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흰쥐에서 음경발기 평가의 척도로서 음경해면체내압측정술 확립
송윤섭,김용준,이광우,김준모,문기혁,박영호,민영기,유형균,김형건 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1
Purpose: Because studies about the control of penile erection at the entral nervous system was dependent on the animal experiments, establishment of measuring penile erection is important to evaluate the effects changes at the central nervous system on the penile erection. Intracavernous pressure measurement in rats has been introduced as a suitable index for the evaluation of penile erection but this method is invasive and technically difficult. So, we established the intracavernous pressure measurement in rats as the experimental index for penile erection. Materials and Methods: 42 male adult Sprague-Dawley rats (250-300gm) were divided to saline or papaverine treated group. Rats were placed on a heating table to maintain their body temparature and anesthetized with 50mg/kg of pentobarbital sodium by intraperitoneal injection. A cannula was inserted to the left carotid artery to measure systemic blood pressure. Saline (0.05, 0.1ml), papaverine(0.05, 0.1, 0.25, 0.5, 1.0, 2.0mg) were injected intracavernously via 26 guage needle filled with saline or papaverine which connected to pressure transducer and polygraph was inserted into the corpus cavernosum on one side to inject the drug and to measure intracavernous presure. Results: Properly executed insertion and intracavernous administration produced a instantaneous but transient rise in intracavernous pressure that substantially stabilized and maintained at 5.4±0.4mmHg. Intracavernous pressure and duration of penile blood flow following intracavernous injection of papaverine are increased comared to those of saline. Conclusions: Monitoring intracavernous pressure in rats represents a suitable index for the evaluation of penile erection in small laboratory animals.
산전 태아사망 환자에서의 Mycoplasma hominis와 Viridans streptococcus감염 1예
김윤숙,문성택,전섭,김종수,최승도,선우재근,배동한 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1
Mycoplasma hominis was isolated from a Bartholin's gland abscess 70 years ago, and ureaplasmas were isolated from the genital tract about 20 years later. Subsequently, reports incriminating mycoplasmas in the known adverse outcomes of pregnancy have been reported. Without doubt these genital mycoplasmas are able to invoke an inflammatory response and take part in the cascade of events that culminate in preterm birth. Amniotic fluid infection results in considerable pregnancy wastage in the pregnancy. In these cases Gram-positive organisms, especially group B streptococcus and Streptococcus viridans were the most common pathogens isolated. In our case, the patient has fever and vaginal discharge at 14+4 weeks gestation and two days after intrauterine fetal death was seen. The vaginal culture and sensitivity shown Mycoplasma hominis and Vihdans streptococcus. We experienced a case of Mycoplasma hominis and Viridans streptococcus infection in a patient with intrautehne fetal death and report with a brief review of literatures.
후두 편평세포암종에서 Galectin-1 및 -7의 발현 의의
김건형,강차영,윤혁수,도남용,조성일,임성철 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
Background and Objectives: The role of different Galectins in the pathogenesis of different types of malignancy is being profoundly investigated recently. In this study, the author investigated the level of Galectin-1 and -7 in the layngeal squamous cell carcinoma tissue to define its relationship to the tumor progression. Materials and Methods: Paraffin-embedded tissue specimens from 77 patients, who were diagnosed as laryngeal squamous cell carcinoma from 1993 to 2007, were immunohistochemically stained for Galectin-1 and -7. Results: Galectin-1 expression was positively correlated with tumor stage and nodal involvement. Galectin-7 expression was increased in better differentiated tumors. Conclusion: Expression of Galectin-1 and -7 can be used as a valuable indicator in laryngeal squamous cell carcinoma under certain limitations.
이상건,송윤관,송광엽 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.3
In addition to continuing the search for more accurate and dimensionally stable materials for denture bases, recently several processing methods for denture base resins which may reduce dimensional change during fabrication has been developed. The purpose of this study was to compare the dimensional accuracy of denture bases cured by four denture base processing methods, using the conventional heat-compression molding method, the continuous-pressure injection method, the microwave curing processing method, and the Sulfone system. A metal die simulating a maxillary edentulous arch and a polyvinylsiloxane impression(Reprosil, L. D. Caulk Co. U.S.A.) were used to construct 40 simulated master casts and denture bases with artificial teeth. Forty simulated denture bases 3 to 4㎜ thick were processed by four denture base processing methods following the manufacturer's instructions. The processed denture bases and casts sectioned through the posterior palatal region to allow measurement of its change by means of an travelling microscope. Observations were made on center of posterior palatal sectioned region. One-way ANOVA and paired samples t-tests were employed to compare the differences in distortion after deflasking and after finishing and polishing. The obtained results were as follows; 1. After deflasking, dimensional changes were diminished in order of conventional heat-compression molding, Sulfone system, continuous-pressure injection method, microwave processing method(p<0.05). 2. After finishing and polishing, dimensional changes were diminished in order of conventional heat-compression molding method, Sulfone system, microwave processing method, continuous-pressure injection method. The significant difference was found between conventional hear-compression method, continuous-pressure injection method(p<0.05). 3. The significant difference was found between after deflasking and after polishing in all methods, except continuous-pressure injection method(p<0.05).