폐경기 여성에서 호르몬 대치 요법시 병행 투여된 프로제스토젠 투여 방법에 따른 골대사의 생화학적 지표에 미치는 영향

이권해,강선영,임경빈,이해혁,구도형,이석민 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

Purpose : To evaluate the impact of added progestogen on biochemical markers of the bone turnover undergoing hormone replacement therapy in the postmenopausal women. Materials and Methods : There are 71 postmentopausal women who are divided into three groups (Group I, Group II, Group III). Group I(continuous combined)is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 2.5mg, day 1-30), Group II(unopposed estrogen) is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 5mg, day 1-12). And there were measured serum osteocalcin, serum total alkaline phosphatase and urinary deoxypyridinoline excretion before starting hormone replacement therapy and 12 months later. Results : The serum osteocalcin, serum total alkaline phosphatase and urinary deoxypyridinoline excretion significantly decreased after hormone replacement therapy (Group, I, II, III). And there was no significance in decreases in biochemical markers of the bone turnover among three groups. Conclusions : It was concluded that the impact of added progestogen on the biochemical markers of the bone turnover undergoing hormone replaced therapy in postmenopausal women was not significant than nothing added group. Thus we concluded that progestogen was not impact on decreasing on the biochemical markers of the bone turnover in postmenopausal women undergoing hormone replacement therapy.

산업보건관리자를 위한 소음성 난청 예방지침서의 개발

이원철,유경혜,장성실,이세훈,구정완,김현욱,노영만,이경재,김형아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1996 韓國의 産業醫學 Vol.35 No.1

Occupational hearing loss became the leading occupational disease by constioution 56% of all work-related diseases in Korea. However, the prevalance rates showed wide variations among the specific medical examination providers and were very low(0.8-1.4%) compared with those 8.4% in Japan. The sources of these variations was regarded in the preview study as 1) Employee audometric estings were primarily conducted by nurses and nurse-aids who had no formal training for audiometry; 2) althought audiometric testing equipment used by the spedific medical examination providers, it should be periodically calibrated, a significant number of them were not properly calibrated : 3) Initial audiometric testings were conducted at any available spaces in workplace or at the testing room without considering bachground noise level. One of solutions that can be done for sloving surrent noise related problems is to provide a noise related manual for the occupational health managers including doctors, nurses and hyginests. This study was done to provide such a manual. The main core of the manual was hearing conservation program. And the contents of the manual was the same as the main frame of hearing conservation program such as noise survey, provided of the diagram showing the core contents of each factor of the hearing conservation program. Hopefully, this manual will be the references of the standardized performances of the specific medical examination providers.

KAL기 추락에 의한 대량재해의 개인식별

강신몽,이원태,고영창,최상규,김윤희,이홍석,서재관,윤중진,이혜경,최득린,김종열,윤창육,변명식,이장홍 大韓法醫學會 1991 대한법의학회지 Vol.15 No.2

Individual identification is an important part in medicolegal field especially in mass disaster. At July, 27, 1989, KAL KE-803 was crashed on landing at Tripoli International Airport, Liba. The plane was caught in fire and sixty eight Koreans were sacrified. The majority of victims were severely charred and injured. The authors examed all dead bodies and successfully identified all the cases through visual, anthropological, odontological, radiological and pathological methods including fingerprint and blood typing.

공원묘지 유실에 의한 대량재해의 개인식별

강신몽,이한영,윤중진,이원태,김종열,이영석,서재관,최득린,서지석,이혜경 大韓法醫學會 1992 대한법의학회지 Vol.16 No.1

Individual identification of severely decomposed or skeletonized bodies is an important part in medicolegal field. 142 bodies were torn up and carried away by flood in a park cemetry, Kwang-Ju, Kyunggi province, Korea at Sept., 10, 1990. The authors examed the 56 bodies, which were gained, through medical, anthropological, odontological, radiological methods, and superimposition for individual identification. Among them, 41 cases were successfully identified, and remaining 15 cases were not identified because of sever destruction and no adequate information.

암환자의 건강문제 분류를 위한 횡단적 조사연구 : 서울시내 일개 종합병원 중심으로

김조자,이원희,유지수,허혜경,진혜영,최혜경 연세대학교 간호학연구소 1989 간호학 논집 Vol.12 No.1

The impact of cancer on human life has been recognized and the demand for care for the patient with cancer is ever increasing. Yet very little study around these concerns has been reported. The subjects of this study were 388 patients with cancer who were receiving treatment .in the outpatient department of Yonsei University Cancer Center. The study dealt with the health problems experienced while receiving this treatment. The research method used in this study was the structured interview technique using a questionnaire. Data collection was done between Dec. 1. l986 and June 30. 1987. The questionnaire used in this study was a revision of three questionnaires, one developed by D.W. McCaffrey(coping with cancer), one developed by C.A. Morris(self concept as altered by the diagnosis) and one developed by M.J. Yasko(management of symptoms associated with chemotherapy). Content validity was treated with oncologists and oneology nurses & nursing faculty members. The results and recommendation of the study areas follows: 1. Results. 1) Characteristics of the Sample The diagnoses of the subjects were as follow: The most frequent diagnosis was cancer of the stomach(26.5%), followed by breast cancer, lymphoma, rectal / colon cancer and lung cancer. The average age was 48.6 years. There were an equal number of men and women. There were 116(30.4%) subjects who received chemotherapy and surgery for the treatment of their disease of the total number of subjects. 264(69.5%) were treated for less than 1 year, and 116(30.5%) were treated for more than 1 year. The average Length of treatment was 12.7 months. 2) In Summary Health problems were categorized under four areas: physical. emotional, social and economical. The patients with lymphoma and stomach cancer experienced more health problems than any others in this study. According to the age of the patients, those in their 20's complained of physical and emotional problems most frequently and of those in their 30's social-economical concerns were most evident. In female gender. physical and emotional problems were identified more frequently than male patients. And yet male patients indicated greater concern with economic problems than female patients. Regardless of the treatment method or length of treatment health problems in different areas were similar and statistically not significant. However, economic concern was statistically significant(F = 2.52. p< 0.5) in those with receiving a combination of chemotherapy and radiation Marital status and health problems were also statistically significant. That is patients who were divorced, separated or widowed had more physical, psychological and economical problems than those who were married. 2. Recommendations. 1) Since the physical symptoms of nausea / muscle weakness and malnutrition were major health problems, the patient's diet and activity need to be carefully detailed and included in the care plan and further research is needed in order to implement physical, psychological. economical & spiritual interventions. 2) A follow up study should be done using a larger number of subjects and indifferent settings to further validate the health problem checklist for cancer patients.

생쥐 뇌조직 체외배양법을 활용한 향산화제의 향독성효과에 관한 연구

이수현,박정은,김희옥,서혜원,조경혜 서울여자대학교 자연과학연구소 2000 자연과학연구논문집 Vol.12 No.-

In an effort to establish an in vitro model of Parkinson's disease (PD), we prepared slice cultures of midbrain from newborn mouse. The slice section containing substantia nigral region was cultured for 10days. The striatal culture was grown to preserve the distribution of interneurons with minimal contamination of any other brain tissue. Using this explant culture containing both glial cells and nitro-striatal dopamine neurons, the protective effect of antioxidant pineal hormone and melatonin on 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) -induced loss of the dopamine neurons was investigated. MPTP selectively damaged dopaminergic neurons, as indicated by immunoblot and immunohistochemistry for glial fibrillary acidic protein (GFAP) and tyrosine hydroxylase, the marker enzymes for glial and dopaminergic neurons, respectively. Twenty-four-hour treatment of MPTP (50 μM) in the explant culture induced 37% loss of dopaminergic neurons while no apparent damage was observed in glial region. Type B monoamine oxidase (MAO-B) that resides in glial cells, produces free radicals during catecholamine metabolism and also oxidizes MPTP to its active form, MPP+, was activated by 2.2 times after MPTP treatment. Melatonin was able to recover both the dopaminergic neuronal loss and the elevated MAO-B activity level fully to the untreated control level. Similar observation was made bur the co-treatment of vitamin E with MPTP, suggesting the generation of oxygen radical species by MPTP. On behalf of pursuing molecular mechanisms of Parkinsonism, the data illustrate the proposed mechanism of MPTP-induced dopaminergic cell death ; namely, MPP+ that is processed by MAO-B in glial cells is taken up avidly by dopaminergic neurons and causes a toxic effect at least partly, if not mostly, through oxidative stress. The culture system, therefore, can serve as an experimental model of PD in which the putative neuroprotective effects of antioxidants can be investigated. This model is also useful for screening novel drugs and growth factors without a massive sacrifice of animals, and ultimately for developing neuroprotective therapies.

장 지오노의「목신의 삼부작」에 나타난 대지의 테마

이경해 한국 프랑스어문교육학회 1999 프랑스어문교육 Vol.7 No.-

Des son enfance, l'imaginaire de Giono se nourrit par immersion dans l'espace de Haute-Prevence qui l'impressionne par de fecondes contrastes-la cruaute ne prenant sens, pour Giono, que rapportee a leur contraire, la generosite. En hiver ce territoire aride et violente donne une vision tragique et au prontemps l'univers de l'oeuvre gionienne change, puisque des forces secretes travaillent la nature en perpetuelle gestation. Malgre le changement irreversible, c'est avec la terre qu'on peut trouver les vraies richesses selon Giono. Apres la guerre de 1914-1918 qui lui fait decouvrir brutalement la peur et l'absurdite des sacirfices inhumains, ce chantre des grandes forces naturelles propose le retour a la terre comme un moyen de resoudre le tragique de l'apres-guerre. Dans La trilogie de Pan il onus assure fortement que les joies naissent du contact avec une terre pure que ne souille aucune civilisation technique. Et il preconise egalement le retour a la terre et le labeur infatigable sur cette terre, ceci afin de chasser l'ennui qui provoque des mechancetes et de jouir de la joie simple et pure. Mais nous nous demandons si on peut devenir, avec nos bagages remplis de civilisation, un personnage gionien qui embrasse la terre. Sa lecon de vie ne nous semble guere susceptible de se realiser.

용인지역 노인의 식습관 및 영양섭취 실태조사

이경희,박혜련 명지대학교 대학원 1997 대학원논문집 Vol.1 No.-

This study was performed to assess the health and nutritional status of 125 elderly living in the Yongin area, Kyonggi-do. Survey questionnaires including 24-hr dietary recall, food habit, anthropometric measurements were applied as the instruments. The average age of the subjects were 77 for male and 75 for female. Mean value of BMI was 23.2. About 30% of the subjects was overweight, which is over 25 of BMI. Caloric intake and protein intake were about 50% of the Korean RDA. Their diets were inappropriate, showing C: P: F ratio = 75: 15: 10. Female elderly showed higher food habit score than male elderly(p<0.05).

甲狀腺製劑 投與中의 甲狀腺機能動態

李圭寶,孫惠卿,黃基錫 慶北大學校 醫科大學 1982 慶北醫大誌 Vol.23 No.2

1982年 1月부터 1982年 8月사이에 慶北醫大附屬病院 核醫學科에서 甲狀腺製劑(Comthyroid)를 投與받고 있는 患者中 3∼6個月사이에 甲狀腺機能檢査를 比較觀察할 수 있었던 35例를 檢査한 結果 다음과 같은 所見을 얻었다. RAIU檢査는 甲狀腺製劑 投與前에 比하여 6時間値나 24時間値가 모두 有意하게 正常以下로 低下되었으나, 血中 T_3와 T_4 値는 少數例에서 上昇되어있었으나 全體的으로 別 有意한 上昇은 없었다. 臨床的으로 腺腫의 約半數例에서 縮小效果가 있었으며 藥濟服用으로 因한 副作用은 없었다. 甲狀腺腫의 抑制法으로 投與하는 甲狀腺製劑의 效果는 臨床的으로 甲狀腺 hormone의 生體에 對한 影響이나 副作用은 없이 뇌하수체-甲狀腺軸에만 作用하여 甲狀腺機能抑制 또는 腺腫縮小를 招來할 수 있다고 思料된다. In order to evaluate the effects of thyroid hormone preparation upon the thyroid function, authors investigated comparative thyroid function tests including of RAIU, serum T_3, and T_4 before and after Comthyroid therapy from January to August 1982 in 35 cases of nontoxic goiter. RAIU both in 6 hrs and 24 hrs were significantly decreased during medication, whereas serum T_4 and T_3 showed no appreciable change. There was no case of side reaction from the regimen, however size of goiter seemed regressed more or less in more than half of the cases.

정신분열병환자의 뇌량에 대한 신경병리적 고찰 : 확산텐서영상(Diffusion Tensor Image)기법의 적용

이경진,신용욱,하태현,이종민,김인영,김선일,문원진,정은철,박해정,오정은,박지영,강경훈,권기원,권준수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4

Objectives : Diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue. It is particularly useful for evaluating white matter abnormalities. In this paper, we investigated the neuropathology of the corpus callosum in patients with schizophrenia through the new methods, diffusion tensor imaging. Methods : Diffuse tensor imaging was performed in 19 schizophrenic patients and 26 healthy controls. One complementary measure, fractional anisotropy (FA), which is considered to be sensitive indices of axonal integrity, was obtained from regions of interest in the five areas of the corpus callosum. Neuropsychological measurement also underwent for measurement of frontal lobe function in two groups. Results : There were no significant differences of FA in the DTI measures for either the schizophrenic patients compared with controls. FA was significantly decreased in women compared with men. Neuropsychological measurements such as Wisconsin card sorting test were correlated with FA of patients with schizophrenia. Conclusion : FA measures revealed no differences between schizophrenia and controls. The findings suggest that the structural integrity of white matter in patient with schizophrenia was not disrupted. The results are discussed in relation to previous studies reporting positive and negative findings. It is concluded that further studies using DTI in larger samples, improved and standardized methods of data acquisition and analysis are needed.