급성 골수성 백혈병 환자에서 관해 유도 항암 화학요법 후 발생한 베르니케 뇌증

황진원,정재현,서광원,최병진,송영진,김종윤,이은지,임홍규,이상민 인제대학교 2009 仁濟醫學 Vol.30 No.-

Wernicke's encephalopathy is characterized by the triad of ocular symptoms, ataxia, and mental confusion and neuropsychiatric condition generally caused by acute thiamine deficiency. Although it is common in the severe alcoholics, several other causes also have been identified, such as total parenteral nutrition (TPN) use, hyperemesis gravidarum, anorexia nervosa, hemodialysis, uremia, and acquired immunodeficiency syndrome(AIDS). Chemotherapy in patient with malignanacy and long term total parenteral nutrition following bone marrow transplantation are related with Wernicke's encephalopathy. A 48-year-old woman had been treated with Daunorubicin and Cytarabine for remission induction chemotherapy of acute myeloblastic leukemia and intravenous hyperalimentation due to persistent hematochezia and ileus caused by infiltration of leukemic cell in terminal ileum. She suddenly complained of diplopia, tremor, and mental confusion at 32th day after chemotherapy and generalized tonic-clonic seizure at 34th day after chemotherapy. The diagnosis of Wernicke's encephalopathy was made with clinical presentations and brain MRI. Brain MR T2-weighted & Flair image revealed a high signal intensity lesions bilaterally at the medial thalamus and peri-acueductal grey matter of the midbrain. The patient was successfully treated with vitamin B1. We presented a case of acute Wernicke's encephalopathy developed after remission induction chemotherapy followed by intravenous hyperalirnentation in a patient with acute myeloblastic leukemia.

골담초의 이소후라본 성분

金光洙,李景道,安丙浚 충남대학교 약학대학 의약품개발연구소 1992 藥學論文集 Vol.8 No.-

Five isoflavones were isolated from the root of Caragana microphylla Lam. and the structures have been identified by means of chemical and physical methods. The isoflavones are 7-hydroxy-4'-methoxyisoflavone(formononetin), formononetin-7-O-β-glucoside(ononin), 7-hydroxy-3', 4'-methylenedioxyisoflavone(pseudobaptigenin), 7-O-β-glucuopyranosyloxy-3'-hydroxy-4'-methoxyi-soflavone(calycosin-7-O-β-gluc-oside) and maackiain.

수축저감제와 혼화재를 병용한 콘크리트의 공학적 특성

金光華,김종,한민철,정평유,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The objective of this paper is to investigate the physical and mechanical properties of concrete incorporating shrinkage reducing admixture(SRA) and mineral admixture(MA) such as fly ash and blast furnace slag powder. According to results, for fresh concrete properties, increase of SRA content leaded to reduce the fluidity and air content sharply. For setting time, use of SRA caused concrete to accelerate setting time, and compared with plain concrete it retarded by incorporating MA. Compressive strength decreased with an increase in SRA content, and when incorporating MA, compared with plain concrete, it shows lower compressive strength in early age but similar or increase by the elapse of age due to the pozzolanic and latent hydration reaction. For drying shrinkage, concrete shows decline tendency with an increase in SRA content due to the relaxation effect at the capillary tension in concrete by SRA. In the scope of this paper, it is found that the use of SRA with 1.0% has optimum effects on the various properties of concrete, and the combinations of SRA and fly ash will ensure the stability for drying shrinkage.

시멘트 제조사 및 W/C 변화에 따른 콘크리트의 초기 강도발현 특성

金光華,裵正烈,김규도,이승훈,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

This study is to investigate the influence of cement manufacturing company and W/C on the properties of fresh concrete, strength of hardened concrete and rebound value of P type Schmidt hammer. According to the result, setting time of concrete is shortened with and increase of W/C, and when cement made in A and B corporation is used in concrete, the final setting time is measured at about 10 hours and 13 hours. Compressive strength increases with elapse of time and decrease of W/C, and concrete using cement made in A corporation shows higher compressive strength and rebound value until 24 hours, but from 3rd day, the contrary tendency is shown. As for the properties of early strength, the strength develop fast with decrease of W/C, and the time when compressive strength of 5MPa is gained and the form can be removed, is about 15, 18, 21 hours and 20, 22, 27 hours at the W/C 40, 45, 50% in concrete using cement made in A and B Co. respectively. The correlativity between compressive strength and the rebound value, which a coefficient of correlation is over 0.97, is very favorable. Therefore this method is effective to estimate the strength of removing the form.

朝鮮人視城中的乾隆皇帝 : 以《熱河日記》爲中心

劉广銘,金英今 中韓人文科學硏究會 2008 한중인문학연구 Vol.24 No.-

박지원 등이 창조한 건륭황제의 형상은 '객관화'됨으로써 동시대와 후세의 조선인들이 건륭황제를 묘사하는 데 있어서 원초적인 경험을 제공해주는 '기본 텍스트'로 작용하여 왔고 앞으로도 장기간에 걸쳐 건륭황제와 그 가족을 해석하는 기틀로 작용하게 될 것이다. 박지원이 묘사한 건륭황제는 조선조시기라는 역사적인 배경에서 이루어진 것인 동시에 박지원은 또한 조선조시기라는 역사적인 배경을 이루는 한 요소이기도 하다. 다시 말하면 사회집단의 상상력과 텍스트 사이의 관계는 전자가 후자를 제약하는 단선적인 영향관계가 아니라 양자가 서로 영향주는 관계, 일종의 교호적인 대화과정에 처해 있으며 부단한 대화과정에서 끊임없이 새로운 의의가 생성되고 새로운 형상이 탄생하게 되는 것이다. The objective image of Emperor Qianlong created by Pak Chi-Won is regarded as the pre-interpretation of the emperor. Such an image not only made the foundation for those Koreans in the same and following periods but also constrained the followers' interpretation of Qianlong and his family for a long time. Though the interpretation of Qianlong by Pak Chi-Won was constrained in the context of Li Dynasty, his interpretation also contributed to the creation of the context. It means the relation between virtual world of the community and text is not that the former one influences and constrains the later one but they interact with each other. They have an iterative dialogue relation. In such iterative dialogues new meanings and new images are continuously created.

할로아세틸시코닌 유도체의 합성 및 항암성 평가 : Synthesis and Evaluation of Antitumor Activity

鄭相國,金光洙,송규용,조훈,안병준 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

The secondary hydroxy group at side chain of shikonin structure was selectively acylated with various haloacetic acids in presence of dicyclohexylcarbodiimide and 4-dimethylaminopyridine to produce haloacetylshikonin derivatives. The cytotoxicity of monohaloacetylshikonin derivatives against L1210 cells increased in the following order: monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖) nonobromoacetylshikonin (ED_50, 0.158㎍/㎖)>monoiodoacetylshikonin (ED_50, 0.173 ㎍/㎖). Introduction of larger halogen atoms decreased the cytotoxic activity, presumably due to steric hinderance. The cytotoxicity of chloroacetylshikonin derivatives was dependent on the number of chlorine atom, thus increasing in the following order : trichloroacetylshikonin (0.032 ㎍/㎖)>dichloroacetylshikonin (0.059 ㎍/㎖)> monochloroacetylshikonin (ED_50, 0.142 ㎍/㎖). Thus, the electron-withdrawing effect seems to be important for the cytotoxicity of chloracetylshikonin derivatives. Consistent with the above, dichloracetylshikonin (T/C, 182%) and trifluoroacetylshikonin (195%) showed higher T/C values than monochloroacetyl-(T/C, 122%), monobromoacetyl-(T/C, 154%) and monoiodoacetylshikonin (T/C, 117%) derivatives. Haloacetylshikonin derivatives showing lower cytotoxic activities against L1210 cells exhibited lower T/C values. It seems that there is a relationship between the cytotoxicity of haloacetylshikonin and their antitumor activity.

수축저감제 혼입률 변화에 따른 콘크리트의 공학적 특성에 관한 연구

한민철,金光華,정규문,정평유,윤성노,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

In this paper, tests are carried out using concrete incorporating shrinkage reducing agent(SR) in order to investigate the engineering properties of concrete. The contents of SR and W/C are varied. According to test results, as for fresh concrete, as SR content increases, slump and air content shows decline tendency, and setting time is accelerated with increase of SR content and decrease of W/C. As for compressive strength, as SR contents increases compressive strength shows to be decreased. As for the effect of SR on drying shrinkage, it shows to be reduced with increase of SR content. This is due to the reduced surface tensile strength of water and tensile strength of capillary pore in concrete.

회수수 안정화제를 사용한 콘크리트의 공학적 특성에 관한 연구

김기정,金光華,이문환,이세현,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

In this study is investigated the engineering properties of concrete using stabilizing agent of recycling water in order to suggest a practical use of recycling water. According to the results. as stabilizing agent is added. fluidity and air content varies slightly with W/C, but does not make a big difference. Bleeding is reduced by adding stabilizing agent, and so it decreases by about 40% at the adding ratio of 0.15%. When stabilizing agent is not added, compressive strength decreases in comparison with plain concrete, but increases by adding stabilizing agent, so it is largest at adding ratio of 0.30%(W/C 30%) and 0.15%(W/C 40, 50%). Length change by drying shrinkage is larger than plain concrete in the case of no adding of stabilizing agent, but decreases by the use of stabilizing agent. Therefore, it is thought that when stabilizing agent is added to recycling water, quality deterioration of concrete is prevented, moreover, quality of concrete can be improved.

트리에탄올아민의 혼입률 변화에 따른 콘크리트의 초기 강도발현 특성

황인성,金光華,김규동,이승훈,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

In this study, the influence of TEA on early strength development of concrete is discussed in order to reduce a construction period in RC structure by early removal of forms. According to the results, as for the properties of fresh concrete, fluidity of concrete shows no difference, and air content increases with an increase of the mixing ratio of TEA. Setting time is shortened upto mixing ratio of 0.025%, but is retarded above the mixing ratio of 0.025%. The time when compressive strength gains 5MPa is fast in about 2 hours in the case of the mixing ratio of 0.05%, but it is retarded above the mixing ratio of 0.05%. The relativity between compressive strength and the rebound value of P-type Schmidt hammer is also favorable at early age, and compressive strength of 5MPa, which the side forms can be removed, is estimated at the rebound value of 23.

국내 레미콘사의 부순모래 사용실태 조사

김기훈,金虎林,金光華,윤기원,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

Crushed sand is made by crushing the rock artificially. With the wide shortage of natural fine aggregates at all regions in Korea. crushed sand has been increasingly consumed as a alternative aggreagtes of natural sand. But there is insufficient information related to the actual situation on the produce. quality and manufacturing company of crushed sand. In this paper. survey is performed in order to know actual consumption situation of crushed sand through ready mixed concrete company in domestic. The remicon companies using crushed sand were estimated with 55%. According to the using method of crushed sand. most remicon company used fine aggregates by mixing natural sand and crushed sand. It is found that natural sand is replaced by crushed sand by about 20~50%. For quality problems in using crushed sand. grain shape. grade and fine particles shall be improved to meet the quality requirement of remicon and wide application. Therefore. it is found that quality improvement of crushed sand is required.