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서문경애,장성옥,조경희,김인아,이수정 대한간호학회 간호행정학회 2006 간호행정학회지 Vol.12 No.1
Purpose: This study was undertaken in order to suggest self-leadership as a way to promote organization efficiency of nursing organization. So the relation between self-leadership and outcome of nursing practice inorganization was studied. Method: The subjects of study were nurses as a population who were working for the 2 of university hospitals which have over 500 beds in Kyong Ki Province as well as who have been working for over 6 months. The data was collected by questionnaires from 215 nurses and analyzed using descriptive statistics, perason correlation coefficient, t-test and ANOVA on SAS Program. Results: Self-leadership of nurse got 3.51 grade out of 5 as a mean point. Each of the segments got 3.74 in self-compensation, 3.57 in self-expectation, 3.53 in goal-setting, 3.45 in rehearsal, 3.37 in self-criticism and 3.30 in constructive thinking in order. Independent performance of nursing practice at each items of outcome of nursing practice showed the highest correlations with the self-expectation among self-leadership segments. Constructive thinking, self-compensation, rehearsal, goal-setting were related like this in order, but self-criticism was related just a little. Dependent nursing practice has the highest correlation with the self-expectation, goal-setting, rehearsal, constructive thinking, self-compensation were similar as aboves in order, but self-criticism didn't show any similar correlations. Relationship practice has the highest correlation with the self-expectation, and goal-setting, constructive thinking, self-compensation, rehearsal were similar, while self-criticism did not show any correlations. Conclusion: In conclusion the result was obtained that self-leadership is much correlated with outcome of nursing practice. Therefore, as a way to promote efficiency of nursing organization, the constant study about self-leadership with the various aspects is needed focusing on self-management and inner motivation as a new leadership paradigm.
위암세포에 의한 종양침윤 림프구의 면역반응 억제기전에 관한 연구
박정규,송규상,서광선,최정목,배진선,장일성,윤완희,노승무,조은경,백태현 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3
Tumor-infiltrating lymphocytes ('1°ILs) interact most closely with tumor cells and thus are more likely to reflect tumor host interactions accurately. But it is unknown whether such T cells are nonspecific inflammatory cells or a subset of specific host immune responses. In this study, there was no clear correlation between the infiltration of T lymphocytes in stomach cancer and the overexpression of c-ErbB-2 or increasing class I MHC expression on tumor cells. A positive correlation was seen between the presence of TILs in the tumor and tumors with diploidy by flow cytometric DNA analysis. The proliferative responses of Ills stimulated with IL-2, anti-CD3 mAb, or both were examined. When compared to normal mucosal-associated lymphoid tissue lymphocytes, the proliferative response of TILs to high dose IL-2 was minimal. A similarly poor response to anti-CD3 mAb plus IL-2 was also observed. The freshly isolated TILs exhibit reduced ability to proliferate in response to IL-2, anti-CD3 mAb or both. The microenvironment of the tumor suppresses the proliferative capacity of the TILs. The mechanism of this suppression remains unknown. It could be mediated by suppressor cells, by soluble substances within the tumor, or both. To examine this question, supernatants of stomach cancer cells (SNSNU-1) were tested for the presence of immunosuppressive factors. Human peripheral blood T-cells and tumor-draining lymph node lymphocytes (TDLNL) were incubated for 3 days with SNSNU-1 and then assessed for proliferative responses to PMA, anti-CD28 mAb, or both and for the inducibility to express IFN- r or IL-4 mRNA to PMA. Peripheral blood T-cells pretreated with SNSNU-1 were unable to proliferate in response to PMA, anti-CD28 mAb or both. SNSNU-1 also produces inhibitory activities of TDLNL proliferative response to PMA or anti-CD28 mAb and PMA (49%, 52%, respectively). In contrast, culture supernatants obtained from HEp-2, K562 or Daudi showed normal proliferative responsiveness of peripheral blood T-cells and TDLNL by PMA, anti-CD28 mAb or both.
Establishment the produce high-quality log cultivation system of entinula edodes through smart farms
Hee Gyeong Jeong,Kyung Je Kim,Seong Woo Jin,Young Woo Koh,Seung Bin Im,Neul-I Ha,Sang Wook Jeong,Seung Eon Ban,Eun Kyoung Jang,Yu Seon Kim,Jae-Keun Lee,Kyong-Won Yun,Kyoung Sun Seo 한국버섯학회 2021 버섯 Vol.25 No.2
( Gyeong Min Jeong ),( Hee Jeong Cha ),( Ji Hun Lim ),( Hawk Kim ),( Jae Cheol Jo ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Myeloproliferative neoplasm is associated with lymphoproliferative disease after cytotoxic drugs or radiation exposure, despite the rarity prior to therapy. Methods: We report a 61-year-old female patient with a history of transient ischemic attack who was simultaneously diagnosed as having follicular lymphoma and unclassi- fiable myeloproliferative neoplasm. Results: The patient complained of palpable mass on epitrochlear area of left arm, recently. Excisional lymph node biopsy revealed the follicular lymphoma (grade 1) with stage I. Laboratory findings showed leukocytosis (white blood cell 16040/μL), erythrocytosis (hemoglobin 17.5g/dL, hematocrit 58.3%), thrombocytosis (platelet 782000/ μL), decreased erythropoietin 6.26mU/mL. Bone marrow biopsy disclosed hypercellularity with predominance of erythroid series and big polylobated megakaryocytes with inceased mitotic figures, and no evidence of lymphomatous infiltration. JAK2 V617F mutation was detected in bone marrow specimen. After local excision of lymph node on left epitrochlear area, radiation is delivered to the involved field at a dose of 24 Gy in 12 fractions. She was started on hydroxyurea 1g bid orally, in 2 weeks passed after the end of the radiation therapy, and has been maintained with hydroxyurea 500mg bid. After 6 months of follow up, her WBC decreased to 7430/μL, hemoglobin to 12.2g/dL and platelet count decreased to 379000/μL and the patient keeps in good condition. A computerized tomography scan of the neck, chest and abdomen also were within normal limits. Conclusion: This is a first case report on follicular lymphoma coexisting with unclassi fiable myeloproliferative neoplasm in a previously healthy patient. On this extremely infrequent disease association, molecular and genetic studies warrant.