chongwon-gun of Chungbuk province has been performed. The metal cation and anion concentrations were measured by atomic absorption spectrometer and ion liquid chromatography, respectively. pH/Ion meter and direct nesslerization method were used for the concentration measurements of H^+ and NH_4^+ ions, respectively. The quantitative orders of the cation and anion average concentrations, correlation coefficients between the ion concentrations, and pH values are used for chemical analysis on the environmental pollution and pollutant sources in the urban, surburban, seaside, and rural areas of the Korean Peninsula.
( Enjin Heo ),( Yoo Young Lee ),( Tae Joong Kim ),( Jun Kuk Choi ),( Taehyun Kim ),( Gun Yun ),( Chel Hun Choi ),( Jeong Won Lee ),( Duk Soo Bae ),( Byoung Gie Kim ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: We investigate the prognostic impact of the interval from surgery to initiation of chemotherapy (ISC) in advanced epithelial ovarian cancer. 방법: We enrolled patients with advanced epithelial ovarian cancer (FIGO stage III and IV) who were treated at Samsung Medical Center from January 1, 2001 to December 31, 2010. We excluded the patients who had neoadjuvant chemotherapy. 결과: 507 patients (stage III; 448, stage IV; 59) were enrolled and the median ISC was 9 days with the rage of 4 and 84 days. When we compare the survival for groups with short ISC (≤ 9 days) and long ISC (> 9 days), long ISC showed significant negative impact on survival in multivariate analysis. In subgroup analysis based on surgical outcomes (gross no residual: n= 109, optimal with residual less than 1 cm: n= 206, suboptimal: n= 192) longer ISC was significantly associated with poorer progression free survival (PFS, p=0.0383) and overall survival (OS, p=0.0002) in optimal surgery group (gross residual less than 1 cm). In this group the hazard ratio for PFS and OS started to be significant with 11 days of ISC (p< 0.05). However, in microscopic disease, the ISC did not show any prognostic impact and only trend of poor OS was observed in suboptimal group (p=0.0867) 결론: Our data suggest that delay of chemotherapy after surgery more than 11 days might entail negative impact on PFS and OS in advanced epithelial ovarian cancer patients who had gross residual disease after surgery.
Kwak, Dong-Hun,Heo, Jeong-Ho,Park, Seung-Ha,Seo, Seok-Jang,Kim, Jin-Kuk Elsevier 2018 ENERGY Vol.148 No.-
<P><B>Abstract</B></P> <P>Liquefied natural gas (LNG) fuelled shipping systems adopts the boil-off gas (BOG) re-liquefaction process to maintain the pressure of storage tank and to minimize methane loss. However, most of previous studies on on-board BOG re-liquefaction process were made for large-scale applications of LNG carriers. This paper focuses on small-scale BOG re-liquefaction process used for LNG fuelled ship. In order to improve energy efficiency of BOG re-liquefaction, process design and optimization study are carried out for the refrigeration process in LNG fuelled ship. The reverse Brayton cycle using nitrogen as a refrigerant fluid is selected and two different configurations without using cryogenic compressor are considered, namely, i) re-liquefaction of BOG feed stream without compression and ii) pre-heating of BOG feed to use compressor operating in ambient temperature. Thermodynamic analysis provides conceptual insights into the key operating variables on the performance of BOG re-liquefaction process, while energy-efficient strategy for achieving minimum power consumptions can be systematically obtained through process optimization. Sensitivity analysis is also performed to understand how the variation of operating conditions affects on system performance of BOG re-liquefaction process under different design conditions and constraints. The case study also illustrates how process modeling and optimization framework proposed in this paper can be effectively utilized to improve energy efficiency in BOG re-liquefaction process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Improving energy efficiency of small-scale BOG re-liquefaction processes. </LI> <LI> Process design and optimization of BOG re-liquefaction for LNG fuelled vessel. </LI> <LI> Systematic consideration of characteristics related to small-scale application. </LI> <LI> Application of heat integration and thermodynamic analysis. </LI> </UL> </P>
경남 남부지방에서 송아지설사병 원인체 바이러스 검출 조사
허정호 ( Jung Ho Heo ),조명희 ( Myung Heui Cho ),이국천 ( Kuk Cheon Lee ),박미남 ( Mi Nam Park ),조은정 ( Eun Jeong Cho ),최만수 ( Man Su Choi ),김충희 ( Chung Hui Kim ),강정부 ( Joung Boo Kang ),김의경 ( Eui Kyung Kim ),김종수 ( 한국가축위생학회 2008 韓國家畜衛生學會誌 Vol.31 No.3
Among calves` diseases, digestive diseases most frequently occur in Korea, and especially viral diarrhea is one of the most important diseases. This study was conducted to get some basic information for the control of the viral diarrhea in calves. The samples were obtained from 319 calves with clinical diarrhea from 195 farms in Gyeongnam south area (Gosung, Tongyung, Hadong) from June 2005 to August 2006. Viral detection was examined by polymerase chain reaction (PCR). Etiological viruses were detected from 171(53.6%) of 319 calves, and bovine rotavirus (BRV) were 130 (40.8%) and bovine viral diarrhea virus (BVDV) 41 (12.9%), and no coronavirus was confirmed. Statistical difference was found in BRV detection between summer (32.6%) and winter (57.7%). However there was no seasonal difference in BVDV. In detection rate of the calves under 19days, BRV was highest (55.1%), but BVDV lowest (5.1%). No big difference was in rate among herd size. However, BRV was lowest (26.8%) in the group over 51 heads, but BVDV was highest (19.5%) in the same.
경남 남부지방에서 사육 중인 송아지의 설사병에 관한 역학적 연구
허정호 ( Jung Ho Heo ),조명희 ( Myung Heui Cho ),이국천 ( Kuk Cheon Lee ),박미남 ( Mi Nam Park ),조은정 ( Eun Jeong Cho ),최만수 ( Man Su Choi ),김충희 ( Chung Hui Kim ),강정부 ( Joung Boo Kang ),김의경 ( Eui Kyung Kim ),김종수 ( 한국가축위생학회 2008 韓國家畜衛生學會誌 Vol.31 No.3
The present study was conducted to investigate the epidemiological characteristics such as isolation rate and antimicrobial drug susceptibility of etiological agents. The specimens (stool or intestine) were collected from 319 calves with clinical diarrhea from 195 farms in Gyeongnam south area (Gosung, Tongyung, Hadong) from June 2005 to August 2006. The isolation rate of Salmonella spp was higher in summer (8.4%) than in winter (4.8%) and the average was 7.2% (23/319 head). Some of Salmonella spp isolated were resistant to penicillin, oxytetracycline, tetracycline, and cephalexin (>90%), but some of them were suscep-tible to norfloxacin, ciprofloxacin, sulfamethoxazole/trimethoprim and amikacin(>30%). There was no statistical difference in the isolation rate of Eimeria spp between summer(48.9%) and winter(42.3%). For the evaluation of infection level of Eimeria spp oocyst per gram of feces(OPG) was examined, and severe, moderate and light infection level were 11.9%, 12.5% and 22.3%, respectively. In the isolation rates of Eimeria spp the calves under 19 days was lowerthan those over 60 days, but there was not different among herd size.
Emission Stability of Semiconductor Nanowires
SeGi Yu(유세기),Taewon Jeong(정태원),Sang Hyun Lee(이상현),Jungna Heo(허정나),Jeonghee Lee(이정희),Cheol Jin Lee(이철진),Jinyoung Kim(김진영),HyungSook Lee(이형숙),YoonPil Kuk(국윤필),J.M. Kim(김종민) 한국진공학회(ASCT) 2006 Applied Science and Convergence Technology Vol.15 No.5
열 화학기상법으로 만든 GaN와 GaP 나노와이어에서 전계 방출과, 산소와 아르곤 분위기에서 안정성에 대해 조사하였다. GaN 나노와이어의 경우 산소 분위기에서 전계 방출이 급격하게 줄었으나, GaP에서는 그렇지 않았다. 두 나노와이어 모두 아르곤 분위기에서는 큰 변화가 없었다. GaP 나노와이어의 외부에 존재하는 산화물 층이 전자 방출 안정성에 크게 기여한 것으로 생각된다. 나노와이어에서 방출된 전자의 에너지 분포를 통해 반도체 나노와이어는 탄소 나노튜브와 그 전계 방출 메카니즘이 다름을 유추할 수 있었다. Field emission of GaN and GaP nanowires, synthesized by thermal chemical vapor deposition, and their emission stabilities under oxygen and argon environments were investigated. The field emission current of GaN nanowires was seriously deteriorated under oxygen environment, while that of GaP was not. Both wires did not show any noticeable change under argon environment. The existence of oxide outer shell layers in the GaP nanowires was proposed to be a main reason for this emission stability behavior. Field emission energy distributions of electrons from these nanowires revealed that field emission mechanism of the semiconductor nanowires were different from that of carbon nanotubes.
열침원의 온도 변화에 따른 초임계 이산화탄소 재압축 사이클의 탈설계 거동 평가
손성민(Seongmin Son),조성국(Seong Kuk Cho),허진영(Jin Young Heo),이정익(Jeong Ik Lee) 한국에너지기후변화학회 2017 에너지기후변화학회지 Vol.12 No.1
Today, securing environmental friendly energy source became an important global issue. Such energy source can be developed by using a new resource or using the existing energy resource more efficiently. Recently substantial attention was given to the supercritical CO₂ power cycle which can transform the existing electricity production method. The supercritical CO₂ power cycle has advantages of small turbomachinery, simple system, and high thermal efficiency. However, due to non-linear properties’ variation near the critical point, the off-design performance prediction of the cycle still requires further research. Thus, the research team have analyzed the off-design behavior of the supercritical CO₂ cycle according to the temperature change of the heat sink. The target cycle in the study is a 100 MW scale supercritical CO₂ recompression Brayton cycle layout, and the off-design behavior was analyzed when the temperature of the heat sink increases from the design point of 32 °C to 50 °C. The system maximum pressure was assumed to be remained the same as the design point. In the analyzed temperature range, the system efficiency is calculated to decrease by 11.5%p from 44% to 32.5%, and the thermodynamic work of the cycle is expected to decrease by about 38MW, from 108 MW to 70 MW. In the process of changing the system minimum pressure during the analysis, necessity for new optimizations to meet the off-design operating condition was found. This suggests that optimizing the rpm of the turbomachinery and the overall system capacity to meet operating conditions will be an important research topic in the future.