Halothane 마취시 수축기 시간간격의 변화 : Part 2

이후전,진홍용,최병권 중앙대부설한국의과학연구소 1986 한국의과학 Vol.18 No.2

학습결손 보충을 위한 학습자료 개발·활용이 수학과 학력신장에 미치는 영향

오후진,이병길 공주대학교 사범대학 과학교육연구소 1998 과학교육연구 Vol.29 No.1

본 연구는 학습결손으로 인하여 수학교과에 흥미가 낮고 기초학력이 저조한 학생들에게 보충학습 자료를 개발하여 적용함으로써 학력을 신장시키고자 연구를 추진하였으며 결론을 요약하면 다음과 같다. 1. 학습과제를 협력학습으로 해결하게 함으로써 교사 중심의 획일적인 수업에서 탈피하고 학생 중심의 학습으로 유도하여 학습의 효율성을 높이고 상호 협력하는 대인관계를 갖게 하였다. 2. 보충학습자료를 통하여 결손학습을 보충해 줌으로써 수학교과에 대한 인식과 태도에 긍정적인 변화를 가져오게 하였으며 학습 동기를 유발하여 학생들로 하여금 학습에 능동적으로 참여하게 하였다. 3. 선행학습의 결손을 발견하고 이에 대한 교정학습이 이루어지도록 보충학습자료를 개발하여 학습에 적용함으로써 학생들로 하여금 학습내용과 학습과제를 파악할 수 있게 하였으며, 그 결과 수학과 학력 신장에 많은 도움이 되었다. The purpose of this study is to enhance the achievement in mathematics by developing compensatory learning materials and applying those to learning. The conclusions of this study are as follows. 1. Solving the learning tasks by cooperative learning guided instruction to learning by students from teaching by teacher, and it made learning effective and students cooperative in personal-relation 2. Learning materials for compensating learning deficit made students motivated and interested in mathematics, and active in learning. 3. By applying the learning materials for compensating prerequisite learning deficit, students could grasp learning contents and learning tasks, and their achievement could be enhanced.

암 환자의 혈장 Transforming Growth Factor-β1 농도

박병규,하우송,이시은,이수진,박순태,박찬후,전지현,장정순 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCINE 1999 Journal of biomedical laboratory sciences Vol.5 No.2

한국인의 대표적인 성인 고형 종양인 위암, 간암, 유방암과 소아 백혈병 및 2종의 소아 고형 종양 환자로부터 혈장 transforming growth factor-ß1 (TGF-ß1) 농도를 sandwich ELISA 분석법을 이용해 측정함으로써 TGF-ß1을 이 질환들에 대한 새로운 종양표지자 (tumor marker)로 사용할 수 있는지 검토하였다. 또한 연령 및 성별에 따른 혈장 TGF-ß1 농도의 정상치를 조사하였다. 신생아에서 70대까지 혈장 TGF-ß1 농도의 차이는 없었고 남녀간의 차이도 없었다. 위암 환자의 혈장TCF-ß1 농도는 16.0±6.8 ng/ml (평균 ±표준편차)로 정상 대조군의 TGF-ß1 농도 (8.3 ±5.0 ng/ml) 보다 유의하게 높았으나 간암, 유방암 환자의 혈장 TGF-ß1 농도는 대조군과 차이가 없었다. 그리고 위암 환자 16명, 간암 환자 8명, 유방암 환자 7명 중 각각 7명 (43.7%), 1명 (12.5%), 1명 (14.3%)에서만 혈장 TGF-ß1 농도가 증가되었다. 5명의 소아 백혈병 환자에서는 관해 (remission) 여부와 상관없이 혈장 TGF-ßl 농도가 모두 정상 범위에 있었으나 2명의 소아 고형암 환자에서는 종양 절제 전에는 혈장TGF-ß1 농도가 높았다가 절제 후 정상으로 떨어졌다. 결론적으로 1)정상인의 혈장 TGF-ßl 농도는 연령 및 성별에 따른 차이가 없다는 것을 알 수 있었고, 2)성인 고형암인 위암, 간암, 유방암에서는 낮은 민감도로 인해 TGF-ß1을 진단을 위한 선별 검사로 이용하기에는 부적절한 것으로 판단되었으며, 3) 정상 대조군보다 혈장 TGF-ß1 농도가 높았던 위암 환자와 종양 절제 전후로 혈장 TGF-ß1 농도가 민감하게 변했던 소아 고형 암 환자에 대해서는 향후 표본 수를 늘려 부가적인 연구를 해 야 할 것으로 사료된다. To evaluate the usefulness of transforming growth factor-ß1 (TGF-ß1)as a new tumor marker, we determined the plasma TGF-ß1 levels using sandwich ELISA assay in cancer patients. Patients with three most common adult cancers in Korea (stomach, liver and breast cancer) and children's cancers (leukemia and two kinds of solid tumor) were enrolled for the study. Furthermore, 39 individuals were subjected to age and sex-stratified plasma TGF-ß1 analysis. No statistical difference was demonstrated with respect to age or sex. The mean plasma TGF-ß1 level (16.0 ng/ml) of stomach cancer patients was significantly higher than that (8.3ng/ml) of controls. However, there was no difference among the mean plasma TGF-ß1 levels of liver, breast cancer patients and controls. Seven of 16 patients (43.7%) with stomach cancer, one of 8 (12.5%) with liver cancer, and one of 7 (14.3%) with breast cancer showed higher TGF-ß1 levels compared to controls. Plasma TGF-ß1 concentrations of five leukemic children remained in the normal range regardless of the remission state. In contrast, initial high TGF-ß1 levels from two children with solid tumors returned to normal range on surgical resection of tumors. From the above results, we could conclude that plasma TGF-ß1 levels of apparently healthy individuals seem to be rather constant irrespective of difference in age or sex, and the plasma TGF-ß1 has the limited value as a screening test for the diagnosis of aforementioned adult cancers because of its low sensitivity. Finally, additional studies need to be pursed for the large number of stomach cancer and pediatric solid tumor patients in order to reach a secure conclusion on the usefulness of plasma TGF-ß1 as a tumor marker in these patients.

충북지역 도시방재계획의 도시계획적 진단과 발전방향 : 도시계획서 분석 및 전문가 의견조사를 중심으로

백기영,황희연,박병호,이만형,황재훈,류을렬 永同大學校 1999 硏究論叢 Vol.5 No.1

본 연구는 도시방재계획의 현황을 도시계획적 차원에서 진단하고 그 발전방향을 도출하고자 하는 목적하에, 충청북도의 조례와 지침중 도시방재 관련 사항을 정리하며, 충청북도 지방도시계획위원회 회의록 및 관련자료를 검토하여 방계계획의 취급 수준을 파악하였다. 실제 도시계획 상황에 대한 진단은 도시계획 보고서를 대상으로 도시방재계획의 위상을 분석하고 평가하였다. 또한 도시방재계획의 위상과 관련 전문가의 인식수준을 평가하고 이를 바탕으로 향후 바람직한 도시방재계획의 위상을 설정하기 위해 필요한 사항을 분석하고자, 도시방재에 관한 일반의식 수준, 도시재해에 관한 대처방안, 도시방재계획의 평가방향 등을 중심으로 설문조사를 실시하였다. 이상과 같은 충북지역의 방재계획에 대한 도시계획적 진단을 바탕으로 도시방재계획 관리체계의 방향 도출과 도시방재계획의 향후방향 제안을 시도하였다. This paper examines the status quo of the existing urban disaster prevention plans in Chungbuk Province and suggests alternative orientations for the future application. Its methodological themes center around the systematic compilation and accountability of disaster-related ordinances, mostly hinged on evaluation of major disaster items documented in various urban master or revision plans. In addition, it recommends the concrete guidelines and contents in disaster prevention plans, both of which are based on the aggregated results of expert opinion survey in and around Chungbuk Province. In order to tackle with diverse and unpredictable disasters which are well observed in modern urban society, this paper urges that the relatively weak legal and planning standards of the existing disaster prevention plans have to be immediately revised. For instance, the paper vividly shows that the present dimension of disaster prevention plans within the existing master plans and perception of specialist are not satisfactory mainly because of the internal limitation of the existing plans. Secondly, it seems imperative for planners to pay attention to systematic operation and management, even starting from the early development stage of urban disasters. Lastly, it proposes the alternative checklists given to measure the suitability of the disaster plans.

2개월 남아에서 발병한 Malignant Ectomesenchymoma

황지영,서지현,김점수,김용숙,이수진,박찬후,김유경,박선후,이정희,안인옥,정기현,박병규 대한소아과학회 2001 小兒科 Vol.44 No.8

Heterologous Expression and Characterization of Glycogen Branching Enzyme from Synechocystis sp. PCC6803

( Byung Hoo Lee ),( Young Hee Yoo ),( Je Hoon Ryu ),( Tae Jip Kim ),( Sang Ho Yoo ) 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.8

Slowly digestible properties of highly branched α-limit dextrins at the level of mammalian mucosal α-glucosidases

Byung-Hoo Lee 한국당과학회 2018 한국당과학회 학술대회 Vol.2018 No.01

α-Amylase first hydrolyzes starch structures to linear maltooligosaccharides and branched α -limit dextrins, then complete hydrolysis to glucose takes place through the mucosal α -glucosidases. In this study, we hydrolyzed waxy corn starch (WCS) by human pancreatic α -amylase to determine the digestion and structural properties of different size fractions of the branched α-limit dextrins. The α-amylolyzed WCS was separated by size exclusion chromatography (SEC), and the analyzed chromatograms showed four main hydrolyzate fractions. The first three eluted peaks (regions I-III) corresponded to branched α-limit dextrins, while region IV was the linear maltooligosaccharides. Region I, II, and III had multiple (>2), two, and one α-1,6 linkages, respectively, and region I was the most slowly hydrolyzed to glucose by mucosal α-glucosidases (hydrolysis rate: Region I< II < III < IV). This study shows the possibility of producing slowly digestible oligosaccharides that may decrease postprandial glycemic response and control glucose delivery to the body, to address metabolic syndrome-associated diseases.

Number of branch points in α-limit dextrins impact glucose generation rates by mammalian mucosal α-glucosidases

Lee, Byung-Hoo,Hamaker, Bruce R. Elsevier 2017 Carbohydrate Polymers Vol.157 No.-

<P><B>Abstract</B></P> <P>α-Amylase first hydrolyzes starch structures to linear maltooligosaccharides and branched α-limit dextrins, then complete hydrolysis to glucose takes place through the mucosal α-glucosidases. In this study, we hydrolyzed waxy corn starch (WCS) by human pancreatic α-amylase to determine the digestion and structural properties of different size fractions of the branched α-limit dextrins. The α-amylolyzed WCS was separated by size exclusion chromatography, and the analyzed chromatograms showed four main hydrolyzate fractions. The first three eluted peaks (regions I–III) corresponded to branched α-limit dextrins, while region IV was the linear maltooligosaccharides. Based on the chromatographic and NMR analyses of the individual peaks, Region I, II, and III had multiple (>2), two, and one α-1,6 linkages, respectively, and region I was the most slowly hydrolyzed to glucose by mucosal α-glucosidases (hydrolysis rate: Region I<II<III<IV). This study shows the possibility of producing slowly digestible oligosaccharides that may decrease postprandial glycemic response and control glucose delivery to the body, to address metabolic syndrome-associated diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Branched α-limit dextrins were chromatographically separated into 3 size fractions. </LI> <LI> Maltooligosaccharides with branch points ≥2 were much slower digesting to glucose. </LI> <LI> Highly branched α-limit dextrins can be applied as slowly digestible carbohydrates. </LI> </UL> </P>

Regulating glucose delivery to the body and physiological importance

Byung-Hoo Lee 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.01

For decades, quality of starch-based foods has been associated with the in vivo measured glycemic index or the in vitro digestion rate-based categories of rapidly digestible, slowly digestible, and resistant starch (RS). Glycemic index has been related to health-based endpoints mostly through correlative or observational studies with mechanisms proposed, but not well established. Here, we bring forth the concept of locational delivery of glucose from dietary starches to the distal small intestine to elicit an “ileal brake” effect. Both effects slow gastric emptying and, in turn, extend nutrient (i.e., energy) delivery to the body and may decrease appetite and promote weight management. Slowly digestible starches are currently a popular topic of research, though where they are digested and the released-glucose is delivered in the small intestine is not known. A proposal is to further study and establish this mechanism of appetite and food intake regulation so that starch-based ingredients and foods can be developed that promote the ileal brake mechanisms.

Structural and gelling properties of very low methoxyl pectin produced by an alkali-treatment

Byung-Hoo Lee,Ho-Tak Jung,Hyun-Seok Kim,Sang-Ho Yoo 한국식품과학회 2021 한국식품과학회지 Vol.53 No.2

Very low methoxyl pectin (VLMP) has different physical and rheological properties compared to high and low methoxyl pectins (HMP and LMP). In this study, we produced LMP and VLMP by alkaline de-esterification, and investigated the structural and textural properties. Apple peel pectin was kept at pH 12 using 5.0M NaOH solution for 3 and 24 h to produce LMP and VLMP, respectively. The molecular weight was decreased due to the removal of an esterified group in the pectin backbones by the alkali treatment, and the VLMP showed a higher calcium ion sensitivity which leads to the production of the gel with increased hardness. The result clearly showed that VLMP has the potential to improve the texture and stability in food products depending on their degree of esterification, and this result can be applied as a functional ingredient in food industrial area application to enhance the current commercial pectins.