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Effects of chlorantraniliprole on detoxification enzymes activities in Locusta migratoria L.
Guangchun Cao,Miao Jia,Xia Zhao,Lei Wang,Xiongbing Tu,Guangjun Wang,Xiangqun Nong,Zehua Zhang 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.3
The broad insecticide chlorantraniliprole causes death by activating the ryanodine receptor, and its effects on detoxification enzymes limit its proper rotation and mixed use with other pesticides. Therefore, we studied the changes in detoxification enzymes activities of Locusta migratoria L. nymphs induced by chlorantraniliprole. When nymphs of locust were treated with chlorantraniliprole only on the first day, the LC50 was 4.8 μg mL−1, and the activities of esterases (ESTs) and glutathione S-transferases (GSTs) increased, but the activity of multifunction oxidases (MFOs) increased only at 3 day after treatment, although the activities fluctuated over 7 days after treatment. When the nymphs of locust were treated for 7 days, the LC50 was 2.3–3.1 μg mL−1, and similarly the activities of ESTs and GSTs increased while that of MFOs decreased significantly in a concentrationdependent manner. Synergism of triphenylphosphate, piperonyl butoxide, and diethyl maleate with chlorantraniliprole toxicity confirmed the correlation between chlorantraniliprole and changes in ESTs, GSTs, and MFOs activities. Herein, we improved the knowledge about the effects of chlorantraniliprole on these detoxification enzymes of L. migratória. These results clarified the effects of chlorantraniliprole on the activities of ESTs, GSTs, and MFOs in L. migratoria, and will provide insight into its proper rotation and mixed use with other pesticides.
Output SNR Analysis of the LPP-Hough Transform
Xiumei Li,Guoqing Yang,Guangchun Gao 한국전자통신연구원 2013 ETRI Journal Vol.35 No.1
Recently, a new method called the local polynomial periodogram-Hough transform (LHT) was proposed for linear frequency modulated (LFM) signal detection. In this letter, a closed-form expression of the output signal-to-noise ratio is derived for the LHT, showing that the method exhibits a threshold effect for LFM signal detection. Comparisons with the pseudo-Wigner-Hough transform (PWHT) show that the threshold of the LHT is lower (better) than that of the PWHT.
Study on Folding Defect Elimination Method of Track Link Forging Based on Preforming Design
Xiqing Ge,Yanan Yu,Huaze Yu,Guangchun Wang 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.1
A high percentage of folding defects were more easily introduced into the outer area of the sleeve hole during the mass production of track link forgings. In this study, it could be found that the folding defects were induced by the end-surface quality of the billet with the streamline characterization and the points tracking simulation. A defect elimination method based on the preforming design was proposed according to the numerical simulation and the experiment. The outer wall of the sleeve hole in the die cavity was shrunk inwards a certain distance to extrude the surface defects of the billet into the flash during the pre-forging. And then, the original flat shape punching wad of the sleeve hole was designed as an oblate-frustum of a cone shape to compensate the shortage of the material volume. The shrinkage range and the justified height of the oblate-frustum preform were recommended by the numerical simulation. As a result, the experiments showed that the proposed preforming design method completely eliminated the folding defects of the track link forgings.
朱奕璇· ( Zhu Yixuan ),李光春· ( Lee Guangchun ),劉子陽 ( Liu Ziyang ) 한국동양예술학회 2019 동양예술 Vol.43 No.-
본 논문의 연구목적은 국가브랜드 이미지와 제품 디자인 경쟁력이 소비자 구매의향에 대해서 명확히 규명하고자 한 것이다. 소비자의 소비행위는 구매의향과 추천의도를 두 층으로 분류가 되었다. 국가브랜드 이미지와 제품 디자인 경쟁력을 자 변량으로 지정하며 소비자 구매의도와 추천의도를 종속변수로 지정하였다. 본 연구에서 설문조사 방법으로 사용해 SPSS23.0을 통해서 신뢰도분석과 타당성 분석을 실시하였다. AMOS통계페키지를 사용해 구조방정식 모형분석으로 실시하였다. 분석결과를 보면 국가 브랜드 이미지와 제품 디자인경쟁력이 소비자 구매의향과 추천의도에 미치는 영향을 얻었다 本文旨在探討國家品牌形象與産品設計競爭力對消費者購買意愿的影響, 幷將消費者的消費行爲分爲購買意愿與推薦意圖兩個層級, 通過構建以國家品牌形象與産品設計競爭力爲自變量, 消費者購買意愿與推薦意圖爲因變量的模型硏究國家品牌形象與産品設計競爭力分別對于消費者購買意愿、推薦意圖的影響。本硏究運用問卷調査法收集數据, 幷通過SPSS統計軟件進行了信度分析和效度分析, 使用了AMOS進行了構造方程式模型分析。 根据分析結果可以得出, 國家品牌形象與産品設計競爭力對于消費者購買意愿與推薦意圖均有顯著的影響。
Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.