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Current medical treatment of uterine fibroids
( Geum Seon Sohn ),( Sihyun Cho ),( Yong Man Kim ),( Chi-heum Cho ),( Mee-ran Kim ),( Sa Ra Lee ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.2
Uterine fibroids (leiomyomas or myomas), benign monoclonal tumors, are the most common benign tumors in women. Heavy or prolonged menstrual bleeding, abnormal uterine bleeding, resultant anemia, pelvic pain, infertility, and/or recurrent pregnancy loss are generally associated with uterine fibroids. Although curative treatment of this tumor relies on surgical therapies, medical treatments are considered the first-line treatment to preserve fertility and avoid or delay surgery. The aim of this review is to provide available and emerging medical treatment options for symptomatic uterine fibroids. Literature review and consensus of expert opinion. Many uterine fibroids are asymptomatic and require no intervention, although it is advisable to follow-up patients to document stability in size and growth. Fibroid-associated symptoms include heavy menstrual bleeding and pain or pelvic discomfort. The association between infertility and fibroids increases with age. Treatment options for symptomatic uterine fibroids ― include medical, surgical, and radiologically guided interventions. Various medical therapies are now available for women with uterine fibroids, although each therapy has its own advantages and disadvantages. Currently, gonadotrophin-releasing hormone (GnRH) agonists and selective progesterone receptor modulators (SPRMs) are the most effective medical therapies, with the most evidence to support their reduction of fibroid volume and symptomatic improvement in menstrual bleeding. The choice of treatment depends on the patient's personal treatment goals, as well as efficacy and need for repeated interventions.
( Geum Seon Sohn ),( Eui Hyeok Kim ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: Neonatal outcomes in deliveries with labor can be different from ones without labor. The purpose of this study is to investigate the association between emergency delivery with labor and the neonatal morbidity and outcomes. Methods: This was a retrospective observational study of singleton liveborn deliveries by cesarean with gestational ages between 38 and 41 weeks at National Health Insurance Service Ilsan Hospital with electronic medical record data from 2013 to 2017. Neonatal outcomes and morbidities in elective cesarean delivery without labor were compared with ones in emergency cesarean delivery with labor. Results: A total of 225 women who underwent a cesarean deliveries was recruited. Of these, 61 infants was delivered by emergency cesarean, while 164 infants by elective cesarean without labor. Maternal age and gestational age was higher in elective cesarean delivery group. The 1 minute and 5-min APGAR score were higher in the elective cesarean delivery group than emergency cesarean (6.59 vs. 6.18, p = 0.014, 7.70 vs. 8.01, p = 0.019). Compared with elective cesarean, the rate of NICU admission and intubation were higher in emergency cesarean group (39.3% vs. 4.3%, p < 0.001, 0.0% vs. 9.8%, p < 0.001). The rate of 5 minutes APGAR score less than 7 and neonatal length of stay, however, were not different and severe neonatal morbidities such as respiratory distress syndrome and tachypnea of newborn also were very low in both groups and were not different between two groups. Conclusion: Compared with newborns delivered by emergency cesarean deliveries, those delivered by elective cesarean delivery around term without labor have a lower risk of morbidities and better transient outcomes, however, serious respiratory morbidity or overall outcomes was not different between two groups.
Geum Seon Lee,Tae Jin Kang 대한약학회 2021 약학회지 Vol.65 No.1
Our previous study reported that cuttlebone (CB) extract shows wound healing activity and enhances cell migration. In the present study, we examined the anti-inflammatory effect of CB in RAW 264.7 cells activated with lipopolysaccharide (LPS) for induction of inflammation. The expression of inflammatory mediators, including proinflammatory cytokines, was measured using enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR) tests. The results showed that CB suppressed nitric oxide (NO) production in macrophages stimulated with LPS. Production of pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNFα), interleukin (IL)-1β, and IL-6, decreased in LPS-induced RAW 264.7 cells after treatment with CB in a dose-dependent manner. Additionally, gene expression was inhibited by CB in a dose-dependent manner in LPS-stimulated macrophages. Furthermore, CB inhibited nuclear factor kappa B (NF-KB) p65 activation in macrophages activated with LPS. Therefore, these results suggest that CB exerts its anti-inflammatory effects via regulation of the NF-KB signaling pathway.
Stress related activities of Sun-ginseng in SD Rats and ICR Mice
( Geum Seon Lee ),( Blendyl Saguan Tan Lee ),( Mi Kang Kim ),( Kyung Uoo Dong ),( Joo Yun Kim ),( Gu Young Yu ),( Jeong Sup Han ),( Hong Sook Ko ),( Il Ho Park ),( Jae Hoon Cheong ) 한국응용약물학회 2004 Biomolecules & Therapeutics(구 응용약물학회지) Vol.12 No.4
Success and Failure of Surgical Endodontic Treatment in Molar Teeth
Geum, Yun-Seon,Lee, Jang-Ryeol,Kim, Hyeon-Cheol,Lee, Sang-Cheol,Kim, Yeong-Uk Korean Academy of Dental Science 2010 Journal of korean dental science Vol.3 No.2
Despite the latest advancement made in its techniques and devices/apparatuses and the resulting rising expectation in the field of dental surgery, apicoectomy performed in the molar teeth remains a technical challenge and lacks evidence substantiated by long-term follow-up studies. This study sought to investigate the treatment outcomes and post-operative success rate in the root-end resected molar teeth accompanied by a high level of surgical risks due to their close proximity to the mandibular canal and maxillary sinus. A total of 68 patients who received treatment at Livingwell Dental Hospital between 2004 and 2010 and underwent apical surgery in the maxillary or mandibular molar area were enrolled in this study. A total of 160 roots collected from 75 molar teeth were subjected to surgical endodontic treatment and subsequently evaluated clinically as well as radiographically. Based on the results of the study, the clinical success rate was found to be 78.8% in cases involving radiological healing. Likewise, 90.7% of the roots recorded a robust clinical survival rate, but with incomplete healing as shown by radiography. The results indicate that the apical procedure involving molar teeth is a prognosis-friendly method that promises positive outcomes and higher success rate based on long-term follow-up observations.
GO-23 : Chemosensitivity testing based on gene expression profiling in patients with ovarian cancer
( Geum Seon Sohn ),( Hyeong Ju Kim ),( Ji Yun Lee ),( Jinkyoung Kong ),( Ji Hee Choi ),( Hanbyoul Cho ),( Eun Ji Nam ),( Sang Wun Kim ),( Sunghoon Kim ),( Jae Hoon Kim ),( Young Tae Kim ),( Doo Byung 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: To evaluate the association between clinical response of treatment agents and results of chemosensitivity testing in ovarian cancer. 방법: Tissue was obtained from 21 ovarian cancer patients and gene expression was evaluated by quantitative real-time polymerase chain reaction (PCR). Selected gene panel with expression of specific genes in the pathways that are related to drug responses in ovarian cancer were analyzed( AKT, Aurora A, BCRP, CD31, ERCC1, GSTpi, HER2, MDR1, Mitosin, PI3 Kinase, RRM1, Survivin, TOP1, TOP2A, TS, VEGF, VEGFR2, XIAP, P73). Gene expression were matched with therapeutic agent including Platinum, Taxanes, Bevacizumab, Gemcitabine, Topoisomerase I Inhibitors, Topoisomerase II Inhibitors, Cyclophosphamide, Herceptin, and 5-fluorouracil for chemosensitivity. 결과: Chemosensitivity testing revealed sensitivity rate of 66%, 81%, 96%, 56% and 61% for Platinum, Taxanes, Topoisomerase I Inhibitors, Topoisomerase II Inhibitors, and Bevacizumab, respectively. Treatment response rate was 70% (Complete Response: 40%, Partial Response: 30%). Treatment response was not significantly increased in the platinum sensitive patients (p=0.613), and overall response rate did not significantly differ according to the chemosensitivity test. 결론: This study may provide useful information in optimizing individual chemotherapy in the treatment of ovarian cancer.