한국인 주요우울장애 환자에서 혈중 ACTH, Cortisol 농도와 해밀턴 우울 평가 척도의 신체증상 항목과의 상관관계

여혜빈,김린,함병주,심세훈,권영준,정희연,정한용,한상우,이민수,이화영 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:Hypothalamic-Pituitary-Adrenocortical(HPA) system dysregulation plays an important role in the pathophysiology of major depressive disorder. Medically unexplained somatic symptoms comprised the predominant complaints of korean patients with major depressive disorder. It might be related to dysregulation of HPA system and somatic symptoms. The aim of this study was to investigate the association between Hamilton Depression Rating Scale severity and the Plasma Adrenocorticotropic Hormone(ACTH) & Serum Cortisol level in Korean patients with major depressive disorder. Methods:Our study design was prospective. A total 111 hospitalized patients with major depressive disorder (DSM-IV) at Anam Hospital, Korea University Medical Center between Jan 2009 and May 2011 were selected. Hamilton Depression Rating Scale was measured by psychiatrist. Plasma ACTH, Serum Cortisol levels were analyzed at the time of admission. Results:There are significant correlations(p<0.05) between Hamilton Depression Rating Scale of somatic component(HAM-D 11-15 item) and Plasma ACTH and Serum Cortisol level. However, other HAM-D sub items were not significantly correlated with Plasma ACTH and Serum Cortisol level except somatic component. Conclusion:Our Study results suggest that hyperactivity of HPA axis might be correlation with somatic symptoms in korean patients with major depressive disorder.

자유진동 변위데이터를 이용한 철골구조물의 모드인자 파악

함희정 江原大學校 産業技術硏究所 2009 産業技術硏究 Vol.29 No.A

The proper orthogonal decomposition (POD) analysis of vibration of a steel frame structure is performed to extract modal parameters. The theoretical background of the POD method is introduced briefly, and this technique is further applied to free vibration displacements of one bay-two story steel frame structure to extract the modal parameters. From the POD analysis of the steel frame structure, it is found that important modal parameters such as true mode shapes, modal kinematic energy, natural frequencies, and damping ratios can be obtained for the building efficiently and in detail. Therefore, it is concluded that the POD method could be one of the useful techniques in analysis of vibration of structures.

접근풍속과 건물 변동풍압력에 대한 연속파동변화법의 적용

함희정 강원대학교 산업기술연구소 2005 産業技術硏究 Vol.25 No.B

Application of proper orthogonal decomposition (POD) and continuous wavelet transform (CWT) is introduced to study wind speed and building roof pressures of flow separation region. In this study, a detailed analysis of the approach wind flow, wind-induced building pressure and the relation between the two fields was carried out using the POD technique and CWT analysis. The results show potential of the application of POD and CWT in characterization of spatio-temporal and spectral properties of the approach wind and its induced dynamic pressure events. Some of findings resulting from the application of this analysis can be summarized as follows: (1) The POD first principle coordinate of the roof pressure in the separated shear layer is closely correlated with the longitudinal component of oncoming flow. (2) The CWT analysis suggests that the extreme peak pressure in the separated shear layer is due to condensed large-scale eddy motions.

방사선적 물리적 특성에 의한 담석의 성분 분석

함희원,성무경,전혜정,선관우 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

In this study, gall stones from 45 patients were analyzed in vitro. Gall stones from 23 patients were cholesterol stones and the others were non-cholesterol. Correlation with each radiologic physical properties(the number of stones, shape, calcification pattern, Hounsfield units measured by computed tomography) and chemical composition(cholesterol or non-cholesterol) were analyzed. The results revealed that the numbers and size were not related to the chemical composition, but there were significant correlation with faceted stones(p=0.002) or stones with no calcification (p=0.010) and cholesterol composition, and with irregular stones(p=0.000) or stones with dense calcification(p=0.015) and non-cholesterol composition. In study of Hounsfield units, it was difficult to fix the boundary, but the difference between cholesterol composition(138.43±281.81) and non-cholesterol composition(404.32±306.06)was significant(p=0.0109).

고층 타워에 작용하는 동적 풍압력의 POD 방법을 이용한 시공간적 특성 해석

이미화,함희정 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.B

The wind and wind-induced dynamic wind pressures fluctuate irregularly according to time and space. In this study, the proper orthogonal decomposition(POD) technique is applied to wind pressures acting on a tall tower model, and the following results are found: the along-wind and across-wind forces can be reconstructed by only four dominant POD modes, and the reconstructed errors are 4.71% and 22%, respectively for across-wind and along-wind directions. The physical meanings for dominant modes are also presented in the paper. The POD analysis can compress complex wind pressure data only by a few dominant modes and interpret spatio-temporal characteristics of wind pressure by novel way while existing statistical methods do not have such benefits.

도시발전에 따른 국지기후의 변화

김상진,이선영,함희정 대한건축학회 2003 대한건축학회논문집 Vol.19 No.5

Rapid urban development has significantly changed the regional climate and caused various environmental problems such as heat island. Air temperature increase in Tokyo during the past hundred years is much more rapid than the global air temperature rising. It is important to clarify the effects of urbanization on climatic change for adequate urban planning. Numerical model is expected a powerful tool which can estimate the effects of urbanization on climatic change. The model for geophysical flow problems developed by Mellor and Yamada is used for turbulence closure. The results of CFD (Computational Fluid Dynamics) analyses of mesoscale climate in the Tokyo area are presented. In this paper, five cases of computations are carried out in order to examine the influences of climatic change about effects of land-use conditions with urban development. We investigate temperature fields and velocity fields as buildings area and paved road area is changed to forest or grass, etc. Futhermore, climatic change from the end of the Japanese Medieval Period (Edo period, around 1830s) to the present is analyzed. By comparing the results of these analyses, the effects of urbanization on the heat island in the Tokyo area are clarified.

개에서 실리콘고무를 골막으로 싸서 안면골 위에 이식시 그 골막에 일어나는 조직학적 변화

박관규,강진성,함희정,한기환,최동원 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.3

Bony depression in the face may occur doe to congenital failure of development trauma or excessive surgical resection. Various materials, autogenous bone, autogenous cartilage and silicone rubber have been employed for bony contour restoration. Since autogenous bone grafts become consolidated with the underlying recipient bones, the incidence of extrusion or deviation of the graft is much fewer. But they may be easily fractured at the time of carving because of their rigidity. Autogenous cartilage grafts do not require contact with the nasal bony framework, but they tend to curl and bend. Using silicone rubber is a simple and fast procedure, but the prosthesis itself is a foreign body which causes occasional foreign body reaction or exposure of the prosthesis. Therefore, the materials, which have such nature as consolidation, complete contact and convenience without complication are considered to be ideal for augmentation of the bony depression. It may be an ideal material for prevention of the complication of the implants, if a new bone formation at the gratted periosteum wrapping the silicone rubber implants develops. To confirm the possibility, biological test with dogs was initiated. Six samples of periosteum and fascia wrapping the silicone rubber implants, respectively were collected from 9dogs at 8, 16 and 24 weeks. Grossly, difference between translucent periosteum and whitish fascia was noticeable at 8 weeks after implantation. However, it is difficult to distinguish between fascia and periosteum at 24 weeks. Histologically, fibrous capsule developed at 8 weeks and there was a marked thickening at 24 weeks on both periosteum and fascia. At one of 6 samples of 24 weeks periosteum, wrapping the silicone rubber implant, formed a new bone. In conclusion it is possible for the grafted periosteum wrapping the silicone rubber implants to make a new bone. Therefore the periosteum and fascia wrapping the silicone rubber are well taken at the recipient site. Also, they play a good role of barrier against exposure of implant. Especially the periosteum is better than the fascia, because of its bony formation and easier obtaining

홍삼류의 섭취가 비만과 혈중 지질의 상호관계에 미치는 영향

박화진,이정희,이소진,함혜선,조현정,임창률,유영빈,박기현 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.4

비만은 동맥경화의 위험인자로서 혈중에 triglyceride의 농도를 종가시키고, 상대적으로 HDL-Cholesterol의 농도를 감소시킴과 동시에 수축기 혈압을 상승시킨다. 본 연구에서 홍삼제품류를 4년 또는 5년 동안 복용해 온 건강한 사람 (ginseng군)과 홍삼제품을 복용하지 않은 건강한 사람 (control군)을 대상으로 하여 신체 계측치로부터 비만지수를 구하고 이것과 혈중의 triglyceride (TG)농도, TG/HDL-Cholesterol ratio 및 수축기 혈압과의 상호관계를 연구한 바, ginseng군에서는 대조군에 비해 혈중의 TG 농도가 일정하게 유지되었고, TG/HDL-Cholesterol ratio 및 수축기 혈압도 일정하게 유지되었다. 이러한 현상은 ginseng군에서 기호품으로 alcohol을 섭취하거나, 흡연을 한 경우에도 상관없이 일정하게 유지 되었다. 이 결과는 홍삼제품류를 장기 복용하면 비만의 저하 및 고혈압 또는 동맥경화의 위험인자가 억제될 수 있고, 결론적으로 비만, 고혈압 및 동맥경화를 예방할 수 있을 것으로 추정한다. Obesity is the risk fcactor of atherosclerosis and not only increases triglyceride concentration in blood but also decreases relatively the ratio of TG to HDL-Cholesterol in blood. In case of obesity, systolic blood pressure is also increased in responding the increase of TG in blood. Index of obesity in red ginseng-taking group (ginseng group) was lower as compared with non-red ginseng-taking group (control group). The TG concentration, the ratio of triglyceride to HDL-cholesterol in blood and systolic blood pressure were decreased in the subjects of ginseng group compared with that in control group. It is inferred that long-term intake of ginseng products may help to prevent the risk of atherosclerosis and obesity.

평면형 Bi-Sb 다중접합 열전변환기의 특성

이현철,유호종,김진섭,함성호,신장규,이종현,이정희,권성원,박세일 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

A planar Bi-Sb multijunction thermal converter for the precise measurements of ac voltage and current has been fabricated and its characteristics was discussed. In order to convert ac power into heat, a bifilar thin film Pt-heater, which could cancel its Thomson and Peltier effects, was prepared on the Si_(3)N_(4)/SiO_(2)/Si_(3)N_(4) diaphragm for the thermal isolation between heater and silicon substrate. To convert the temperature or the heat generated by the heater into dc voltage and current, hot and cold junctions of the Bi-Sb thermopile, which has a large difference in Seebeck coefficients, were formed on the dielectric diaphragm and the silicon substrate, respectively. The respective thermal sensitivity of the thermal converter with a bifilar heater was about 10.1 mV/mW and 14.8 mV/mW in the air and vacuum, which is about eight times higher than that of commercial 3-dimensional thermal converter. In the case of ac 2 V-input voltage, the ac-dc voltage transfer difference was about ±2.0 ppm, and in the case of ac 10 mA-input current, the ac-dc current transfer difference was about ± 0.6 ppm, in the frequency range from 10 Hz to 10 kHz.

톨루엔을 포함한 유기용제의 직업적 폭로로 인한 신경내분비계 영향

이채언,이종태,정의화,손혜숙,문덕환,전진호,강정학,이창희,김휘동,김종한,정귀옥 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2

Long term occupational exposure to solvent mixtures may cause adverse effects to the central nervous system with neurobehavioral symptoms. And some organic slovents have been suggested to cause impairment of tuberoinfundibular dopaminergic activity and neurochemical mechanisms controlling pituitary secretion. For the purpose of assessing neuroendocrine effects in occupational solvents exposure, hormonal study settings (shoes-manufacturing industry & fishing products industry) and compared with nonexposed controls(33 men, 85 women). Male workers exposed to solvent mixtures had significantly lower plasma level of follicle-stimulating hormone(FSH) than nonexposed male controls. While female workers exposed to solvent mixtures had significantly lower plasma levels of growth hormone(GH), and thyroid-stimulating hormone(TSH) than nonexposed female controls. The results of significant decrease in plasma concentrations of pituitary hormones(FSH, GH, and TSH) in workers exposed solvent mixtures indicate that occupational exposure to solvent mixtures may induce neuroendocrine effects through an effect on hypothalamic pituitary axis.