방사선 치료를 받는 암 환자들의 사회적 지지와 삶의 질과의 관계

정주희,류소연,윤혜은,남택근,오윤경,안현옥,박계남,이영선 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Objective : This study was performed to investigate the relationship between social support and quality of life among cancer patients receiving radiation therapy. Matehals and Methods : The data were collected from 98 patients, who were receiving radiation therapy at two university hospitals located in GwangUJu, used by structured questionnaire. For statistical analyses of the association between quality of life and various characteristics, data were analyzed using t-test, ANOVA, Pearson 's correlation, and multiple regression analysis. Results: 1. There were 56(57.1%) males and 42(42.9%) females. Age ranged from 21 to 82 years. The primary sites of cancer were gastrointestinal tract (24.5%), lung (23.5%), breast (21.4%), and head and neck (11.2%) in order. 2. The mean scores of social, family, and medical support were 4.30 0.58, 4.49 0.78, 4.11 0.65, respectively. The score of quality of life was 5.83 1.63 (range: 1.95 ~ 9.05). 3. An analysis of the association between several factors of patients and quality of life showed that the statistically significant factors were age, the presence of distant metastasis, family support, medical support and social support. 4. As a result of the multiple regression analysis, only social support was significant (β=0.932, P=0.02) with quality of life, but age and presence of distant metastasis were not significant. Conclusion : This suggests that quality of life in cancer patients could be improved by strengthening the social support which consists of family and medical support. Further study would be necessary to evaluate separately several aspects of quality of life among cancer patients.

다양한 트래픽에 대한 여러 가지 LAN의 성능 비교 분석

권오성,정계갑,김준년 중앙대학교정보통신연구소 2002 정보통신연구소논문집 Vol.4 No.1

전기통신의 발전에 따라 여러 가지 랜 프로토콜들이 개발되었고 설치되어왔다. 이제는 설치된 망 위에서 새로운 트래픽에 대한 요구가 생기고 있다. 본 논문은 기존에 설치된 방과 현재 설치되고 있는 망에 대해 다양한 트래픽을 적용하여 그 지연과 접속 지연을 살펴봄으로써 진화하는 트래픽에 잘 적응할 수 있는 프로토콜의 모델을 찾는 과정의 일부를 보여준다. 이더넷과 토큰링과 무선랜의 세 가지 프로토콜에 대해서 모의 실험을 통해 검증하였고, 데이터 트래픽에 대해서는 무선랜이 음성 트래픽에 대해서는 이더넷에 상대적으로 우월한 성능을 보여주었다.

Streptozotocin 유도 당뇨쥐에서의 Phospholipase A₂, Cyclooxygenase 활성과 Thromboxane 및 Prostacyclin합성

양정아,김성옥,최정화,곽오계,이순재,장현욱 영남대학교 약품개발연구소 1998 영남대학교 약품개발연구소 연구업적집 Vol.8 No.-

당뇨병에서의 혈전생성 기전에 관련된 주된 요인을 관찰코져 흰쥐를 4주간 사육한 후 streptozotocin(STZ)으로 당뇨를 유발한 후 6일째에 희생하여 당뇨쥐에 있어서의 phospholipase A₂ 활성변화에 따른 조직의 과산화적 손상과 혈소판 응집능 등의 변화를 관찰한 결과는 다음과 같다. 체중증가는 STZ를 투여한 후에는 STZ 투여군에서 현저하게 감소하였다. 식이섭취에 있어 STZ injection 후, DM군은 16% 증가하였다. 식이효율은 STZ injection 후 DM군은 정상군에 비해 유의적으로 감소하였다. 혈청 중의 총 지질과산화물가는 정상군에 비해 DM군은 2.5배 높았다. HDL 중의 TBARS는 정상군에 비해 DM군은 약 1.6배 정도 높았고 LDL 중의 TBARS는 정상군에 비해 DM군에서 4.8배의 높은 증가를 보였다. 혈소판 phospholipase A₂ 활성은 DM군은 정상군에 비해 42% 증가하였다. 혈소판 cyclooxygenase 활성은 정상군에 비해 DM군이 2배 정도 높은 수준이었다. 혈소판 중의 TXA₂ 농도는 정상군과 비교하여 DM군에서 169%로 현저하게 높았고 대동백 PGI₂의 농도는 정상군에 비해 DM군은 낮은 수준을 보였으며 대동맥 PGI₂와 혈소판 TXA₂의 비는 DM군에서 정상군에 비해 55% 낮았다. 결론적으로 STZ 유발 당뇨쥐에 있어서는 혈청 지질과산화물 수준의 증가와 더불어 phospholipase A₂ 활성이 증가되었으며 따라서 cyclooxygenase가 유도하는 AA cascade 활성화에 의해 TXA₂ 생성증가 및 PGI₂/TXA₂ ratio의 감소가 관찰되었다. 이러한 결과는 당뇨병 질환에서 나타나는 동맥경화증, 심혈관계 질환 등의 여러 혈관계의 병리적 현상들이 당뇨 상태에서의 지질대사 이상으로 인한 지질과산화물의 증가와 그의 독성으로 인한 여러 혈소판 관련 인자들의 활성화와 밀접하게 연관되어 나타나는 것을 시사하는 것이라 하겠다. The relation between lipid peroxidation and thrombotic reaction were investigated in streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley male rats weighing 100±10gm were randomly assigned to normal and STZ-induced diabetic group(DM). Diabetes was experimentally induced by intravenous injection of 55mg/kg of body weight of STZ in citrate buffer(pH 4.3) after 4 weeks feeding of basal diet. Animals were sacrificed at the 6th day of diabetic states. Body weight gains were lower in diabetic group after STZ injection. Serum levels of thiobarbituric acid reacting substances(TBARS) that were markedly increased in DM group compared with of normal group. TBARS levles of HDL and LDL were similar patterns to total TBARS of serum. Activities of platelet phospholipase A₂(PLA₂) were higher in diabetic group than those of normal group. Activities of platelet cyclooxygenase were 106% in DM group than normal group. Platelet thromboxane A₂(TXA₂) formation was increased in DM group than normal group. Production of aortic prostacyclin(PGI₂) was lower in diabetic group than that of normal group. PGI₂/TXA₂ ratios were decreased by 55% in DM groups than those of normal group. The present results indicate that STZ-induced diabetic rats are more sensitive to oxidative stess which leads to acceleration of lipid peroxidation and platelet aggregability. In conclusion, accelerating effect of lipid peroxidation and thrombogenesis in diabetic state is regarded to be resulted from enhancement of PLA₂ activity and arachidonic acid metabolism, inhibition of antiaggregating agent and aortic PGI₂ formation.

과산화수소의 농도와 적용시간이 상아질의 깊이에 따라 레진 수복물의 미세인장결합강도에 미치는 영향

손정룡,이계영,강유미,오영택,이광원,김태균 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.5

본 연구의 목적은 심부 상아질과 치수실 상아질에 H₂O₂를 각기 다른 적용시간과 농도로 적용하였을 때, 레진수복물과의 미세인장결합강도에 미치는 영향을 평가하는 것이다. 준비된 각각의 치아에 전형적인 근관와동을 형성하고 다음과 같이 무작위로 1개의 대조군과, 4개의 실험군으로 나누었다: 1군, 전처리를 시행하지 않았다; 2군, 20% H₂O₂를 20분, 10분, 5분간 적용하였다; 3군, 10% 를 20분, 10분, 5분간 적용하였다; 4군 5% H₂O₂를 20분, 10분, 5분간 적용하였다; 5군, 2.5% H₂O₂를 20분, 10분, 5분간 적용하였다. 위와 같이 처리한 후 와동 내를 Superbond C&B(Sunmedical, Co., Shiga, Japan)로 충전하였다. 각 치아는 증류수에 24시간 저장한 뒤 심부 상아질과 치수실 상아질로 잘라 미세인장결합강도 시험을 시행하였다. 각 군에서 측정된 미세인장결합강도를 3-way ANOVA와 Tukey post hoc test로 통계 처리하였다(p < 0.05). 실험 결과 모든 군에서 심부 상아질(D1)의 미세인장 결합강도가 치수실 상아질(D2)보다 높게 나타났다. 평균 결합강도는 H₂O₂의 농도와 적용 시간이 증가할수록 감소하였다. 통계분석에서 상아질의 깊이, H₂O₂농도와 적용 시간이라는 세 가지 변수간의 교호작용 효과는 없으나(p > 0.05). 상아질의 깊이와 H₂O₂농도 사이, H₂O₂농도와 적용 시간 사이에서는 교호작용 효과가 있었다(p < 0.05). SEM 관찰에서는 H₂O₂의 농도가 증가할수록 상아세관이 좀 더 개방된 양상을 보였다. The purpose of this study was to examine the effect of hydrogen peroxide at different application time and concentrations on the microtensile bond strength of resin restorations to the deep and the pulp chamber dentin. A conventional endodontic access cavity was prepared in each tooth, and then the teeth were randomly divided into 1 control group and 4 experimental groups as follows: Group 1, non treated; Group 2, with 20% Hydrogen peroxide (H₂O₂); Group 3, with 10% H₂O₂; Group 4, with 5% H₂O₂; Group 5, with 2.5% H₂O₂; the teeth of all groups except group 1 were treated for 20, 10, and 5min. The treated teeth were filled using a Superbond C&B (Sun medical Co., Shiga, Japan). Thereafter, the specimens were stored in distilled water at for 24-hours and then sectioned into the deep and the chamber dentin. The microtensile bond strength values of each group were analyzed by 3-way ANOVA and Tukey post hoc test(p < 0.05). In this study, the microtensile bond strength of the deep dentin (D1) was significantly greater than that of the pulp chamber dentin (D2) in the all groups tested. The average of microtensile bond strength was decreased as the concentration and the application time of H₂O₂ were increased. Analysis showed significant correlation effect not only between the depth of the dentin and the concentration of H₂O₂ but also between the concentration of H₂O₂ and the application time(p < 0.05), while no significant difference existed among these three variables(p > 0.05). The higher H₂O₂ concentration, the more opened dentinal tubules under a scanning electron microscope(SEM) examination.

Acid etching of glass-infiltrated zirconia and its biological response

Van Thi Vu,Gye-Jeong Oh2,Kwi-Dug Yun,Hyun-Pil Lim,Ji-Won Kim,Thao Phuong Thi Nguyen,Sang-Won Park 대한치과보철학회 2017 The Journal of Advanced Prosthodontics Vol.9 No.2

PURPOSE. The purpose of this study was to evaluate the influence of acid etching treatment on surface characteristics and biological response of glass-infiltrated zirconia. MATERIALS AND METHODS. A hundred zirconia specimens were divided into four groups depending on surface treatments: untreated zirconia (group Z); acid-etched zirconia (group ZE); glass-infiltrated zirconia (group ZG); and glass-infiltrated and acid-etched zirconia (group ZGE). Surface roughness, surface topography, surface morphology, and Vickers hardness of specimens were evaluated. For biological response test, MC3T3-E1 cell attachment and proliferation on surface of the specimens were examined. The data were statistically analyzed using one-way ANOVA and Tukey’s HSD test at a significance level of 0.05. RESULTS. Group ZGE showed the highest surface roughness (Ra = 1.54 μm) compared with other groups (P < .05). Meanwhile, the hardness of group Z was significantly higher than those of other groups (P < .05). Cell attachment and cell proliferation were significantly higher in group ZGE (P < .05). CONCLUSION. We concluded that effective surface roughness on zirconia could be made by acid etching treatment after glass infiltration. This surface showed significantly enhanced osteoblast cell response.

Analysis of Removal Torque of Injection Molded Zirconia Implants; An Experimental Study on Beagles.

Oh, Gye-Jeong,Ban, Jae-Sam,Lim, Hyun-Pil,Yun, Kwi-Dug,Lee, Kwang-Min,Vang, Mong-Sook,Yang, Hong-So,Kang, Seong-Soo,Shin, Jin-Ho,Kim, Ga-Hyun,Ji, Min-Kyung,Park, Sang-Won,Fisher, John G American Scientific Publishers 2015 Journal of Nanoscience and Nanotechnology Vol.15 No.1

<P>This study compared the removal torque between injection molded zirconia implants and titanium implants with resorbable blast media (RBM) surfaces in beagle humeri. Fifteen screw-shaped implants were classified into 3 groups; titanium implant with RBM surface (Group RT), injection molded zirconia implant (Group Zr) and injection molded zirconia implant with sand-blasted surface (Group ZrS). Implants were inserted into beagle humeri. After 12 weeks, removal torque values were measured. The Zr group has a slightly higher removal torque value than the RT and ZrS groups but there were no significant differences among groups. Zirconia implants shows a similar removal torque to RBM titanium implants. This in vivo study showed injection molded zirconia implants could be an alternative to RBM titanium implants in terms of removal torque.</P>

Surface Characteristics of Bioactive Glass-Infiltrated Zirconia with Different Hydrofluoric Acid Etching Conditions

Oh, Gye-Jeong,Yoon, Ji-Hye,Vu, Van Thi,Ji, Min-Kyung,Kim, Ji-Hyun,Kim, Ji-Won,Yim, Eun-Kyung,Bae, Jung-Chan,Park, Chan,Yun, Kwi-Dug American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.4

<P>The purpose of this study was to examine the surface characteristics of bioactive glass-infiltrated zirconia specimens that underwent different hydrofluoric acid (HF) etching conditions. Specimens were classified into the following six groups: Zirconia, Zirliner, Porcelain, Bioactive glass A1, Bioactive glass A2, and Bioactive glass A3. Zirliner and porcelain were applied to fully sintered zirconia followed by heat treatment. Bioactive glass was infiltrated into presintered zirconia using a spin coating method followed by complete sintering. All the specimens were acid-etched with 10% or 20% HF, and surface roughness was measured using a profiler. The surface roughness of the zirconia group was not affected by the etching time or the concentration of the acid. The roughness of the three bioactive glass groups (A1, A2, and A3) was slightly increased up until 10 minutes of etching. After 1 hour of etching, the roughness was considerably increased. The infiltrated bioactive glass and acid etching did not affect the adhesion and proliferation of osteoblasts. This study confirmed that surface roughness was affected by the infiltration material, etching time, and acid concentration. For implant surfaces, it is expected that the use of etched bioactive glass-infiltrated zirconia with micro-topographies will be similar to that of machined or sand-blasted/acid-etched (SLA) titanium.</P>

Sintering behavior and mechanical properties of zirconia compacts fabricated by uniaxial press forming

Gye-Jeong Oh,Kwi-Dug Yun,Kwang-Min Lee,Hyun-Pil Lim,Sang-Won Park 대한치과보철학회 2010 The Journal of Advanced Prosthodontics Vol.2 No.3

PURPOSE. The purpose of this study was to compare the linear sintering behavior of presintered zirconia blocks of various densities. The mechanical properties of the resulting sintered zirconia blocks were then analyzed. MATERIALS AND METHODS. Three experimental groups of dental zirconia blocks, with a different presintering density each, were designed in the present study. Kavo Everest(R). ZS blanks (Kavo, Biberach, Germany) were used as a control group. The experimental group blocks were fabricated from commercial yttria-stabilized tetragonal zirconia powder (KZ-3YF (SD) Type A, KCM. Corporation, Nagoya, Japan). The biaxial flexural strengths, microhardnesses, and microstructures of the sintered blocks were then investigated. The linear sintering shrinkages of blocks were calculated and compared. RESULTS. Despite their different presintered densities, the sintered blocks of the control and experimental groups showed similar mechanical properties. However, the sintered block had different linear sintering shrinkage rate depending on the density of the presintered block. As the density of the presintered block increased, the linear sintering shrinkage decreased. In the experimental blocks, the three sectioned pieces of each block showed the different linear shrinkage depending on the area. The tops of the experimental blocks showed the lowest linear sintering shrinkage, whereas the bottoms of the experimental blocks showed the highest linear sintering shrinkage. CONCLUSION. Within the limitations of this study, the density difference of the presintered zirconia block did not affect the mechanical properties of the sintered zirconia block, but affected the linear sintering shrinkage of the zirconia block.

Eurotium cristatum ssp.가 발현된 미생물발효차의 특성 분석

정유석(Yu Seok Jeong),박상기(Sang Gi Park),조경환(Kyoung Hwan Cho),김용덕(Yong Duck Kim),황정규(Jeong Gye Hwang),이종국(Jong Gug Lee),강은주(Eun-Ju Kang),오수정(Soo-Jeong Oh),김종철(Jong Cheol Kim) 한국차학회 2015 한국차학회지 Vol.21 No.3

본 연구는 하동녹차연구소에서 분리된 Eurotium cristatum ssp. (KACC93171P)이 발현된 미생물 발효차 (S1, S2)와 중국 제품(S4, S5)의 이화학적 특성 분석을 목적으로 하였다. 실험 결과 총 유리아미노산 함량은 기존 제품과 비교하여 약 8배 이상 높게 측정되었으며, 총 카테킨류 함량은 약 4배 높게 측정되었다. DPPH 소거 활성 측정 결과 최대 28% 가량 높게 측정되었으며, FRAP 활성 측정에 서도 금화균이 발현된 미생물 발효차 시료(S1, S2)에서 최대 30% 높게 측정되었다. 이상의 결과로 보아 발효 및 숙성 기간이 길어짐에 따라서 차에 있는 유효물질들이 줄어든다는 것을 확인할 수 있었으며, 카페인의 경우 모든 샘플에 서 유의성이 없다고 판단된다. Fe +2 킬레이팅 활성과 EGCG 함량과의 유의성은 낮다고 확인되었다. 결과적으로 숙성기간이 긴 미생물발효차의 경우 유리아미노산, 카테킨류, 총 폴리페놀, 플라보노이드, 항산화활성 등 대부분 의 성분들이 감소하는 것을 확인하였다. 따라서 숙성기간이 단축된 미생물발효차 개발을 통하여 차의 유효 성분의 감소를 최소화하며, 차 본연의 풍부한 맛의 보존이 가능하 다. 또한 단일 균주의 증식을 통한 안전성이 확보된 미생물 발효차 제품 생산을 통하여 지역 농가의 재고차 소모와 농가소득 증대를 기대할 수 있을 것으로 판단된다. The high quality Chinese Fuzhuan brick-tea grows mainly a yellow colored fungus, Eurotium sp., which called a golden flowering tea. Eurotium species are the sexual states of Aspergillus species. A few studies have showed that the extracts from microbial fermented teas contain natural antimicrobial components that have an inhibitive effect on several food-borne pathogen and spoilage bacteria. This study examined the physicochemical characteristics of microbial fermented tea (S1 and S2) using Eurotium cristatum ssp. (KACC93171P) compared to Chinese Fuzhuan brick-tea (S4 and S5). The total free amino acids contents of the teas (S1 and S2) were eight times higher than the Chinese Fuzhuan brick-teas and also total catechin contents of the teas were 4 times higher than the Chinese tea's but the amounts of caffeine were similar in all the different samples. The DPPH radical scavenging activity and FRAP reducing power of the teas were increased by up to 28% and 30%, respectively. On the other hand, there is no significance in the Fe +2 -chelating activity and EGCG contents. In conclusion, the health beneficial materials of the microbial fermented tea should be surveyed and characterized in a further study.

[P10-189] The Effects of Dangkwisoosan and Native Copper on TGF-β1 Expression on the Fracture Healing

Gye Yeop Kim,Il Moon Jeong,Eun Jung Kim,Jin Sung Chun,Ki Bok Choi,Ki Cheol Sim,Myung Hwa Oh,Ki Won Nam,Young Eok Kim,Kyoung Yoon Kim 한국식품영양과학회 2006 한국식품영양과학회 학술대회발표집 Vol.2006 No.10