기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.

갑상선 수질암종과 유두암종의 동시 발생된 1례

고진우,김도형,김미경,김현옥,최영식 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

저자들은 태생학적 기원, 면역조직화학적, 분자생물학적으로 완전히 별개의 암종인 갑상선 수질암종과 유두암종이 동시에 동일한 갑상선에 발생하는 매우 드문 사례를 경험하였고 이러한 현상이 우연한 동시 발생인지, 공통의 줄기세포 기원인지 혹은 공통의 암 유발인자에 의한 것인지는 여전히 논쟁의 여지를 남겨두고 있다. It is generally believed that the origins of medullary and papillary carcinoma of thyroid are embryologically different. So mixed medullary-papillary thyroid carcinomas are rare. The two separate tumors of the present case may be coincidental double primaries. It can be assumed that at least some of the mixed papillary and parafollicular cell carcinomas are results of collision of carcinomas derived from two embryogenetically different cell types. Recently, we experienced a case of mixed medullary-papillary thyroid carcinomas. A 50-year-old woman was found to have mixed medullary thyroid carcinoma and papillary thyroid carcinoma on the same lobe with lymph node metastases. We report a this case with literature review

조선업 도장작업자의 유사노출군과 노출변이; 크실렌 노출을 중심으로

고상백,노영만,임현우,신용철,김수근,최홍열,김재용,장성훈 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : 조선업 도장 작업자의 크실렌 노출을 평가하기 위하여, 수행직무 및 밀폐특성에 따라 유사노출군으로 구분하여 노출 변이 및 동질성을 파악하고자 하였다. 방법 : 3회 이상 반복측정이 이루어진 근로자 중동일공정에서 직무상 변동이 없는 근로자 총 28명을 대상으로 하였다. 노출농도 값을 대수전환(lOgtransformation)하여 근로자간, 근로자내 노출 분산요소을 추정하기 위하여, nested randomeffects ANOVA model을 활용하였다. 선정된 유사노출군 내 구성원의 측정 평균이 동일하다고 할수 있는지를 검정하기 위하여 분산요인(9f)을 산출하였고, 쿨즈0.031일 경우 동일하다고 생각하였다.또한 노출 값을 대수전환하여 95 %의 근로자(b-R9s)가 2배수 범위 내에 측정값을 가질 경우 동일하다고 생각하였다. bwRSS의 값을 유사노출군내의 근로자들간(between worker)의 기하표준편차(bwsy)를 구한 후 exp(3.92 bwsy)로 계산하여 산출하였고, 그 값이 2이하이면 동일하다고 생각하였다. 결과 : 일반적으로 유사노출군은 노출농도가 비슷한 것이라는 생각과는 달리, 직무에 근거한 유사노출군은 동질성 검정상 이질적이었다. 분무도장과 붓도장 모두 bwRss은 2를 초과하였고, 룰 또한 0.031를 초과하여 변이 폭이 컸다. 그러나 밀폐특성에 따른 노출 분포의 변이성은 직무만으로 구분했을 때의 변이지표 보다 그 수치가 낮아 밀폐특성으로 직무의 변이성을 설명 할 수 있었다. 결론 : 직무에 근거한 유사노출군이 동질적이지알다는 결과는 유사노출군으로 구분된 근로자의 업무특성이 하나의 유사노출군으로 설정할 수 없다는 점을 시사한다. 따라서 향후 작업환경 측정 시 직무뿐만 아니라 특정 업무(specific task) 또는 세부작업현황까지 파악할 필요성을 제시하고 있다. Objectives : This study was conducted to assess the concentration of xylene exposure and exposure variability of a similar exposure group (SEG) in accordance with job title and confined space. Method : The study subjects included 28 workers working in the painting process in the ship-building industry. Measurement of subjects were repeated three times. Within and between-worker exposure valiance components were estimated from log-transformed exposure concentrations employing a one-way nested random effects analysis of variance model. A uniformly exposed group was defined as one where the between-worker variance(σB2) was less than or equal to 0.031 or bwR95 ≤2, where bwR95 =exp(3.92 bwSy) , representing the radio of the mean exposures of the 97.5th and 2.5th percentile groups of the workers sampled. Result : The results indicated that, contrary to popular belief, similar exposed groups based on job title were heterogeneous. The between-worker variance(σB2) is large(≥0.031) and the ratios of the 97.5th and 2.5th percentile workers of the log normally distributed exposures of each group of worriers was more than 2. However dividing job title into confined space (in-block, out-block, in/out-block) decreased the between-worker exposure variability. Conclusion : This study focused on the quantitative aspects of exposure in painters in the ship-building industry. We cannot accept the assumption that SEG are uniformly exposed, as a major component of variation in exposure relates to differences in tacks or other factors. Therefore, the observational schemes can be improved by investigating Job-specific task and practice.

저장물의 적재방법에 따른 저온저장고의 열성능 분석

김석우,김성만,현명택,최동호,고정삼,박영하 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

The heat performance in a forced circulating cool storage room was numerically investigated. A commercial PHOENICS package was used to simulate 3-D airflow. For solving the governing equations a standard k-ε turbulent model was implemented to calculate steady state turbulent velocity and temperature distributions. The results show that the large air contacting area of products increases the storage quality, because the airflow between products helps to remove the heat from the products by convective heat transfer.

농가용 저온저장고의 제어변수에 따른 성능평가

김석우,김성만,현명택,최동호,고정삼,박영하 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

The low temperature storage method has been used to increase the value of agricultural products by reducing quality deterioration and controlling respiration rate. The respiration rate of agricultural products depends on several factors such as temperature, moisture, gas composition and microbe inside the storage room. Among that temperature is the most important factor, which affects respiration rate and causes severe damage. The results obtained from these experiments are that electric consumption is decreased as setting temperature is decreasing and temperature deviation is increasing. In the ventilation experiment, the case ventilated four times a day(every six hours a day) with ten minutes operation each time, was inspected require as much electric consumption as non-ventilation case.

급성 백혈병환자에서 발생한 급성 심근 경색증의 치료로 시행된 Primary Coronary Stenting

김영우,하종권,심원흠,고윤웅 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.8

各種 食品에서 分離한 眞菌 培養液으로 處理된 마우스 肝細胞의 電子顯微鏡學적 觀察 : Ⅰ. 數種 mycotoxin 分泌菌株(Reference株)에 對한 成績 Ⅰ. Results of Several Reference Strains

등영건,高春明,金聖光,孫瑀鍾,崔大卿 최신의학사 1974 最新醫學 Vol.17 No.4

The purpose of present study is to determine the toxicity of several mycotoxin-producing fungi, named A. flavus ATCC 15517, A. parasiticus RIB 1037, A. toxicarium RIB 4002, P. citrinum SWU 238, P. islandicum IFO 5235, P. tardum IFO 5787, and P. brunneum by observing the ultrastructural changes in the mouse liver cells. The results as follows: 1. All of the experimental animals treated with reference strains were observed the focal necrosis and inflammatory infiltration of liver parenchymal cell. 2. It showed cytoplamic changes such as dilatation of endoplasmic reticulum, swelling of mitochondria, detachment of ribosomes, increased number of lipid droplets and glycogens. 3. Nuclear and nucleolar alterations were also noted the nucleolar capping, segregation of nucleolar elements and irregularity of nuclear envelopes.

Thioacetamide에 의한 BALB/c 마우스 간의 시간별 약물대사효소 억제 양상 : A Time-Course Study

이정운,고우석,김갑호,배연경,하현정,한상섭,천영진,정태천 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

Thioacetamide is a potent hepatotoxicant which requires metabolic activation by cytochrome P450s (P450s) for toxicity. In the present study, the elevation kinetic of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities by thioacetamide treatment was investigated in male BALB/c mice. Inaddition, the inhibitory effects of thioacetamide on liver microsomal P450 enzymes were further investigated. Thioacetamide at 100 mg/kg/ was treated intraperitoneally for 6, 12, 24, 36, 48 and 72 hr. The blood was collected at the designated time for assaying the serum enzyme activities. To determine the P450 isozyme-specific activities. ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), and benzyloxyresorufin O-debenzylase (BROD) activities were determined for P450 1A1, 1A2 and 2B1, respectively, in liver microsomal fractions. The activities of ALT and AST were started to be elevated 6 hr after thioacetamide treatment andreached the maximun at 36 hr after the treatment. The elevated activities were dramatically recovered at 72 hr. The microscopic exmination of the liver specimen also showed a similar profile of hepatotoxicity. All P450-associated enzyme activities were time-dependently inhibited by the treatiment with thioacetamide. The maximum inhibition of P450 enzymes was observed 36 hr after the treatment. Because the inhibition of P450 enzymes by thioacetamide was time-dependent, our present results suggest that thioacetamide might inhibit P450 enzymes in mechanism-based inactivation.

역형성 핍지교세포종의 임상 분석에 대한 연구

이현성,최우진,고영초,이채혁,박효일 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objectives : In this study, the author reviewed the clinical features of the patients with anaplastic oligodendroglioma and evaluated the efficacy of surgery, radiation therapy and chemotherapy as a treatment modality. The study was intended to provide the standardized treatment option for this rare disease. Methods : The author present ten cases of pathologically proven anaplastic oligodendrogliomas from 1988 to 2002. A retrospective analysis of clinical presentation. radiological and pathological features, and the effectiveness of treatment was performed and the factors affecting prognosis were investigated. Fesults : The ten patients comprised of four males and six females. The mean age at diagnosis was 34.4 (8-70). The mean follow-up duration was 40.5 months. and two patents died of tumor progression during the follow-up(70, 86 months, respectively). The most common presenting symptom was seizure(70%). All patients underwent surgery and the tumors were removed as much as possible. Postoperatively, Radiation therapy was applied to seven patients. and PCV(procarbazine CCNU-vincristine) based chemotherapeutic agent was administered to five patients. Total removal was achieved in five cases and subtotal removal was possible in the rest. In the group with PCV therapy, complete remission was observed in two, partial remission, stable disease, and disease progression to death in one, respectively. The patients well tolerated the toxicity of chemotherapy. During the follow-up, tumor recurrences were observed in four patients, and they were treated with additional operations and/or chemotherapy. Mixed anaplastic oligoastrocytoma showed earlier recurrence than anaplastic oligodendrogliomas in this study(P=0.014), but the other clinical factors and treatment modalities were not related to the time of recurrence of the tumor. Conclusions : In this study, the authors confirmed the good response of postoperative radiological treatment and chemotherapy in patients with anaplastic oligodendroglioma. PCV chemotherapy should be considered as primary treatment method for the patients with anaplastic oligodendroglioma.

전두엽 상내측 신경교종의 수술 수 발생하는 운동보조영역 증후군

김재현,고영초,이채혁,권오기,최우진,박효일 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objective : This retrospective study was aimed to correlate characteristic neurologic deficits of transient contralateral motor weakness with or without speech disturbance(Supplementary Motor Area, SMA syndrome) after the resection of the gliomas in the superior frontal gyrus, especially with the extent of resection of the tumors. Method : Ten patients with medial superior frontal glioma, who underwent gross total or subtotal resection of the tumor, as well as, partial or complete resection of the spolementary motor area were studied. The following parameters were evaluate 1) tumor location 2) extent of resection 3) degree and duration of postoperative deficits. Result : Postoperative neurologic deficits were transient contralateral motor weakness with or without motor dysphasia. As a whole, postsurgical SMA syndrome occurred in 3 patients out of 10 patients with medial superior frontal gliomas(30%), who underwent gross total or subtotal resection of the tumors. Motor deficits were present in 3 out of 10 patients and speech disturbances in 2 out of 3 left frontal gliomas. Recovery of neurological dysfunction was rapid occurring between the 5th 14th POD and their neurological function returned almost normal in two patients. In the remaining one patient, who had preoperative mild motor weakness showed incomplete recovery of the worsened motor weakness and newly developed speech disturbance till 1yr postoperatively. Conclusion : The postsurgical SMA syndrome in patients with glioma in the medial superior frontal gyrus was not so uncommon phenomenon and well correlated with the extent of surgical resection of the supplementary motor area. Thus, preoperative awareness and warning about the possibility of the development of this charicteristic SMA syndrome is necessary.