응급실에 내원한 환자에서 어지럼증의 원인과 임상양상의 분석

문원식,정경운,위준선,문정미,전병조,김용권,소정일,류진호,허탁,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: Recently, The number of patients who have been complaining of the vertigo or dizziness has been increasing due to rapid growth of elderly population and senile disease. The differentiation of dizzy patients is not familiar to most emergency physicians. This study was designed to differentiate true vertigo and to investigate the clinical difference among central vertigo, peripheral vertigo, and other causes of dizziness. Methods: The authors analyzed the cases of 237 dizzy patients who visited the emergency department of Chonnam University Hospital during the recent 2 years. For the base of dizziness, associated past illnesses, severity, nystagmus type, and the causes of central and peripheral vertigo. Results: Female patients were 142(59.9%) and male patients were 95(40.1%). The most common age group was the 6th decade. The origin of dizziness was classified as peripheral cause(25.3%), central cause(32.9%), and others(41.8%). As to nature of the dizziness, the rotatory sense was dominant in peripheral vertigo and the floating sense and blurred vision in central vertigo. Peripheral vertigo was triggered by position change of head and body, and central vertigo by the eye movement. Audiograms I showed that most patients with central vertigo had normal hearing, but 46.7% of thoswith peripheral vertigo had an abnormal hearing disturbance. Nystagmus was more prevalent in peripheral vertigo Conclusion: History taking and physical examination played an important role in the diagnosis of dizzy patients. An important part of the diagnosis of a dizzy patient could be to evaluate the peripheral origin, the central origin and others causes. Because central vertigo may be associated with a significant neurological pathology, spectral radiological studies, including MRI and CT, are mandatory to rule out a devastating brain lesion.

Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

공탄성시스템의 확률론적 제어에 대한 실험적 연구

김대중,박상태,정재욱,허훈,Kim, Dae-Jung,Park, Sang-Tae,Jeong, Jae-Uk,Heo, Hun 대한기계학회 1999 大韓機械學會論文集A Vol.23 No.11

A Newly proposed control methodology applied to the aeroelastic system experiencing flutter is investigated and its performance is verified experimentally. The flexible cantilever beam slicked with piezofilm sensor and piezoceramic actuator is modelled in physical domain. Dynamic moment equation for the system is derived via Ito's stochastic differential equation and F-P-K equation. Also system's characteristics in stochastic domain is analyzed simultaneously. LQG controller is designed and used in physical and stochastic domain. It is shown experimentally that the vibration of beam is controlled effectively by designed LQG controller in physical domain. By comparing the result with that of LQG controller designed in stochastic domain, it is shown that the new control method, called Heo-stochastic control technique, has better performance as a controller.

방광 소세포암:1예 보고

허정남,김용수,조온구,고병희,임현철,함창곡 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2

Small cell carcinoma(also known as oat cell carcinoma) of the urinary bladder is an extremely rare malignancy and is derived from neuroendocrine stem cells. It is usually biologically aggressive tumor with early vascular and muscle invasion, so it has poor prognosis. Radiological findings of small cell carcinoma are similar to other malignancies of urinary bladder, therefore it is impossible to distinguish small cell carcinoma from other malignancies. Pathologic study is an only useful method for differential diagnosis of bladder tumor. We report here the case of 74th years old woman presented with painless gross hematuria.

열 전처리에 의한 섬유소분해효소생산 미생물의 선발

정허진,김훈,김정호 順天大學校 1996 論文集 Vol.15 No.1

30 개의 토양과 퇴비 시료로 부터 섬유소 분해효소를 생산하는 3 종류의 미생물을 분리하였다. 분리는 carboxymethyl-cellulose (CMC)를 함유하는 고체 평판배지를 이용하였으며, 분리된 3 종류 중 2 종류 (H12, H15)는 열 전처리한 시료로 부터, 1 종류 (N01)는 열 전처리하지 않은 시료로 부터 얻어졌다. H12와 H15의 섬유소분해활성은 N01보다 높은 것으로 조사되었다. H12와 H15는 액체배지에서 배양한 경우 37℃와 42℃에서 균체증식과 CMCase 생산이 좋았다. N01은 37℃에서는 잘 자라지 못 하였고, 42℃에서는 H12, H15와 비슷하게 성장하였으나 효소 생성은 거의 없었다. H12와 H15 균주에서 CMC 첨가에 따른 효소 생성의 유도는 전혀 관찰되지 않았다. 분리된 3 균주를 TSB에서 배양한 결과 LB 배지에서 보다 적어도 2배 이상의 많은 CMCase를 생산하였다. 이상의 결과는 시료의 열 전처리가 CMCase를 생산하는 균주를 선발하는 데 보다 좋은 방법일 수 있음을 시사한다. Three microorganisms producing carboxymethyl-cellulase (CMCase) were isolated from 30 soil and compost samples. CMCase activity, on plates containing CMC, of the two isolates, H12 and H15, screened by heat-pretreatment procedure, was higher than that of N01, the one screened by nonheat-treatment procedure. H12 and H15 were able to grow and produce the enzyme well at 37 and 42℃ in liquid culture media. N01 did not grow well at 37℃ but could grow moderately at a little higher temperature, 42℃. However, N01 did not produce CMCase in liquid culture media at 42℃. For H12 and H15, addition of CMC to the media did not increase the production of CMCase at all. All of the three isolates produced at least about 2 times higher CMCase activity in TSB medium than in LB medium. From these results, it is suggested that heat-pretreatment of samples can provide a better way of screening CMCase producing strains.

선택적 버퍼링을 이용한 MPEG 비디오 스트림 다중화 기법

허정석,윤상호,김명균 울산대학교 2000 공학연구논문집 Vol.31 No.1

ATM 망에서 MPEG 비디오 스트림은 CBR과 VBR 서비스를 이용하여 전송한다. 그러나 MPEG 스트림 트래픽은 시간에 따라 크게 변하는 특성을 가지고 있어 대역폭을 낭비하지 않고 효율적으로 전송하는 것은 매우 어렵다. 지금까지 하나의 MPEG 비디오 스트림의 트래픽 특서 및 제어에 대한 연구는 많은 연구자들에 의해 이루어져 왔지만 여러 개의 MPEG비디오 스트림이 다중화기에 의해 다중화된 트래픽의 특성 및 제어에 대한 연구는 이루어지지 않았다. 본 연구에서는 이러한 다중화기에 의해 다중화된 프래픽의 가변성 및 최대 셀 전송률을 줄이기 위한 다중화 방법을 제안한다. 다중화 트래픽의 최대 셀 전송률을 줄임으로써 이러한 트래픽을 가능한 대역폭의 낭비를 줄이면서 효율적으로 전송할 수 있게 된다. On ATM networks, MPEG videl stream is transferred using CBR or VBR services. But, because the MPEG video traffic varies greatly from time to time, it is very difficult to transfer the MPEG stream efficiently without loss of transmission bandwidth. Until now, the study on the traffic analysis and control on a single MPEG videl stream has been done by many researchers, but the trafic analysis and control on a multiplexed traffic of multiple MPEG video streams has not been studied by any researcher. This paper proposes a multiplexing method to reduce the PCR and traffic variance of a multiplexed traffic of multiple MPEG video streams. By reducing the PCR of the multiplexed traffic, the multiplexed VBR traffic can be transferred efficiently with less loss of transmission bandwidth.

형광등과 발광다이오드의 혼합광 조사가 아게라텀, 메리골드 및 살비아 실생묘의 생장 및 형태형성에 미치는 영향

허정욱,이춘우 충북대학교 첨단원예기술개발연구센터 1999 연구보고서 Vol.4 No.-

One of the factors to decide seedling quality has been known to control the plant height on production of plug seedlings. The growth inhibitor, physical stimulation, or DIF technique for controlling the plant height was commonly used. The experiment was conducted by mixing light with fluorescent lamps and Blue, Red, and Far-red Light-Emitting Diodes (LEDs) as a light source to investigate the effects of light quality on the growth and morphogenesis of flowering plants. Ageratum (cv. Blue Field), Marigold (cv. Orange Boy), and Salvia (cv. Red Vister) plants which developed with two true leaves were placed for 70 days in growth chamber, where air temperature and relative humidity were maintained at 25℃ and 70%, respectively. Photosynthetic photon flux on the culture shelf was kept at 10 μmol m-2 s-1, and photoperiod was provided at 16 h per day. In FL+Blue, FL+Red, and FL+Far-red treatments, total dry weight of Salvia plants was above 2 times greater than in FL treatment. Plant height of the flowering plants was the tallest in mixing light treatment with fluorescent lamp (FL) and Far-red LED. The plant height in all the plants was not significantly different between the FL treatment and the mixing light treatment with FL and Red LED. Number of flowers in Marigold and Salvia plants was not significantly different in all the treatments. Flowering rate of Ageratum plants on day 70 was 100% in all the treatments regardless of light qualities, although Marigold plants never bloomed in FL+Blue and FL+Far-red treatments during the culture period.

二次元 彈性有限要所解析에서의 效果的인 Mesh 構成에 관한 硏究

허정환,양원호 成均館大學校 科學技術硏究所 1991 論文集 Vol.42 No.1

Finite element method is widely used in analysis of engineering problems such as mechanical design and structural analysis. Recently, its use has been increased according as its rapid developement of theory, computer hardware and good general-purpose sotfwares. Due to such developement, complex and various engineering problems are analyzed quickly. But, because much cost are consumed in preprocessing, applicative efficiency of finite element analysis doesn't come up to such development. And finite element analysis depends upon experience of user in modeling, mesh design and analytic method. Therefore, user must be accustomed to use finite element method which is a burden to designer and user. Thus automatization of adaptive mesh generation is imperative to reduce much cost. There are many kinds of the method for automatic mesh generation such as node connection method, mapping method, cell decomposition method, etc. In this study, however, discrete transfinite mapping were used. And C language was used in automatic mesh generation routine. Error indicator and error estimator are defined using error of energy norm. Synthetic results of above study are as follows 1) The mesh which has good correlation with boundary curve is obtained using discrete transfinite mapping. 2) User input error can be minimized by minimum input data. 3) Fine mesh is easily generated using weight value, therefore drawback of discrete transfinite mapping method is settled. 4) User can easily use the program using pull-down menu and and pop-up window. 5) Mesh refinement well be applicated in stress concentration problems.

사회복지시설 종사자의 근로실태를 통해 본 복지행정의 문제점과 그 개선방안

허병도,감정기 慶南大學校法學硏究所 2004 慶南法學 Vol.19 No.-

Korea's Constitutional Law regulates the realization of a welfare state's ideology as a responsibility and obligation of the state. Welfare institutions play a very important role in this realization as the workers in these places accomplish this. However, workers in the social welfare work under unsatisfactory conditions and for low wages. The reason for this is that politicians in South Korea failed to appropriate properly the funds in the budget for them. In general, politicians do not understand enough about social welfare and the administration is still under a kind of authoritarianism. So their welfare administration cannot exercise their just rights. Certain things need to be done. First, employers must pay proper wages to workers of the social welfare service institutions in proportion to the quality and quantity of their work. Also, the government must budget adequate funds so that employers observe legal working conditions. Many parts of the administration guidelines differ from the Labor Standards Law, and thus revisions are required so that the operation of these institutions is self-regulated and does not un in opposition to the law. In addition, the workers of welfare institutions who want to keep their rights and interests themselves must exercise labors' three basic rights pertinently, but they also must make propositions to persuade the government. These kinds of efforts will be better as labor unions solidify solidarity with industrial unions. In this case, workers had better not disregard the fact that healthy labor union activities must not harm the clients of the institutions. I hope the government is very considerate to workers even before they engage in violent struggles and treat them well so that they do not need to oppose the law. This will help workers pour out their passion into their duties and responsibilities instead of into exercising their rights.

입자상 오염물질의 대기환경기준에 관한 연구

허정숙,남보현,황인조,김동술 경희대학교 환경연구소 1999 環境硏究 論文集 Vol.9 No.-

We provide various fundamental statistics for PM-10 based on air quality monitoring data('96-'98) operated by the Ministry of Environment. The purposes of this paper are to examine the distribution of PM-10 level computed on the basis of a reference method adapted by USEPA and to review national ambient air quality standards for particulate matter in Korea. When we calcualted the 3-year('96-'98) average of the annual mean PM-10 concentrations at 24 monitoring sites. 21 sites were not met 50㎍/m(annual PM-10 standard in USA). Especially. Duckchon-dong and Shinpyung-dong sites at Pusan were recorded the highest concentration. Also, when we considered the 3-year average of the 99^(th) percentile values, 14 sites including Ssangmun-dong at Seoul and Duckchon-dong at Pusan among 23 were classified non-attainment area exceeding 150㎍/m(24-hour PM-10 standard in USA). We suggest that the air quality standards for PM-10 and PM2.5 in Korea must be actually regulated based on scientific review and the public health.