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c-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-β Type II Receptor
Zuo, W.,Huang, F.,Chiang, Y.,Li, M.,Du, J.,Ding, Y.,Zhang, T.,Lee, H.,Jeong, L.,Chen, Y.,Deng, H.,Feng, X.H.,Luo, S.,Gao, C.,Chen, Y.G. Cell Press 2013 Molecular cell Vol.49 No.3
Transforming growth factor β (TGF-β) is a potent antiproliferative factor in multiple types of cells. Deregulation of TGF-β signaling is associated with the development of many cancers, including leukemia, though the molecular mechanisms are largely unclear. Here, we show that Casitas B-lineage lymphoma (c-Cbl), a known proto-oncogene encoding an ubiquitin E3 ligase, promotes TGF-β signaling by neddylating and stabilizing the type II receptor (TβRII). Knockout of c-Cbl decreases the TβRII protein level and desensitizes hematopoietic stem or progenitor cells to TGF-β stimulation, while c-Cbl overexpression stabilizes TβRII and sensitizes leukemia cells to TGF-β. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TβRII at Lys556 and Lys567. Neddylation of TβRII promotes its endocytosis to EEA1-positive early endosomes while preventing its endocytosis to caveolin-positive compartments, therefore inhibiting TβRII ubiquitination and degradation. We have also identified a neddylation-activity-defective c-Cbl mutation from leukemia patients, implying a link between aberrant TβRII neddylation and leukemia development.
TEM investigation of hydrogen-implanted and annealed single-crystal SrTiO3
G.K.H. Pang,C.W. Tai,Y. Wang,W.L. Liu,Z.T. Song,S.L. Feng,H.L.W. Chan,C.L. Choy 한국물리학회 2006 Current Applied Physics Vol.6 No.3
In this study, the structural properties of single-crystal SrTiO3 implanted with H+ have been investigated by transmission electronmicrocopy (TEM). The investigation was carried out on an as-implanted sample and samples after annealing at 500.C and 700 .Cfrom the implanted energy similar to the process in the case of silicon. The as-implanted sample shows large out-of-plane strain alsosimilar to the report in silicon. The microcavities are lled with amorphous material as the result of complicated interaction of the defectsduring the annealing.
재래 흑돼지와 중국 재래돈간의 Melanocortin Receptor 1(MC1R) 유전자의 유전자형 분석
이성수,양보석,정진관,고서봉,오성종,양영훈,김규일,이찬동,풍서당 한국동물자원과학회 2001 한국축산학회지 Vol.43 No.1
PCR-RFLP analysis of Melanocortin receptor 1 (MC1R) gene was carried out to investigate the genotype distribution in Korean-Native and Chinese-Native pig breeds(Neijiang, Putian, Wannanhua and Jinhua). Allelic variants of MC1R in pigs were analyzed by digestion of BspH I , AccII and Hha I . Ncijiang. Wannanhua and Jinhua had only MC1R*2 allele which is considered to be typical genotype for Meishan and Large Black. Among 20 Korean-Native Pigs and 5 Putian pigs, 10 and 2 heads had the MC1R*3 allele (*2/3 or 3/3), respectively, which was detected in European pig breeds such as Hampshire, Large White, and Pietrain. The remaining animals possessed the genotype MC1R*2/2, probably reflecting the genetic introgression of MC1R*3 allele into Korean-Native and Putian pig breeds by the crossbreeding for improvement. The alleles MC1R*l and MC1R*4, which are considered to be typical allele for European Wild Boar with wild-type coat color and Duroc with red coat color, respectively, were not detected in pig breeds used in this experiment. These results indicate that the analysis of genotype frequencies of MC1R gene may be a useful tool for the conservation of Korean-Native and Chinese-Native pig breeds.
The Effects of Stress Related Genes on Carcass Traits and Meat Quality in Pigs
H. J. Jin,B. Y. Park,J. C. Park,I. H. Hwang,S. S. Lee,S. H. Yeon,C. D. Kim,C. Y. Cho,Y. K. Kim,K. S. Min,S. T. Feng,Z. D. Li,C. K. Park,C. I. Kim 아세아·태평양축산학회 2006 Animal Bioscience Vol.19 No.2
The current study was conducted to investigate the relationship between stress related gene and meat quality in pigs. A total number of 212 three-way cross bred (Landrace-Yorkshire횞Duroc) and 38 Duroc were sampled from the Korean pig industry to determine genotype requency of porcine stress syndrome (PSS) and heat shock protein 70 kDa (HSP70) genes and their relationship with carcass traits and longissimus meat quality. Screen of HSP70 was performed by the single strand conformation polymorphism (SSCP) technique. Based on the analysis of restriction fragment length polymorphism (RFLP) in ryanodine receptor 1 (RYR1) gene, genetic disorder of PSS was related to a mutation at 18,168th (C to T) of exon 17. There was no significant difference in ultimate meat pH and backfat thickness between HSP70 K1-AA type and -BB type in pure Duroc breed. In Landrace-Yorkshire횞Duroc (L-YxD) cross bred pig, our results indicated that HSP70 derivate type in Duroc had a limited effect on backfat thickness, but L-YxD type had a noticeable linkage with HSP70 K1-AA and K3-AB. This tendency was also observed in hot carcass weight where HSP70 K1-AA and K3-AB resulted in heavier weight with 86.3 kg compared to HSP70 K1-AB and K3-BB of 74.3 kg. Results imply that stress related HSP70 genotype has a potential association with backfat thickness and carcass weight.
Development of the 3.7 GHz LHCD System on HL-2A
B. Lu,M. Huang,H. Zeng,X. Y. Bai,X. H. Mao,Z. H. Lu,J. Liang,Z. H. Kang,M. W. Wang,K. Feng,H. Wang,C. Wang,J. Q. Wang,S. Wei,T. Yao,Y. N. Bu,J. Feng,G. Y. Cheng,S. D. Song,D. H. Xia,J. Rao 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.8
A 2 MW-3.7 GHz lower hybrid current drive (LHCD) system is under development for physicsexperiments on the HL-2A device. The RF Power is generated by four TH2103A klystron amplifiersand propagates in the TE10 mode through WR284 waveguides. The transmission lines with a lengthof 20 m to 30 m are pressurized with 2 bars of nitrogen to decrease the possibility of arcing. Thelauncher, based on the passive-active multi-junction (PAM) concept, has been developed and iscurrently being realized. It was designed for a power spectrum peaked at Nk = 2.75 with goodcoupling properties over a wide range of plasma parameters. The four klystrons are fed by ahigh-voltage power supply (HVPS) based on the pulse step modulation (PSM) concept with a fastswitch-off time of less than ten μs. This system is expected to be in operation within 1 years and willexplore many international thermonuclear experimental reactor (ITER) related LH experiments inthe following years.
Determination of the molar mass of argon from high-precision acoustic comparisons
Feng, X J,Zhang, J T,Moldover, M R,Yang, I,Plimmer, M D,Lin, H BUREAU INTERNATIONAL DES POIDS ET MESURES 2017 METROLOGIA -BERLIN- Vol.54 No.3
<P>This article describes the accurate determination of the molar mass <I>M</I> of a sample of argon gas used for the determination of the Boltzmann constant. The method of one of the authors (Moldover <I>et al</I> 1988 <I>J. Res. Natl. Bur. Stand</I>. <B>93</B> 85–144) uses the ratio of the square speed of sound in the gas under analysis and in a reference sample of known molar mass. A sample of argon that was isotopically-enriched in <SUP>40</SUP>Ar was used as the reference, whose unreactive impurities had been independently measured. The results for three gas samples are in good agreement with determinations by gravimetric mass spectrometry; (〈<I>M</I> <SUB>acoustic</SUB>/<I>M</I> <SUB>mass-spec</SUB>〉 − 1) = (−0.31 ± 0.69) × 10<SUP>−6</SUP>, where the indicated uncertainty is one standard deviation that does not account for the uncertainties from the acoustic and mass-spectroscopy references.</P>
Morphology Changes of E. coli in Ag-HAp Observed by TEM
Kim, T.N.,Feng, Q.L.,Kim, Y.J.,Yim, H.J.,Lim, D.Y.,Hwang, D.S.,Kim, J.W.,Cui, F.Z. The Korean Vacuum Society 1998 Applied Science and Convergence Technology Vol.7 No.1
The antimicrobial effects of HAp and Ag-HAp was observed using periprosthetic infection bacteria such as Pseudomonas Aeruginosa, Staphylococcus Epidermidis, Escherichia coli (DH5$\alpha$). Ag-HAp showed good antimicrobial effects. TEM study of E. coli with and without Ag treatment in HAp was experimented in order to find the mechanism of Ag in antimicrobial effects. It was observed that the shape of Ag-treated E. coli was changed, the cells walls became inhomogeneous. The vaculoes at cytoplasm formed into E. coli and finally it was discovered by EDAX that there were many dark granules which contain the Ag element inside the cells.
Fabrication of blue top-emitting organic light-emitting devices with highly saturated color
Chin H.Chen,Chung-Chun Lee,Andrew T.Hu,Shih Feng Hsu 한국물리학회 2004 Current Applied Physics Vol.4 No.6
Blue top-emitting organic light-emitting devices (TOLEDs) with highly saturated color were developed by microcavity eect. Thedevice structure studied was glass/reective silver/indium-tin oxide (ITO)/organic electroluminescent stack/semi-transparent cathode(calcium/silver). By changing the thicknesses of ITO and organic layers in the microcavity structure device doped withp-bis(p-N,N-di-phenyl-aminostyryl)benzene (DSA-ph), highly saturated color with Commission Internationale de L’Eclairage chromaticitycoordinates (CIEx;y) of (0.14, 0.08) was obtained.