농촌지역 여성고령자의 현미덤벨체조가 체조성, 체력 및 식습관에 미치는 영향

이기철 ( Lee Gi Cheol ),정창주 ( Jeong Chang Ju ),손기수 ( Son Gi Su ),우임수 ( U Im Su ),이원경 ( Lee Won Gyeong ),공무현 ( Gong Mu Hyeon ),이수천 ( Lee Su Cheon ) 한국운동영양학회 2003 Physical Activity and Nutrition (Phys Act Nutr) Vol.7 No.2

The present study evaluated the possibility of dumbbell exercise as to improve the physical fitness and the health starus of old people in rural area. Although eighty seven volunteers of old women (over 64) living in Seonsan, Gumi city were subjected, twenty of them were attended the whole program for 6 months and the data from the twenty was analysed in this study. The results were drawn out from comparison of the body constitutuion, the physical strength, the medical aspectrs, and the questionaires of before and after this program. They showed increased physical fithess tested by grip strength (left), bar gripping reaction time, standing trunk flexibility, on foot standing test through dumbbell exercise for 6 months. Questionaire revealed the betterment of dietary pattem during this program. In the light of in these results, it is possible to conclude that dumbbell exercise had improved the basic physical condition and the health status through the increasement of physical fitness and dietary pattem change. Therefore, dumbbell exercise would be a useful program for the old people in reual area to improved their health status.

Clinical characteristics of green nail syndrome: A retrospective analysis

( Gi-wook Lee ),( Dae-lyong Ha ),( Jin-hwa Son ),( Jung-soo Lee ),( Kihyuk Shin ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Green nail syndrome (GNS) is an infectious disease developing greenish discoloration of the nail with accompanying nail disorder such as onycholysis and paronychia. However the data about its clinical characteristics and treatment response has been limited. Objectives: To investigate the clinical characteristics of green nail syndrome in Korean patients. Methods: We retrospectively reviewed medical records and clinical photos of 80 patients with 96 GNS lesions who diagnosed with GNS in the Pusan National University Hospitals (Busan and Yangsan) from 2009 through 2020. Results: 52 patients (65%) had risk factors for GNS include frequent wet conditions, immunosuppressive conditions, and trauma. Involvement of the thumbnail or great toenail was found in 62 lesions (64.6%). Pseudomonas aeruginosa was detected on 23 nails (48.9%) among 47 nails showing positive bacterial culture, and fungal infection was found on 19 nails (19.7%). Several treatments including bleaching and drying nail, topical antibiotics, topical antifungals, and surgical avulsion were tried. And there were some differences of therapeutic responses according to the selected treatment modalities. Bleaching and drying showed better effect on color changes of nail, while topical antibiotics and antifungal cream showed better effect on preventing spreading. Conclusion: The result of this study could be helpful for dermatologists when encountering patients with greenish nail change.

Systemic Sclerosis Sine Scleroderma

김채기 ( Chae Gi Kim ),류헌모 ( Hun Mo Rhoo ),권중구 ( Joong Goo Kwon ),이창형 ( Chang Hyeong Lee ),송용호 ( Yong Ho Song ),최정윤 ( Jung Yoon Choe ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.3

Systemic sclerosis (SSc) is a generalized connective tissue disorder of unknown etiology. Clinically, there is a broad spectrum of disease ranging from widespread severe skin thickening to skin thickening limited to the distal extremities. In rare cases of systemic sclerosis, no cutaneous change only with internal organ involvement has been reported, which is called `systemic sclerosis sine scleroderma (ssSSc)`. We describe a patient with Raynaud`s phenomenon, who showed intestinal pseudoobstruction as a presenting symptom but did not show any skin change. She had also an esophageal motility disorder, but other organ involvement was not evident. Antinuclear antibody was positive. Her obstruction symptoms were improved by decompression by nasogastric tube and pharmaceutical treatment with erythromycin and octreotide.

가동원전에서 공정모델링을 통한 PID 튜닝 시뮬레이션 방법

민문기(Moon-Gi Min),정창규(Chang-Gyu Jung),이광현(Kwang-Hyun Lee),이재기(Jae-Ki Lee),김희제(Hee-Je Kim) 대한전기학회 2014 전기학회논문지 P Vol.63 No.4

PID(Proportional, Integral, Derivative) controller is the most popular process controllers in nuclear power plants. The optimized parameter setting of the process controller contributes to the stable operation and the efficiency of the operating nuclear power plants. PID parameter setting is tuned when new process control systems are installed or current process control systems are changed. When the nuclear plant is shut down, a lot of PID tuning methods such as the Trial and Error method, Ultimate Oscillation method operation, Ziegler-Nichols method, frequency method are used to tune the PID values. But inadequate PID parameter setting can be the cause of the unstable process of the operating nuclear power plant. Therefore the results of PID parameter setting should be simulated, optimized and finally verified. This paper introduces the simulation method of PID tuning to optimize the PID parameter setting and confirms them of the actual PID controller in the operating nuclear power plants. The simulation method provides the accurate process modeling and optimized PID parameter setting of the multi-loop control process in particular.

CO2 농도 및 기온 상승이 현사시나무의 수분생리 특성에 미치는 영향

이솔지 ( Sol Ji Lee ),한심희 ( Sim Hee Han ),오창영 ( Chang Young Oh ),김기우 ( Ki Woo Kim ),김판기 ( Pan Gi Kim ) 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-

기후변화에 적응력이 높은 조림수종을 탐색하기 위하여 CO2 농도 및 기온 상승이 현사시나무의 수분생리에 미치는 영향을 조사하였다. 현사시나무는 CO2 농도 및 기온이 상승된 조건에서 엽량 및 엽면적이 감소하였고, 섬모의 엽면 피복도가 현격하게 증가하였다. 또한, 기공전도도 및 증산속도는 낮은 값을 유지하였으며, 광도 및 CO2 농도 상승에 따른 변화가 거의 나타나지 않았다. 이로써 처리구의 수분이용효율 및 상태함수율은 대조구에 비해 높은 값을 가질 수 있었다. 이러한 결과로부터 CO2 농도 및 기온 상승된 조건에서 현사시나무는 엽면경계층과 기공저항의 증가로 수분손실을 억제하는 능력이 뛰어남을 알 수 있었다. 현사시나무는 수분스트레스에 대한 높은 가소성과 조직의 형태를 변화시키는 기작으로 기후변화 환경에 적응하고 있는 것으로 사료된다. This study was conducted to investigate the water physiology characters of Populus alba× glandulosa cuttings in response to elevated CO2 concentration and air temperature for selecting tree species adaptive to climate change. The poplars under the elevated treatment showed a decrease in the leaf number and area, compared with those under the ambient condition. Having denser leaf hairs, the poplars under the treatment maintained lower stomatal conductance and slower transpiration rate. These results indicate that increased leaf boundary layer and stomatal resistance of poplars under elevated treatment allowed higher water use efficiency and water retentivity. The phenotypic plasticity of leaves in response to water stress would probably enable the poplars to cope with possible climate change conditions.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

R&D 투자 영향평가 기반 구축 및 시범분석

황석원(Seog-Won, Hwang),오승환(Seung-Hwan, Oh),우청원(Ceung-Won, Woo),장필성(Pil-Seoung, Jang),홍사균(Sa-Gyun, Hong),강희종(Hee-Jong, Kang),최창택(Chang-Taek, Choi),김기환(Gi-Hwan, Kim),이재진(Jae-Jin, Lee),김지훈(Ji-Hoon, Kim) 과학기술정책연구원 2016 정책연구 Vol.- No.-

This study is a late study of “An Exploratory Study on STI policy impact assessment”. In the research of 2015, in principle, it is necessary to evaluate not only R&D investment but also general policies such as various promotion systems, standards and regulations by putting the term “policy impact assessment” in front of it We emphasized the points. However, it is practically very difficultto collect and analyze detailed data of all STI policies. In addition, it is also restricted to allow policy researchers to access data within a certain range. Therefore, this study focuses on the impact assessment of R&D investment, which accounts for the largest percentage of STI policies. In this research, the impact assessment system of R&D investment is analyzed by classifying it into evaluation of economic impact and social impact assessment. Also, the evaluation of economic impact was analyzed separating into a micro viewpoint and a macro viewpoint. First, The analysis of the economic impact assessment of the micro viewpoint relates to how the government’s R&D investment affects enterprises. Specifically, the main analysis target was the employment and investment of companies, the impact on sales and profits. Second, The Analysis for macroeconomic impact assessment on the economy is related to the influence of government’s R&D investment such as national economic growth, employment etc. We also analyzed the spillover effect by industry according to R&D investment. Third, The social impact assessment is to analyze how R&D investment has impacted technology-based social change. This study is a very difficult attempt. However, we analyzed from the point of view of the consumer considering all social change areas as much as possible. The results of the study are summarized as follows. First, the study of economic impact evaluation shows the effect of R&D investment and it can be used as a basis to improve the efficiency and goal of R&D investment in future sectors such as employment, economic growth and investment. Second, through research on social impact assessment, government R&D investment has focused on specific areas in terms of improving the quality of life and social development of people, and confirmed that most social sectors are neglected. In addition, we proposed policy priorities for specific social change indicators and social sectors and proposed long-term R&D investment strategies. Finally, this study is expected to contribute to the establishment of future strategy of private enterprise through the measurement of social change index, the social influence of private research and development, and the influence of technology shock from abroad.

상피성 암세포주에 대한 녹차 Catechin의 효과

박정현(Jeong Hyun Park),김대중(Dae Joong Kim),한장희(Jang Hee Hahn),김홍태(Hong Tae Kim),정용욱(Yong Wook Jung),성훈기(Hoon Ki Sung),김주영(Joo Young Kim),송인환(In Hwan Song),성언기(Eon Gi Sung),이융창(Yung Chang Lee) 대한해부학회 2001 Anatomy & Cell Biology Vol.34 No.5

Catechin은 녹차에서 추출되는 폴리페놀의 주요성분으로 고혈압 및 동맥경화의 예방효과, 당뇨억제효과, 항산화작용, 항암작용 등에 직접 관여하는 물질이다. 본 연구에서는 태평양에서 제공받은 녹차 catechin을 이용하여 상피성 암세포주인 A549 (폐암)와 EATC (복수암)세포에 투여한 후 처리농도와 시간에 따른 변화를 비교, 관찰함으로써 녹차의 효과와 작용기전을 밝혀내는데 목적이 있었다. 본실험은 A549 세포와 EATC 세포를 배양한 후 녹차 catechin을 1, 10, 100, 500 μg/ml의 농도로 48시간 동안 처리하였고, 광학현미경, 공초점현미경, 전자현미경 등을 이용하여 세포의 구조적 변화를 확인하였으며 MTT분석, 전기영동, 유세포분석기 등을 사용하여 세포 손상정도를 파악하였다. A549 세포에서는 catechin 1 μg/ml와 10 μg/ml 농도에서는 대조군에 비하여 큰 변화를 관찰할 수 없었다. 100 μg/ml catechin을 처리하였을 때 세포내의 검은 과립들의 수가 증가하였고 층판소체의 손상이 나타났다. 세포주기의 장애가 나타나 DNA 합성전기에 있는 세포들의 수가 급격히 증가하였다. 500 μg/ml 농도에서는 층판소체와 사립체의 파괴가 심하게 나타났으며 세포생존율이 감소하였고 세포주기의 장애도 관찰되었다. EATC 세포에서는 catechin의 농도가 A549 세포의 경우보다 낮은 농도에서도 세포증식 억제 및 세포손상 효과가 나타났다. 10 μg/ml 농도에서도 세포의 위축과 생존율의 감소가 일어났으며 전기영동상에 괴사되는 세포들이 파악되었다. 100μg/ml catechin을 처리하였을 때 자연사의 형태학적 관찰, 전기영동, 유세포분석 등에서 자연사 과정에 있는 세포들이 많이 나타났다. 결과적으로 녹차 catechin을 배양한 상피성 암세포에 투여함으로서 세포의 생존율과 증식이 억제되었고 그 과정에서 괴사, 자연사, 세포주기의 장애 등이 관여하는 것으로 생각된다. 그러나 일련의 세포손상과정을 유도하는 데 있어 세포의 종류, 처리 시간, 농도에 따라 다소 차이가 있음을 확인하였다. Catechin is main component of polyphenol extracts from green tea, it is associated with prevention of hypertension and atherosclerosis, anti-diabetic effect, antioxidant, antitumor. The purpose of this research is to investigate the effect and its mechanism of green tea catechin on epithelial cancer cell lines in various concentrations and durations. For this study, epithelial cancer cell lines, A549 (lung cancer), EATC (Ehrlich-Lettre ascites tumor cell) were used. Inverted, light, confocal and electron microscopes were applied to find morphological changes. MTT assay, flowcytometric analysis, gel electrophoresis were used to compare severity of cellular damages to control after exposure to 1, 10, 100 and 500 μg/ml catechin for 48 hours. In the A549 cells, after 1 μg/ml and 10 μg/ml catechin treatments, there was no notable changes. However, exposure to 100 μg/ml catechin induced increase of cytoplasmic granules, destruction of lamellar body, inhibition of cell cycle, especially G0/G1. In the early phase of 500 μg/ml catechin administration, decrease of cell population, severe destruction of lamellar bodies and mitochondria, derangement of cell cycle were shown. In the EATC, such as those effects occurred after exposure to lower concentration of catechin than in that of A549 cells. After exposure of 10 μg/ml catechin, rounded-up cells and necrotic cells were found. Whereas, most of cells were under apoptotic changes-cytoplasmic condensation, nuclear fragmentation, cellular shrinkage, ladder pattern in the electrophoresis, when administrated 100 μg/ml catechin. These results suggested that exposure of catechin induced severe cellular damage and growth inhibition in dose- and time-dependent manner. And we confirmed that these effects of catechin were involved with apoptosis, necrosis and cell cycle arrest and were quite different according to cancer type. Therefore, much more research would be demanded before clinical application of catechin to human cancer therapy and this study would be the basic source for further study of green tea.

급성 백혈병 관해유도요법후 발생한 다발성 비장농양 1예

이홍기,김선운,박경동,이현성,주영돈,손창학 인제대학교 2000 仁濟醫學 Vol.21 No.1

Splenic abscess is a rare illness. Its incidence has ranged from 0.14 to 0.7 % in various autopsies conducted in the US. Even in the most recently published articles, diagnosis was made only in autopsies in 37 % of the cases. While splenic abscess may arise occasionally from contiguous spread of infection or direct trauma to the spleen, usually it develops with hematogenous spread or infection. But, bacterial endocarditis is the most common cause. RUQ pain of abdomen developed in only half of series. Splenomegaly, fever and leucocytosis was also present. When splenic abscesses are being considered in a differential diagnosis, CT scan of the abdomen has been the most sensitive diagnostic tool. Streptococcal species are the most common bacterial isolates from splenic abscesses, S. aureus is the next most common. Salmonella species are seen commonly in patients with sickle cell hemoglobinopathy. Because of the high mortality related for splenic abscess, the treatment of choice is splenectomy with adjunctive antibiotics. However, percutaneous drainage has been successful alternative. We reported a 19-years old female patient who had splenic abscess after remission induction chemotherapy of acute leukemia, successfully treated with splenectomy.

Furosemide와 Cephapirin의 相互作用에 관한 硏究

李淇範,鄭址昌,高啓昌,鄭柱浩 慶熙大學校 1988 論文集 Vol.17 No.-

Cephapirin is a semisynthetic cephalosporin antibiotic with an unusually broad antibacterial spectrum, which is stable in beta-lactamase and is poorly absorbed from the gastro-intestinal tract and is given by intramuscular of intravenous injection as the sodium salt. High concentrations of furosemide and cephapirin are excreted in the urine by proximal tubular secretion. In order to investigate the drug-interaction between furosemide and cephapirin, the influences of cephapirin on the diuretic action of furosemide were studied in the rabbits. In comparison of diuretic effects of furosemide alone group with those of furosemide-cephapirin combined group, the furosemide-cephapirin combined group showed significant increase in urine flow and urinary electrolytes amounts. These findings seem to be resulted chiefly from marked inhibition of sodium and chloride reabsorption in the renal tubule without a little alteration of glomerular filtration rate. It is concluded from the result that synergistic effect of cephapirin on diuretic action of furosemide might be due to the competitive inhibition of plasma protein binding with furosemide by cephapirin. It is also postulated that the cephapirin-elimination through the renal tubule may de delayed by the competition between furosemide and cephapirin in renal tubular secretion.