빈혈판정 지표로서의 헤모글로빈, 헤마토크릿 및 혈청 페리틴

정해랑,문현경,송범호,김미경 이화여자대학교 생명과학연구소 1991 생명과학연구논문집 Vol.2 No.-

본 연구는 생화학적 검사에 의한 철 영양상태의 판정시 검사항목에 따른 판정의 정확도를 보기 위하여 외견상 건강한 18!21세의 여대생 57명을 대상으로 혈액성분 중 Hb, Hct, serum ferritin을 측정하고 그 상관성을 분석하였다. 1) 조사대상자의 Hb는 평균이 13.9±0.96g/dl, 중앙값이 14.2g/dl였다. Hct의 평균은 41.4±2.85%, 중앙값은 42.0%였고,ferritin은 평균 20.7±15.5ng/ml, 중앙값 16.5ng/ml,최빈값 3.40ng/ml였다. Hb, Hct, ferritin값 모두 Kolmogorov-Smirnov test결과 정규분포 하는 것으로 나타났다. 2) Hb와 Hct간에는 r=0.9467(p<0.001)로 <Hct=2.28+2.81×Hb>의 회귀관계를 보였다. Hb와 ferritin간에 r=0.5591((P<0.001)로 <log(ferritin)= -1.73+0.07×Hct>의 회귀식이 구해졌다. 3) 빈혈발현율은 Hb 12g/dl를 기준시 5.3%, Hct 36% 기준시 10.5%, ferritin 12ng/ml 기준시 36.8%였다. 4) fFerritin함량을 기준하여 Hb, Hct판정에 대한 신뢰도를 분석한 결과, 빈혈 판정시 많이 이용되는 Hb 12g/dl 미만이나 Hct 36% 이하를 기준했을 때 두 방법 모두 sensitivity가 매우 낮았으며 specificity는 매우 높은 값을 보여, 빈혈 발현율이 높은 우리나라의 경우 Hb나 Hct의 판정기준치를 높일 필요가 있는 것으로 나타났다. 5) 빈혈 판정을 위한 검사방법으로서의 Hb측정은 sensitivity, specificity등을 고려할 때 판정 기준치를 14g/dl로 하는 것이 타당할 것으로 보인다. Hct의 경우 판정치를 40%로 높일 경우에 false-negative rate가 42.9로 낮아졌다. The iron status of 57female college students was evaluated by measurements of hemoglobin(Hb). hematocrit(Hct) and serum ferritin(Ferritin). Mean values for Hb. Hct and Ferritin were 13.9±0.96g/dl. 41.4±2.85% and 20.7±15.5ng/ml. respectively. Ferritin as well as Hb. Hct were not statistically different from normal distribution. although ferritin were skewed to the right. The prevalence of anemia defined by Hb<12g/dl. Hct≤36% and Ferritin<12ng/ml were found to be 5.3,10.3 and 36.8%. respectively. By using Hb as a screening tool at a cutoff point fo 12g/dl. 2.8% of healthy subjects will be incorrectly classified as anemic and 90.5% of anemic as healthy. Sensitivity and specificity were calculated at various cutoff points of Hb and Hct. The estimates of sensitivity and specificity allow Hb 14.0g/dl as cutoff point for good predictor of anemia.

Culture conditions of gametes and their evaluating systems in mouse /

박기상,송해범 대구대학교 생명과학연구소, 2003 생명과학연구 Vol.2 No.2

기능성척추측만증에 근막이완요법 및 전침치료 증례

김성욱,강영화,이상훈,권혜연,조태성,송춘호,안창범 동의대학교 한의학연구소 2001 동의한의연구 Vol.5 No.-

목적 : 우리는 신체를 근막의 통합된 전체로 보는 근막이완요법과 TrP를 파괴하는 전침요법을 기능성 척추측만증에 적용시킬수 있는지 알아보았다. 방법 : 22세의 기능성 척추측만증을 가진 남성에게 다양한 형태의 근막이완요법을 적용하였고, 중둔근, 요방형근, 슬괵근에 전침요법을 적용하였다. 결과 : 3주시술후 다리길이차이, 근막구축, Cobb's 각과 척추회전변위가 감소되었고 흉부압박감 같은 전신적증상이 호전되었다. 결론 : 근막이완요법과 전침병행치료가 신체를 근막의 일체로 보는 관점으로 인체의 구조적불균형을 바로 잡아줄수 있는 새로운 치료법의 기능성을 찾았다. Objective: We investigated this study in order to see the adaptation capability of myofascial release that translating the body being integrated fascial totality and electroacupuncture treatment that breaking trigger points in functional scoliosis. Methods: We applied myofascial relase by three patterns and electroacupuncture in TrPs of gluteus medius, Quadratus lumborum and Hamstring muscle to 22 year-old who have had functional scoliosis. Results: After 3 weeks, The leg length, fascial restriction. Cobb's angle and rotation scoliosis are decreased. Systemic symptoms, for example; chest discomfort are improved. conclusion: Myofascial release and electroacupuncture treatment is new methods that treating the sturctural unbalance in view of body's fascial network.

A Facile Synthesis of 5(4H)-Oxazolones

Song, Sang-Yup,Jung, Bok-Yung,Lee, Kyung-Hae,Kim, Hong-Bum Korean Chemical Society 1994 Bulletin of the Korean Chemical Society Vol.15 No.7

위장관 폴립 치료에서의 전기소작절제술과 레이저조사술의 비교연구

송인성,이진호,김해련,노임환,유권,정현채,이효석,윤용범,김종룡 대한내과학회 1990 대한내과학회지 Vol.38 No.1

The gastrointestinal polyp is a premalignat lesion in varying degrees, according to the size, the pathology and the location of polyps. Polyps in the gastrointestinal tract can be removed by surgical excision, electrosurgery, cryotherapy, contact radiotherapy and laser therapy with each some limitations. We compared the effectiveness and the safety of electrosurgical polypectomy and laser irradiation conomonly used for polyp removal. The patients were diagnosed as having gastrointestinal polyps endoscopically and benign polyps pathologically with endoscopic biopsy(n= 143) from January in 1984 to April 1989. Then, the results were as followes by grouping gasting polyps(n=74) and colorectal polyps(n=69). 1) The mean age of patients were 54 years in gastric polyps group and 52 years in colorectal polyps group. The gastric polyps were more frequent in woment but colorectal polyps in men of men: women ratio, 1:1.5 and 2.3:1 respectively. 2) Epigastric discomfort were the most frequent symptoms in gastric polyp patients and anal bleeding in colorectal polyp patients(32%, 31%). 3) The gastric polyps were located in pyloric antrum most frequently(53%), and colorectal polyps in rectum ,and sigmoid colon(37%, 35%). 4) The gatric polyps were even in gross type of polyps, but the colorectal polyps were frequent of Yamada type Ⅳ(42%). The most gastric polyps were hyperplastic type in histological typs(75%), but the most colorectal polyps adenomatous type(72%), containing frequent villous component(16%). 5) The malignant foci were found in a case of gastric electrically polypectomized specimen(6.3%) and in 2 cases of colorectal electrically polypectomizd specimen(6.9%). 6) The mean size of polyps wer 0.95% cm in gastric polyps and 1.09 cm in colorectal polyps (p>0.05). 7) The effectiveness of each methods were assessed by session number of treatment. All electrosurgical polypectomy were completed in 2 sessions. But, laser therapy were extended over 3 sessions in 25% of cases. 8) The safety of each methods were assessed by the frequency of complications, such as ulcer and erosion of minor complications and massive bleeding requiring transfusion and bowel perforation of major complication. Ulcer and erosion developed in 24% and 6% of electrosurgical polypectomy patients and in 52% and 15% of laser therapy patients(p<0.05). One case of the massive bleeding and 2 cases of bowel perforation developed in electrosurgically polypectomized patients. But no case of major complications developed in laser irradiated patients. So, the electrosurgical polypectomy was more effective but laser therapy was safter than electrosurgical therapy. We recommended that the electrosurgical polypectomy be tried initially, especially in Yamada type Ⅳ polyps, and laser therapy in other cases including inoperable malignant polyps.

생식선자극(生殖腺刺戟) 호르몬 처리가 산양의 배란난자(排卵卵子) 및 난포란(卵胞卵) 채취에 미치는 영향

송해범,입곡명 한국낙농학회 1986 韓國酪農學會誌 Vol.8 No.4

本 硏究는 成熱 및 未成熱 雌山羊에 生植腺剌載호르몬 처리가 排卵卵子 및 卵胞卵 채취에 미치는 영향을 검토하기 위하여 18 頭의 成熱雌山羊과 21 頭의 未成熱雌山羊을 公試하여 실시하였다. 實驗結果를 要約하면 다음과 같다. 1. 穎粒膜細胞에 둘러 쌓인 卵胞卵은 未成熱雌山羊에서 호르몬 무처리구 22.7개, PMSG처리구 54.2개, PMSG와 HCG 처리구 25.8개였으며, 成熱雌山羊에서는 PMSG 처리구 16.3개, PMSG와 HCG 처리구 7.8개였다. 2. 擴散된 穎粒膜細胞에 둘러 쌓인 卵胞卵은 PMSG와 HCG 처리구에서 成熱雌山羊은 1.7개, 未成熱雌山羊은 8.0개로 未成熱雌山羊이 成熱雌山羊보다 生植腺剌載호르몬 처리에 더욱 민감한 반응을 보였다. 3. PMSG와 HCG 처리구에서 排卵點은 成熱雌山羊은 7.4개, 未成熱雌山羊은 3.9개였으며, 採卵率은 각각 57%와 51%였다.

구연발표 : Fibricola seoulensis 에 감염된 마우스소장 미소융모막효소의 활성도

김해련(Hae Ryeon Kim),이진호(Jin Hoo Lee),이효석(Hyo Suk Lee),윤용범(Yong Bum Lee),송인성(In Sung Song),김정룡(Chung Yong Kim),허선(Sun Hu),홍성태(Sung Tae Hong),이순형(Son Hyoung Lee) 대한소화기학회 1987 대한소화기학회 추계학술대회 Vol.1987 No.-

문헌의 식품중 콜레스테롤 함량에 관한 고찰

정해랑,문현경,송범호 한국지질학회 1991 韓國脂質學會誌 Vol.1 No.1

Since the level of blood choledterol known to be one of the major risk factor for the cardiovascular disease and hypertension, there have been many research to lower the level of blood cholesterol. Because it is known that dietary cholesterol is one of the factor affecting the levels of blood cholesterol, the choleaterol content of foods have been used to guide patient, to educate people for the prevention, and also to do research in the area of nutritional epidemiology. In the published literature, there are different levels of cholesterol for the same food, because of different sampling and analysis methods. Because it is necessary to know the range of cholesterol levels for the same food to use properly, the published literatures are reviewed for the cholesterol content of foods. There were many methods for the analysis of cholesterol contents in foods. Presently, enzyme methods and gas chromatography methods are prevailed. Gas choromatograph methods are known to be more reliable and valid method than other methods.

Clinical Follow-up of Conjunctival Malignant Melanoma

( Jung Bum Choi ),( Min Kim ),( Hae Song Park ),( Sang Yeul Lee ) 대한안과학회 2005 Korean Journal of Ophthalmology Vol.19 No.2

Purpose: To investigate the clinical features and course of conjunctival malignant melanoma in Korea. Methods: The medical records of 15 patients, 5 males and 10 females, diagnosed with conjunctival malignant melanoma who had been treated at Severance Hospital from May 1991 to March 2004 were reviewed retrospectively. The clinical parameters of the patients, tumors, and treatment were analyzed for Results: The mean age at the time of diagnosis was 53.4 years (±11.7 years). In all cases, the disease was unilateral and all patients had experienced at least one recurrence. Local lymph node metastasis was found in 3 patients (20%) and the mean time to metastasis was 3.5 years. Systemic metastasis was found in 6 patients (40%) and the mean time to metastasis was 9.3 years. There were 5 cases of tumor-related death (33.3%), 4 of which were attributed to systemic metastasis. The Kaplan-Meier estimates of cumulative survival rate were 90% at 30 months and 56.6% at 70 months. Conclusions: Although conjunctival malignant melanoma is a rare disease, it is life-threatening and complete tumor excision at an early stage is mandatory, as is additional therapy to prevent local recurrence and systemic metastasis.

지상발표 : 만성적인 알콜섭취가 쥐소장에 미치는 영향

김해련(Hae Ryeon Kim),임경욱(Kyoung Wook Yim),이효석(Hyo Suck Lee),윤용범(Young Bum Yoon),송인성(In Sung Song),김정룡(Jung Lyong Kim) 대한소화기학회 1987 대한소화기학회 추계학술대회 Vol.1987 No.-