http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김춘희,변찬석,서경희,유은정,이효신,전헌선,최성규 大邱大學校 特殊敎育·再活科學硏究所 2000 特殊敎育硏究 Vol.23 No.1
본 논문은 발달장애유아 언어행동발달 컨텐츠 개발에 요구되는 기초연구로써 연구의 이론적 바탕을 확립하고자 하였다. 연구에 사용된 방법은 문헌조사 방법 및 현장 인터뷰기법을 병행하였다. 본 연구의 주된 목적은 크게 3가지로 구분된다. 첫째, 발달장애유아의 가정 내 교육 욕구를 분석하고자 하였다. 둘째, 발달장애유아의 언어발달 양상을 검토하고자 하였다. 세 번째 목적은 유아의 언어행동발달 컨텐츠 구성의 주요 지침을 설정하고자 하였다. 이상의 연구목적에 따른 연구결과를 요약하면 다음 몇 가지로 제시된다. 1.가정 내 부모-유아간 관계형성이 우선 고려 되어야하고, 이에 따른 상호작용은 발달적 애착형성이 가능한 방향으로 정립되어야한다. 2.발달장애유아의 언어행동발달양상을 검토한 결과에 따르면, Piaget는 언어행동발달에 있어 감각운동기적 환경탐색 기능을 강조하고 있고, 이는 현재까지 중요한 유아 발달의 기저로 정착되었다. 따라서, 발달장애유아의 언어행동발달을 위한 컨텐츠 개발 내용에 있어서도 이러한 기저에 충실함이 합리적이다. 3.발달장애유아들에게는 언어행동 양상의 갈래가 크게 운동장애 및 감각결함으로 나누어질 수 있으므로, 이 두 가지 갈래의 각기 다른 특성이 컨텐츠 구성에서 충분히 고려되어야한다. 4.자폐성과 같은 중증 전반적 발달장애 유아를 위한 언어행동발달 컨텐츠 구성에서 특히 고려해야 할 두 가지 요소는 모방행동기능과 반복단순훈련기능 향상으로 결론지을 수 있다. This article planed to establish the theoretical foundations of the research as a basic study needed for developing the contents of verbal(language) behavior development for the infants with developmental disabilities. The methods used in the study was previous literature researches and interviews with subjects. The purposes of the study were divided into three parts. First, it was to analyze the educational needs of the infants with developmental disabilities in home settings. Second, it was to review and discover the language patterns of the infants with developmental disabilities. The third purpose was to devise the major guidelines of their language development's contents. The results of the study were described as the followings. 1.The relationships between the infants with developmental disabilities and their parents and their interactions should move to build the developmental attachments between them. 2.According to the literature findings of their language development patterns, Piaget concentrated on the functions of sensory motor environmental exploring in the language behavior development. The functions have been settled down into the important foundation for the infants' development. Thus, it was resonable that the content's development of the language behaviors for the infants with developmental disabilities should based on the function addressed by Piaget. 3.The language behaviors' patterns of the infants with developmental disabilities generally were classified into motor disabilities and sensory defect(deficiency). Therefore, the two factors should be considered for the constructions of the contents. 4.Constructing the contents of the language behavior developments for the infants with severely pervasive developmental disabilities such as autism, the improvements of two functions, imitative behavior and repetitive simple training should be considered.
마우스 대장암 모델 구축 및 항암제 활성 평가를 위한 예비 연구
김예솔,강봉석,이상은,이은주,이경록,정상헌,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-
Abstract – Aberrant crypt foci (ACF) are early imorphological changes observed in rodents after administration of colon-specific carcinogen such as azoxymethane (AOM). ACF are considered to be putative preneoplastic lesions and are widely used as a surrogate biomarker to rapidly evaluate chemopreventive potential of compounds. The size of colorectal cancer was evaluated after administration of three anticancer drugs, 1 parent drug and 2 prodrugs. The body weights of mice were measured daily and considered as a surrogate for evaluation of general wellbeing. Colons were removed, cut along the longitudinal axis and flushed with phosphate-buffered saline. Each colon was cut into three equal lengths and fixed flat between filter papers. The fixed colon sections were stained with methylene blue. The number of ACF per colon, the number of aberrant crypts observed in each focus and the location of each focus were recorded. After single administration of AOM and multiple doses of anticancer drugs, no significant changes in the body weights of the mice was observed which was recorded for 52 days. However, an expected ACF was not observed in any treated groups. These findings suggest the induction of ACF in mice requires the promotion by dextran sulfate sodium as well as the initiation by AOM.
Hardware-in-the-loop Simulation Method for a Wind Farm Controller Using Real Time Digital Simulator
Kim, Gyeong-Hun,Kim, Jong-Yul,Jeon, Jin-Hong,Kim, Seul-Ki,Kim, Eung-Sang,Lee, Ju-Han,Park, Minwon,Yu, In-Keun The Korean Institute of Electrical Engineers 2014 Journal of Electrical Engineering & Technology Vol.9 No.5
A hardware-in-the-loop simulation (HILS) method for a wind farm controller using a real time digital simulator (RTDS) is presented, and performance of the wind farm controller is analyzed. A 100 MW wind farm which includes 5 MW wind power generation systems (WPGS) is modeled and analyzed in RSCAD/RTDS. The wind farm controller is implemented by using a computer, which is connected to the RTDS through transmission control protocol/internet protocol (TCP/IP). The HILS results show the active power and power factor of the wind farm, which are controlled by the wind farm controller. The proposed HILS method in this paper can be effectively utilized to validate and test a wind farm controller under the environment in practice without a real wind farm.
Hardware-in-the-loop Simulation Method for a Wind Farm Controller Using Real Time Digital Simulator
Gyeong-Hun Kim,Jong-Yul Kim,Jin-Hong Jeon,Seul-Ki Kim,Eung-Sang Kim,Ju-Han Lee,Minwon Park,In-Keun Yu 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.5
A hardware-in-the-loop simulation (HILS) method for a wind farm controller using a real time digital simulator (RTDS) is presented, and performance of the wind farm controller is analyzed. A 100 MW wind farm which includes 5 MW wind power generation systems (WPGS) is modeled and analyzed in RSCAD/RTDS. The wind farm controller is implemented by using a computer, which is connected to the RTDS through transmission control protocol/internet protocol (TCP/IP). The HILS results show the active power and power factor of the wind farm, which are controlled by the wind farm controller. The proposed HILS method in this paper can be effectively utilized to validate and test a wind farm controller under the environment in practice without a real wind farm.
Real time simulation and analysis techniques for Jeju power system using RTDS
김경훈(Gyeong-Hun Kim),김진근(Jin-Guen Kim),이효근(Hyo-Guen Lee),김남원(Namwon Kim),황철상(ChulSang Hwang),김상용(Sang-Yong Kim),서효룡(Hyo-Rong Seo),배형택(Hyeong-Teak Bae),박정도(Jung-Do Park),이동영(Dong-Young Yi),이상진(Sangjin L 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.7
A new high voltage direct current (HVDC) system from Jindo-to-Seojeju and 80 ㎿ wind farms will be installed in Jeju-island in the near future. The real time simulation for Jeju power system is needed for analysing newly installed systems in advance. This paper provides real time simulation techniques for Jeju power system using a real time digital simulator (RTDS). Simulation results show the frequency and power output variations under variable wind speed patterns of each wind farm.
A-Rong Kim,Gyeong-Hun Kim,Kwang-Min Kim,Jin-Geun Kim,Dae-Won Kim,Minwon Park,In-Keun Yu,Seok-Ho Kim,Kideok Sim,Ki-Chul Seong IEEE 2010 IEEE transactions on applied superconductivity Vol.20 No.3
<P>The Superconducting Magnetic Energy Storage (SMES) system is a key technology for overcoming the voltage sag, swell, interruption, and frequency fluctuation with the fast response speed of current charge and discharge. A toroidal-type SMES is designed using a 3D CAD program, and the inductance and AC loss characteristic during operation are analysed using Finite Element Method (FEM) program. The toroidal-type magnet consists of 30 double pancake coils (DPC). The single pancake coils (SPC), constituting the double pancake coils, are arranged at an angle of 6° from each other, based on the central axis of the toroidal-type magnet. The conduction cooling method is used for the toroidal-type SMES cooling. To evaluate the characteristics of the over-mega-joule class grid-connected HTS SMES system, the authors implemented a simulation by which the SMES coil could be connected to the Real Time Digital Simulator (RTDS). Using the simulation, users can perform voltage sag and frequency stabilization simulations with a real SMES coil in real time and easily change the capacity of the SMES system as much as they need. The effectiveness of the toroidal-type HTS SMES system is demonstrated through the RTDS-based simulation and the results are briefly discussed.</P>
MS-1020 is a novel small molecule that selectively inhibits JAK3 activity
Kim, Byung-Hak,Oh, Sei-Ryang,Yin, Chang-Hong,Lee, Sangku,Kim, Eun-Ah,Kim, Min-Seok,Sandoval, Claudio,Jayabose, Somasundaram,Bach, Erika A.,Lee, Hyeong-Kyu,Baeg, Gyeong-Hun Blackwell Publishing Ltd 2010 British journal of haematology Vol.148 No.1
<P>Summary</P><P>In order to identify Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling inhibitors, a cell-based high throughput screening was performed using a plant extract library that identified <I>N</I>b-(&agr;-hydroxynaphthoyl)serotonin called MS-1020 as a novel JAK3 inhibitor. MS-1020 potently inhibited persistently-active STAT3 in a cell type-specific manner. Further examination showed that MS-1020 selectively blocked constitutively-active JAK3 and consistently suppressed interleukin-2-induced JAK3/STAT5 signalling but not prolactin-induced JAK2/STAT5 signalling. Furthermore, MS-1020 affected cell viability only in cancer cells harbouring persistently-active JAK3/STATs, and <I>in vitro</I> kinase assays showed MS-1020 binds directly with JAK3, blocking its catalytic activity. Therefore, the present study suggested that this reagent selectively inhibits JAK3 and subsequently leads to a block in STAT signalling. Finally, MS-1020 decreased cell survival by inducing apoptosis via down-regulation of anti-apoptotic gene expression. These results suggest that MS-1020 may have therapeutic potential in the treatment of cancers harbouring aberrant JAK3 signalling.</P>